公开(公告)号：US20090084949A1

公开(公告)日：2009-04-02

申请号：US12037506

申请日：2008-02-26

申请人： Jochen Franzen ,  Karsten Michelmann

发明人： Jochen Franzen ,  Karsten Michelmann

IPC分类号： B01D59/44

CPC分类号： H01J49/42 ,  H01J49/0036 ,  H01J49/027

摘要： The invention relates to mass spectrometers in which ion clouds are stored in two spatial directions by radial forces while oscillating largely harmonically at a mass-specific frequency in a third spatial direction perpendicular to the other two, in a potential minimum, the shape of which is as close to a parabola as possible. Analysis of the oscillation frequencies of these ion clouds, preferably by a Fourier analysis, leads via a frequency spectrum to a mass spectrum. The frequency spectrum is analyzed to identify false signals in the frequency spectrum as harmonics and eliminating them where necessary.

摘要翻译： 本发明涉及质谱仪，其中离子云通过径向力在两个空间方向上存储，同时以与另外两个垂直的第三空间方向上的质量特定频率大量谐波地振荡，其形状为 尽可能接近抛物线。 这些离子云的振荡频率的分析优选通过傅立叶分析，经由频谱到质谱。 分析频谱以将频谱中的伪信号作为谐波识别，并在必要时消除它们。

公开(公告)号：US07504640B2

公开(公告)日：2009-03-17

申请号：US11522112

申请日：2006-09-15

申请人： Jochen Franzen ,  Karsten Michelmann

发明人： Jochen Franzen ,  Karsten Michelmann

IPC分类号： H01J27/00 ,  H01J49/04 ,  B01D59/44

CPC分类号： G01N27/62 ,  H01J49/0463 ,  H01J49/0481 ,  H01J49/145

摘要： An ion source generates ions from analyte molecules which are desorbed from a sample on the surface of a sample support in a pressure range of approximately 30 to 300 pascal. Reactant ions are generated in a separate ion source and guided by ion guides to the point in front of the sample or to a reaction chamber in which the desorbed molecules are located. The reactant ions ionize the desorbed molecules to form analyte ions. The analyte molecules can be mixed in matrix material or adsorbed on the sample support surface without additives. The desorption can be continuous or pulsed, for example by light from lasers or diodes.

摘要翻译： 离子源从分析物分子产生离子，其在约30至300帕斯卡的压力范围内从样品载体表面上的样品解吸。 反应物离子在单独的离子源中产生并由离子导向器引导到样品前面的点或解吸的分子位于其中的反应室。 反应物离子离子解吸分子形成分析离子。 分析物分子可以在基质材料中混合或吸附在样品支持体表面上而无添加剂。 解吸可以是连续的或脉冲的，例如通过来自激光器或二极管的光。

公开(公告)号：US20080251715A1

公开(公告)日：2008-10-16

申请号：US12056630

申请日：2008-03-27

申请人： Evgenij Nikolaev ,  Jochen Franzen

发明人： Evgenij Nikolaev ,  Jochen Franzen

IPC分类号： H01J49/26

CPC分类号： G21K1/093 ,  H01J49/065 ,  H01J49/38

摘要： In a mass spectrometer that uses a space-restricted magnetic field, such as an ion cyclotron resonance mass spectrometer, ions with a wide mass range generated in an ion supply located outside the magnetic field are transported in the direction of the magnetic field lines to an ion storage device located inside the magnetic field without losing ions by guiding the ions through the region in which the magnetic field strength increases with a special ion guide. This ion guide consists of an arrangement of coaxial ring diaphragms which are alternately supplied with the phases of an RF voltage. In an alternative embodiment, the ion guide uses two wires wound in a double helix where each wire is supplied with one phase of a two-phase RF voltage.

摘要翻译： 在使用诸如离子回旋共振质谱仪的空间受限的磁场的质谱仪中，在位于磁场外部的离子供体中产生的质量范围宽的离子在磁场线的方向上被传送到 离子存储装置，其位于磁场内部，而不会通过引导离子通过特殊离子导向器的磁场强度增加的区域而损失离子。 该离子导向器由交替地提供有RF电压的相位的同轴环形隔膜的布置组成。 在替代实施例中，离子导向器使用缠绕在双螺旋线中的两条线，其中每条线被提供有两相RF电压的一相。

公开(公告)号：US20080128614A1

公开(公告)日：2008-06-05

申请号：US11943904

申请日：2007-11-21

申请人： Evgenij Nikolaev ,  Jochen Franzen

发明人： Evgenij Nikolaev ,  Jochen Franzen

IPC分类号： H01J49/16

CPC分类号： H01J49/0463 ,  G01N2001/045 ,  G01N2001/383 ,  H01J49/165

摘要： A mass spectrometric analysis of surface material is performed by vaporizing the surface material with pulses of laser light and then collecting the vaporized material by dissolving it in a liquid. The liquid with the dissolved material is then fed to an ionization process, preferably an electrospray ionization process. The resulting ions are then analyzed with a mass spectrometer. The method is particularly suited for use with imaging mass spectrometry.

