公开(公告)号：US07094849B2

公开(公告)日：2006-08-22

申请号：US10737591

申请日：2003-12-15

申请人： Steven Luo ,  William M. Cole ,  Yoichi Ozawa

发明人： Steven Luo ,  William M. Cole ,  Yoichi Ozawa

IPC分类号： C08F4/05

CPC分类号： C08F36/06 ,  C08F4/545

摘要： A method of producing cis-1,4-polydienes, the method comprising the step of contacting conjugated diene monomer with a lanthanide-based catalyst system in the presence of less than 20% by weight of organic solvent based on the total weight of monomer, organic solvent, and resulting polymer, where the lanthanide-based catalyst system is the combination of or reaction product of (a) a lanthanide compound, (b) an organoaluminum hydride, (c) a trihydrocarbylaluminum, and (d) a halogen-containing compound.

摘要翻译： 一种制备顺式-1,4-聚二烯的方法，该方法包括在少于20重量％的有机溶剂存在下，以单体总重量计，使共轭二烯单体与镧系元素基催化剂体系接触的步骤， 有机溶剂和所得聚合物，其中镧系元素基催化剂体系是（a）镧系元素化合物，（b）有机铝氢化物，（c）三烃基铝和（d）含卤素的化合物的组合或反应产物 复合。

公开(公告)号：US07037548B2

公开(公告)日：2006-05-02

申请号：US10852757

申请日：2004-05-25

申请人： Yoichi Ozawa ,  Akihiro Nakatani ,  Hitoshi Sato ,  Osamu Mori ,  Yukio Akiyama ,  Yasushi Morinaga ,  Yuji Nakata

发明人： Yoichi Ozawa ,  Akihiro Nakatani ,  Hitoshi Sato ,  Osamu Mori ,  Yukio Akiyama ,  Yasushi Morinaga ,  Yuji Nakata

IPC分类号： A23D9/007

CPC分类号： C11B1/06 ,  A23D9/00 ,  A23L11/20

摘要： The purpose of the present invention is to extract oil from the soybean material containing soybean germ as a main component, and to utilize it.The present invention relates to a method for producing a soybean material, comprising crudely crushing selected soybeans into a size of less than ½, and separating and concentrating a soybean germ fraction by means of sieving, sorting with air, separation based on the grain shape and the like, to the soybean germ fraction produced by said method, to oil prepared from the soybean material containing soybean germ as a main component, to oil containing 0.8% by weight or more of sterols' content, and to foods containing said oil.

摘要翻译： 本发明的目的是从含有大豆胚芽的大豆原料中提取油作为主要成分，并利用它。 本发明涉及大豆原料的制造方法，其特征在于，将选择的大豆粗粉碎成小于1/2的大小，通过筛分，空气分选，谷物形状的分离，分离浓缩大豆胚芽部分， 对由通过所述方法生产的大豆胚芽部分，以含有大豆胚芽为主要成分的大豆原料制备的油为含有0.8重量％以上的甾醇含量的油以及含有所述油的食品。

公开(公告)号：US20060030677A1

公开(公告)日：2006-02-09

申请号：US11244999

申请日：2005-10-06

申请人： Yoichi Ozawa ,  H. Miller ,  Koji Masaki ,  Tatsuo Fujimaki ,  Takuo Sone ,  Iwakazu Hattori ,  Koichi Morita

发明人： Yoichi Ozawa ,  H. Miller ,  Koji Masaki ,  Tatsuo Fujimaki ,  Takuo Sone ,  Iwakazu Hattori ,  Koichi Morita

IPC分类号： C08F8/00

CPC分类号： C08C19/44 ,  C08F136/04 ,  C08K3/36 ,  C08L7/00 ,  C08L9/06 ,  C08L19/006 ,  C08F4/545 ,  C08L2666/08

摘要： A method for preparing a functionalized polymer comprising the steps of preparing a pseudo-living polymer by polymerizing conjugated diene monomer with a lanthanide-based catalyst, and reacting the pseudo-living polymer with at least one functionalizing agent defined by the formula (I) where A is a substituent that will undergo an addition reaction with a pseudo-living polymer, R1 is a divalent organic group, R2 is a monovalent organic group, and each R4, which may be the same or different, is a monovalent organic group or a substituent defined by —OR5 where R5 is a monovalent organic group, with the proviso that A, R1, R2, R4, and R5 are substituents that will not protonate a pseudo-living polymer. Also, the functionalized polymer and a vulcanizable composition containing the polymer.

