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136 条记录 (耗时 0.037 秒)

    High-density lipoprotein coated medical devices
    93.
    发明申请
    High-density lipoprotein coated medical devices 有权
    高密度脂蛋白包被的医疗器械

    公开(公告)号：US20050175666A1

    公开(公告)日：2005-08-11

    申请号：US11027822

    申请日：2004-12-29

    申请人： Ni Ding

    发明人： Ni Ding

    IPC分类号： A61K38/17 ,  A61K48/00 ,  A61L31/10 ,  A61L31/16 ,  A61F2/00

    CPC分类号： A61L31/16 ,  A61F2/82 ,  A61K38/1709 ,  A61L31/10 ,  A61L2300/252 ,  A61L2300/416

    摘要： An implantable medical device is disclosed comprising a high-density lipoprotein (HDL), recombinant HDL, high-density lipoprotein mimics (HDLm), or a combination thereof. Method are also disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.

    摘要翻译： 公开了一种植入式医疗装置，其包括高密度脂蛋白（HDL），重组HDL，高密度脂蛋白模拟物（HDLm）或其组合。 还公开了局部和全身给药HDL，重组HDL或HDLm用于预防，治疗或改善血管疾病，疾病或闭塞如再狭窄或易损斑块的方法。

    Method for manufacturing an expandable stent
    94.
    发明授权
    Method for manufacturing an expandable stent 失效
    用于制造可扩张支架的方法

    公开(公告)号：US06249952B1

    公开(公告)日：2001-06-26

    申请号：US09264550

    申请日：1999-03-08

    申请人： Ni Ding

    发明人： Ni Ding

    IPC分类号： B23P1904

    CPC分类号： A61F2/90 ,  A61F2/0077 ,  A61L31/084 ,  A61L31/10 ,  Y10T29/49888 ,  Y10T29/49982 ,  Y10T29/49986

    摘要： A method of making a balloon expandable braided stent with a restraint to initially prevent self-expansion and the resulting product. Multiple strands of a resilient metal or plastic are braided to form a tubular configuration of a predetermined outside diameter which assumes a lesser diameter when the tubular stent is longitudinally stretched. When in its stretched condition, it is coated with a polymeric material which is then cross-linked to effectively “freeze” the intersections of the braided structure holding it in its reduced diameter configuration. The tubular stent is designed to be placed within a body vessel using a balloon stent delivery catheter. When the balloon surrounded by the braided wire stent is inflated, the stent expands initially to an extent to break the bonds of plastic material between the intersections of the strands, thereby permitting self-expansion to take place. The coating may also comprise a hydrogel or an elastomeric impregnated with the water soluble particles which softens and/or deteriorates upon exposure to an aqueous media, such as blood.

    摘要翻译： 制造具有约束力的球囊可扩张编织支架的方法，以最初防止自膨胀和所得产品。 编织弹性金属或塑料的多股线以形成具有预定外径的管状构造，当管状支架纵向拉伸时呈现较小的直径。 当处于拉伸状态时，其被涂覆有聚合材料，然后将其交联以有效地“冻结”其缩小直径构型的编织结构的交叉点。 管状支架被设计成使用球囊支架输送导管放置在体内容器内。 当由编织线支架包围的气囊膨胀时，支架首先膨胀到一定程度，以破坏在股线的交叉点之间的塑性材料的接合，从而允许发生自膨胀。 涂层还可以包含水凝胶或浸渍有水溶性颗粒的弹性体，其在暴露于含水介质如血液时会软化和/或劣化。

    Method of applying drug-release coatings
    96.
    发明授权
    Method of applying drug-release coatings 失效
    使用药物释放涂层的方法

    公开(公告)号：US5980972A

    公开(公告)日：1999-11-09

    申请号：US935371

    申请日：1997-09-22

    申请人： Ni Ding

    发明人： Ni Ding

    IPC分类号： A61M31/00 ,  A61F2/00 ,  A61F2/82 ,  A61K47/48 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61L33/00 ,  B05D1/34 ,  A61L27/00 ,  B05D1/02 ,  B05D1/18

