公开(公告)号：US10253193B2

公开(公告)日：2019-04-09

申请号：US15994206

申请日：2018-05-31

申请人： Surmodics, Inc.

发明人： Aleksey V. Kurdyumov ,  Dale G. Swan

IPC分类号： C07F9/145 ,  C09D7/63 ,  A61L17/14 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C07F7/10 ,  C07F9/12 ,  C07F9/40 ,  C08F2/48 ,  C07F7/18 ,  C07F9/06 ,  C08K5/51 ,  C08K5/5419 ,  C08K5/544

摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

公开(公告)号：US09994721B2

公开(公告)日：2018-06-12

申请号：US15283818

申请日：2016-10-03

申请人： Surmodics, Inc.

发明人： Aleksey V. Kurdyumov ,  Dale G. Swan

IPC分类号： C07F7/10 ,  C09D7/12 ,  A61L17/14 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C07F7/18 ,  C07F9/12 ,  C07F9/145 ,  C07F9/40 ,  C08F2/48 ,  C07F9/06 ,  C08K5/51 ,  C08K5/5419 ,  C08K5/544

CPC分类号： C09D7/63 ,  A61L17/145 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/18 ,  A61L2420/02 ,  C07F7/10 ,  C07F7/1804 ,  C07F7/184 ,  C07F9/06 ,  C07F9/12 ,  C07F9/145 ,  C07F9/4025 ,  C07F9/4084 ,  C08F2/48 ,  C08K5/51 ,  C08K5/5419 ,  C08K5/544 ,  C09D7/1233

摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

公开(公告)号：US09993441B2

公开(公告)日：2018-06-12

申请号：US14669571

申请日：2015-03-26

申请人： SurModics, Inc.

发明人： Joseph Schmidt McGonigle ,  Aleksey V. Kurdyumov ,  Jeffrey J. Missling ,  Nathan A. Lockwood ,  Kevin W. Burton ,  Beth A. Petersen

IPC分类号： A61F2/00 ,  A61K9/70 ,  A61K31/573 ,  A61K9/00 ,  A61K47/34 ,  A61L29/06 ,  A61L29/14 ,  A61L29/16 ,  A61L31/04 ,  A61F2/07 ,  A61F2/82 ,  A61L31/10

CPC分类号： A61K9/7007 ,  A61F2/07 ,  A61F2/82 ,  A61K9/0024 ,  A61K31/573 ,  A61K47/34 ,  A61L29/06 ,  A61L29/14 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L2300/404 ,  A61L2300/406 ,  C08L67/04

摘要： A biocompatible polymeric controlled release matrix barrier structure for delivery of one or more bioactive agents from an implantable medical device is described. In an embodiment, a biocompatible polymeric controlled release matrix barrier structure is included. The biocompatible polymeric controlled release matrix can include a body structure formed of a compliant material comprising one or more compliant biocompatible polymers and one or more bioactive agents. The body structure can define a central aperture through which a subcutaneous element of an implantable medical device passes. Other embodiments are included herein.

公开(公告)号：US20170022375A1

公开(公告)日：2017-01-26

申请号：US15283818

申请日：2016-10-03

申请人： Surmodics, Inc.

发明人： Aleksey V. Kurdyumov ,  Dale G. Swan

IPC分类号： C09D7/12 ,  C07F7/10 ,  C08K5/51 ,  A61L31/10 ,  C08K5/5419 ,  C08K5/544 ,  C07F7/18 ,  C07F9/06

CPC分类号： C09D7/63 ,  A61L17/145 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/18 ,  A61L2420/02 ,  C07F7/10 ,  C07F7/1804 ,  C07F7/184 ,  C07F9/06 ,  C07F9/12 ,  C07F9/145 ,  C07F9/4025 ,  C07F9/4084 ,  C08F2/48 ,  C08K5/51 ,  C08K5/5419 ,  C08K5/544 ,  C09D7/1233

摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

摘要翻译： 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。

公开(公告)号：US20150166801A1

公开(公告)日：2015-06-18

申请号：US14541768

申请日：2014-11-14

申请人： SurModics, Inc.

发明人： Aleksey V. Kurdyumov ,  Dale G. Swan

IPC分类号： C09D7/12 ,  C07F7/10 ,  C08K5/51 ,  A61L31/10 ,  C08K5/5419 ,  C08K5/544 ,  C07F7/18 ,  C07F9/06

CPC分类号： C09D7/63 ,  A61L17/145 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L2400/18 ,  A61L2420/02 ,  C07F7/10 ,  C07F7/1804 ,  C07F7/184 ,  C07F9/06 ,  C07F9/12 ,  C07F9/145 ,  C07F9/4025 ,  C07F9/4084 ,  C08F2/48 ,  C08K5/51 ,  C08K5/5419 ,  C08K5/544 ,  C09D7/1233

摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

摘要翻译： 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。

公开(公告)号：US20190367748A1

公开(公告)日：2019-12-05

申请号：US16378222

申请日：2019-04-08

申请人： Surmodics, Inc.

发明人： Aleksey V. Kurdyumov ,  Dale G. Swan

IPC分类号： C09D7/63 ,  C08K5/544 ,  C08K5/5419 ,  C08K5/51 ,  C07F9/06 ,  C07F7/18 ,  C07F9/40 ,  C08F2/48 ,  C07F9/145 ,  C07F9/12 ,  C07F7/10 ,  A61L31/10 ,  A61L29/08 ,  A61L27/34 ,  A61L17/14

摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.

公开(公告)号：US09375519B2

公开(公告)日：2016-06-28

申请号：US13926357

申请日：2013-06-25

申请人： SurModics, Inc.