公开(公告)号：US20060025539A1

公开(公告)日：2006-02-02

申请号：US11243874

申请日：2005-10-05

申请人： Yoichi Ozawa ,  H. Miller ,  Koji Masaki

发明人： Yoichi Ozawa ,  H. Miller ,  Koji Masaki

IPC分类号： C08C19/22 ,  C08F8/30

CPC分类号： C08C19/44 ,  C08F136/04 ,  C08L19/006 ,  C08F4/545

摘要： A method for preparing a functionalized polymer comprising the steps of preparing a pseudo-living polymer by polymerizing conjugated diene monomer with a lanthanide-based catalyst, where said pseudo-living polymer is characterized by having greater than about 85 percent of the polymer in the cis microstructure and less than about 3 percent of the polymer is in the 1,2- or 3,4-microstructure, and reacting the pseudo-living polymer with at least one functionalizing agent defined by the formula (I) or (II) where Z is a substituent that will react or interact with organic or inorganic fillers; R1 is a single bond or a divalent organic group; R2 is a monovalent organic group or a divalent organic group that forms a cyclic organic group with R13 or R14; R3 is a single bond, a divalent organic group, or a trivalent organic group that forms a cyclic organic group with R4 or R5; R13 is a single bond, a divalent organic group, or a trivalent organic group that forms a cyclic organic group with R2 or R14; R4 is a monovalent organic group or a divalent organic group that forms a cyclic organic group with R3 or R5; R14 is a monovalent organic group or a divalent organic group that forms a cyclic organic group with R2 or R13; and R5 is a monovalent organic group or a divalent organic group that forms a cyclic organic group with R3 or R4; with the proviso that each group attached to the imino carbon is attached via a carbon atom and R1, R2 R3, R4, R5, R13, R14 and Z are substituents that will not protonate a pseudo-living polymer.

公开(公告)号：US06992147B1

公开(公告)日：2006-01-31

申请号：US10296084

申请日：2000-11-10

申请人： Yoichi Ozawa ,  H. Jerrold Miller ,  Koji Masaki ,  Tatsuo Fujimaki ,  Takuo Sone ,  Iwakazu Hattori ,  Koichi Morita

发明人： Yoichi Ozawa ,  H. Jerrold Miller ,  Koji Masaki ,  Tatsuo Fujimaki ,  Takuo Sone ,  Iwakazu Hattori ,  Koichi Morita

IPC分类号： C08C19/00 ,  C08F8/00

CPC分类号： C08C19/44 ,  C08F136/04 ,  C08K3/36 ,  C08L7/00 ,  C08L9/06 ,  C08L19/006 ,  C08F4/545 ,  C08L2666/08

摘要： A method for preparing a functionalized polymer comprising the steps of preparing a pseudo-living polymer by polymerizing conjugated diene monomer with a lanthanide-based catalyst, and reacting the pseudo-living polymer with at least one functionalizing agent defined by the formula (I) where A is a substituent that will undergo an addition reaction with a pseudo-living polymer, R1 is a divalent organic group, R2 is a monovalent organic group, and each R4, which may be the same or different, is a monovalent organic group or a substituent defined by —OR5 where R5 is a monovalent organic group, with the proviso that A, R1, R2, R4, and R5 are substituents that will not protonate a pseudo-living polymer. Also, the functionalized polymer and a vulcanizable composition containing the polymer.

摘要翻译： 一种制备官能化聚合物的方法，包括以下步骤：通过使共轭二烯单体与镧系元素基催化剂聚合制备假活性聚合物，并使假活性聚合物与至少一种由式（I）定义的官能化试剂反应，其中 A是将与假活性聚合物进行加成反应的取代基，R 1是二价有机基团，R 2是一价有机基团，并且每个R 可以相同或不同的一价有机基团或由-OR 5定义的取代基，其中R 5是一价 有机基团，条件是A，R 1，R 2，R 4和R 5都是 不会将假活性聚合物质子化的取代基。 此外，官能化聚合物和含有聚合物的可硫化组合物。

公开(公告)号：US06638964B2

公开(公告)日：2003-10-28

申请号：US10098421

申请日：2002-03-18

申请人： Toru Haneda ,  Akihiko Tsuruoka ,  Junichi Kamata ,  Tadashi Okabe ,  Keiko Takahashi ,  Kazumasa Nara ,  Shinichi Hamaoka ,  Norihiro Ueda ,  Takashi Owa ,  Toshiaki Wakabayashi ,  Yasuhiro Funahashi ,  Taro Semba ,  Naoko Hata ,  Yuji Yamamoto ,  Yoichi Ozawa ,  Noako Tsukahara

