公开(公告)号：US3195355A

公开(公告)日：1965-07-20

申请号：US24381962

申请日：1962-12-11

申请人： CONTINENTAL OIL CO

发明人： BOYER ERNEST W ,  MCKELVEY ERNEST E

IPC分类号： G01N1/00 ,  H01J49/04

CPC分类号： H01J49/0431 ,  H01J49/0495

公开(公告)号：US20240326055A1

公开(公告)日：2024-10-03

申请号：US18579231

申请日：2022-07-14

申请人： DH Technologies Development Pte. Ltd.

发明人： Thomas R. COVEY ,  Chang LIU

IPC分类号： B01L3/00 ,  H01J49/04

CPC分类号： B01L3/502784 ,  H01J49/0431 ,  B01L2200/027 ,  B01L2300/0829 ,  B01L2400/0436

摘要： Methods and systems for handling and/or analyzing samples are provided. In one example, a method comprises: introducing (406), with a liquid handler (322), at least one assisting agent into a sample well (310) of a well plate (312), wherein the sample comprises a sample volume; and ejecting (408), with an acoustic droplet ejector, ADE, (306), a mixture comprising the sample mixed with the at least one assisting agent from the sample well, wherein the at least one assisting agent interacts (406) with an analyte of the sample to limit gel formation at a top surface of the sample volume, prior to the mixture ejection.

公开(公告)号：US12002670B2

公开(公告)日：2024-06-04

申请号：US17597046

申请日：2019-07-04

申请人： SHIMADZU CORPORATION

发明人： Kazuma Maeda

IPC分类号： H01J49/00 ,  G01N30/72 ,  H01J49/04

CPC分类号： H01J49/0431 ,  G01N30/7266 ,  H01J49/0036

摘要： A chromatograph mass spectrometer includes: a chromatograph unit configured to separate components in a sample; a mass spectrometer configured to perform measurement on ions having a specific mass-to-charge ratio derived from each compound temporally separated by the chromatograph unit, an analysis condition setting unit configured to allow a user to set, as an analysis condition, molecular-weight-related information and a mass-spectrometry-related parameter including an ion polarity, a type of an adduct, a number of polymerizations of a multimer and/or an ion valence for each measurement target compound; and an analysis method creator configured to calculate a mass-to-charge ratio of one or a plurality of types of ions according to the analysis condition set by the analysis condition setting unit for the each measurement target compound, and create an analysis method for performing mass spectrometry on the one or a plurality of types of ions in a time division manner.

公开(公告)号：US11990325B2

公开(公告)日：2024-05-21

申请号：US17427300

申请日：2020-02-03

申请人： DH Technologies Development Pte. Ltd.

发明人： Thomas R. Covey ,  Chang Liu ,  Gary J. Van Berkel

IPC分类号： H01J49/00 ,  H01J49/04 ,  H01J49/06

CPC分类号： H01J49/0004 ,  H01J49/0418 ,  H01J49/0431 ,  H01J49/063

摘要： A method for the repeated analysis of a sample bearing location. The sample bearing location may include, for instance, a sampled point in a tissue slice that is spatially and temporally correlated to the original slice. The slice may be in whole, or in part, a complete item or a portion of a complete item such as, for example, a human organ. The method improves the analysis process, such as mass spectrometry analysis, by providing a much more complete characterization of the target. The method also allows for the splitting of the sample and chemical/physical alteration of the aliquots for enhanced chemical analysis.

公开(公告)号：US11982654B2

公开(公告)日：2024-05-14

申请号：US17519416

申请日：2021-11-04

申请人： Thermo Finnigan LLC

发明人： Raman Mathur ,  Thi Le ,  David E. Minkler

IPC分类号： G01N30/00 ,  G01N30/72 ,  H01J49/04

CPC分类号： G01N30/7233 ,  H01J49/0431

摘要： Determining a level of a liquid in a container is described. In one aspect, a container includes a calibrant liquid used for calibrating a mass spectrometer. A conductive layer is placed to float upon the calibrant liquid, and a circuit board with electrodes is arranged around the container. A controller circuit then drives and measures various electrodes to first identify which two electrodes the level of the calibrant liquid is between, and then subsequently identify a more precise location for the level between the two electrodes.

