公开(公告)号：US20160128558A1

公开(公告)日：2016-05-12

申请号：US14934663

申请日：2015-11-06

申请人： University of Houston System

发明人： Kirill V. Larin ,  Jiasong Li ,  Manmohan Singh ,  Chen Wu ,  Salavat Aglyamov

IPC分类号： A61B3/00 ,  A61B8/08 ,  A61B5/00 ,  A61B8/10 ,  A61B3/10 ,  A61B3/16

CPC分类号： A61B3/0025 ,  A61B3/102 ,  A61B3/16 ,  A61B3/165 ,  A61B5/0051 ,  A61B5/0053 ,  A61B5/0066 ,  A61B5/0093 ,  A61B5/0097 ,  A61B8/10 ,  A61B8/485 ,  A61B2576/00

摘要： An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (IOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).

摘要翻译： 与数据分析算法结合使用的激发力（内部或外部）和相敏光学相干弹性成像（OCE）系统能够测量和定量原位和体内组织的生物力学参数。 该方法被认为并证明了该系统的一个实例，其结合了能够在晶状体表面上产生声辐射力的脉冲超声系统和相敏光学相干断层扫描（OCT）系统，用于测量由 声辐射力。 该方法允许组织机械性质的无创和非破坏性定量。 非侵入性测量方法还利用相位稳定的扫频源光学相干弹性成像（PhS-SSOCE）来区分组织刚度，例如归因于疾病的组织刚度，以及由外部因素引起的测量刚度的影响，例如施加到组织上的压力 。 优选地，该方法用于检测组织刚度并评估其刚度的存在，即使其受角膜，巩膜或透镜的情况下的其他因素如眼内压（IOP）的影响。 这种非侵入性方法可以评估体内组织的生物力学性质，以检测退行性或其他疾病（如圆锥角膜）的发生和发展。

公开(公告)号：US09326681B2

公开(公告)日：2016-05-03

申请号：US14246430

申请日：2014-04-07

申请人： CANON KABUSHIKI KAISHA

发明人： Yuki Shimozato

IPC分类号： A61B5/00 ,  A61B3/16

CPC分类号： A61B3/165

摘要： An excessive amount of pressurized air is inhibited from being blown to an eye of a patient during measurement of a corneal shape deformation amount. In a non-contact tonometer having a piston, a driving unit to drive the piston, a fluid ejection unit to blow air pressurized by driving the piston toward a cornea of an eye to be inspected, and an intraocular pressure measuring unit to detect a deformed state of the cornea and measure an intraocular pressure, there are provided a piston displacement restricting unit that restricts a displacement amount when the piston pressurizes the air, and a changing unit to change the displacement amount to be restricted by the piston displacement restricting unit.

摘要翻译： 在测量角膜形状变形量期间，抑制过量的加压空气被吹送到患者的眼睛。 在具有活塞的非接触式眼压计中，驱动活塞的驱动单元，流体喷射单元，通过将活塞朝向要检查的眼睛的角膜驱动而吹送空气，以及眼压测量单元，用于检测变形 提供角膜状态并测量眼内压，设置有当活塞对空气加压时限制排出量的活塞位移限制单元和改变由活塞位移限制单元限制的位移量的改变单元。

公开(公告)号：US09320430B2

公开(公告)日：2016-04-26

申请号：US12751281

申请日：2010-03-31

申请人： David A. Luce

发明人： David A. Luce

IPC分类号： A61B3/16 ,  A61B3/00

CPC分类号： A61B3/165 ,  A61B3/0025

摘要： In an ophthalmic instrument that directs a fluid pulse at a cornea to cause reversible deformation of the cornea and monitors the corneal deformation to generate a deformation signal, the shape of the deformation signal is analyzed with respect to deformation signal data from a statistical population of eyes to calculate a deformation signal score indicating a degree of probability that the deformation signal corresponds in shape to a normal deformation signal for normal eyes in the population. In calculating the deformation signal score, significant geometrical signal parameters are calculated and combined. The deformation signal score may be used as a basis to keep or discard intraocular pressure measurements in a non-contact tonometer, and/or as a basis to conduct further diagnostic screening.