摘要翻译： 表面材料的质谱分析通过用激光脉冲蒸发表面材料，然后通过将其溶解在液体中来收集蒸发的材料来进行。 然后将具有溶解材料的液体进料至电离过程，优选电喷雾离子化过程。 然后用质谱仪分析所得离子。 该方法特别适用于成像质谱法。

公开(公告)号：US07368711B2

公开(公告)日：2008-05-06

申请号：US11197129

申请日：2005-08-04

申请人： Jochen Franzen ,  Evgenij Nikolaev

发明人： Jochen Franzen ,  Evgenij Nikolaev

IPC分类号： B01D59/44

CPC分类号： H01J49/38

摘要： The invention relates to a measuring cell for an ion cyclotron resonance mass spectrometer (FTMS). The invention provides a measuring cell which, on the one hand, consists of two ion-repelling RF grids at the front ends as trapping electrodes and thus produces a pure cyclotron motion of the ions without the usually co-existing magnetron motion and, on the other hand, measures a multiplied cyclotron frequency by means of a plurality of detection electrodes, whereby either a higher mass accuracy or a shorter measuring time can be achieved.

摘要翻译： 本发明涉及一种用于离子回旋共振质谱仪（FTMS）的测量池。 本发明提供了一种测量电池，其一方面由前端的两个离子排斥RF栅格组成，作为捕获电极，从而产生离子的纯回旋加速器，而不需要通常共存的磁控管运动，并且在 另一方面，通过多个检测电极测量相乘的回旋加速器频率，由此可以实现更高的质量精度或更短的测​​量时间。

公开(公告)号：US20080048113A1

公开(公告)日：2008-02-28

申请号：US11843753

申请日：2007-08-23

申请人： Jochen Franzen ,  Gokhan Baykut

发明人： Jochen Franzen ,  Gokhan Baykut

IPC分类号： H01J49/42

CPC分类号： H01J49/4225 ,  H01J49/063 ,  H01J49/4295

摘要： The invention relates to instruments for storing ions in more than one ion storage device and to the use of the storage bank thus created. The ion storage bank includes several storage cells configured as RF multipole rod systems, where the cells contain damping gas and are arranged in parallel. Each pair of pole rods is used jointly by two immediately adjacent storage cells such that the ions collected can be transported from one storage cell to the next by briefly applying DC or AC voltages to individual pairs of pole rods. The ions can thus be transported to storage cells in which they are fragmented or reactively modified, or from which they can be fed to other spectrometers. In particular, a circular arrangement of the storage cells on a virtual cylindrical surface makes it possible to accumulatively fill the storage cells with ions of specific fractions from temporally sequenced separation runs.

摘要翻译： 本发明涉及用于将离子存储在多于一个离子存储装置中的仪器以及由此产生的储存库的使用。 离子存储库包括配置为RF多极杆系统的多个存储单元，其中单元包含阻尼气体并且并联布置。 每对极杆由两个紧邻的存储单元联合使用，使得通过向单个极杆对简单地施加DC或AC电压，所收集的离子可以从一个存储单元传送到下一个存储单元。 因此，离子可以被运送到它们被分段或反应性修饰的存储单元中，或者从这些离子将它们送入其它光谱仪。 特别地，在虚拟圆柱形表面上的存储单元的圆形布置使得可以从时间上排序的分离行程累积地填充具有特定级分的离子的存储单元。

公开(公告)号：US20070068817A1

公开(公告)日：2007-03-29

申请号：US11534252

申请日：2006-09-22

申请人： Evgenij Nikolaev ,  Jochen Franzen

发明人： Evgenij Nikolaev ,  Jochen Franzen

IPC分类号： G01N27/00

CPC分类号： G01N27/447

摘要： Components of a mixture are separated by feeding charged molecules of the components into a end surface of a suitable medium, for example a gel. The molecules are drawn in a first direction through the medium by means of an DC electric field, while at the same time being subjected to an alternating voltage with a strongly asymmetric profile in a direction transverse to the first direction. The nonlinear behavior of the electrically-generated migration causes a large number of molecules to migrate transversely out of the medium while only a small number of molecules reach the opposite end surface of the medium. A superimposed DC voltage in the transverse direction selects which of the mixture components migrate all the way through the medium in the first direction. The separated components can be sampled from the opposite end surface and from points on the upper and lower medium surfaces.

