公开(公告)号：US11976101B2

公开(公告)日：2024-05-07

申请号：US17465145

申请日：2021-09-02

申请人： Wake Forest University Health Sciences

发明人： Waldemar Debinski ,  Hetal Pandya ,  Denise Gibo

IPC分类号： C07K14/54 ,  A61K47/64 ,  C07K14/005 ,  C07K14/195 ,  C07K14/21 ,  C07K14/34 ,  C07K19/00 ,  G01N33/50 ,  G01N33/532 ,  G01N33/68 ,  A61K38/00

CPC分类号： C07K14/5437 ,  A61K47/642 ,  C07K14/005 ,  C07K14/195 ,  C07K14/21 ,  C07K14/34 ,  C07K19/00 ,  G01N33/5008 ,  G01N33/5091 ,  G01N33/532 ,  G01N33/6869 ,  A61K38/00 ,  C07K2319/01 ,  C07K2319/09 ,  C07K2319/74 ,  G01N2333/025 ,  G01N2333/195 ,  G01N2333/5437

摘要： A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.

公开(公告)号：US11913073B2

公开(公告)日：2024-02-27

申请号：US18185153

申请日：2023-03-16

申请人： PML Screening, LLC ,  The Université Paris-Saclay ,  The Assistance Publique—Hôpitaux de Paris (APHP) ,  The Institut National de la Santé et de la Recherche Médicale (INSERM)

发明人： Eli Hatchwell ,  Peggy S. Eis ,  Edward B. Smith, III ,  Yassine Taoufik

IPC分类号： C12Q1/6883 ,  A61K39/00 ,  C07K16/28 ,  G01N33/569

CPC分类号： C12Q1/6883 ,  C07K16/2839 ,  G01N33/56983 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  G01N2333/025 ,  G01N2800/065 ,  G01N2800/285 ,  G01N2800/52

摘要： This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

公开(公告)号：US20230265519A1

公开(公告)日：2023-08-24

申请号：US18185153

申请日：2023-03-16

申请人： PML Screening, LLC ,  The Université Paris-Saclay ,  The Assistance Publique - Hôpitaux de Paris (APHP) ,  The Institut National de la Santé et de la Recherche Médicale (INSERM)

发明人： ELI HATCHWELL ,  Peggy S. Eis ,  Edward B. Smith, III ,  Yassine Taoufik

IPC分类号： C12Q1/6883 ,  C07K16/28 ,  G01N33/569

CPC分类号： C12Q1/6883 ,  C07K16/2839 ,  G01N33/56983 ,  G01N2333/025 ,  A61K2039/545

摘要： This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

公开(公告)号：US10006914B2

公开(公告)日：2018-06-26

申请号：US15361556

申请日：2016-11-28

申请人： Ralf Hilfrich

发明人： Ralf Hilfrich

IPC分类号： G01N33/558 ,  G01N33/52 ,  G01N33/569 ,  G01N33/68

CPC分类号： G01N33/56983 ,  G01N33/558 ,  G01N33/6854 ,  G01N2333/025

摘要： A rapid test for a qualitative and/or quantitative assay of antibodies present in body fluid against human papilloma viruses (HPV) includes mixing a specimen of body fluid with a reagent which essentially comprises a predetermined quantity of physiologically acting liquid and a predetermined quantity of at least one HPV-specific antigen. The mixture is fed to an analysis which utilizes a change that is at least one of measurable or perceivable by a user.

公开(公告)号：US20180172691A1

公开(公告)日：2018-06-21

申请号：US15888662

申请日：2018-02-05

申请人： The General Hospital Corporation ,  Imperial College London

发明人： Mark C. Poznansky ,  Hajah Siti Fatimah Jaafar ,  Dulcie V. Coleman ,  Pierre LeBlanc

IPC分类号： G01N33/574

CPC分类号： G01N33/57484 ,  G01N33/574 ,  G01N33/57411 ,  G01N33/57449 ,  G01N33/57492 ,  G01N2333/025 ,  G01N2333/522 ,  G01N2800/52 ,  G01N2800/56

摘要： The invention generally features compositions and methods for the diagnosis, treatment, and monitoring of neoplasia in a subject, as well as methods of treatment selection.