摘要翻译： 在眼科仪器中，指示角膜上的流体脉冲引起角膜的可逆变形并监测角膜变形以产生变形信号，相对于来自统计学上的眼睛的变形信号数据分析变形信号的形状 计算出变形信号得分，其表示变形信号的形状对于群体中正常眼睛的正常变形信号的概率。 在计算变形信号得分时，计算并组合了重要的几何信号参数。 变形信号得分可以用作在非接触眼压计中保持或丢弃眼压测量的基础，和/或作为进一步诊断筛查的基础。

公开(公告)号：US09295389B2

公开(公告)日：2016-03-29

申请号：US14094884

申请日：2013-12-03

申请人： Novartis AG

发明人： Robert Sanchez ,  Michael Morelli ,  Alex G. Fermin ,  Michael LeRoy Gelvin

IPC分类号： A61B5/00 ,  A61B3/16 ,  A61F9/007 ,  A61B5/03

CPC分类号： A61B3/16 ,  A61B5/031 ,  A61F9/00781

摘要： An IOP monitoring device for implantation in an eye of a patient may include a first tube having a first opening, the first tube being configured to extend into the anterior chamber. An intraocular pressure sensing (IOP) device for implantation in an eye of a patient may include a pressure sensor, a pressure sensor cap, and a tube coupled to a chamber inlet. The pressure sensor cap may include a recess having an inner surface, the recess configured to receive the pressure sensor such that a chamber is formed by the pressure sensor and the inner surface and a chamber inlet permitting a fluid to communicate with the chamber and be primed in a bubble-free manner. The tube may be coupled to the chamber inlet to allow fluid communication between an anterior chamber of the eye and the chamber.

摘要翻译： 用于植入患者眼睛的IOP监测装置可以包括具有第一开口的第一管，所述第一管被配置为延伸到前房中。 用于植入患者眼睛的眼压检测（IOP）装置可以包括压力传感器，压力传感器盖和联接到腔室入口的管。 压力传感器盖可以包括具有内表面的凹部，凹部被配置成接收压力传感器，使得腔由压力传感器和内表面形成，并且腔室入口允许流体与腔室连通并被引燃 以无泡沫的方式。 管可以联接到腔室入口以允许眼睛的前房与腔室之间的流体连通。

公开(公告)号：US20160051145A1

公开(公告)日：2016-02-25

申请号：US14831430

申请日：2015-08-20

申请人： California Baptist University

发明人： Matthew RICKARD ,  Creed JONES

IPC分类号： A61B3/16 ,  A61B3/00 ,  A61B5/00 ,  A61B3/14

CPC分类号： A61B3/16 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/0083 ,  A61B3/1241 ,  A61B3/145 ,  A61B5/0013 ,  A61B5/076 ,  A61B5/1116 ,  A61B5/4842 ,  A61B5/4884 ,  A61B5/6803 ,  A61B5/686 ,  A61B5/6898 ,  A61B5/7275 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2562/0219 ,  A61B2562/0261 ,  A61B2562/0266 ,  A61B2562/164 ,  G01B7/18 ,  G01B11/165 ,  G01B2210/58 ,  G01M5/0008 ,  G01M5/0033 ,  G01M5/0083 ,  G16H40/63 ,  G16H50/30

摘要： Systems and methods for monitoring eye health. The systems and methods monitor eye health by measuring scleral strain by way of an implantable monitor, a wearable monitor configured in eyeglasses, or an external monitor using a portable tablet computing device.Certain embodiments of the strain monitor may be utilized to measure the strain on any surface to which it is attached, including, but not limited to, the skin of a patient or the surface of a structure such as a building or a bridge.

