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公开(公告)号：US20160262917A1
公开(公告)日：2016-09-15
申请号：US15066649
申请日：2016-03-10
Applicant: BOSTON SCIENTIFIC SCIMED, INC.
Inventor： JOHN J. CHEN , STEVEN L. KANGAS , YEN-LANE CHEN , HONGXIA ZENG , RAGHAV GOEL
CPC classification number: A61F2/90 , A61F2/04 , A61F2210/0076 , A61F2230/0069 , A61F2240/001 , A61L2/007 , A61L31/06 , A61L31/14 , A61L31/148 , A61L2400/18 , B29C35/0266 , B29C35/0805 , B29C35/0866 , B29C48/0022 , B29C48/022 , B29C48/09 , B29C2035/0827 , B29C2035/0877 , B29K2995/006 , B29L2023/22 , B29L2031/7546 , C08L67/04
Abstract: A medical device includes a tubular network of struts including a bioerodible polymer. The tubular network can include a plurality of bands and a plurality of connector struts. Each band can include a plurality of peaks between adjacent band struts. Each band can be connected to one or more adjacent bands by at least two connector struts at a plurality of connector intersections. The bioerodible polymer can include a plurality of polymer chains functionalized with a photo active group.
Abstract translation: 医疗装置包括支柱的管状网络，其包括生物可蚀解聚合物。 管状网络可以包括多个带和多个连接器支柱。 每个带可以包括相邻带支柱之间的多个峰。 每个带可以通过在多个连接器交叉点处的至少两个连接器支柱连接到一个或多个相邻带。 生物可腐蚀的聚合物可以包括多个用光活性基团官能化的聚合物链。
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公开(公告)号：US20150343101A1
公开(公告)日：2015-12-03
申请号：US14762235
申请日：2014-01-08
Applicant: LIFECELL CORPORATION
Inventor： Gary Monteiro , Martin J. Byrne , Rick T. Owens
IPC: A61L2/00
CPC classification number: A61L2/0011 , A01N25/00 , A01N37/16 , A61L2/007 , A61L2/0088
Abstract: The present disclosure provides methods for reducing bioburden on a tissue product, as well as the tissue products produced according to the disclosed methods. In particular, the disclosure relates to methods of electroporating tissue in the presence of one or more bactericides in order to reduce bioburden. The methods allow for reduced exposure to electrical energy and/or bactericide while reducing bioburden.
Abstract translation: 本公开提供了减少组织产品上的生物负载的方法以及根据所公开的方法生产的组织产品。 特别地，本公开涉及在一种或多种杀菌剂存在下电穿孔组织以减少生物负载的方法。 该方法允许减少暴露于电能和/或杀菌剂同时减少生物负载。
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93.发明申请公开(公告)号：US20150329697A1
公开(公告)日：2015-11-19
申请号：US14808220
申请日：2015-07-24
Applicant: Arkema Inc.
Inventor： Saeid Zerafati
IPC: C08K3/22
CPC classification number: C08K3/22 , A61L2/0035 , A61L2/0041 , A61L2/007 , A61L2/081 , A61L2/082 , A61L2/087 , C08J7/123 , C08J2300/102 , C08J2327/16 , C08K5/0058 , C08K2003/2296 , C08L27/16
Abstract: The invention relates to fluoropolymer articles that have been irradiated with at least 5 Kilo Gray of radiation, where the resulting articles have low levels of leachable or extractable fluoride ion. The low fluoride ion migration from the irradiated article is due to the presence of low levels of metallic salts or oxides in the fluoropolymer composition. The invention is especially useful for fluoropolymer articles in which the fluoropolymer layer contacts a biological or pharmaceutical fluid, and that are subjected to sterilization by irradiation.
