公开(公告)号：US10988451B2

公开(公告)日：2021-04-27

申请号：US16857021

申请日：2020-04-23

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Tae H. Hwang ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  John E. Knox ,  Scott E. Lazerwith ,  Xiaofen Li ,  David W. Lin ,  Jonathan W. Medley ,  Michael L. Mitchell ,  Devan Naduthambi ,  Zachary Newby ,  Neil H. Squires ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang

IPC: C07D513/08 ,  A61K31/553 ,  C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K45/06

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US10577352B2

公开(公告)日：2020-03-03

申请号：US16045518

申请日：2018-07-25

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Chienhung Chou ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Roland D. Saito ,  Neil H. Squires ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright

IPC: C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20200061024A1

公开(公告)日：2020-02-27

申请号：US16403247

申请日：2019-05-03

Applicant: GILEAD SCIENCES, INC.

Inventor： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC: A61K31/403 ,  A61K31/4192 ,  A61K31/38 ,  A61K31/16 ,  A61K31/03 ,  A61P31/20 ,  C07D519/00 ,  C07D487/04

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20200017471A1

公开(公告)日：2020-01-16

申请号：US16510647

申请日：2019-07-12

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Devan Naduthambi ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D401/14 ,  C07D471/08 ,  A61K39/395 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/444 ,  A61K31/497

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20190270727A1

公开(公告)日：2019-09-05

申请号：US16274106

申请日：2019-02-12

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D403/14 ,  A61P35/02 ,  A61P31/20 ,  C07D519/00 ,  A61K31/496

Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20190248807A1

公开(公告)日：2019-08-15

申请号：US16391673

申请日：2019-04-23

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chienhung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary B. Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D498/04 ,  C07D495/04 ,  C07D471/04 ,  C07D417/14 ,  C07D409/14 ,  C07B59/00 ,  C07D413/14 ,  C07D405/14 ,  C07D401/14 ,  C07D401/12

CPC classification number: C07D498/04 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US10253019B2

公开(公告)日：2019-04-09

申请号：US16020777

申请日：2018-06-27

Applicant: Gilead Sciences, Inc.

Inventor： Zhimin Du ,  Juan A. Guerrero ,  Joshua A. Kaplan ,  John E. Knox, Jr. ,  Jennifer R. Lo ,  Scott A. Mitchell ,  Devan Naduthambi ,  Barton W. Phillips ,  Chandrasekar Venkataramani ,  Peiyuan Wang ,  William J. Watkins ,  Zhongdong Zhao

IPC: C07D405/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D491/113 ,  C07D498/04 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/541

Abstract: Compounds having the following formula (I) and methods of their use and preparation are disclosed:

公开(公告)号：US10221197B2

公开(公告)日：2019-03-05

申请号：US14735939

申请日：2015-06-10

Applicant: Gilead Sciences, Inc.

Inventor： Zhimin Du ,  Jerry Evarts ,  Joshua Kaplan ,  Musong Kim ,  Devan Naduthambi ,  Leena Patel ,  Stephane Perreault ,  Barton W. Phillips ,  Gary Phillips ,  Kirk L. Stevens ,  Jennifer A. Treiberg ,  Joshua Van Veldhuizen ,  William J. Watkins ,  Suet Chung Yeung

IPC: C07D513/04 ,  C07D403/12 ,  C07D413/14 ,  C07D403/14 ,  C07D239/91 ,  C07D487/04 ,  C07D401/14 ,  C07D473/34

Abstract: The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, or a mixture thereof, wherein n, m, q, A′, W1, W2, W3, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

公开(公告)号：US20190016705A1

公开(公告)日：2019-01-17

申请号：US16045518

申请日：2018-07-25

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Chienhung Chou ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Roland D. Saito ,  Neil H. Squires ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright

IPC: C07D403/12 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20180305315A1

公开(公告)日：2018-10-25

申请号：US15957739

申请日：2018-04-19

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Todd Appleby ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Juan A. Guerrero ,  Salman Y. Jabri ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Gregory Notte ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Chandrasekar Venkataramani ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D213/69 ,  A61K45/06 ,  A61K31/444 ,  C07D401/14 ,  A61K31/4545 ,  C07D213/85 ,  A61K31/44 ,  C07D213/30 ,  C07D295/088 ,  A61K31/5377

CPC classification number: C07D213/69 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/85 ,  C07D295/088 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107 ,  C07D498/04 ,  C07D519/00

Abstract: Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.