公开(公告)号：US08311648B1

公开(公告)日：2012-11-13

申请号：US12973800

申请日：2010-12-20

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/05

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A delivery apparatus for accessing the pericardial space of a heart including an elongated body defining a lumen and a piercing member that extends from a distal portion of the elongated body for piercing tissue of the heart. A spring expands from a distal end of the piercing member in response to the distal end of the piercing member passing through the tissue and into the pericardial space. An electrode located on the spring in order to sense signals indicative of a distal end of the spring passing through the tissue and into the pericardial space.

摘要翻译： 一种用于进入心脏的心包空间的输送装置，包括限定内腔的细长主体和从细长主体的远端部分延伸以刺穿心脏的组织的穿刺构件。 响应于刺穿构件的远端穿过组织并进入心包空间，弹簧从穿刺构件的远端膨胀。 位于弹簧上的电极，用于感测指示穿过组织并进入心包空间的弹簧的远端的信号。

公开(公告)号：US08257272B2

公开(公告)日：2012-09-04

申请号：US13018631

申请日：2011-02-01

申请人： Michael Yang ,  Wenbo Hou

发明人： Michael Yang ,  Wenbo Hou

IPC分类号： A61B5/0295

CPC分类号： A61B5/688 ,  A61B5/0295 ,  A61B5/1107 ,  A61B5/6833 ,  A61B5/6869 ,  A61B2562/0261

摘要： An implantable sensor is provided that includes a piezopolymer sensor element including a body having a plurality of layers of a piezopolymer, and an attachment device configured to hold the piezopolymer sensor element in direct contact with at least one of a bodily fluid and bodily tissue such that the piezopolymer sensor element is configured to bend in response to motion of the at least one of bodily fluid and bodily tissue. A pair of electrodes is attached to the piezopolymer sensor element and the electrodes are configured to collect an electrical charge that is generated within the piezopolymer sensor element due to the bending of the piezopolymer sensor element.

摘要翻译： 提供了一种植入式传感器，其包括压电聚合物传感器元件，其包括具有多个压电聚合物层的主体，以及附接装置，其构造成将压敏聚合物传感器元件保持为与体液和身体组织中的至少一个直接接触，使得 压敏聚合物传感器元件被配置为响应于体液和身体组织中的至少一个的运动而弯曲。 一对电极连接到压电聚合物传感器元件，并且电极被配置为收集由于压电聚合物传感器元件的弯曲而在压电聚合物传感器元件内产生的电荷。

公开(公告)号：US20120172867A1

公开(公告)日：2012-07-05

申请号：US12980586

申请日：2010-12-29

申请人： Kyungmoo Ryu ,  Thao T. Ngo ,  Euljoon Park ,  Stuart Rosenberg ,  Allen Keel ,  Wenbo Hou ,  Steve Koh ,  Kjell Noren ,  Michael Yang

发明人： Kyungmoo Ryu ,  Thao T. Ngo ,  Euljoon Park ,  Stuart Rosenberg ,  Allen Keel ,  Wenbo Hou ,  Steve Koh ,  Kjell Noren ,  Michael Yang

IPC分类号： A61B18/14

CPC分类号： A61B18/1206 ,  A61B5/1107 ,  A61B8/488 ,  A61B18/082 ,  A61B18/1492 ,  A61B18/20 ,  A61B34/20 ,  A61B2018/00351 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00863 ,  A61B2018/0088 ,  A61B2018/00892 ,  A61B2018/0212 ,  A61B2034/2051 ,  A61B2034/2059 ,  A61B2218/002 ,  A61N7/022

摘要： A system and method for treating an arrhythmia in a heart are provided. The system includes an electronic control unit configured to monitor movement of one or more position sensor over a period of time. The position sensors may, for example, comprise electrodes or coils configured to generate induced voltages and currents in the presence of electromagnetic fields. The positions sensors are in contact with portions of heart tissue and changes in position are representative of motion of that tissue. The electronic control unit is further configured to generate an indicator, responsive to the movements of the sensors over the period of time, of a characteristic of the heart affected by delivery of ablation energy to heart tissue. In this manner, the effectiveness and safety of cardiac tissue ablation for treatment of the arrhythmia can be assessed and a post-ablation therapy regimen determined.