Abstract translation: 本发明涉及已经用至少5千克雷的辐射照射的氟聚合物制品，其中所得制品具有低水平的可浸出或可萃取的氟离子。 来自照射制品的低氟离子迁移是由于氟聚合物组合物中存在低水平的金属盐或氧化物。 本发明特别适用于其中含氟聚合物层接触生物或药物流体并且通过照射进行灭菌的含氟聚合物制品。
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94.发明授权公开(公告)号：US09120912B2
公开(公告)日：2015-09-01
申请号：US14118981
申请日：2012-05-23
Applicant: Saeid Zerafati
Inventor： Saeid Zerafati
CPC classification number: C08K3/22 , A61L2/0035 , A61L2/0041 , A61L2/007 , A61L2/081 , A61L2/082 , A61L2/087 , C08J7/123 , C08J2300/102 , C08J2327/16 , C08K5/0058 , C08K2003/2296 , C08L27/16
Abstract: The invention relates to fluoropolymer articles that have been irradiated with at least 5 Kilo Gray of radiation, where the resulting articles have low levels of leachable or extractable fluoride ion. The low fluoride ion migration from the irradiated article is due to the presence of low levels of metalic salts or oxides in the fluoropolymer composition. The invention is especially useful for fluoropolymer articles in which the fluorpolymer layer contacts a biological or pharmaceutical fluid, and that are subjected to sterilization by irradiation.
Abstract translation: 本发明涉及已经用至少5千克雷的辐射照射的氟聚合物制品，其中所得制品具有低水平的可浸出或可萃取的氟离子。 来自照射制品的低氟离子迁移是由于氟聚合物组合物中存在低水平的金属盐或氧化物。 本发明对于其中氟聚合物层接触生物或药物流体并且通过照射进行灭菌的含氟聚合物制品特别有用。
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公开(公告)号：US20150044093A1
公开(公告)日：2015-02-12
申请号：US14381551
申请日：2013-02-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael E. Goodwin , Nephi D. Jones , Bradley H. Buchanan
Abstract: A system for sterilizing a fluid includes a fluid source and a sterilization container bounding a fluid flow path that is in fluid communication with the fluid source. The sterilization container is comprised of one or more polymeric walls. An electron beam generator is configured to direct an electron beam through at least a portion of the fluid flow path of the sterilization container, the electron beam being sufficient to sterilize a fluid within the fluid flow path.
Abstract translation: 用于对流体灭菌的系统包括流体源和限定与流体源流体连通的流体流动路径的灭菌容器。 灭菌容器由一个或多个聚合物壁组成。 电子束发生器被配置为引导电子束通过灭菌容器的流体流动路径的至少一部分，电子束足以对流体流动路径内的流体进行消毒。
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Patent Agency Ranking
公开(公告)号：US08802652B2
公开(公告)日：2014-08-12
申请号：US12429127
申请日：2009-04-23
Applicant: Matthew Franco Myntti , Dana A. Oliver , Brian Vaccaro
Inventor： Matthew Franco Myntti , Dana A. Oliver , Brian Vaccaro
CPC classification number: A61K31/722 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0046 , A61K9/0085 , A61K9/06 , A61K31/045 , A61K31/717 , A61K31/718 , A61K47/36 , A61K47/38 , A61L2/007 , A61L2/081 , A61L2/087 , A61L27/20 , A61L27/26 , A61L27/52 , A61L27/56 , A61L2300/404 , A61L2400/06 , C08B15/005 , C08B37/003 , C08B37/0042 , C08G2210/00 , C08J3/124 , C08L1/286 , C08L5/08 , C08L1/26 , C08L2666/26
Abstract: Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.
Abstract translation: 可以使用由自由流动的基本上无胶原的可再水化多糖颗粒和可再水化的多糖海绵制成的水合组合物来保护组织和其它身体结构。 可以进行将颗粒分散在生物相容性的水混溶性极性分散剂如乙醇中并将该分散体与足够的水溶剂混合以使颗粒转化为粘性水凝胶的颗粒的再水化。 水合组合物可以帮助将损伤的，发炎的或手术修复的表面恢复到正常状态，例如通过一种或多种愈合机制，例如调节炎症反应，吞噬作用，粘膜重塑，复发或其他全部或部分恢复正常 功能。
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公开(公告)号：US20140110885A1
公开(公告)日：2014-04-24
申请号：US14139740
申请日：2013-12-23
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
IPC: B29C35/02
CPC classification number: B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。
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公开(公告)号：US20130144068A1
公开(公告)日：2013-06-06
申请号：US13737213
申请日：2013-01-09
Applicant: Cephalon, Inc..
