-
公开(公告)号：US06268398B1
公开(公告)日：2001-07-31
申请号：US09299044
申请日：1999-04-23
申请人： Soumitra Ghosh , Robert E. Davis
发明人： Soumitra Ghosh , Robert E. Davis
IPC分类号： A61K31155
CPC分类号： A61K31/5375 , A61K31/155 , A61K31/196
摘要： Compounds, compositions and methods are disclosed for treating mitochondria-associated diseases, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have structure (I) below, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Ar and L are as defined herein. The methods of this invention are directed to treating a mitochondria-associated disease by administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.
摘要翻译： 公开了用于治疗线粒体相关疾病如癌症，牛皮癣，中风，阿尔茨海默病和糖尿病的化合物，组合物和方法。 本发明的化合物具有以下结构（I），包括其立体异构体，前药和药学上可接受的盐，其中Ar和L如本文所定义。 本发明的方法涉及通过向有需要的温血动物施用有效量的通常为药物组合物形式的结构（I）的化合物来治疗线粒体相关疾病。
-
公开(公告)号：US6027883A
公开(公告)日：2000-02-22
申请号：US757438
申请日：1996-11-27
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q1/6858 , C12Q2600/156 , C12Q2600/16
摘要： A sample preparation procedure for mitochondrial (mt) DNA analysis is described. The present method for isolating mtDNA uses sedimentation techniques for separating erythrocytes from lymphocytes and platelets (crude buffy coat fraction), followed by DNA extraction from the crude buffy coat fraction by boiling in water. This approach improves the yield of mutant DNA, enhancing the sensitivity of subsequent mutation interrogation techniques and allowing for meaningful statistical treatment of the degree of heteroplasmy within the mitochondrial DNA.
摘要翻译： 描述了线粒体（mt）DNA分析的样品制备程序。 目前用于分离mtDNA的方法使用沉淀技术从淋巴细胞和血小板（粗血沉棕黄层级分离）中分离红细胞，然后通过在水中沸腾从粗血沉棕黄层级分提取DNA。 这种方法提高了突变DNA的产量，提高了随后的突变询问技术的敏感性，并允许有意义的统计学处理线粒体DNA内的异质性程度。
-
93.发明授权
公开(公告)号：US5900383A
公开(公告)日：1999-05-04
申请号：US581836
申请日：1996-01-02
摘要： A process for increasing the activity of a zeolite-containing particulate solid containing contaminants which block the pores of the zeolite and adversely affect the activity thereof wherein the contaminated zeolitic material is slurried with a liquid containing an acid, detergent or surfactant, the slurry is agitated to liberate the pore-blocking contaminants from the zeolite pores so that they are suspended in the liquid, a portion of the liquid is withdrawn from the slurry and filtered to remove the suspended contaminants, the resulting liquid is returned to the slurry, and the treated zeolite-containing particulate solid is liquid from the solution and recovered.
摘要翻译： 一种提高含有沸石的颗粒固体的活性的方法，该固体含有阻碍沸石孔隙并且不利地影响其活性的污染物，其中污染的沸石材料用含有酸，洗涤剂或表面活性剂的液体浆化，搅拌浆液 为了释放孔隙阻塞污染物从沸石孔中，使得它们悬浮在液体中，一部分液体从浆料中排出并过滤以除去悬浮的污染物，将所得液体返回到浆料中，并将处理过的 含沸石的颗粒状固体是溶液中的液体并回收。
-
94.发明授权
公开(公告)号：US5840493A
公开(公告)日：1998-11-24
申请号：US734564
申请日：1996-10-21
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K41/00 , A61K45/00 , A61K48/00 , C07D219/08 , C07K14/47 , C07K16/40 , C12N5/06 , C12N5/08 , C12N9/00 , C12N9/02 , C12N15/09 , C12P21/04 , C12P21/08 , C12Q1/00 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12N9/93 , C07D219/08 , C07K14/4711 , C07K14/4713 , C12N9/0053 , C12Q1/6806 , C12Q1/6883 , A61K38/00 , C12Q2600/156
摘要： The present invention relates to genetic mutations in mitochondrial genes that segregate with diabetes mellitus. The invention provides methods for detecting such mutations, as a diagnostic for diabetes mellitus, either before or after the onset on clinical symptoms. Examples of specific mutations in the mitochondrial ATP synthase 8/6 gene and tRNA lysine gene are given. The invention also provides treatments for dysfunctions due to mitochondrial genes that segregate with diabetes mellitus. Cybrid cell lines are described which are useful as model systems for the study of the mitochondrial metabolic disorders that are associated with diabetes mellitus, and for identifying therapeutic compounds and treatments for this disease.