摘要翻译： 用于监测眼睛健康的系统和方法。 该系统和方法通过可植入式监视器测量巩膜应变来监测眼睛的健康状态，使用眼镜配置的佩戴式监视器，或使用便携式平板计算装置的外部监视器。 应变监测器的某些实施方案可用于测量其所连接的任何表面上的应变，包括但不限于患者的皮肤或诸如建筑物或桥梁的结构的表面。

公开(公告)号：US20160015266A1

公开(公告)日：2016-01-21

申请号：US14868219

申请日：2015-09-28

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Hyuck Choo ,  David Sretavan ,  Myung-Ki Kim

IPC分类号： A61B3/16

CPC分类号： A61B3/16 ,  B82Y5/00 ,  B82Y15/00 ,  G01L1/247 ,  G01L9/0077

摘要： Systems and methods of sensing intraocular pressure are described. An example miniaturized intraocular pressure (IOP) monitoring system is provided using a nanophotonics-based implantable IOP sensor with remote optical readout that can be adapted for both patient and research use. A handheld detector optically excites the pressure-sensitive nanophotonic structure of the IOP-sensing implant placed in the anterior chamber and detects the reflected light, whose optical signature changes as a function of IOP. Optical detection eliminates the need for large, complex LC structures and simplifies sensor design. The use of nanophotonic components improves the sensor's resolution and sensitivity, increases optical readout distance, and reduces its size by a factor of 10-30 over previous implants. Its small size and convenient optical readout allows frequent and accurate self-tracking of IOP by patients in home settings.

摘要翻译： 描述了感测眼内压的系统和方法。 使用具有远程光学读出器的纳米光子学可植入IOP传感器提供可适用于患者和研究用途的示例性小型眼内压（IOP）监测系统。 手持式检测器光学激发放置在前房中的IOP感测植入物的压敏纳米光子结构，并检测其光学特征作为IOP的函数而变化的反射光。 光学检测消除了对大型复杂LC结构的需求，简化了传感器设计。 使用纳米光子组件可以提高传感器的分辨率和灵敏度，增加光学读出距离，并将其尺寸比以前的种植体减小10-30倍。 它的小尺寸和方便的光学读数允许患者在家庭环境中频繁和准确地自我跟踪IOP。

公开(公告)号：US20150359427A1

公开(公告)日：2015-12-17

申请号：US14833077

申请日：2015-08-22

申请人： Joshua Noel Hogan

发明人： Joshua Noel Hogan

IPC分类号： A61B3/16 ,  A61B3/10

CPC分类号： A61B3/16 ,  A61B3/102

摘要： The invention teaches a method, apparatus and system for measuring bio-medical attributes of the eye, such as internal or intraocular pressure. The invention enables taking measurements of the relative location of various surfaces of components of the eye under different conditions. The invention provides for applying a pressure disturbance to the eye acoustically and, using non-invasive optical techniques to perform measurements of vibrations or measurements of the time varying relative location of one or more surfaces or structures in a manner correlated with the pressure disturbance.

摘要翻译： 本发明教导了一种用于测量眼睛的生物医学属性的方法，装置和系统，例如内部或眼内压。 本发明能够在不同条件下测量眼睛各部分的各个表面的相对位置。 本发明提供了在声学上对眼睛施加压力干扰，并且使用非侵入式光学技术以与压力干扰相关的方式执行振动的测量或测量一个或多个表面或结构的时变相对位置。

公开(公告)号：US09078613B2

公开(公告)日：2015-07-14

申请号：US13903728

申请日：2013-05-28

申请人： Purdue Research Foundation

发明人： Pedro P. Irazoqui ,  Eric Y. Chow ,  William J. Chappell ,  Chin-Lung Yang ,  Babak Ziaie

IPC分类号： A61B5/00 ,  A61B3/16

CPC分类号： A61B3/16 ,  A61B5/0004 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/03 ,  A61B5/6803 ,  A61B5/686 ,  A61B2562/0247

摘要： A system is provided for monitoring intraocular pressure, the system comprising: a sensor package configured to be disposed in the suprachoroidal space of a patient's eye; a pressure sensor; a wireless transceiver disposed within the sensor package and coupled to the pressure sensor; an external transceiver, the external receiver being wirelessly coupled to the wireless transceiver when the transceiver is disposed proximate to the patient's eye.

