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111 条记录 (耗时 0.049 秒)

    Cosmid DNA constructs and methods of making and using same
    93.
    发明授权
    Cosmid DNA constructs and methods of making and using same 有权
    粘粒DNA构建体及其制备和使用方法

    公开(公告)号：US08529884B2

    公开(公告)日：2013-09-10

    申请号：US10168694

    申请日：2000-12-22

    申请人： David B. Weiner ,  Jeong-Im Sin ,  Donghui Zhang

    发明人： David B. Weiner ,  Jeong-Im Sin ,  Donghui Zhang

    IPC分类号： A01N63/00 ,  A01N43/04

    CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/54 ,  C12N2710/16634

    摘要： Methods of inducing immune responses in individuals against a pathogen are disclosed. Methods of treating individuals susceptible to or suffering from a disease associated with a genetic defect which results in the non-production or under production of a protein or the production of a non-functioning or partially functioning protein are disclosed. Methods of delivering a protein to an individual are disclosed. Pharmaceutical compositions that comprise cosmids are disclosed.

    摘要翻译： 公开了在针对病原体的个体中诱导免疫应答的方法。 公开了治疗导致非生产或正在产生蛋白质或产生不起作用或部分功能的蛋白质的遗传缺陷相关疾病或患有疾病的个体的方法。 公开了向个体递送蛋白质的方法。 公开了包含粘粒的药物组合物。

    VACCINES AND IMMUNOTHERAPEUTICS USING CODON-OPTIMIZED IL-15 AND METHODS FOR USING THE SAME
    95.
    发明申请
    VACCINES AND IMMUNOTHERAPEUTICS USING CODON-OPTIMIZED IL-15 AND METHODS FOR USING THE SAME 有权
    使用优化的IL-15的疫苗和免疫应答及其使用方法

    公开(公告)号：US20120213815A1

    公开(公告)日：2012-08-23

    申请号：US13463805

    申请日：2012-05-03

    申请人： David B. Weiner ,  Michele Kutzler

    发明人： David B. Weiner ,  Michele Kutzler

    IPC分类号： A61K39/12 ,  C12N15/38 ,  A61P31/12 ,  A61K39/00 ,  A61K48/00 ,  A61P31/22 ,  A61P35/04 ,  A61P37/00 ,  C12N15/24 ,  C12N15/82 ,  C12N15/49 ,  A61P31/18

    CPC分类号： C07K14/5443 ,  A61K2039/55522 ,  Y02A50/394

    摘要： Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid molecules with additional modifications such as the absence of coding sequences for IL-15 signal sequences and/or the absence of IL-15 untranslated sequences and/or inclusion of non-IL-15 signal sequences are also disclosed. Vectors, including plasmids and viral vectors, comprising such nucleic acid molecules; and to host cells comprising such nucleic acid molecules are disclosed as well as methods of using such nucleic acid molecules alone or in combination with nucleic acid sequences encoding immunogens which are part of the nucleic acid molecules and/or part of a different nucleic acid molecule. Recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed.

    摘要翻译： 公开了编码IL-15或其片段的核酸分子，其以比具有IL-15的天然编码序列的核酸分子更高的水平表达蛋白质。 还公开了具有附加修饰的核酸分子，例如不存在IL-15信号序列的编码序列和/或不存在IL-15非翻译序列和/或包含非IL-15信号序列。 包含这种核酸分子的载体，包括质粒和病毒载体; 以及包含这种核酸分子的宿主细胞以及使用这些核酸分子单独或与编码作为核酸分子和/或不同核酸分子的一部分的免疫原的核酸序列组合的方法。 公开了重组疫苗和编码融合蛋白的活减毒病原体及其使用方法。

    Method of inducing cell death using West Nile virus capsid protein
    99.
    发明授权
    Method of inducing cell death using West Nile virus capsid protein 失效
    使用西尼罗病毒衣壳蛋白诱导细胞死亡的方法

    公开(公告)号：US07348138B2

    公开(公告)日：2008-03-25

    申请号：US10966576

    申请日：2004-10-14

    申请人： David B. Weiner ,  Joo-Sung Yang ,  Karuppiah Muthumani

    发明人： David B. Weiner ,  Joo-Sung Yang ,  Karuppiah Muthumani

    IPC分类号： C12Q1/70 ,  A61K39/12

    CPC分类号： A61K38/162 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/005 ,  C07K2319/02 ,  C12N2740/16222 ,  C12N2770/24122 ,  C12N2770/24322 ,  G01N33/56983 ,  G01N2469/20 ,  Y02A50/394

    摘要： This invention provides methods of inducing cell death with Flavivirus or Pestivirus capsid protein, such as West Nile virus (WNV) capsid protein, and functional fragments thereof. The invention also provides methods of treating patients suffering from diseases characterized by hyperproliferating cells by administering pharmaceutical compositions comprising WNV or other virus including Flavivirus or Pestivirus capsid or other protein or a nucleic acid molecule encoding the same. Methods of identifying compounds which have anti-viral and/or anti-WNV and/or anti-Flavivirus and/or anti-Pestivirus capsid or other protein activity are disclosed. The invention also provides vaccine compositions comprising capsid or other proteins, or fragments thereof, or nucleic acids encoding same, from WNV or other virus including Flavivirus or Pestivirus and a pharmaceutically acceptable carrier. The invention also provides diagnostic methods and kits for identifying individuals exposed to WNV or other viruses including Flavivirus or Pestivirus.

    摘要翻译： 本发明提供了用黄病毒或瘟病毒衣壳蛋白（例如西尼罗河病毒（WNV）衣壳蛋白）及其功能片段诱导细胞死亡的方法。 本发明还提供了通过施用包含WNV或其它病毒（包括黄病毒或瘟病毒衣壳或其他蛋白质）的药物组合物或其编码的核酸分子来治疗患有特征在于过度增殖细胞的疾病的患者的方法。 公开了鉴定具有抗病毒和/或抗WNV和/或抗黄病毒和/或抗瘟病毒衣壳或其它蛋白质活性的化合物的方法。 本发明还提供包含衣壳或其它蛋白质或其片段，或编码其的核酸的疫苗组合物，来自WNV或其它病毒，包括黄病毒或瘟病毒和药学上可接受的载体。 本发明还提供用于鉴定暴露于WNV或其它病毒（包括黄病毒或瘟病毒）的个体的诊断方法和试剂盒。