摘要翻译： 提供了用于治疗心脏心律失常的系统和方法。 该系统包括电子控制单元，其构造成在一段时间内监测一个或多个位置传感器的移动。 位置传感器可以例如包括配置成在存在电磁场的情况下产生感应电压和电流的电极或线圈。 位置传感器与心脏组织的部分接触并且位置变化代表该组织的运动。 电子控制单元还被配置为响应于传感器在一段时间内的移动，产生受到将消融能量递送到心脏组织的心脏特征的指示器。 以这种方式，可以评估心脏组织消融治疗心律失常的有效性和安全性，并确定消融后治疗方案。

公开(公告)号：US20110295137A1

公开(公告)日：2011-12-01

申请号：US13206395

申请日：2011-08-09

申请人： Stuart Rosenberg ,  Allen Keel ,  Kyungmoo Ryu ,  Wenbo Hou ,  Kjell Norén ,  Thao Thu Nguyen ,  Michael Yang

发明人： Stuart Rosenberg ,  Allen Keel ,  Kyungmoo Ryu ,  Wenbo Hou ,  Kjell Norén ,  Thao Thu Nguyen ,  Michael Yang

IPC分类号： A61B5/0402

CPC分类号： A61N1/3627 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/1107 ,  A61B5/6876 ,  A61B2562/043 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/37252

摘要： An exemplary method includes providing a mechanical activation time (MA time) for a myocardial location, the location defined at least in part by an electrode and the mechanical activation time determined at least in part by movement of the electrode; providing an electrical activation time (EA time) for the myocardial location; and determining an electromechanical delay (EMD) for the myocardial location based on the difference between the mechanical activation time (MA time) and the electrical activation time (EA time).

摘要翻译： 示例性方法包括提供用于心肌位置的机械活化时间（MA时间），至少部分地由电极限定的位置和至少部分地通过电极的移动确定的机械激活时间; 为心肌位置提供电激活时间（EA时间）; 并且基于机械激活时间（MA时间）和电激活时间（EA时间）之间的差异来确定心肌位置的机电延迟（EMD）。

公开(公告)号：US20110184274A1

公开(公告)日：2011-07-28

申请号：US12695815

申请日：2010-01-28

申请人： Stuart Rosenberg ,  Thao Thu Nguyen ,  Kyungmoo Ryu ,  Kjell Noren ,  Allen Keel ,  Wenbo Hou ,  Steve Koh ,  Michael Yang

发明人： Stuart Rosenberg ,  Thao Thu Nguyen ,  Kyungmoo Ryu ,  Kjell Noren ,  Allen Keel ,  Wenbo Hou ,  Steve Koh ,  Michael Yang

IPC分类号： A61B5/05 ,  A61N1/05

CPC分类号： A61B5/0538 ,  A61B5/0536 ,  A61B2562/0209 ,  A61N1/05 ,  A61N1/056

摘要： An exemplary method includes positioning a lead in a patient where the lead has a longitudinal axis that extends from a proximal end to a distal end and where the lead includes an electrode with an electrical center offset from the longitudinal axis of the lead body; measuring electrical potential in a three-dimensional potential field using the electrode; and based on the measuring and the offset of the electrical center, determining lead roll about the longitudinal axis of the lead body where lead roll may be used for correction of field heterogeneity, placement or navigation of the lead or physiological monitoring (e.g., cardiac function, respiration, etc.). Various other methods, devices, systems, etc., are also disclosed.

