公开(公告)号：US20180169032A1

公开(公告)日：2018-06-21

申请号：US15840540

申请日：2017-12-13

Applicant: Surmodics,Inc.

Inventor： Timothy M. Kloke

IPC: A61K9/70 ,  A61L29/16 ,  A61L29/08 ,  A61L31/10 ,  A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61K31/337 ,  A61K31/436 ,  A61K47/34 ,  A61K47/32

CPC classification number: A61K9/7007 ,  A61K31/337 ,  A61K31/436 ,  A61K47/32 ,  A61K47/34 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/08 ,  C08L77/00

Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, a drug delivery coating is included herein having a base polymeric layer, the base polymeric layer including a hydrophilic polyether block amide copolymer and having a hydrophilic surface. The drug delivery coating can further include a therapeutic agent layer forming an exterior surface the drug delivery coating, the therapeutic agent layer contacting the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer including a particulate hydrophobic therapeutic agent and a cationic agent. Other embodiments are also included herein.

公开(公告)号：USD817894S1

公开(公告)日：2018-05-15

申请号：US29581755

申请日：2016-10-21

Applicant: Surmodics, Inc.

Designer： Karl Ganske

公开(公告)号：US09895516B2

公开(公告)日：2018-02-20

申请号：US15227458

申请日：2016-08-03

Applicant: Surmodics, Inc.

Inventor： James Howard Arps ,  Andrew G. Bach

IPC: A61L29/16 ,  A61L29/08 ,  A61L27/54 ,  A61M25/10 ,  A61L29/14 ,  A61K31/337 ,  A61L29/04

CPC classification number: A61M25/1002 ,  A61K31/337 ,  A61L29/041 ,  A61L29/085 ,  A61L29/145 ,  A61L29/148 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/622 ,  A61M25/104 ,  A61M2025/1004 ,  A61M2025/105 ,  C08L3/02

Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.

公开(公告)号：US20170072057A1

公开(公告)日：2017-03-16

申请号：US15357496

申请日：2016-11-21

Applicant: Surmodics, Inc.

Inventor： Joseph Ventura ,  Shannon Wadman ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

IPC: A61K47/34 ,  A61K9/08 ,  A61K31/337

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/337 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/416 ,  A61L2300/63 ,  A61L2400/06 ,  C08L79/02

Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

Abstract translation: 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在更具体的实施方案中，阳离子递送剂包括支链PEI。 还公开了制备递送组合物的方法，以及试剂盒和使用方法。

公开(公告)号：US20160339214A1

公开(公告)日：2016-11-24

申请号：US15227458

申请日：2016-08-03

Applicant: Surmodics, Inc.

Inventor： James Howard Arps ,  Andrew G. Bach

IPC: A61M25/10 ,  A61L29/08 ,  A61L29/16 ,  A61L29/14

CPC classification number: A61M25/1002 ,  A61K31/337 ,  A61L29/041 ,  A61L29/085 ,  A61L29/145 ,  A61L29/148 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/622 ,  A61M25/104 ,  A61M2025/1004 ,  A61M2025/105 ,  C08L3/02

Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.

Abstract translation: 本发明提供具有与含有生物活性剂的微粒和涂层材料相关联的弹性表面的可插入医疗装置。 弹性表面膨胀时，微粒可以释放到受试者身上。

公开(公告)号：US20160271300A1

公开(公告)日：2016-09-22

申请号：US15165650

申请日：2016-05-26

Applicant: SurModics, Inc.

Inventor： David E. Babcock

IPC: A61L29/08 ,  A61L29/14

CPC classification number: A61L29/085 ,  A61L27/34 ,  A61L29/14 ,  A61L31/10 ,  A61L2400/10 ,  A61L2420/06 ,  A61L2420/08 ,  C08L39/06

Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; anda first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

Abstract translation: 包含至少两个光反应性基团的第一交联剂; 设置在第一层上的第二层包含用光反应性基团衍生的聚乙烯吡咯烷酮; 包含至少两个光反应性基团的第二交联剂; 和包含聚丙烯酰胺的聚合物，所述聚合物用至少一种光反应性基团衍生化。 本文还包括其它实施例。

公开(公告)号：US20160256668A1

公开(公告)日：2016-09-08

申请号：US15061234

申请日：2016-03-04

Applicant: SurModics, Inc.

Inventor： Ralph A. Chappa ,  Andrew G. Bach ,  Mark MacGregor

IPC: A61M25/10

CPC classification number: A61M25/1029 ,  A61L29/08 ,  A61M25/1027 ,  A61M2025/1031 ,  A61M2025/105 ,  B05B13/0442

Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.