摘要翻译： 提供了一种用于监测眼内压的系统，所述系统包括：传感器封装，其被配置为设置在患者眼睛的脉络膜上空间中; 压力传感器; 布置在所述传感器封装内并耦合到所述压力传感器的无线收发器; 外部收发器，当收发器被布置成靠近病人的眼睛时，外部接收器无线耦合到无线收发器。

公开(公告)号：US09078612B2

公开(公告)日：2015-07-14

申请号：US13309920

申请日：2011-12-02

申请人： Terry A. Fuller ,  Yongping Wang ,  Anthony Bellezza ,  William Lai

发明人： Terry A. Fuller ,  Yongping Wang ,  Anthony Bellezza ,  William Lai

IPC分类号： A61B3/16 ,  A61B5/03

CPC分类号： A61B5/031 ,  A61B3/14 ,  A61B3/16 ,  A61B5/7278

摘要： Provided are systems and methods for noninvasively assessing intracranial pressure by controllably applanating at least a portion of a subject's ocular globe so as to collapse an intraocular blood vessel and correlating the collapse pressure to intracranial pressure. Also provided are ophthalmic components useful in ophthalmic imaging applications, as well as methods of assessing intracranial pressure that are based, at least in part, on the degree of papilledema, if any, present in the subject.

摘要翻译： 提供了用于通过可控制地压迫受试者的眼球的至少一部分以塌缩眼内血管并将塌陷压力与颅内压相关联来非侵入性地评估颅内压的系统和方法。 还提供了可用于眼科成像应用的眼科成分，以及至少部分地基于受试者中存在的乳头水肿程度（如果有的话）评估颅内压的方法。

公开(公告)号：US20150133743A1

公开(公告)日：2015-05-14

申请号：US14395624

申请日：2013-03-20

申请人： NETSCIENTIFIC LIMITED

发明人： Ehud Baron

IPC分类号： A61B5/00 ,  A61B8/08 ,  A61M5/172 ,  A61B5/0205 ,  A61B5/0402 ,  A61B5/022 ,  A61B3/16 ,  A61B5/04

CPC分类号： A61B5/4839 ,  A61B3/165 ,  A61B5/0006 ,  A61B5/0024 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/02216 ,  A61B5/04011 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/7485 ,  A61B8/06 ,  A61B8/0808 ,  A61B8/0883 ,  A61B8/13 ,  A61B8/483 ,  A61B8/488 ,  A61B8/565 ,  A61B2560/0443 ,  A61B2562/08 ,  A61M5/1723 ,  G06F19/3468 ,  G16H40/40 ,  G16H40/63

摘要： A patient data capture and processing system comprises: a programmable, platform medical device comprising at least one patient sensor interface; a processor coupled to said sensor interface and to a communications interface; programmable memory, coupled to said processor. The memory is programmable via the communications interface to define a plurality of different patient sensing functions to implement, in software, a plurality of different medical devices. A patient medical device controller comprises a further communications interface coupled to the communications connection; a processor; memory, coupled to said processor, storing signal processing code to retrieve the medical device data from one or more of the programmable platform medical devices via the communications connection, to filter clinically significant events from said retrieved medical device data to detect clinically significant events, and to output the filtered data for one or both of storage and review by a physician.

摘要翻译： 患者数据采集和处理系统包括：可编程的平台医疗装置，其包括至少一个患者传感器接口; 耦合到所述传感器接口和通信接口的处理器; 可编程存储器，耦合到所述处理器。 存储器可通过通信接口来编程，以定义多个不同的患者感测功能，以软件实现多个不同的医疗设备。 病人医疗设备控制器包括耦合到通信连接的另外的通信接口; 处理器 存储器，耦合到所述处理器，存储信号处理代码以经由通信连接从一个或多个可编程平台医疗设备检索医疗设备数据，以从所述检索到的医疗设备数据中过滤临床上重要的事件以检测临床重要事件;以及 输出用于医师的存储和审查中的一个或两个的过滤数据。