公开(公告)号：US20180113132A1

公开(公告)日：2018-04-26

申请号：US15793531

申请日：2017-10-25

申请人： Feng-Di Lung ,  Ye-song Gu ,  Bor-rung Ou ,  Chi-Sheng Cheng ,  Man-Yee Chan

发明人： Feng-Di Lung ,  Ye-song Gu ,  Bor-rung Ou ,  Chi-Sheng Cheng ,  Man-Yee Chan

IPC分类号： G01N33/574 ,  G01N33/569 ,  C07K7/08

CPC分类号： G01N33/57407 ,  C07K7/08 ,  G01N33/56983 ,  G01N33/57488 ,  G01N2333/025

摘要： The present application discloses a THLW peptide, an amino acid sequence of which is represented by SEQ ID No. 1. The THLW peptide can be used as a biomarker for diseases, such as oral cancer and cervical cancer, etc., relating to infection of human papilloma virus (HPV), therefore, THLW peptide as an antigen or an anti-THLW peptide antibody prepared can be used to detect the risk of developing cancer for sample providers.

公开(公告)号：US09953208B2

公开(公告)日：2018-04-24

申请号：US15081987

申请日：2016-03-28

申请人： Metal Industries Research & Development Centre

发明人： Yen-Chun Chen ,  Ming-Hui Cheng ,  Yu-Fen Kuo ,  Po-Wei Pan ,  Tsung-Chih Yu

IPC分类号： G06K9/00 ,  G01N33/483 ,  G06T7/00 ,  G06T7/40

CPC分类号： G06K9/00147 ,  G01N33/483 ,  G01N2333/025 ,  G06K9/0014 ,  G06K9/48 ,  G06K2009/485 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/13 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/20084 ,  G06T2207/30004 ,  G06T2207/30024

摘要： The present invention discloses a method for detecting whether cells are infected with human papillomavirus (HPV), and the method includes: (a) capturing a contour of a cell of a cell image, wherein the contour has a contour pixel thereon; (b) identifying a tangent of the contour pixel on the contour to define in relation to the tangent a first side and a second side opposite to the first side, wherein the first side indicates the intracellular region of the cell and the second side indicates the extracellular region of the cell; (c) calculating an optical parameter average of the plurality of pixels on both of the first side and the second side; and (d) determining whether the cell is infected with HPV based on whether the optical parameter average on the first side is smaller than that on the second side.

公开(公告)号：US20180037635A1

公开(公告)日：2018-02-08

申请号：US15678965

申请日：2017-08-16

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan GRIMM ,  Roland MARTIN ,  Benoit COMBALUZIER ,  Ivan JELCIC

IPC分类号： C07K16/08 ,  C07K14/005 ,  G01N33/569 ,  C12N7/00 ,  A61K39/42 ,  A61K45/06 ,  G01N33/68

CPC分类号： C07K16/084 ,  A61K39/42 ,  A61K45/06 ,  C07K14/005 ,  C07K16/081 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/22022 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/025

摘要： Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.

公开(公告)号：US09885714B2

公开(公告)日：2018-02-06

申请号：US13254503

申请日：2010-03-03

申请人： Yassine Taoufik

发明人： Yassine Taoufik

IPC分类号： A61K31/704 ,  C07J1/00 ,  A61K31/569 ,  A61K31/58 ,  A61K31/695 ,  G01N33/569 ,  C12Q1/70 ,  G01N33/68

CPC分类号： G01N33/56983 ,  C12Q1/701 ,  G01N33/56972 ,  G01N33/6863 ,  G01N2333/025 ,  G01N2800/28 ,  G01N2800/50 ,  C12Q2545/114 ,  C12Q2531/113

摘要： The invention relates to an immunological method for detecting an extra renal active infection by JC virus in a patient candidate for a treatment with an immunosuppressive treatment or during the course of this treatment.

公开(公告)号：US09884894B2

公开(公告)日：2018-02-06

申请号：US14907421

申请日：2013-08-05

申请人： Guangzhou Hengsun Pharmaceutical Technology Co. Ltd. ,  Riting Liu

发明人： Riting Liu ,  Wanxiang Xu

IPC分类号： C07K14/025 ,  A61K39/12 ,  C07K14/005 ,  C07K16/08 ,  G01N33/569 ,  C12N7/00 ,  A61K39/00 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/585 ,  A61K2039/64 ,  C07K16/084 ,  C07K2317/33 ,  C07K2317/34 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12Q1/708 ,  C12Q2600/158 ,  G01N33/56983 ,  G01N2333/025

摘要： This invention relates to the minimal motif of an epitope on the E6 protein from human papilloma virus (HPV), and this minimal motif of the epitope induces a monoclonal antibody having cross-reactivity with some homologous proteins of HPVs. The inventors are the first to identify a fine antigenic epitope only existing conservatively on the E6 proteins of high risk HPV16, 33, 52 or 58). Therefore, the peptides comprising this epitope can be used to prepare immunogen or serological detection antigen against the HPV E6 proteins, or to prepare specific universal antibodies for a variety of high-risk/carcinogenic HPVs.