摘要翻译： 通过将组分的带电分子送入合适的介质例如凝胶的端表面来分离混合物的组分。 分子通过DC电场沿着第一方向通过介质被拉伸，同时在横向于第一方向的方向上经受具有强非对称轮廓的交流电压。 电生成迁移的非线性行为导致大量分子横向移出介质，而只有少量分子到达介质的相对端面。 横向上的叠加的直流电压选择哪个混合组分在第一方向上一直迁移通过介质。 分离的组件可以从相对端表面和上介质和下介质表面上的点进行采样。

公开(公告)号：US07193223B2

公开(公告)日：2007-03-20

申请号：US11003017

申请日：2004-12-02

申请人： Jochen Franzen

发明人： Jochen Franzen

IPC分类号： H01J27/00 ,  H01J49/10

CPC分类号： H01J49/165 ,  G01N30/7266 ,  H01J49/0463

摘要： The invention relates to the ionization of analyte molecules on a solid surface close to atmospheric pressure as an ion source for mass spectrometers. The invention uses a spray mist from an electrospray apparatus to ionize the analyte molecules, for example a spray mist created by spraying pure water, which generates predominantly multiply charged ions of the analyte molecules which are particularly suitable for fragmentation.

摘要翻译： 本发明涉及作为质谱仪离子源的分析物分子在接近大气压的固体表面上的离子化。 本发明使用来自电喷雾装置的喷雾来离子化分析物分子，例如通过喷射纯水产生的喷雾，其主要产生特别适合于碎裂的分析物分子的多电荷离子。

公开(公告)号：US20060027743A1

公开(公告)日：2006-02-09

申请号：US11197129

申请日：2005-08-04

申请人： Jochen Franzen ,  Evgenij Nikolaev

发明人： Jochen Franzen ,  Evgenij Nikolaev

IPC分类号： H01J49/40 ,  B01D59/44

CPC分类号： H01J49/38

摘要： The invention relates to a measuring cell for an ion cyclotron resonance mass spectrometer (FTMS). The invention provides a measuring cell which, on the one hand, consists of two ion-repelling RF grids at the front ends as trapping electrodes and thus produces a pure cyclotron motion of the ions without the usually co-existing magnetron motion and, on the other hand, measures a multiplied cyclotron frequency by means of a plurality of detection electrodes, whereby either a higher mass accuracy or a shorter measuring time can be achieved.

摘要翻译： 本发明涉及一种用于离子回旋共振质谱仪（FTMS）的测量池。 本发明提供了一种测量电池，其一方面由前端的两个离子排斥RF栅格组成，作为捕获电极，从而产生离子的纯回旋加速器，而不需要通常共存的磁控管运动，并且在 另一方面，通过多个检测电极测量相乘的回旋加速器频率，由此可以实现更高的质量精度或更短的测​​量时间。

公开(公告)号：US20050109933A1

公开(公告)日：2005-05-26

申请号：US10779333

申请日：2004-02-16

申请人： Gerhard Weiss ,  Jochen Franzen

发明人： Gerhard Weiss ,  Jochen Franzen

IPC分类号： F24F11/00 ,  H01J49/42 ,  B01D59/44

CPC分类号： H01J49/065 ,  F24F11/30 ,  F24F11/61 ,  F24F11/62 ,  F24F2110/10 ,  H01J49/0481 ,  H01J49/401

摘要： The invention relates to a device and a method for producing, from any previously configured ion beams, precisely localized small packages of ions which all fly at the same velocity. The invention consists of damping the ions in a damping-gas filled series of apertured diaphragms (which are firstly subjected alternately to the two phases of an RF voltage and secondly to a multiphase low-frequency travelling field voltage) into the axis of the apertured diaphragm arrangement and packaging the ions in bundles which are propelled axially at the same velocity for ions of different specific masses. These ion packages, which are restricted both in an axial and a radial direction, can be used to advantage for injection into different types of mass spectrometer, both storage ion-trap mass spectrometers, such as cyclotron resonance mass spectrometers or quadrupole ion traps and, especially, for time-of-flight mass spectrometers with orthogonal injection. The arrangement of a damping-gas filled series of apertured diaphragms can also be used for ion fragmentation.

摘要翻译： 本发明涉及一种用于从任何先前配置的离子束产生精确定位的全部以相同速度飞行的离子的小包装的装置和方法。 本发明包括阻尼气体填充系列的有孔隔膜中的离子（其首先交替进入RF电压的两相并且其次是多相低频行进电场电压）到有孔隔膜的轴线 以不同特定质量的离子以相同的速度轴向推进的束中的离子的排列和包装。 在轴向和径向均受限制的这些离子包装可以用于注入不同类型的质谱仪，存储离子阱质谱仪，如回旋加速器共振质谱仪或四极离子阱中， 特别是具有正交注射的飞行时间质谱仪。 阻尼气体填充系列的有孔隔膜的布置也可用于离子碎裂。