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91.发明申请METHODS AND COMPOSITIONS FOR ATTENUATING EXON SKIPPING ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSES 审中-公开用于减轻外部逃跑的方法和组合抗病毒转运载体免疫应答公开(公告)号：US20160074372A1
公开(公告)日：2016-03-17
申请号：US14846967
申请日：2015-09-07
IPC分类号： A61K31/436 , A61K48/00 , C12N7/00
CPC分类号： A61K48/00 , A61K9/1271 , A61K9/5115 , A61K9/5153 , A61K31/436 , A61K31/7088 , A61K39/001 , A61K45/06 , A61K47/593 , A61K47/6923 , A61K47/6929 , A61K47/6935 , A61K47/6937 , A61K48/005 , A61K2039/545 , A61K2039/577 , C12N7/00 , C12N15/86 , C12N2710/00041 , C12N2710/10032 , C12N2710/10043 , C12N2740/10041 , C12N2740/15032 , C12N2740/15043 , C12N2740/16043 , C12N2750/14132 , C12N2750/14141 , C12N2750/14143 , G06Q99/00 , A61K2300/00
摘要： Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
摘要翻译： 本文提供了用于施用病毒转移载体和抗原呈递细胞靶向免疫抑制剂的方法和相关组合物。
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92.发明申请METHODS AND COMPOSITIONS FOR TREATMENT WITH SYNTHETIC NANOCARRIERS AND IMMUNE CHECKPOINT INHIBITORS 审中-公开用合成纳米颗粒和免疫检测点抑制剂治疗的方法和组合物公开(公告)号：US20150374815A1
公开(公告)日：2015-12-31
申请号：US14751106
申请日：2015-06-25
IPC分类号： A61K39/385 , C12N7/00 , A61K39/00 , A61K39/39 , A61K39/12
CPC分类号： A61K39/385 , A61K9/0019 , A61K9/5153 , A61K31/7088 , A61K38/00 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K39/39558 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/585 , A61K2039/60 , A61K2039/6093 , C07K16/2827 , C12N7/00 , C12N2710/20034 , Y02A50/386 , Y02A50/388 , Y02A50/401 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/419 , Y02A50/422 , Y02A50/423 , Y02A50/466 , Y02A50/469 , Y02A50/47 , Y02A50/478 , Y02A50/48 , Y02A50/484 , Y02A50/487 , Y02A50/489 , Y02A50/491 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions and immune checkpoint inhibitor compositions and related methods for administration to a subject.
摘要翻译： 公开了用于给予受试者的合成纳米载体组合物和免疫检查点抑制剂组合物和相关方法。
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93.发明申请TOLEROGENIC SYNTHETIC NANOCARRIERS TO REDUCE IMMUNE RESPONSES TO THERAPEUTIC PROTEINS 审中-公开耐多药合成纳米颗粒降低对治疗蛋白质的免疫应答公开(公告)号：US20150335762A1
公开(公告)日：2015-11-26
申请号：US14810427
申请日：2015-07-27
摘要： Disclosed are synthetic nanocarrier compositions, and related methods, comprising therapeutic protein APC presentable antigens and immunosuppressants that provide tolerogenic immune responses specific to therapeutic proteins.
摘要翻译： 公开了合成纳米载体组合物和相关方法，其包括治疗性蛋白质APC可呈递抗原和免疫抑制剂，其提供对治疗性蛋白质特异性的耐受性免疫应答。
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公开(公告)号：US20150328333A1
公开(公告)日：2015-11-19
申请号：US14810418
申请日：2015-07-27
摘要： This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.
摘要翻译： 本发明至少部分涉及包含导致免疫抑制作用的合成纳米载体和免疫抑制剂的组合物。 这样的组合物可进一步包含抗原并提供抗原特异性耐受性免疫应答。
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95.发明申请TOLEROGENIC SYNTHETIC NANOCARRIERS FOR ANTIGEN-SPECIFIC DELETION OF T EFFECTOR CELLS 有权用于抗原特异性删除T效应细胞的耐热合成纳米颗粒公开(公告)号：US20150320884A1
公开(公告)日：2015-11-12
申请号：US14810472
申请日：2015-07-27
IPC分类号： A61K47/48 , A61K38/38 , A61K39/385 , A61K31/436 , G01N33/50 , G01N33/569
摘要： Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering immunosuppressants and MHC Class I-restricted and/or MHC Class II-restricted epitopes that can generate tolerogenic immune responses (e.g., antigen-specific T effector cell deletion).
摘要翻译： 公开了合成纳米载体方法和相关组合物，其包括施用免疫抑制剂和可产生致耐受免疫应答（例如抗原特异性T效应细胞缺失）的MHC I类限制性和/或MHC II类限制性表位。
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96.发明申请TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS 审中-公开具有敏感性释放免疫调节剂的靶向合成纳米颗粒公开(公告)号：US20140242173A1
公开(公告)日：2014-08-28
申请号：US14273099
申请日：2014-05-08
发明人： Charles Zepp , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
IPC分类号： A61K39/385 , A61K39/39
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译： 本发明涉及靶细胞中诸如抗原呈递细胞（APC）的作用位点的合成纳米载体的组合物和相关方法，并且包含以pH敏感的方式从合成纳米载体解离的免疫调节剂。 还公开了与合成纳米载体相关的组合物和方法，其包封以pH敏感方式从合成纳米载体解离的不稳定免疫调节剂。
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公开(公告)号：US20140199340A1
公开(公告)日：2014-07-17
申请号：US14161660
申请日：2014-01-22
发明人： Roberto A. Maldonado
IPC分类号： A61K39/00
CPC分类号： A61K39/385 , A61K9/127 , A61K9/14 , A61K9/51 , A61K9/5115 , A61K9/5146 , A61K9/5153 , A61K31/192 , A61K38/13 , A61K38/1816 , A61K38/38 , A61K39/00 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/36 , A61K47/50 , A61K47/52 , A61K47/544 , A61K47/593 , A61K47/643 , A61K47/69 , A61K47/6923 , A61K47/6929 , A61K47/6937 , A61K2039/5154 , A61K2039/55511 , A61K2039/55555 , A61K2039/577 , B82Y5/00 , B82Y40/00 , G01N33/505 , G01N33/56972 , G01N2333/7051 , G01N2333/70514 , G01N2333/70517 , Y02A50/401 , Y02A50/41 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier methods, and related compositions, comprising B cell and/or MHC Class II-restricted epitopes and immunosuppressants in order to generate tolerogenic immune responses, such as the generation of antigen-specific regulatory B cells.
摘要翻译： 公开了合成纳米载体方法和相关组合物，其包含B细胞和/或MHC II类限制性表位和免疫抑制剂，以产生耐受性免疫应答，例如产生抗原特异性调节性B细胞。
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