公开(公告)号：US20240128072A1

公开(公告)日：2024-04-18

申请号：US18485311

申请日：2023-10-12

申请人： SHIMADZU CORPORATION

发明人： Shunki SHIBA ,  Tomoyoshi MATSUSHITA

IPC分类号： H01J49/24 ,  F25B41/42 ,  H01J49/04

CPC分类号： H01J49/24 ,  F25B41/42 ,  H01J49/0431

摘要： A flow rate switching mechanism including: a first section including: a first housing with a passage internally bored through, the passage having a narrowed portion at a distance from one end of the passage, and the narrowed portion having a smaller cross-sectional area than the cross-sectional area of the passage at the one end; a capillary having an internal passage having a smaller cross-sectional area than the cross-sectional area of the narrowed portion; and a hermetic support member supporting the capillary and to provide a seal; a second section having a second housing identical in shape to the first housing, without having the capillary and the hermetic support member; and a three-way valve being alternatively switchable between a first state in which the outlet end is connected to the first inlet end and a second state in which the outlet end is connected to the second inlet end.

公开(公告)号：US20240087865A1

公开(公告)日：2024-03-14

申请号：US18254625

申请日：2021-11-30

申请人： DH Technologies Development Pte. Ltd.

发明人： Gary J. Van Berkel

IPC分类号： H01J49/04

CPC分类号： H01J49/0431

摘要： The disclosure provides systems and methods for segmented flow analysis. More particularly, the disclosure relates to introducing a liquid sample and a segmenting liquid into a transport capillary for segmented flow analysis, wherein the liquid sample and/or the segmenting liquid are dispensed into the transport capillary as discrete droplets.

公开(公告)号：US11885778B2

公开(公告)日：2024-01-30

申请号：US18111346

申请日：2023-02-17

申请人： UT-BATTELLE, LLC

发明人： Gary J. Van Berkel

IPC分类号： G01N1/20 ,  G01N30/72 ,  H01J49/04 ,  G01N1/00 ,  G01N35/10 ,  A61B5/00 ,  A61B10/02 ,  G01N30/02 ,  G01N1/02 ,  G01N1/04

CPC分类号： G01N30/7233 ,  A61B5/443 ,  A61B10/02 ,  G01N1/00 ,  G01N1/20 ,  G01N35/1095 ,  H01J49/0404 ,  H01J49/0431 ,  A61B5/44 ,  A61B5/4845 ,  G01N2001/028 ,  G01N2001/045 ,  G01N2030/027

摘要： A system for sampling a sample material includes a probe which can have an outer probe housing with an open end. A liquid supply conduit within the housing has an outlet positioned to deliver liquid to the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust conduit within the housing is provided for removing liquid from the open end of the housing. A liquid exhaust system can be provided for removing liquid from the liquid exhaust conduit at a second volumetric flow rate. A droplet dispenser can dispense drops of a sample or a sample-containing solvent into the open end of the housing. A sensor and a processor can be provided to monitor and maintain a liquid dome present at the open end.

公开(公告)号：US20240021425A1

公开(公告)日：2024-01-18

申请号：US18254617

申请日：2021-11-30

申请人： DH Technologies Development Pte. Ltd.

发明人： Gary J. Van Berkel

IPC分类号： H01J49/04

CPC分类号： H01J49/0431

摘要： The disclosure provides systems and methods for introducing a sample into an open port interface of an analytical device. More particularly, the disclosure relates to a sampling system that includes a dispenser, a hollow tip that releasably couples to the dispenser, and a gantry for receiving the tip. The gantry can be mounted to the open port interface of an analytical device.

公开(公告)号：US20230386815A1

公开(公告)日：2023-11-30

申请号：US18227417

申请日：2023-07-28

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Livia Schiavinato EBERLIN ,  Thomas MILNER ,  Jialing ZHANG ,  John LIN ,  John RECTOR ,  Nitesh KATTA ,  Aydin ZAHEDIVASH

IPC分类号： H01J49/04 ,  H01J49/00 ,  A61B10/00 ,  G01N33/487 ,  B01L3/00 ,  G01N33/68 ,  G01N1/02 ,  G01N30/72 ,  G01N33/574

CPC分类号： H01J49/0431 ,  H01J49/0031 ,  A61B10/0045 ,  G01N33/487 ,  B01L3/502 ,  G01N33/6848 ,  G01N1/02 ,  G01N30/72 ,  H01J49/04 ,  G01N33/574 ,  G01N2560/00 ,  B01L2400/0655 ,  B01L2200/0605 ,  B01L3/0293

摘要： Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.