发明人： Kyle Eastenson ,  Aleksey V. Kurdyumov ,  Darin DuMez ,  Klaus Wormuth ,  Nathan A. Lockwood

IPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61K47/48 ,  C08G69/40 ,  C08G69/44 ,  C08L77/06 ,  C08L77/12 ,  A61L27/18 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L31/06

CPC分类号： A61L31/10 ,  A61K47/6957 ,  A61L27/18 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2400/06 ,  C08G69/40 ,  C08G69/44 ,  C08L77/06 ,  C08L77/12

摘要： Bioerodable poly(etheresteramides) and matrices formed therefrom, such as medical device coatings, are described. The matrices show desirable erosion properties desirable for therapeutic use. The matrices can include a bioactive agent which can be used to treat medical conditions.

摘要翻译： 描述了由生物可侵蚀的聚（醚醚酰胺）和由其形成的基质，例如医疗器械涂层。 基质显示理想的治疗用途所需的侵蚀性质。 基质可包括可用于治疗医疗状况的生物活性剂。

公开(公告)号：US08956682B2

公开(公告)日：2015-02-17

申请号：US13855260

申请日：2013-04-02

申请人： SurModics, Inc.

发明人： Nathan A. Lockwood ,  Bruce M. Jelle ,  Aleksey V. Kurdyumov

IPC分类号： A61L33/00 ,  A61F2/00 ,  A61K9/14 ,  B05B5/00 ,  A01N35/00 ,  A61K31/12 ,  C09D5/22 ,  C09D5/00 ,  B05D3/06 ,  A61L29/08 ,  A61L29/14 ,  A61L29/18

CPC分类号： C09D5/22 ,  A61L29/085 ,  A61L29/14 ,  A61L29/18 ,  A61L2420/02 ,  B05D3/067 ,  C09D5/00 ,  Y10T428/31725 ,  Y10T428/31938 ,  C08L39/06

摘要： The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.

摘要翻译： 本发明涉及医疗器械涂层，例如涂覆的导线和导管，其包含在环境或应用光下为涂层提供颜色的可视化部分。 涂层允许对涂层性能进行视觉或机器检查，例如覆盖的均匀性。 在一些实施方案中，涂层包括可视化部分和活化的UV光电子组，其用于在涂层中提供共价键合。 可视化部分可以是颗粒形式并夹带在涂层中，或者可以共价键合到亲水性聚合物主链上。 在其它实施方案中，可视化部分包括茋化学基团。 示例性涂层包括亲水性乙烯基吡咯烷酮聚合物，其可以提供对器件表面的润滑性以及着色性质。

公开(公告)号：US20140200411A1

公开(公告)日：2014-07-17

申请号：US14152667

申请日：2014-01-10

申请人： SurModics, Inc.

发明人： Bruce M. Jelle ,  Aleksey V. Kurdyumov ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother ,  Nathan A. Lockwood ,  Joseph Ventura ,  Sean M. Stucke

IPC分类号： A61L31/10 ,  A61L31/14

CPC分类号： A61L31/10 ,  A61B2562/125 ,  A61L31/14 ,  A61N1/0404 ,  A61N1/05 ,  C07D495/04 ,  C07D519/00 ,  C08G61/02 ,  C08G61/124 ,  C08G61/126 ,  C08G73/0266 ,  C08G2261/1424 ,  C08G2261/1426 ,  C08G2261/1428 ,  C08G2261/143 ,  C08G2261/144 ,  C08G2261/145 ,  C08G2261/148 ,  C08G2261/3221 ,  C08G2261/3223 ,  C08G2261/3422 ,  C08G2261/43 ,  C08G2261/76 ,  C08G2261/77 ,  C08G2261/90 ,  C08G2261/94 ,  C09D5/24 ,  H01B1/127 ,  Y10T428/31507 ,  Y10T428/31533

摘要： Disclosed herein are activatable conductive compositions and methods of making and using activatable conductive compositions. In particular, activatable conductive monomers polymers are described and electrically conductive coatings that include activatable conductive polymers.

摘要翻译： 本文公开了可激活的导电组合物和制备和使用可活化导电组合物的方法。 特别地，描述了可激活的导电单体聚合物和包括可激活的导电聚合物的导电涂层。

公开(公告)号：US20130261566A1

公开(公告)日：2013-10-03

申请号：US13855260

申请日：2013-04-02

申请人： SURMODICS, INC.

发明人： Nathan A. Lockwood ,  Bruce M. Jelle ,  Aleksey V. Kurdyumov

IPC分类号： C09D5/22 ,  B05D3/06 ,  C09D5/00

CPC分类号： C09D5/22 ,  A61L29/085 ,  A61L29/14 ,  A61L29/18 ,  A61L2420/02 ,  B05D3/067 ,  C09D5/00 ,  Y10T428/31725 ,  Y10T428/31938 ,  C08L39/06

摘要： The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.

摘要翻译： 本发明涉及医疗器械涂层，例如涂覆的导线和导管，其包含在环境或应用光下为涂层提供颜色的可视化部分。 涂层允许对涂层性能进行视觉或机器检查，例如覆盖的均匀性。 在一些实施方案中，涂层包括可视化部分和活化的UV光电子组，其用于在涂层中提供共价键合。 可视化部分可以是颗粒形式并夹带在涂层中，或者可以共价键合到亲水性聚合物主链上。 在其它实施方案中，可视化部分包括茋化学基团。 示例性涂层包括亲水性乙烯基吡咯烷酮聚合物，其可以提供对器件表面的润滑性以及着色性质。