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310 条记录 (耗时 0.096 秒)

    Diagnostic methods using antibodies to Neutrokine-alpha
    94.
    发明授权
    Diagnostic methods using antibodies to Neutrokine-alpha 有权
    使用Neutrokine-α抗体的诊断方法

    公开(公告)号：US06562579B1

    公开(公告)日：2003-05-13

    申请号：US09588947

    申请日：2000-06-08

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： G01N3353

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Antibodies to human tumor necrosis factor receptor TR10
    95.
    发明授权
    Antibodies to human tumor necrosis factor receptor TR10 失效
    人类肿瘤坏死因子受体TR10的抗体

    公开(公告)号：US06506569B1

    公开(公告)日：2003-01-14

    申请号：US09580212

    申请日：2000-05-26

    申请人： Jian Ni ,  Craig A. Rosen

    发明人： Jian Ni ,  Craig A. Rosen

    IPC分类号： C07K1628

    CPC分类号： C12Q1/6883 ,  A61K38/17 ,  A61K48/00 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026 ,  C12Q2600/158 ,  G01N33/6863 ,  G01N2333/715 ,  G01N2510/00

    摘要： The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides and anti-TR10 antibodies are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族和TRAIL受体亚家族成员的新蛋白质TR10。 特别地，提供编码人TR10蛋白的分离的核酸分子。 还提供TR10多肽和抗TR10抗体，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR10活性的激动剂和拮抗剂的筛选方法。

    Antibody to human endokine alpha and methods of use
    96.
    发明授权
    Antibody to human endokine alpha and methods of use 失效
    人内因素α抗体

    公开(公告)号：US06406867B1

    公开(公告)日：2002-06-18

    申请号：US09513584

    申请日：2000-02-25

    申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： C07K1622

    CPC分类号： C07K14/7151 ,  A61K38/00 ,  C07K14/5255 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S514/885

    摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and antibody fragments which specifically bind the polypeptides of the invention are also provided, as well as methods for detecting the polypeptides of the invention using said antibodies and antibody fragments. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.

    摘要翻译： 本发明涉及细胞因子的肿瘤坏死因子（TNF）家族的新成员。 特别地，提供了分离的核酸分子，其编码内丝蛋白α蛋白。 还提供了内含子α多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了特异性结合本发明多肽的抗体和抗体片段，以及使用所述抗体和抗体片段检测本发明的多肽的方法。 还提供了关于TNF家族相关疾病的诊断和治疗方法。

    Use of an antibody that binds human tumor necrosis factor receptor-like 2
    97.
    发明授权
    Use of an antibody that binds human tumor necrosis factor receptor-like 2 有权
    使用结合人类肿瘤坏死因子受体的抗体2

    公开(公告)号：US07824675B2

    公开(公告)日：2010-11-02

    申请号：US12241203

    申请日：2008-09-30

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    IPC分类号： A61K39/00 ,  A61K39/395

    CPC分类号： C07K16/2878 ,  C07K2317/73 ,  C07K2319/30

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。

    Human Tumor Necrosis Factor Receptor-Like 2
    99.
    发明申请
    Human Tumor Necrosis Factor Receptor-Like 2 失效
    人类肿瘤坏死因子受体样2

    公开(公告)号：US20090131319A1

    公开(公告)日：2009-05-21

    申请号：US12235837

    申请日：2008-09-23

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen Patricia Lyn ,  Mark Robert Hurle

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen Patricia Lyn ,  Mark Robert Hurle

    IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/63 ,  C12N15/09 ,  C12N5/00 ,  C12P21/06 ,  C07K14/00 ,  C07K16/00

    CPC分类号： C07K14/7151

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。

    CD33-Like Protein
    100.
    发明申请
    CD33-Like Protein 审中-公开
    CD33样蛋白

    公开(公告)号：US20090081727A1

    公开(公告)日：2009-03-26

    申请号：US12020205

    申请日：2008-01-25

    申请人： Jian Ni ,  Reiner L. Gentz ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner L. Gentz ,  Craig A. Rosen

    IPC分类号： C12P21/02 ,  C07H21/00 ,  C12N15/63 ,  C07K16/28 ,  C12N15/87 ,  C12N5/10

    CPC分类号： C07K14/70596

    摘要： The present invention concerns a novel CD33-like protein. In particular, isolated nucleic acid molecules are provided encoding the CD33-like protein. Recombinant CD33-like polypeptides are also provided as are recombinant vectors and host cells. The invention further provides methods useful during tumor or inflammatory disease diagnosis or prognosis and therapeutic treatments targeting cells expressing CD33-like polypeptides.

    摘要翻译： 本发明涉及一种新型的CD33样蛋白。 特别地，提供编码CD33样蛋白质的分离的核酸分子。 重组载体和宿主细胞也提供重组CD33样多肽。 本发明还提供了在针对表达CD33样多肽的细胞的肿瘤或炎性疾病诊断或预后和治疗性治疗期间有用的方法。