摘要翻译： 一种示例性方法包括将引线定位在患者体内，其中引线具有从近端延伸到远端的纵向轴线，并且其中引线包括具有偏离引线主体的纵向轴线的电中心的电极; 使用所述电极测量三维势场中的电位; 并且基于电气中心的测量和偏移，确定围绕引线主体的纵轴的引导辊，其中引导辊可用于校正磁场异质性，引线的放置或导航或生理监测（例如，心脏功能 ，呼吸等）。 还公开了各种其它方法，装置，系统等。

公开(公告)号：US20110106233A1

公开(公告)日：2011-05-05

申请号：US13005448

申请日：2011-01-12

申请人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

发明人： Kevin L. Morgan ,  Steven R. Conger ,  Anna Barlow ,  Stuart Rosenberg ,  Wenbo Hou ,  Michael Yang ,  Sheldon Williams

IPC分类号： A61N1/05

CPC分类号： A61N1/059 ,  A61N1/057 ,  A61N1/0587 ,  A61N2001/058

摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the pericardial space to anchor the distal end portion of the lead body relative to the pericardial tissue.

摘要翻译： 心包内引线包括具有近端部分和柔性的预弯曲远端部分的引线体。 远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。 远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开 以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。 导线部件在输送到心包空间之后再膨胀至正常状态，以相对于心包组织锚固引线主体的远端部分。

公开(公告)号：US20110100295A1

公开(公告)日：2011-05-05

申请号：US12987962

申请日：2011-01-10

申请人： Ming Xi ,  Michael Yang ,  Hui Zhang

发明人： Ming Xi ,  Michael Yang ,  Hui Zhang

IPC分类号： C23C16/52 ,  C23C16/455

CPC分类号： H01L21/76846 ,  H01L21/28562 ,  H01L28/75 ,  H01L28/84 ,  H01L28/90

摘要： An apparatus for processing a substrate is provided. The apparatus includes a process chamber, and a dual-mode gas distribution plate disposed within the process chamber. The dual-mode gas distribution plate comprises a first gas distribution zone disposed in a center of the gas distribution plate, and a second gas distribution zone surrounding the first gas distribution zone, the second gas distribution zone being fluidly isolated from the first gas distribution zone, wherein the first gas distribution zone is coupled to a valve system to deliver sequential pulses of a first gas to the first gas distribution zone to perform a cyclical deposition process, and the second gas distribution zone is in communication with a flow controller to deliver a second gas to perform a chemical vapor deposition process.

摘要翻译： 提供了一种用于处理衬底的设备。 该装置包括处理室和设置在处理室内的双模气体分配板。 双模式气体分配板包括设置在气体分配板的中心的第一气体分配区和围绕第一气体分配区的第二气体分配区，第二气体分配区与第一气体分配区流体隔离 ，其中所述第一气体分配区域联接到阀系统以将第一气体的顺序脉冲输送到所述第一气体分配区域以执行循环沉积过程，并且所述第二气体分配区域与流量控制器连通以递送 第二气体进行化学气相沉积工艺。

公开(公告)号：US20110066202A1

公开(公告)日：2011-03-17

申请号：US12562007

申请日：2009-09-17

申请人： Stuart Rosenberg ,  Thao Thu Nguyen ,  Kyungmoo Ryu ,  Kjell Norèn ,  Allen Keel ,  Wenbo Hou ,  Michael Yang

发明人： Stuart Rosenberg ,  Thao Thu Nguyen ,  Kyungmoo Ryu ,  Kjell Norèn ,  Allen Keel ,  Wenbo Hou ,  Michael Yang

IPC分类号： A61N1/00

CPC分类号： A61N1/372 ,  A61B5/015 ,  A61B5/042 ,  A61B5/061 ,  A61B5/1107 ,  A61B5/6846 ,  A61B5/6852 ,  A61B5/6885 ,  A61B2017/00053 ,  A61B2562/043 ,  A61N1/36185 ,  A61N1/36521 ,  A61N1/3686 ,  A61N1/3962

摘要： A method includes selecting an electrode located in a patient wherein the electrode comprises a lead-based electrode; acquiring position information with respect to time for the electrode, during both loaded and unloaded conditions of the lead, where the acquiring uses the electrode for repeatedly measuring electrical potentials in an electrical localization field established in the patient; calculating a both loaded and unloaded stability metrics for the electrode based on the acquired position information with respect to time; and comparing the unloaded and loaded stability metrics to decide whether the electrode, as located in the patient, comprises a stable location for delivery of therapy.

