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公开(公告)号：US09603976B2
公开(公告)日：2017-03-28
申请号：US14323816
申请日：2014-07-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Dirk Pacetti
CPC classification number: A61L31/10 , A61L27/00 , A61L27/14 , A61L27/34 , A61L31/08 , A61L31/148 , A61L2420/00 , A61L2420/02
Abstract: Biodegradable coatings for implantable medical devices are disclosed.
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公开(公告)号：US09603943B2
公开(公告)日：2017-03-28
申请号：US14750732
申请日：2015-06-25
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , Syed Hossainy , Stephen Pacetti , Jessica DesNoyer
IPC: A61K31/74 , A61K47/48 , A61K9/00 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K47/34 , C08L77/12 , A61K31/727
CPC classification number: A61K47/48207 , A61K9/0024 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/4745 , A61K31/727 , A61K47/34 , A61K47/593 , A61K47/595 , A61K47/60 , C08L77/12 , C08L2205/02 , C08L2666/20
Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
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公开(公告)号：US09603727B2
公开(公告)日：2017-03-28
申请号：US14151021
申请日：2014-01-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Diem Uyen Ta , Timothy A. Limon , Andy E. Denison
CPC classification number: A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2250/0037 , A61F2250/0067
Abstract: An expandable stent for implantation in a body lumen, such as an artery, is disclosed. The stent consists of a plurality of radially expandable cylindrical rings generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting links placed so that the stent is flexible in the longitudinal direction. The link pattern is optimized to reduce strain on the links and enhance longitudinal flexibility and security of the stent. The stent includes a distal end ring and a proximal end ring that have a length that is shorter than the length of the body rings.
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104.发明授权公开(公告)号：US09592323B2
公开(公告)日：2017-03-14
申请号：US14109795
申请日：2013-12-17
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Florencia Lim , Mikael O. Trollsas , Syed F.A. Hossainy , Stephen D. Pacetti
CPC classification number: A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , Y10T24/258 , C08L67/04
Abstract: The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
Abstract translation: 本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。
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公开(公告)号：US09585778B2
公开(公告)日：2017-03-07
申请号：US14333344
申请日：2014-07-16
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： John E. Papp , Syed Faiyaz Ahmed Hossainy , Michael Ngo , Chad Abunassar , Boris Anukhin , Mikael Trollsas , Lewis B. Schwartz
CPC classification number: A61F2/915 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/958 , A61F2002/826 , A61F2002/9155 , A61F2002/91591 , A61F2210/00 , A61F2230/0013 , A61F2230/0054 , A61F2240/001 , B29C35/0805 , B29C65/64 , B29C66/1248 , B29C66/71 , B29C2035/0838 , B29K2067/046 , B29K2995/006 , B29L2031/7534
Abstract: Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.
Abstract translation: 公开了由具有重叠端环的断开的支架段组成的分段支架。 还公开了具有至少一个不连续链节的支架。
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Patent Agency Ranking
公开(公告)号：US09579492B2
公开(公告)日：2017-02-28
申请号：US15145620
申请日：2016-05-03
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： John A. Simpson , Sarah A. Nelson , Jonathan P. Durcan
IPC: A61M25/10 , A61F2/958 , A61L29/04 , A61L29/14 , B29C49/18 , B29C49/22 , A61M25/00 , A61L29/06 , B29C49/04 , B29L31/00
CPC classification number: A61M25/1029 , A61F2/958 , A61L29/04 , A61L29/06 , A61L29/14 , A61L2420/08 , A61M25/0009 , A61M25/10 , A61M25/1027 , A61M25/104 , A61M2025/1075 , B29C49/04 , B29C49/185 , B29C49/22 , B29L2031/7543 , Y10T428/1334 , Y10T428/1352 , Y10T428/1386 , Y10T428/1393
Abstract: Multilayer balloon for a catheter comprises a first layer of a first elastomeric polymeric material, and a second layer of a second elastomeric polymeric material having a lower maximum blow up ratio (BUR) than the first elastomeric polymeric material and being an outer layer relative to the first layer. The multilayer balloon is formed by blow-molding such that the multilayer balloon is blown, in at least a first stage, to a final working radial dimension, wherein an area draw-down ratio (ADDR) of 2.0 for the multilayer balloon is targeted.
