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151 条记录 (耗时 0.096 秒)

    Antibodies that immunospecifically bind to TRAIL receptors
    91.
    发明申请
    Antibodies that immunospecifically bind to TRAIL receptors 有权
    免疫特异性结合TRAIL受体的抗体

    公开(公告)号：US20050129699A1

    公开(公告)日：2005-06-16

    申请号：US10986047

    申请日：2004-11-12

    申请人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

    发明人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

    IPC分类号： A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

    CPC分类号： A61K39/395 ,  A61K31/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/565 ,  C07K2317/622 ,  A61K2300/00

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4i. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

    摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4i的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。

    Human G-protein coupled receptors
    92.
    发明申请
    Human G-protein coupled receptors 审中-公开
    人类G蛋白偶联受体

    公开(公告)号：US20050123961A1

    公开(公告)日：2005-06-09

    申请号：US10968990

    申请日：2004-10-21

    申请人： Yi Li ,  Steven Ruben

    发明人： Yi Li ,  Steven Ruben

    IPC分类号： C12N15/09 ,  C07K14/705 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/74

    CPC分类号： C07K14/705

    摘要： Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.

    摘要翻译： 公开了两种人G-蛋白偶联受体多肽和编码每种这样的多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽鉴定这种多肽的拮抗剂和激动剂的方法。 还公开了用于检测每个G蛋白偶联受体的核酸序列中的突变的诊断方法。

    FRUIT PEELER
    93.
    发明申请
    FRUIT PEELER 失效
    水果皮

    公开(公告)号：US20050066529A1

    公开(公告)日：2005-03-31

    申请号：US10674310

    申请日：2003-09-30

    申请人： Steven Ruben

    发明人： Steven Ruben

    IPC分类号： A47J17/02 ,  A47J43/28

    CPC分类号： A47J17/02

    摘要： A hand utensil for peeling and pitting a fruit, such as a mango, has a spoon-shaped bowl through which a plurality of elongated generally parallel slots laterally extend in a lower region of the concave surface between the proximal end and the distal end of the bowl. In addition, a series of arcuate ridges project from the concave surface of the bowl, wherein each arcuate ridge has a radius of curvature extending from a center point on a longitudinal axis defined by the bowl.

    摘要翻译： 用于剥离和点蚀水果（如芒果）的手工具具有勺形碗，多个细长的大致平行的狭槽通过该勺形碗横向延伸在凹形表面的下端区域中， 碗。 此外，一系列弧形凸起从碗的凹面突出，其中每个弧形脊具有从由碗定义的纵向轴线上的中心点延伸的曲率半径。

    Human oncogene induced secreted protein I
    94.
    发明申请
    Human oncogene induced secreted protein I 失效
    人类致癌基因诱导分泌蛋白I

    公开(公告)号：US20050003437A1

    公开(公告)日：2005-01-06

    申请号：US10909386

    申请日：2004-08-03

    申请人： Henrik Olsen ,  Steven Ruben

    发明人： Henrik Olsen ,  Steven Ruben

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/64

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： The present invention relates to a novel protein, the Human Oncogene Induced Secreted Protein I (“HOIPS I”) protein. In particular, isolated nucleic acid molecules are provided encoding the human HOIPS I protein. HOIPS I polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting abnormal cell proliferation and differentiation disorders and therapeutic methods for treating the same.

    摘要翻译： 本发明涉及一种新的蛋白质，即人癌基因诱导的分泌蛋白I（“HOIPS I”）蛋白质。 特别地，提供编码人HOIPS I蛋白的分离的核酸分子。 还提供HOIPS I多肽，载体，宿主细胞和用于制备其的重组方法。 还提供了用于检测异常细胞增殖和分化障碍的诊断方法及其治疗方法。

    Polynucleotide encoding macrophage inflammatory protein .gamma.
    95.
    发明授权
    Polynucleotide encoding macrophage inflammatory protein .gamma. 失效
    多核苷酸编码巨噬细胞炎症蛋白γ

    公开(公告)号：US5556767A

    公开(公告)日：1996-09-17

    申请号：US173209

    申请日：1993-12-22

    申请人： Craig A. Rosen ,  Haodong Li ,  Steven Ruben ,  Mark D. Adams

    发明人： Craig A. Rosen ,  Haodong Li ,  Steven Ruben ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C07K16/24 ,  C12N15/12

    CPC分类号： C07K14/523 ,  C07K16/24 ,  A61K38/00

    摘要： There is disclosed a human macrophage inflammatory protein-1 .gamma. (MIP-1 .gamma.) polypeptide and DNA(RNA) encoding such polypeptide. There is also provided a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide. Another aspect of the invention provides a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of various associated diseases.

    摘要翻译： 公开了人巨噬细胞炎症蛋白-1（MIP-1γ）多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽并产生针对这种多肽的抗体的方法。 本发明的另一方面提供本发明的多肽和合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗各种相关疾病。

    LUNG CANCER MARKERS, AND USES THEREOF
    96.
    发明申请
    LUNG CANCER MARKERS, AND USES THEREOF 有权
    肺癌标志物及其用途

    公开(公告)号：US20090176228A1

    公开(公告)日：2009-07-09

    申请号：US12273994

    申请日：2008-11-19

    申请人： Charles BIRSE ,  Marcia LEWIS ,  Steven Ruben ,  Mehdi Meari

    发明人： Charles BIRSE ,  Marcia LEWIS ,  Steven Ruben ,  Mehdi Meari

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/8114 ,  G01N2333/96486 ,  G01N2800/56

    摘要： Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

    摘要翻译： 提供了使用肺癌标志物（LCM）评估（例如诊断），治疗和预防疾病，特别是癌症和特定肺癌的方法和组合物。 为这些和其他用途提供了单个LCM和包含多个LCM的面板。 还提供了用于确定或预测治疗的有效性或使用LCM选择治疗的方法和组合物。 还提供了使用LCM调节细胞功能的方法和组合物。 还提供了调节LCM的组合物（例如拮抗剂或激动剂），例如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义剂），以及其药物组合物。 还提供了筛选调节LCM的试剂的方法以及通过这些筛选方法鉴定的试剂。

    HEMCM42 antibodies
    97.
    发明申请
    HEMCM42 antibodies 有权
    HEMCM42抗体

    公开(公告)号：US20080004432A1

    公开(公告)日：2008-01-03

    申请号：US11801040

    申请日：2007-05-07

    申请人： Steven Ruben ,  Craig Rosen ,  Gregory Endress

    发明人： Steven Ruben ,  Craig Rosen ,  Gregory Endress

    IPC分类号： C07K16/00 ,  C07K16/18

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K16/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

    Human G-protein chemokine receptor (CCR5) HDGNR10
    99.
    发明申请
    Human G-protein chemokine receptor (CCR5) HDGNR10 有权
    人类G蛋白趋化因子受体（CCR5）HDGNR10

    公开(公告)号：US20070122405A1

    公开(公告)日：2007-05-31

    申请号：US11518949

    申请日：2006-09-12

    申请人： Viktor Roschke ,  Craig Rosen ,  Steven Ruben

    发明人： Viktor Roschke ,  Craig Rosen ,  Steven Ruben

    IPC分类号： G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K16/2866 ,  C07K14/7158 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N2333/715

    摘要： The present invention relates to a human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this human protein and these human antibodies.

    摘要翻译： 本发明涉及称为人G蛋白趋化因子受体（CCR5）HDGNR10的人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该人类蛋白质和这些人抗体相关的疾病，病症和/或病症的诊断和治疗方法。