公开(公告)号：US12209206B2

公开(公告)日：2025-01-28

申请号：US18814146

申请日：2024-08-23

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Phillip B. Messersmith ,  Subhajit Pal ,  Kelsey G. Defrates ,  Jisoo Shin

IPC: C09J181/04 ,  A61L24/04 ,  C08G75/14 ,  C08G75/26

Abstract: Adhesive compositions for medical and non-medical uses are provided. The adhesive compositions can include cyclic disulfide monomers, oligomers of reactions between the cyclic disulfides, polymers of the cyclic disulfides, solid articles formed formed from the polymers, and any combination thereof. Methods of making, using, and recycling the adhesive compositions are provided, including use of the adhesive compositions on a variety of substrates that include biological tissue; biomaterials, including synthetics and natural such as bone, wood, and cellulosics; metals and alloys; polymers, plastics, and rubbers; ceramics; composites; and, any combination of these materials. The adhesives can adhere to substrates in a variety of environmental conditions that include ambient atmospheric conditions, wet conditions that include adhering materials underwater, and in a wide variety of temperatures and pressures, such as those temperatures and pressures found in medical environments, including in living tissue, as well as many residential, commercial, industrial, and manufacturing environments.

公开(公告)号：US12201978B2

公开(公告)日：2025-01-21

申请号：US17412841

申请日：2021-08-26

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ahmed Zobi ,  Justin Stovner ,  Hugo Salas ,  David Duarte ,  Jered Haun ,  Alan Widgerow ,  Derek Banyard

IPC: B01L3/00 ,  B01L9/00 ,  B04B5/04 ,  B04B9/10 ,  G01N35/00 ,  G01N35/04

Abstract: Provided herein are devices and methods of processing a sample that include, in several embodiments, rotating one or more microfluidic chips that are mounted on a support plate using a motor driven rotational chuck. By spinning one or more of the microfluidic chips about a common center of rotation in a controlled manner, high flow rates (and high shear forces) are imparted to the sample in a controlled manner. Each microfluidic chip can be rotated 180° on the support plate so that the sample can be run back-and-forth through the microfluidic devices. Because the support plate can be driven at relatively high RPMs, high flow rates are generated within the microfluidic chips. This increases the shear forces on the sample and also decreases the processing time involved as the sample can quickly pass through the shear-inducing features of the microfluidic chip(s).

公开(公告)号：US12201945B2

公开(公告)日：2025-01-21

申请号：US18204702

申请日：2023-06-01

Applicant: The Regents of the University of California

Inventor： Shuvo Roy

IPC: B01D63/08 ,  A61M1/16 ,  A61M1/36 ,  B01D61/24 ,  B01D61/28 ,  B01D71/02

Abstract: Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

公开(公告)号：US12201833B2

公开(公告)日：2025-01-21

申请号：US18142318

申请日：2023-05-02

Applicant: The Regents of The University of California

Inventor： Victor Reggie Edgerton ,  Yury P. Gerasimenko ,  Parag Gad ,  Nicholas A. Terrafranca

IPC: A61N1/36 ,  A61N1/04 ,  A61N1/06

Abstract: A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and/or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and/or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal. The second electrode is in communication with the first electrode through a hardwire or wireless connection.

公开(公告)号：US12201655B2

公开(公告)日：2025-01-21

申请号：US17220308

申请日：2021-04-01

Applicant: The Regents of the University of California

Inventor： Teruaki Nakatsuji ,  Richard L. Gallo

IPC: A61K35/741 ,  A61K9/00 ,  A61K9/06 ,  A61K9/14 ,  A61K35/00 ,  A61K35/744 ,  A61K38/16 ,  A61K38/17 ,  A61P17/00 ,  A61P31/04 ,  C07K14/31

Abstract: Methods and compositions comprising hogocidin peptides (SH-lantibiotics), derivatives and variants are provided. Also provided are methods and compositions comprising probiotic compositions utilizing strains of S. hominis and S. epidermidis that produce hogocidin, hogocidin-like peptides, or other inhibitors of skin pathogens. Methods of treatment for microbial skin infections and atopic dermatitis are also provided.

公开(公告)号：US12201598B2

公开(公告)日：2025-01-21

申请号：US18474108

申请日：2023-09-25

Applicant: The Regents of the University of California

Inventor： Nisarg Shah ,  David A. McBride ,  Nunzio Bottini

IPC: A61K31/203 ,  A61K9/00 ,  A61K9/50 ,  A61P19/02

Abstract: Described herein are compositions and methods for treating inflammatory arthritic conditions that are effective systemically without causing generalized immunosuppression when administered locally into an inflammatory arthritis-affected joint or a draining lymph node of the arthritis-affected joint of a patient.

公开(公告)号：US20250020591A1

公开(公告)日：2025-01-16

申请号：US18818406

申请日：2024-08-28

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Eric D. Diebold ,  Bahram Jalali ,  Brandon Buckley

IPC: G01N21/64 ,  G01N21/05 ,  G02B21/00 ,  G02B21/16 ,  G02B27/10 ,  G02F1/11

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

公开(公告)号：US12199245B2

公开(公告)日：2025-01-14

申请号：US16620856

申请日：2018-06-11

Applicant: The Regents of the University of California

Inventor： Ping Liu ,  Byoung-Sun Lee ,  Xing Xing

IPC: H01M10/0585 ,  H01M4/36 ,  H01M4/38 ,  H01M4/40 ,  H01M4/485 ,  H01M4/587 ,  H01M10/052 ,  H01M10/056

Abstract: Compositions, manufacturing processes, articles of manufacture, and structures/batteries for self-forming batteries and self-healing solid electrolytes are disclosed. Example embodiments include a self-forming battery. The battery may include a first electrode material and a second electrode material. Assembly of the two electrode materials may result in a chemical reaction that forms an electrolyte layer between the two electrode materials.

公开(公告)号：US12199238B2

公开(公告)日：2025-01-14

申请号：US17960042

申请日：2022-10-04

Applicant: NanoTech Energy, Inc. ,  The Regents of the University of California

Inventor： Maher F. El-Kady ,  Brian T. McVerry ,  Ethan Rao ,  Richard B. Kaner

IPC: H01M10/0565 ,  H01M4/04 ,  H01M4/131 ,  H01M4/133 ,  H01M4/1391 ,  H01M4/1393 ,  H01M10/0525

Abstract: Provided herein are energy storage devices high energy and power densities, cycle life, and safety. In some embodiments, the energy storage device comprise a non-flammable electrolyte that eliminate and/or reduce fire hazards for improved battery safety, with improved electrode compatibility with electrode materials.

公开(公告)号：US12197232B2

公开(公告)日：2025-01-14

申请号：US17752335

申请日：2022-05-24

Applicant: The Regents of the University of California

Inventor： Stavros Vougioukas ,  Chen Peng ,  Dennis L. Sadowski

IPC: G05D1/00 ,  A01D90/16 ,  G06Q10/0631 ,  G06Q50/02

Abstract: A system, apparatus and method are provided for robotically assisting the harvest of a crop. Instrumented picker carts include sensors for detecting amounts of harvested crop (e.g., fill ratios) of containers carried by the carts, communication modules for communicating their locations and detected crop amounts to a field computer, and components for signaling for robotic service. The field computer predicts when a cart that requests service will have a full container and where it will be located at that time, then decides whether to approve the request. If the request is approved, a robot is assigned and is given (or generates) a path to the cart's predicted location, and begins moving toward the location so as to arrive near (and preferably before) the predicted time. Robots include means for moving (e.g., wheels, motors, steering components, power sources), navigation modules, computing components for controlling their movement, and communication modules.