Abstract translation: 用于导管的多层气囊包括第一弹性体聚合物材料的第一层和具有比第一弹性体聚合物材料更低的最大吹胀比（BUR）的第二弹性体聚合物材料的第二层，并且相对于 第一层 通过吹塑成形多层气囊，使得多层气囊在至少第一阶段被吹送到最终工作径向尺寸，其中针对多层气囊的面积缩小比（ADDR）为2.0。
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107.发明授权Sheaths reducing recoil and loss of retention for polymer scaffolds crimped to balloons 有权护套减少聚合物支架的后坐力和失去保留力，卷曲到气球公开(公告)号：US09579181B2
公开(公告)日：2017-02-28
申请号：US14716715
申请日：2015-05-19
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Jhoan Bayogo
CPC classification number: A61F2/0095 , A61F2/958 , A61F2/962 , A61F2/97 , A61F2002/011 , A61F2002/9522 , A61F2002/9583 , A61F2240/001 , A61F2250/0059 , B23P11/005 , Y10T29/49826 , Y10T29/49838 , Y10T29/49909 , Y10T29/49915
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A single piece sheath is placed over the scaffold immediately following crimping of the scaffold to the balloon. The single piece sheath is replaced by a two-piece sheath, which is removed prior to performing a medical procedure using the medical device.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 在将支架压合到气囊之后立即将单件护套放置在支架上方。 单件护套由两件式护套代替，其在使用医疗装置执行医疗程序之前被移除。
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公开(公告)号：US20170042816A1
公开(公告)日：2017-02-16
申请号：US15242403
申请日：2016-08-19
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Mikael Trollsas , John Stankus , James Su , Syed Hossainy , Joshua Takeshi Smith , Shadid Askar
CPC classification number: A61K9/146 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K38/215 , A61K47/10 , A61K2039/505 , C07K16/241 , C07K16/40 , C07K2317/21
Abstract: Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm.
Abstract translation: 公开了提供对体内空间的生物治疗剂的受控的持续释放的制剂和方法。 更具体地，公开了包含多个亲水性聚合物链的制剂，以及形成和施用这些制剂的方法。 在一些实施方案中，制剂在生物治疗的三十至九十天内显示爆发释放，初始释放，三相释放和释放。 在一些实施方案中，制剂将生物治疗剂的可逆沉淀显示为具有约50nm至约10μm直径的沉淀物。
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109.发明授权Radiopaque intraluminal stents comprising cobalt-based alloys containing one or more platinum group metals, refractory metals, or combinations thereof 有权不透射线的腔内支架，其包含含有一种或多种铂族金属的钴基合金，难熔金属或其组合公开(公告)号：US09566147B2
公开(公告)日：2017-02-14
申请号：US13830404
申请日：2013-03-14
Applicant: Abbott Cardiovascular Systems, Inc.
Inventor： Pamela A. Kramer-Brown , Kayla L. Calvert , John A. Simpson , Stephen D. Pacetti , Austin M. Leach
IPC: C22C19/07 , A61F2/06 , A61L31/02 , A61L31/18 , C22C1/04 , C22C19/05 , C22C27/00 , C22C27/04 , C22C27/06
CPC classification number: A61F2/82 , A61F2/06 , A61F2250/0098 , A61L31/022 , A61L31/18 , C22C1/0433 , C22C19/05 , C22C19/07 , C22C27/00 , C22C27/04 , C22C27/06
Abstract: Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium and one or more platinum group metals, refractory metals, precious metals, or combinations thereof. Platinum group metals include platinum, palladium, ruthenium, rhodium, osmium, and iridium. Refractory metals include zirconium, niobium, rhodium, molybdenum, hafnium, tantalum, tungsten, rhenium, and precious metals include silver and gold. In one embodiment, the one or more included platinum group or refractory metals substitute at least partially for nickel, such that the alloy exhibits reduced nickel content, or is substantially nickel free. The stents exhibit improved radiopacity as compared to similar alloys including greater amounts of nickel.
Abstract translation: 实施例涉及由包含钴，铬和一种或多种铂族金属，难熔金属，贵金属或其组合的钴基合金形成的不透射线的可植入结构（例如，支架）。 铂族金属包括铂，钯，钌，铑，锇和铱。 耐火金属包括锆，铌，铑，钼，铪，钽，钨，铼，贵金属包括银和金。 在一个实施方案中，所述一种或多种包括的铂族或难熔金属至少部分地代替镍，使得该合金显示出降低的镍含量或基本上不含镍。 与包括更大量的镍的类似合金相比，支架表现出改善的射线不透性。
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公开(公告)号：US20170038144A1
公开(公告)日：2017-02-09
申请号：US15296982
申请日：2016-10-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Sidney Watterodt , Sang joon Park , David Rego , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Bryan D. Glenn , Matthew J. Gillick , John E. Papp
CPC classification number: F26B25/003 , A61F2/91 , B23K26/402 , B23K2103/42 , B23K2103/50 , F26B15/04 , F26B15/18 , F26B25/06 , F26B25/12
Abstract: Various embodiments of methods and devices for drying coated stents in an oven are described herein.
Abstract translation: 本文描述了用于在烘箱中干燥涂层支架的方法和装置的各种实施例。
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