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    Cosmid dna constructs and methods of making and using same
    1.
    发明申请
    Cosmid dna constructs and methods of making and using same 有权
    粘粒dna构建及其制作和使用方法

    公开(公告)号：US20080219953A1

    公开(公告)日：2008-09-11

    申请号：US10168694

    申请日：2000-12-22

    申请人： David B. Weiner ,  Jeong-Im Sin ,  Donghui Zhang

    发明人： David B. Weiner ,  Jeong-Im Sin ,  Donghui Zhang

    IPC分类号： A61K48/00 ,  A61K31/445 ,  C12N15/86

    CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/54 ,  C12N2710/16634

    摘要： Methods of inducing immune responses in individuals against a pathogen are disclosed. Methods of treating individuals susceptible to or suffering from a disease associated with a genetic defect which results in the non-production or under production of a protein or the production of a non-functioning or partially functioning protein are disclosed. Methods of delivering a protein to an individual are disclosed. Pharmaceutical compositions that comprise cosmids are disclosed.

    摘要翻译： 公开了在针对病原体的个体中诱导免疫应答的方法。 公开了治疗导致非生产或正在产生蛋白质或产生不起作用或部分功能的蛋白质的遗传缺陷相关疾病或患有疾病的个体的方法。 公开了向个体递送蛋白质的方法。 公开了包含粘粒的药物组合物。

    Cosmid DNA constructs and methods of making and using same
    2.
    发明授权
    Cosmid DNA constructs and methods of making and using same 有权
    粘粒DNA构建体及其制备和使用方法

    公开(公告)号：US08529884B2

    公开(公告)日：2013-09-10

    申请号：US10168694

    申请日：2000-12-22

    申请人： David B. Weiner ,  Jeong-Im Sin ,  Donghui Zhang

    发明人： David B. Weiner ,  Jeong-Im Sin ,  Donghui Zhang

    IPC分类号： A01N63/00 ,  A01N43/04

    CPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/54 ,  C12N2710/16634

    摘要： Methods of inducing immune responses in individuals against a pathogen are disclosed. Methods of treating individuals susceptible to or suffering from a disease associated with a genetic defect which results in the non-production or under production of a protein or the production of a non-functioning or partially functioning protein are disclosed. Methods of delivering a protein to an individual are disclosed. Pharmaceutical compositions that comprise cosmids are disclosed.

    摘要翻译： 公开了在针对病原体的个体中诱导免疫应答的方法。 公开了治疗导致非生产或正在产生蛋白质或产生不起作用或部分功能的蛋白质的遗传缺陷相关疾病或患有疾病的个体的方法。 公开了向个体递送蛋白质的方法。 公开了包含粘粒的药物组合物。

    Compositions for and methods of using herpes simplex virus glycoprotein D to suppress immune responses
    3.
    发明授权
    Compositions for and methods of using herpes simplex virus glycoprotein D to suppress immune responses 有权
    使用单纯疱疹病毒糖蛋白D的组合物和方法来抑制免疫应答

    公开(公告)号：US07569218B2

    公开(公告)日：2009-08-04

    申请号：US10333802

    申请日：2001-07-27

    申请人： David B. Weiner ,  Jeong-Im Sin

    发明人： David B. Weiner ,  Jeong-Im Sin

    IPC分类号： A61K48/00

    CPC分类号： A61K48/00 ,  A61K38/162 ,  A61K39/385 ,  A61K2039/53 ,  A61K2039/6075 ,  C07K14/005 ,  C12N2710/10343 ,  C12N2710/16622

    摘要： Methods of delivering a desired polypeptide to an individual are disclosed. The methods comprise administering to the individual an immunogenic vector comprising a nucleic acid encoding the desired polypeptide operably linked to regulatory elements in combination with one or more of gD protein, a function fragment of gD protein, a nucleic acid encoding gD protein operably linked to regulatory elements, or a nucleic acid encoding a functional fragment of gD protein operably linked to regulatory elements. Compositions comprising an immunogenic vector that comprises a nucleic acid encoding the desired polypeptide operably linked to regulatory elements; and one or more of gD protein, a function fragment of gD protein, a nucleic acid encoding gD protein operably linked to regulatory elements, or a nucleic acid encoding a functional fragment of gD protein operably linked to regulatory elements are disclosed. Methods for inhibiting an undesirable immune response in an individual are disclosed.

    摘要翻译： 公开了将期望的多肽递送给个体的方法。 所述方法包括向个体施用免疫原性载体，其包含编码所需多肽的核酸，其与调节元件结合使用，所述多核苷酸可与gD蛋白，gD蛋白的功能片段，编码可调控的 元件或编码与调节元件可操作地连接的gD蛋白的功能性片段的核酸。 包含免疫原性载体的组合物，其包含编码可操作地连接到调节元件的所需多肽的核酸; 并且公开了一种或多种gD蛋白，gD蛋白的功能片段，编码与调控元件可操作地连接的gD蛋白的核酸，或编码与调节元件可操作地连接的gD蛋白的功能性片段的核酸。 公开了抑制个体中不期望的免疫应答的方法。

    Expression system for cloning toxic genes
    7.
    发明授权
    Expression system for cloning toxic genes 有权
    用于克隆有毒基因的表达系统

    公开(公告)号：US06881558B1

    公开(公告)日：2005-04-19

    申请号：US09888860

    申请日：2001-06-25

    申请人： David B. Weiner ,  Donghui Zhang ,  Adam Cohen

    发明人： David B. Weiner ,  Donghui Zhang ,  Adam Cohen

    IPC分类号： C12N15/72 ,  C12P21/06 ,  C07H21/04 ,  C12N1/12 ,  C12N15/00 ,  C12P21/04

    CPC分类号： C12N15/72

    摘要： Methods of cloning and/or amplifying toxic genes in bacteria using a vector which amplifies the toxic gene in bacteria and also allows subsequent expression in mammalian systems is provided. A vector having an origin of replication, a first promoter, a polylinker, a second promoter in reverse orientation with respect to the first promoter, a poly adenylation signal, and a gene encoding a selectable marker, and optionally an enhancer operably connected to the first promoter, and/or a nucleotide sequence encoding a toxic protein is also provided.

    摘要翻译： 使用扩增细菌中的毒性基因并允许随后在哺乳动物系统中表达的载体来克隆和/或扩增细菌中的有毒基因的方法。 具有复制起点的载体，第一启动子，多接头体，相对于第一启动子反向取向的第二启动子，多腺苷酸化信号和编码可选择标记的基因，以及任选地可增强的与第一启动子连接的增强子 启动子，和/或编码毒性蛋白质的核苷酸序列。