    CPC分类号： A61L33/0011 ,  A61K47/48992 ,  A61L31/047 ,  A61L31/10 ,  A61L31/16 ,  A61F2/82 ,  A61F2250/0067 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/02 ,  B05B13/0442

    摘要： The invention is directed to a method of applying drug-release coatings whereby a polymer can be dissolved in a first solvent (solvent A) to form a polymer system and a drug can be dissolved or suspended in a second solvent (solvent B) to form a drug system. The coating or layer of coating so formed comprises a substantially uniform combination of the drug and polymer. Solvent B can be the same as or different than solvent A. The coating can be applied on a stent body by separately spraying or dipping the polymer system and the drug system onto the devices. The coating can be accomplished by either applying the polymer and drug systems sequentially or simultaneously. In certain embodiments, a drug can be suspended in solvent B. In some cases, three or more systems can be utilized. For instance, a third system containing pure solvent A or B can smooth the coating surface, if the solvent of the third spraying system is compatible with the polymer matrix.

    摘要翻译： 本发明涉及一种施用药物释放涂层的方法，其中聚合物可以溶解在第一溶剂（溶剂A）中以形成聚合物体系，并且药物可以溶解或悬浮在第二溶剂（溶剂B）中以形成 一个药物系统。 如此形成的涂层或涂层包括药物和聚合物的基本均匀的组合。 溶剂B可以与溶剂A相同或不同。涂层可以通过将聚合物体系和药物系统分别喷涂或浸渍到装置上而施加在支架体上。 可以通过依次或同时施用聚合物和药物体系来实现涂层。 在某些实施方案中，药物可以悬浮在溶剂B中。在一些情况下，可以使用三种或更多种系统。 例如，如果第三喷射系统的溶剂与聚合物基质相容，则含有纯溶剂A或B的第三体系可平滑涂层表面。

    Drug-releasing coatings for medical devices
    97.
    发明授权
    Drug-releasing coatings for medical devices 失效

    公开(公告)号：US5879697A

    公开(公告)日：1999-03-09

    申请号：US841747

    申请日：1997-04-30

    申请人： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    发明人： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    IPC分类号： A61F2/82 ,  A61L27/34 ,  A61L27/50 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61F13/00

    CPC分类号： A61L27/50 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/258 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2300/802

    摘要： The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the surface of medical devices through a reservoir concept. Specifically, the coating comprises at least two layers: an outer layer containing at least one drug-ionic surfactant complex overlying a reservoir layer containing a polymer and the drug which is substantially free of an ionic surfactant. Upon exposure to body tissue of a medical device covered with such coating, the ionically bound drug in the outer layer is released into body fluid or tissue. Following release of such bound drug, the ionic surfactant binding sites in the outer layer are left vacant. To maintain the pharmacological activity after delivery of the ionically bound drug, additional amounts of the drug are embedded or incorporated in the reservoir layer in a manner which allows the drug, which is substantially free of ionic surfactants, to complex with the vacant binding sites of the ionic surfactant of the outer layer. As a result, the surface of the medical device is enriched with the drug to provide sustained pharmacological activity to prevent the adverse reaction due to the presence of the medical device. The invention is further directed to medical devices with stabilized drug-releasing coatings. The coatings are stabilized by exposure to a low energy, relatively non-penetrating energy source, e.g., gas plasma or an electron beam energy source.