公开(公告)号：US20160082110A1

公开(公告)日：2016-03-24

申请号：US14955528

申请日：2015-12-01

Applicant: SurModics, Inc.

Inventor： Kevin W. Burton ,  Howard Bowman ,  Danielle Biggs ,  Peter Markland

IPC: A61K47/34 ,  A61M5/19 ,  A61K9/00

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K31/56 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/622 ,  A61M5/19 ,  A61N1/375 ,  A61N1/3968 ,  C08L67/04

Abstract: Described herein are terpolymer compositions, kits comprising the compositions, implant devices comprising the compositions, and methods of making and using same, including point of use methods.

Abstract translation: 本文描述的是三元共聚物组合物，包含该组合物的试剂盒，包含该组合物的植入装置及其制备和使用方法，包括使用方法。

公开(公告)号：US20150196497A1

公开(公告)日：2015-07-16

申请号：US14669571

申请日：2015-03-26

Applicant: SurModics, Inc.

Inventor： Joseph Schmidt McGonigle ,  Aleksey V. Kurdyumov ,  Jeffrey J. Missling ,  Nathan A. Lockwood ,  Kevin W. Burton ,  Beth A. Petersen

IPC: A61K9/70 ,  A61K31/573

CPC classification number: A61K9/7007 ,  A61F2/07 ,  A61F2/82 ,  A61K9/0024 ,  A61K31/573 ,  A61K47/34 ,  A61L29/06 ,  A61L29/14 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L2300/404 ,  A61L2300/406 ,  C08L67/04

Abstract: A biocompatible polymeric controlled release matrix barrier structure for delivery of one or more bioactive agents from an implantable medical device is described. In an embodiment, a biocompatible polymeric controlled release matrix barrier structure is included. The biocompatible polymeric controlled release matrix can include a body structure formed of a compliant material comprising one or more compliant biocompatible polymers and one or more bioactive agents. The body structure can define a central aperture through which a subcutaneous element of an implantable medical device passes. Other embodiments are included herein.

Abstract translation: 描述了用于从可植入医疗装置递送一种或多种生物活性剂的生物相容性聚合物控制释放基质屏障结构。 在一个实施方案中，包括生物相容性聚合物控制释放基质屏障结构。 生物相容性聚合物控制释放基质可以包括由包含一种或多种顺应性生物相容性聚合物和一种或多种生物活性剂的柔顺材料形成的体结构。 身体结构可以限定可植入医疗装置的皮下元件通过的中心孔。 本文还包括其它实施例。

公开(公告)号：US20150017219A1

公开(公告)日：2015-01-15

申请号：US14303309

申请日：2014-06-12

Applicant: SURMODICS, INC.

Inventor： Joram Slager ,  Aleksey V. Kurdyumov ,  Toni M. Heyer

IPC: A61L29/16 ,  C07D498/18

CPC classification number: A61L29/16 ,  A61K9/0019 ,  A61K9/14 ,  A61K31/436 ,  A61L2300/416 ,  C07D498/18 ,  Y10T428/2982

Abstract: The invention provides therapeutic particulates including a macrolide, such as rapamycin, in solid state crystalline form, having a size of 20 μm or less, or 10 μm or less. The particulates are formed in one method by preparing a composition with a macrolide and first (e.g., xylene) and second (e.g., an alcohol, acetone, or acetonitrile) solvents. In the composition a maximum solubility for the macrolide that is greater than a maximum solubility of the macrolide dissolved in either the first or second solvent individually. The first and second solvents are then evaporated from the composition to provide the macrolide particulates. In another method, the particulates can be formed by a method including sonication and stirring/evaporation steps, and the particulates can be obtained from a supersaturated solution, formed during the process. Particulates display desirable low polydispersity, and can be used in therapeutic compositions, or can be associated with an implantable or insertable medical device for the treatment of a subject.

Abstract translation: 本发明提供治疗性微粒，其包括固体状结晶形式的大环内酯如雷帕霉素，其尺寸为20μm或更小或10μm或更小。 通过制备具有大环内酯和第一（例如二甲苯）和第二（例如醇，丙酮或乙腈）溶剂的组合物来形成颗粒。 在组合物中，大环内酯的最大溶解度大于单独溶解在第一或第二溶剂中的大环内酯的最大溶解度。 然后将第一和第二溶剂从组合物中蒸发以提供大环内酯颗粒。 在另一种方法中，颗粒可以通过包括超声处理和搅拌/蒸发步骤的方法形成，并且颗粒可以从在过程中形成的过饱和溶液获得。 颗粒显示出期望的低多分散性，并且可以用于治疗组合物，或者可以与用于治疗受试者的可植入或可插入的医疗装置相关联。