Inventor： Rachel Y. LaBell , Piyush R. Patel
IPC: A61L2/00
CPC classification number: A61L2/0023 , A61K31/4184 , A61L2/0035 , A61L2/007
Abstract: The present application is directed to methods of sterilizing bendamustine and its pharmaceutically acceptable salt forms. Preferred sterilization methods include dry heat sterilization, gamma irradiation, and e beam radiation. Sterile pharmaceutical compositions are also described.
Abstract translation: 本申请涉及灭菌苯达莫司汀及其药学上可接受的盐形式的方法。 优选的灭菌方法包括干热灭菌，γ照射和电子束辐射。 还描述了无菌药物组合物。
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99.发明申请公开(公告)号：US20110262300A1
公开(公告)日：2011-10-27
申请号：US13125344
申请日：2009-10-22
Applicant: Holger Rahn , Hans-Peter Leinenbach , Stefan Kuhn , Franz-Josep Gerner
Inventor： Holger Rahn , Hans-Peter Leinenbach , Stefan Kuhn , Franz-Josep Gerner
CPC classification number: A61L2/007 , A61L2/0035 , A61L2/08 , A61L2202/122 , A61M1/168 , A61M1/169
Abstract: A method and an arrangement for sterilizing, in particular for sterilizing an adsorber, which has an adsorber housing that is to be filled with an adsorbent, are such that, instead of the adsorbent-filled adsorber housing being sterilized, the adsorbent is sterilized in a separate container, which is dimensioned such that the adsorbent spreads out in a thin layer in the container. Together with the adsorber housing, the container for sterilizing the adsorbent forms a closed system, such that the adsorbent can be transferred into the adsorber housing without the need for an aseptic environment. The container for receiving the adsorbent is preferably a bag, in which the adsorbent spreads out in a thin layer when the bag is lying flat on a plane surface. Since the adsorbent in the bag spreads out in a thin layer, the sterilization requires only a relatively small dose of radiation, which cannot damage the adsorbent. The bag is irradiated with high-energy radiation, in particular ionizing radiation. The adsorbent is then transferred from the bag into the adsorber housing. During the transfer of the adsorbent into the adsorber housing, the air and/or excess liquid present in the adsorber housing is removed from the adsorber housing preferably into one or more empty bags.
Abstract translation: 特别是消毒吸附器的方法和装置，其特征在于，具有吸附器壳体的要被填充吸附剂的灭菌器是这样的：代替吸附剂填充的吸附器壳体被消毒，吸附剂在 分离的容器的尺寸使得吸附剂在容器中的薄层中展开。 与吸附器壳体一起，用于消毒吸附剂的容器形成封闭系统，使得吸附剂可以被转移到吸附器壳体中，而不需要无菌环境。 用于接收吸附剂的容器优选为袋，其中当袋平躺在平面上时，吸附剂以薄层展开。 由于袋中的吸附剂散布在薄层中，所以灭菌只需要较小剂量的辐射，这不会损伤吸附剂。 用高能量辐射照射袋子，特别是电离辐射。 然后将吸附剂从袋中转移到吸附器壳体中。 在将吸附剂转移到吸附器壳体期间，存在于吸附器壳体中的空气和/或多余的液体优选地从吸附器壳体移除到一个或多个空袋中。
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公开(公告)号：US20110260358A1
公开(公告)日：2011-10-27
申请号：US13093755
申请日：2011-04-25
Applicant: Yungbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
Inventor： Yungbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
IPC: B29C71/00
CPC classification number: B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。
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