摘要翻译： 一种方法包括选择位于患者体内的电极，其中所述电极包括引线基电极; 在所述负载和所述引线的负载和卸载条件期间获取所述电极的时间的位置信息，其中所述获取使用所述电极在所述患者中建立的电定位区域中重复测量电位; 基于获取的相对于时间的位置信息，计算电极的负载和卸载稳定性度量; 以及比较未加载和加载的稳定度度量以决定位于患者体内的电极是否包括用于递送治疗的稳定位置。

公开(公告)号：US20110066201A1

公开(公告)日：2011-03-17

申请号：US12562003

申请日：2009-09-17

申请人： Stuart Rosenberg ,  Thao Thu Nguyen ,  Kyungmoo Ryu ,  Kjell Norèn ,  Allen Keel ,  Wenbo Hou ,  Michael Yang

发明人： Stuart Rosenberg ,  Thao Thu Nguyen ,  Kyungmoo Ryu ,  Kjell Norèn ,  Allen Keel ,  Wenbo Hou ,  Michael Yang

IPC分类号： A61N1/00

CPC分类号： A61N1/3702 ,  A61B5/042 ,  A61B5/0424 ,  A61B2560/0276 ,  A61N1/368 ,  A61N1/371

摘要： A method includes selecting an electrode located in a patient; acquiring position information with respect to time for the electrode where the acquiring uses the electrode for repeatedly measuring electrical potentials in an electrical localization field established in the patient; calculating a stability metric for the electrode based on the acquired position information with respect to time; and deciding if the selected electrode, as located in the patient, has a stable location for sensing biological electrical activity, for delivering electrical energy or for sensing biological electrical activity and delivering electrical energy. Position information may be acquired during one or both of intrinsic or paced activation of a heart and respective stability indexes calculated for each activation type.

摘要翻译： 一种方法包括选择位于患者体内的电极; 获取相对于所述电极的时间的位置信息，其中所述电极在所述患者中建立的电定位场中使用所述电极重复测量电位; 基于获取的相对于时间的位置信息计算电极的稳定性度量; 并且确定位于患者体内的所选择的电极是否具有用于感测生物电活动的稳定位置，用于传递电能或用于感测生物电活动和递送电能。 位置信息可以在心脏的固有或起搏激活和对于每种激活类型计算的各个稳定性指标的一个或两个期间获取。

公开(公告)号：US20110054560A1

公开(公告)日：2011-03-03

申请号：US12553473

申请日：2009-09-03

申请人： Stuart Rosenberg ,  Kyungmoo Ryu ,  Allen Keel ,  Wenbo Hou ,  Thao Thu Nguyen ,  Steve Koh ,  Kjell Norén ,  Michael Yang

发明人： Stuart Rosenberg ,  Kyungmoo Ryu ,  Allen Keel ,  Wenbo Hou ,  Thao Thu Nguyen ,  Steve Koh ,  Kjell Norén ,  Michael Yang

IPC分类号： A61N1/08

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3684

摘要： An exemplary method generates a map of a pacing parameter, a sensing parameter or one or more other parameters based in part on location information acquired using a localization system configured to locate electrodes in vivo (i.e., within a patient's body). Various examples map capture thresholds, qualification criteria for algorithms, undesirable conditions and sensing capabilities. Various other methods, devices, systems, etc., are also disclosed.