摘要翻译： 本发明涉及与糖尿病分离的线粒体基因中的遗传突变。 本发明提供在临床症状发作之前或之后检测这种突变作为糖尿病诊断的方法。 给出了线粒体ATP合成酶8/6基因和tRNA赖氨酸基因中特异突变的实例。 本发明还提供了由于与糖尿病分离的线粒体基因引起的功能障碍的治疗。 描述了杂交细胞系，其可用作研究与糖尿病相关的线粒体代谢紊乱的模型系统，并且用于鉴定该疾病的治疗化合物和治疗。
-
公开(公告)号：US5338732A
公开(公告)日：1994-08-16
申请号：US882218
申请日：1992-05-13
IPC分类号： A61K9/08 , A61K9/00 , A61K9/107 , A61K31/57 , A61K47/10 , A61K47/26 , A61P31/12 , A61P35/00 , A61K31/56
CPC分类号： A61K9/0095 , A61K31/57 , A61K47/10 , A61K47/26
摘要： The present invention relates to a novel oral pharmaceutical composition of micronized megestrol acetate at a concentration of 15 to 150 mg/mL comprising polysorbate at a concentration of 0.005% to 0.015% weight/volume and polyethylene glycol at a concentration of 5-30% weight/volume which composition forms a stable flocculated suspension in water. The invention further comprises the micronized megestrol acetate formulation described above with added preservatives, buffers, sweeteners and flavoring agents.
摘要翻译： 本发明涉及浓度为0.005至0.015％重量/体积的聚山梨醇酯，浓度为5-30％重量的聚乙二醇的浓度为15至150mg / mL的微粉化醋酸甲地孕酮的新型口服药物组合物 /体积，该组合物在水中形成稳定的絮凝悬浮液。 本发明还包括上述添加的防腐剂，缓冲剂，甜味剂和调味剂的上述微粉化的醋酸甲孕酮制剂。
-
公开(公告)号：US5280652A
公开(公告)日：1994-01-25
申请号：US836790
申请日：1992-02-14
摘要： A pantyhose or the like garment having a novel waistband construction comprising an anchor portion and an integrally knit wide band portion. The waistband is substantially wider than conventional waistbands, the anchor portion consisting of a narrow turned welt portion and a wide single ply band portion, each incorporating textured nylon and elastomer yarns.
摘要翻译： 一种连裤袜或类似的衣服，其具有包括锚定部分和整体编织宽带部分的新颖腰带结构。 该腰带基本上比常规腰带宽，该锚固部分由狭窄的转动的边缘部分和宽的单层带部分组成，每一个都包含纹理的尼龙和弹性纱线。
-
公开(公告)号：US5093759A
公开(公告)日：1992-03-03
申请号：US527110
申请日：1990-05-21
申请人： Robert E. Davis , John E. Hockett
发明人： Robert E. Davis , John E. Hockett
CPC分类号： H05K7/20545 , H05K7/1411
摘要： An electronics box includes a cover and a bottomwall spaced from the cover by opposed sidewalls of the box. A motherboard having circuit card connectors thereon is mounted in the electronics box adjacent the cover. The box further includes in-line connectors mounted adjacent the motherboard with the in-line connectors interconnected with the connectors in the motherboard. The bottomwall and sidewalls include circuit card edge guides formed therein for retaining circuit cards connected to the motherboard.The arrangement of the in-line connectors adjacent to the motherboard provides for relatively direct and short runs for the interconnecting harness cable, thereby minimizing the amount of space within the box devoted to internal interconnect cables.The in-line connectors provide for straight-line connection or disconnection, making possible direct mounting with a simple jackscrew arrangement.
摘要翻译： 电子盒包括盖和通过箱的相对侧壁与盖隔开的底壁。 在其上具有电路卡连接器的母板安装在电子盒中，与盖相邻。 盒子还包括与母板相邻的在线连接器，其中与主板中的连接器互连的直列连接器。 底壁和侧壁包括形成在其中的电路卡边缘引导件，用于保持连接到母板的电路卡。 与母板相邻的串联连接器的布置为相互连接的线束电缆提供相对直接和短的运行，从而最小化箱内用于内部互连电缆的空间量。 直列连接器提供直线连接或断开连接，可以通过简单的起重螺丝装置直接安装。
-
公开(公告)号：US5042528A
公开(公告)日：1991-08-27
申请号：US548865
申请日：1990-07-06
申请人： Frank R. England , Robert E. Davis
发明人： Frank R. England , Robert E. Davis
IPC分类号： F17C13/00
CPC分类号： F17C13/00 , F17C2250/0636 , F17C2260/015 , F17C2265/06 , F17C2270/07 , Y10T137/87676
摘要： A gas service tee designed to facilitate tamper-proof termination of gas service to a residential or business location and/or removal of the gas meter without interruption of gas service. The gas service tee is characterized in a first preferred embodiment by a tee fitting located in the gas service line downstream from the gas meter and an adaptor having a tamper-proof adaptor stem mounted in the tee fitting, which adaptor stem can be adjusted to stop the flow of gas through the line. In a second preferred embodiment of the invention the adaptor stem is hollow and is provided with spaced stem openings and a stem grip may be provided for threadably rotating the stem inside an adaptor fitting located in the tee fitting. A tube fitting may also be provided on the stem or stem grip for receiving the hose of an auxiliary gas supply bottle and supplying gas to the residential or business location while the gas meter is being repaired or replaced.