    Process for hydrophilicization of hydrophobic polymers
    98.
    发明授权
    Process for hydrophilicization of hydrophobic polymers 失效
    疏水聚合物亲水化方法

    公开(公告)号：US5849368A

    公开(公告)日：1998-12-15

    申请号：US851052

    申请日：1997-05-05

    申请人： Fritz Hostettler ,  Michael N. Helmus ,  Ni Ding

    发明人： Fritz Hostettler ,  Michael N. Helmus ,  Ni Ding

    IPC分类号： A61L29/00 ,  A61L31/00 ,  C08F8/06 ,  C08F8/30 ,  C08J3/28 ,  C08J7/00 ,  C08J7/04 ,  C08J7/12 ,  B05D3/00 ,  C23C16/00 ,  H05H1/00

    CPC分类号： C08J7/123 ,  C08J7/04 ,  C08J7/047 ,  C08J7/12 ,  C08J2315/00 ,  C08J2475/00

    摘要： A process for rendering the surfaces of polymeric plastic or rubber materials, which are intrinsically non-polar or only slightly polar, and hydrophobic, polar or more polar, and hydrophilic, so that amine-containing functional groups, and ultimately, a durable tenaciously adhering, slippery polyurethane or polyurethane-urea hydrogel coating may subsequently be applied to the polymer surface, is disclosed. The process involves dual plasma-treatment of a polymeric plastic or rubber substrate material; the first treatment being with an oxygen-containing plasma gas, to affix hydroxyl, carboxyl and carbonyl groups to the substrate surface, thereby rendering the surface more polar and activated; and the second treatment being with a nitrogen-containing plasma gas, to affix amine and amino groups to the substrate surface to make it more hydrophilic and reactive toward terminal isocyanate groups of a polyurethane or polyurethane/urea prepolymer adduct intermediate tie-coat which is subsequently applied to the substrate surface and then converted to a tenaciously adhering, slippery hydrogel coating. The process is especially suited to the hydrophilicization of intrinsically non-polar and hydrophobic polymeric plastic materials, such as polyethylenes, nylons-11 and nylons-12.

    摘要翻译： 使本体非极性或仅极微小的聚合物塑料或橡胶材料表面的方法，以及疏水，极性或更极性和亲水性的方法，使得含胺官能团，最终持久坚固地粘附 ，可以随后将湿滑的聚氨酯或聚氨酯 - 尿素水凝胶涂层施加到聚合物表面。 该方法涉及聚合物塑料或橡胶基材材料的双等离子体处理; 用含氧等离子体气体进行第一次处理，将羟基，羧基和羰基粘合到基材表面，从而使表面更加极性和活化; 并且第二次处理是用含氮等离子体气体，以将胺和氨基固定在基材表面上，使其对聚氨酯或聚氨酯/脲预聚物加合物中间粘结层的末端异氰酸酯基团更亲水并具有反应性 施加到基材表面，然后转化成坚固粘附，滑滑的水凝胶涂层。 该方法特别适用于本征非极性和疏水性聚合物塑料材料如聚乙烯，尼龙-11和尼龙-12的亲水化。

    Methacrylate copolymers for medical devices
    100.
    发明授权
    Methacrylate copolymers for medical devices 有权
    用于医疗器械的甲基丙烯酸酯共聚物

    公开(公告)号：US09011831B2

    公开(公告)日：2015-04-21

    申请号：US10957265

    申请日：2004-09-30

    申请人： Ni Ding

    发明人： Ni Ding

    IPC分类号： A61K31/74 ,  A61F2/00 ,  A61L31/16 ,  A61L31/10

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/222 ,  A61L2300/254 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/606 ,  A61L2420/06 ,  C08L33/12

    摘要： A polymer of hydrophobic monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains the polymer and another biocompatible polymer. The polymer or polymer blend and optionally a biobeneficial material and/or a bioactive agent can form a coating on an implantable device such as a drug delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    摘要翻译： 提供疏水单体和亲水单体的聚合物。 还提供了含有聚合物和另一种生物相容性聚合物的聚合物共混物。 聚合物或聚合物共混物和任选的生物有益材料和/或生物活性剂可以在可植入装置如药物递送支架上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，卵圆孔未闭，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。