发明人： Toru Haneda ,  Akihiko Tsuruoka ,  Junichi Kamata ,  Tadashi Okabe ,  Keiko Takahashi ,  Kazumasa Nara ,  Shinichi Hamaoka ,  Norihiro Ueda ,  Takashi Owa ,  Toshiaki Wakabayashi ,  Yasuhiro Funahashi ,  Taro Semba ,  Naoko Hata ,  Yuji Yamamoto ,  Yoichi Ozawa ,  Noako Tsukahara

IPC分类号： A61K31405

CPC分类号： C07D401/12 ,  C07D209/04 ,  C07D209/30 ,  C07D209/42 ,  C07D403/12 ,  C07D409/12

摘要： The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof: In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1˜C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1˜C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded. Further, when the ring A is cyanophenyl group, 2-amino-5-pyridyl group or a 2-halo-5-pyridyl group and R1 is cyano group or a halogen atom, at least one of R2 and R3 should not be a hydrogen atom.

摘要翻译： 本发明创造出一种新型抗血管生成剂，并提供与常规抗肿瘤剂相比显示出高安全性的抗肿瘤剂，具有确定的作用并且能够长时间施用。 也就是说，其提供由下式（I）表示的吲哚化合物，其药理学上可接受的盐或水合物：在式中，R 1表示氢原子，卤素原子或氰基; R 2和R 3各自代表氢原子，C 1 -C 4低级烷基或卤素原子; R 4表示氢原子或C 1 -C 4低级烷基; 并且环A表示氰基苯基，氨基磺酰基苯基，氨基吡啶基，氨基嘧啶基，卤代吡啶基或氰基噻吩基，条件是所有R 1，R 2和R 3均为氢原子的情况，其中 R 2和R 3都是氢原子，或者其中环A是氨基磺酰基并且R 1和R 2都是卤素原子。 此外，当环A为氰基苯基，2-氨基-5-吡啶基或2-卤代-5-吡啶基，R 1为氰基或卤素原子时，R 2和 R 3不应该是氢原子。

公开(公告)号：US6025450A

公开(公告)日：2000-02-15

申请号：US112913

申请日：1998-07-09

申请人： David F. Lawson ,  Mark L. Stayer, Jr. ,  David Saffles ,  Koichi Morita ,  Yoichi Ozawa ,  Ryota Fujio ,  Thomas A. Antkowiak

发明人： David F. Lawson ,  Mark L. Stayer, Jr. ,  David Saffles ,  Koichi Morita ,  Yoichi Ozawa ,  Ryota Fujio ,  Thomas A. Antkowiak

IPC分类号： B60C1/00 ,  B60C15/06 ,  C08C19/44 ,  C08F36/04

CPC分类号： C08C19/44 ,  B60C1/00 ,  B60C1/0016 ,  B60C1/0025 ,  B60C15/06 ,  C08F36/04 ,  Y10S152/905

摘要： A functionalized polymer includes a polymer chain carrying at least one functional group selected from alkyl, dialkyl and cycloalkyl amine radicals having the general formula ##STR1## and cyclic amine radicals having the general formula ##STR2## where R.sub.1 is an alkyl, cycloalkyl or aralkyl having from 1 to about 12 carbon atoms, and R.sub.2 is an alkylene, substituted alkylene, oxy- or N-alkylamino-alkylene group having from about 3 to about 16 methylene groups. The invention also provides products based upon such polymers.

摘要翻译： 官能化聚合物包括携带至少一种选自具有通式的烷基，二烷基和环烷基胺基的官能团的聚合物链和具有以下通式的环胺基：其中R1是具有1至约12个碳原子的烷基，环烷基或芳烷基 原子，并且R 2是具有约3至约16个亚甲基的亚烷基，取代的亚烷基，氧基或N-烷基氨基 - 亚烷基。 本发明还提供了基于这样的聚合物的产品。

公开(公告)号：US5883183A

公开(公告)日：1999-03-16

申请号：US467363

申请日：1995-06-06

申请人： Takashi Kitamura ,  David F. Lawson ,  Koichi Morita ,  Yoichi Ozawa

发明人： Takashi Kitamura ,  David F. Lawson ,  Koichi Morita ,  Yoichi Ozawa

IPC分类号： C08F4/48 ,  B60C1/00 ,  C08F4/00 ,  C08F4/08 ,  C08F4/42 ,  C08F36/04 ,  C08F236/10 ,  C08K3/04 ,  C08L21/00 ,  C08F8/42

CPC分类号： C08F36/04 ,  B60C1/00 ,  B60C1/0016 ,  Y10T152/10495

摘要： The present invention is directed toward anionic polymerization employing lithio amines mixed with an organic alkali metal compound and optionally, a chelating reagent. The lithio amines have the general formula (A)Li(SOL)y, where SOL is a solubilizing component, A is an alkyl, dialkyl, cycloalkyl or dicycloalkyl amine radical or a cyclic amine, and y is 0 or is from about 0.5 to about 3. The invention is also directed toward polymers and other products made using the initiator, and methods therefor. Further, the invention contemplates a polymer, a polymer composition and products therefrom, which include a functional group from the reaction product of an amine and an organolithium compound. The resulting polymers may be terminated with a terminating, coupling or linking agent, which may provide the polymer with a multifunctionality.