摘要翻译： 一个燃气服务发球台，旨在便于窜改终止燃气服务到住宅或商业场所和/或拆除燃气表，而不会中断燃气服务。 燃气服务三通的特征在于第一优选实施例中，位于燃气表下游的燃气服务线中的三通配件和具有安装在三通配件中的防窜改适配器杆的适配器，该适配器杆可以被调节以停止 气流通过线路。 在本发明的第二优选实施例中，适配器杆是中空的并且设置有间隔开的杆开口，并且可以设置杆把手，用于在位于三通配件中的适配器配件内螺纹地旋转杆。 还可以在阀杆或阀杆把手上设置管接头，用于接收辅助气体供应瓶的软管并且在修理或更换燃气表时将气体供应到住宅或商业位置。
-
99.发明授权
公开(公告)号：US4674447A
公开(公告)日：1987-06-23
申请号：US153012
申请日：1980-05-27
申请人： Robert E. Davis
发明人： Robert E. Davis
摘要： Processes for operating gasoline engines with spark plug ignition of gasolines containing manganese compound additives such as pentadienyl manganese tricarbonyl (MMT), the gasoline being essentially free of lead, sodium and barium compounds, thereby avoiding fouling of the spark plugs with glass-like deposits formed from the oxide reaction products of sodium or barium and manganese; the lubricating oils in the crankcase of said engines being essentially free from lead, sodium and barium compounds; processes for operating gasoline engines having an exhaust system with a catalytic converter for conversion of hydrocarbon emissions and carbon monoxide emissions to water and carbon dioxide with the same types of gasolines, and preventing fouling of the catalyst in said converter by glass-like deposits formed thereon by oxidation products of sodium and/or barium compounds with manganese by operating said engine in the absence of lead, sodium and barium compounds in the combustion chambers of the engine, its exhaust system, and the crankcase lubricating oils; and gasoline fuels for internal combustion engines containing a small amount of a manganese compound additive, e.g., MMT, said gasoline being essentially free of lead, sodium and barium compounds.
摘要翻译： 用含有锰化合物添加剂如戊二烯基三羰基锰（MMT）的汽油的火花塞点燃的汽油发动机的工艺，汽油基本上不含铅，钠和钡化合物，从而避免形成玻璃状沉积物的火花塞 从钠或钡和锰的氧化物反应产物; 所述发动机的曲轴箱中的润滑油基本上不含铅，钠和钡化合物; 具有排气系统的汽油发动机的工艺具有催化转化器，用于将碳氢化合物排放和一氧化碳排放转换为具有相同类型汽油的水和二氧化碳，并且通过在其中形成的玻璃状沉积物防止所述转化器中的催化剂结垢 通过在发动机的燃烧室，其排气系统和曲轴箱润滑油中不存在铅，钠和钡化合物的情况下操作所述发动机，通过具有锰的钠和/或钡化合物的氧化产物; 和含有少量锰化合物添加剂例如MMT的内燃机的汽油燃料，所述汽油基本上不含铅，钠和钡化合物。
-
公开(公告)号：US4623374A
公开(公告)日：1986-11-18
申请号：US719381
申请日：1985-04-02
申请人： Wilbur O. Doud , Robert E. Davis , Fred R. Sawyer
发明人： Wilbur O. Doud , Robert E. Davis , Fred R. Sawyer
CPC分类号： C03B9/3866 , C03B9/1936 , C03B9/3825 , C03B9/3833 , C03B9/3875
摘要： A parison mold portion (20) of a glassware forming machine, of the type having a parison mold (22) and a parison plunger (240), is provided with means for cooling the parison plunger (240). The means for cooling the parison plunger (240) includes a central cooling passage (258) that communicates with an end surface (246) and that extends longitudinally toward a nose (254), and a plurality of umbrella passages (162) that communicate with the end surface (246) radially outward from the central cooling passage (258), that are circumferentially spaced, and that intercept the central cooling passage (258) proximal to the nose (254). A tube (264) is inserted into the central cooling passage (258), is longitudinally adjustable, and is effective to adjustably determine the longitudinal position wherein the umbrella passages (162) communicate with the central cooling passage; whereby cooling of portions of the parison plunger (240) proximal to the nose (254) versus portions distal from the nose (254), is selectively controlled.
摘要翻译： 具有型坯模具（22）和型坯柱塞（240）的类型的玻璃器皿成形机的型坯模具部分（20）设置有用于冷却型坯柱塞（240）的装置。 用于冷却型坯柱塞（240）的装置包括：中央冷却通道（258），其与端面（246）连通并且纵向延伸朝向鼻部（254）延伸;以及多个伞形通道（162），其与 从中央冷却通道（258）径向向外的端面（246），其周向间隔开，并且拦截靠近鼻部（254）的中央冷却通道（258）。 管（264）插入到中央冷却通道（258）中，可纵向调节，并且有效地可调节地确定伞形通道（162）与中央冷却通道连通的纵向位置; 由此选择性地控制靠近鼻部（254）的型坯柱塞（240）的部分相对于远离鼻部（254）的部分的冷却。
-
-
-
-
-
-
-
-
-
搜索结果
105 条记录 (耗时 0.054 秒)
