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289 条记录 (耗时 0.038 秒)

    Human Rhinovirus (HRV) Antibodies
    91.
    发明申请
    Human Rhinovirus (HRV) Antibodies 审中-公开
    人类鼻病毒（HRV）抗体

    公开(公告)号：US20140341923A1

    公开(公告)日：2014-11-20

    申请号：US14449948

    申请日：2014-08-01

    申请人： Theraclone Sciences, Inc.

    发明人： Po-Ying Chan-Hui

    IPC分类号： C07K16/10 ,  A61K39/125 ,  A61K45/06 ,  C12N7/00 ,  C07K14/005

    CPC分类号： C07K16/1009 ,  A61K39/125 ,  A61K45/06 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C12N7/00 ,  C12N2770/32734

    摘要： The invention provides isolated fully human monoclonal anti-HRV antibodies, as well as method of making and using these antibodies. Anti-HRV antibodies of the invention prevent or treat subjects having HRV-infections, and related diseases, including, but not limited to, the common cold, nasopharyngitis, croup, pneumonia, bronchiolitis, asthma, chronic obstructive pulmonary disease (COPD), sinusitis, bacterial superinfection, and cystic fibrosis.

    摘要翻译： 本发明提供了分离的完全人单克隆抗-HRV抗体，以及制备和使用这些抗体的方法。 本发明的抗-HRV抗体预防或治疗患有HRV感染的受试者和相关疾病，包括但不限于感冒，鼻咽炎，痉挛，肺炎，细支气管炎，哮喘，慢性阻塞性肺病（COPD），鼻窦炎 ，细菌超感染和囊性纤维化。

    NOROVIRUS AND SAPOVIRUS ANTIGENS
    98.
    发明申请
    NOROVIRUS AND SAPOVIRUS ANTIGENS 审中-公开
    NOROVIRUS和SAPOVIRUS抗原

    公开(公告)号：US20110104192A1

    公开(公告)日：2011-05-05

    申请号：US12965344

    申请日：2010-12-10

    申请人： Doris COIT ,  Michael Houghton ,  Colin McCoin ,  Angelica Medina-Selby ,  Michael Vajdy

    发明人： Doris COIT ,  Michael Houghton ,  Colin McCoin ,  Angelica Medina-Selby ,  Michael Vajdy

    IPC分类号： A61K39/125 ,  C12P21/02 ,  C07K14/08 ,  A61P31/14 ,  A61P37/04

    CPC分类号： C12N9/14 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55544 ,  A61K2039/55555 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2770/16022 ,  C12N2770/16034

    摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.

    摘要翻译： 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。 还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

    Extracellular Matrix Materials as Vaccine Adjuvants for Diseases Associated with Infectious Pathogens or Toxins
    99.
    发明申请
    Extracellular Matrix Materials as Vaccine Adjuvants for Diseases Associated with Infectious Pathogens or Toxins 审中-公开
    细胞外基质材料作为与感染性病原体或毒素相关疾病的疫苗佐剂

    公开(公告)号：US20100136050A1

    公开(公告)日：2010-06-03

    申请号：US12578359

    申请日：2009-10-13

    申请人： Mark A. Suckow ,  William R. Wolter ,  Paul J. Hall

    发明人： Mark A. Suckow ,  William R. Wolter ,  Paul J. Hall

    IPC分类号： A61K39/12 ,  A61K39/08 ,  A61K39/145 ,  A61K39/125 ,  A61K39/09 ,  A61K39/05 ,  A61K39/085

    CPC分类号： A61K39/39 ,  A61K39/08 ,  A61K2039/55511 ,  A61K2039/55588 ,  Y02A50/41 ,  Y02A50/412

    摘要： Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvants are demonstrated to enhance the immunogenicity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.

    摘要翻译： 公开了可用于治疗和/或预防与感染性病原体（例如破伤风）相关的感染和疾病以及与生物毒素相关的疾病的疫苗和疫苗佐剂。 还提供了制备佐剂和含有佐剂的疫苗的方法。 还提供了用于疫苗接种/免疫动物免受感染和与感染性病原体相关疾病（例如破伤风）以及与生物毒素相关的其它疾病的方法。 呈现从细胞外基质材料制备的辅助材料。 证明佐剂增强感染性病原体抗原或感兴趣的生物毒素抗原的免疫原性，以及增强免疫动物的存活。