摘要翻译： 本发明涉及使用与有机碱金属化合物和任选的螯合剂混合的锂胺进行阴离子聚合。 所述锂胺具有通式（A）Li（SOL）y，其中SOL是增溶组分，A是烷基，二烷基，环烷基或二环烷基胺基或环状胺，y是0或约0.5至 本发明还涉及使用引发剂制备的聚合物和其它产品及其方法。 此外，本发明涉及聚合物，聚合物组合物及其产物，其包括来自胺和有机锂化合物的反应产物的官能团。 所得聚合物可以用终止的，偶联或连接剂终止，其可以为聚合物提供多功能性。

公开(公告)号：US5767283A

公开(公告)日：1998-06-16

申请号：US785610

申请日：1997-01-17

申请人： Hiroshi Yoshino ,  Takashi Owa ,  Tatsuo Okauchi ,  Kentaro Yoshimatsu ,  Naoko Sugi ,  Takeshi Nagasu ,  Yoichi Ozawa ,  Nozomu Koyanagi ,  Kyosuke Kito

发明人： Hiroshi Yoshino ,  Takashi Owa ,  Tatsuo Okauchi ,  Kentaro Yoshimatsu ,  Naoko Sugi ,  Takeshi Nagasu ,  Yoichi Ozawa ,  Nozomu Koyanagi ,  Kyosuke Kito

IPC分类号： C07D209/14 ,  A61K31/40 ,  A61K31/404 ,  A61K31/635 ,  A61P35/00 ,  C07D209/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/32 ,  C07D209/34 ,  C07D209/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D401/12 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D231/56 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04

摘要： Novel heterobicyclic sulfonamide and sulfonic ester derivatives represented by the following general formula (I), which exhibit an antitumor activity and are lowly toxic, and processes for the preparation thereof. A sulfonamide derivative and a sulfonic ester derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein variables A, W, X, B, C, Y, Z are as defined in the specification.

摘要翻译： 由以下通式（I）表示的具有抗肿瘤活性和低毒性的新型杂双环磺酰胺和磺酸酯衍生物及其制备方法。 通式（I）表示的磺酰胺衍生物和磺酸酯衍生物或其药学上可接受的盐：其中变量A，W，X，B，C，Y，Z如说明书中所定义 。

公开(公告)号：US5393721A

公开(公告)日：1995-02-28

申请号：US962373

申请日：1992-10-16

申请人： Takashi Kitamura ,  David F. Lawson ,  Koichi Morita ,  Yoichi Ozawa

发明人： Takashi Kitamura ,  David F. Lawson ,  Koichi Morita ,  Yoichi Ozawa

IPC分类号： C08K3/04 ,  B60C1/00 ,  C08F4/00 ,  C08F4/42 ,  C08F4/48 ,  C08F36/04 ,  C08F236/10 ,  C08L21/00

CPC分类号： C08F36/04 ,  B60C1/0016

摘要： The present invention is directed toward artionic polymerization employing lithio amines mixed with an organic alkali metal compound and optionally, a chelating reagent. The lithio amines have the general formula (A)Li(SOL)y, where SOL is a solubilizing component, A is an alkyl, dialkyl, cycloalkyl or dicycloalkyl amine radical or a cyclic amine, and y is 0 or is from about 0.5 to about 3. The invention is also directed toward polymers and other products made using the initiator, and methods therefor. Further, the invention contemplates a polymer, a polymer composition and products therefrom, which include a functional group from the reaction product of an amine and an organolithium compound. The resulting polymers may be terminated with a terminating, coupling or linking agent, which may provide the polymer with a multifunctionality.

摘要翻译： 本发明涉及使用与有机碱金属化合物和任选的螯合剂混合的锂胺进行挥发聚合。 所述锂胺具有通式（A）Li（SOL）y，其中SOL是增溶组分，A是烷基，二烷基，环烷基或二环烷基胺基或环状胺，y是0或约0.5至 本发明还涉及使用引发剂制备的聚合物和其它产品及其方法。 此外，本发明涉及聚合物，聚合物组合物及其产物，其包括来自胺和有机锂化合物的反应产物的官能团。 所得聚合物可以用终止的，偶联或连接剂终止，其可以为聚合物提供多功能性。