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204 条记录 (耗时 0.033 秒)

    Chalcones
    103.
    发明授权
    Chalcones 失效
    笛卡尔

    公开(公告)号：US06620842B2

    公开(公告)日：2003-09-16

    申请号：US10075626

    申请日：2002-02-15

    申请人： Ezio Bombardelli ,  Piero Valenti

    发明人： Ezio Bombardelli ,  Piero Valenti

    IPC分类号： A61K3135

    CPC分类号： C07D409/06 ,  A61K31/35 ,  C07D311/30 ,  C07D311/86 ,  A61K31/335 ,  A61K2300/00

    摘要： Disclosed are novel chalcone derivatives having the formula (I) The compounds possess antiproliferative activity and are useful for the manufacture of a medicament for the treatment or prevention of neoplasms, particularly those located in the uterus, ovary or breast. The compounds of the invention may also be useful in the manufacture of a medicament for the treatment or prevention of menopausal disorders and osteoporosis.

    摘要翻译： 公开了具有式（I）的新型查耳酮衍生物。该化合物具有抗增殖活性，并且可用于制备用于治疗或预防赘生物，特别是位于子宫，卵巢或乳腺中的肿瘤的药物。 本发明的化合物还可用于制备用于治疗或预防绝经障碍和骨质疏松症的药物。

    Process for preparing baccatin
    104.
    发明授权
    Process for preparing baccatin 有权
    制备浆果赤霉素的方法

    公开(公告)号：US06514732B1

    公开(公告)日：2003-02-04

    申请号：US09582223

    申请日：2000-07-20

    申请人： Ezio Bombardelli ,  Birgitta Menhard ,  Meinhart Hans Zenk

    发明人： Ezio Bombardelli ,  Birgitta Menhard ,  Meinhart Hans Zenk

    IPC分类号： C12P1702

    CPC分类号： C12P17/02 ,  C07D305/14 ,  C12N9/1025 ,  C12N9/1029

    摘要： A process for preparing baccatin and/or baccatin derivatives is described in which 10-deacetylbaccatin or a 10-deacetylbaccatin derivative is reacted in the presence of an isolated enzyme and an acetyl donor, the enzyme used being an acetyl transferase having a molecular weight of from 70 to 72 kD, determined by SDS-PAGE, which acetyl transferase is obtainable from Taxus chinensis cell cultures.

    摘要翻译： 描述了制备浆果赤霉素和/或浆果赤霉素衍生物的方法，其中10-脱乙酰基浆果赤霉素或10-脱乙酰基浆果赤霉素衍生物在分离的酶和乙酰供体的存在下反应，所用的酶是分子量为 70-72kD，通过SDS-PAGE测定，乙酰转移酶可从中华红豆杉细胞培养物获得。

    Tanacetum parthenium extract and method of obtaining same
    105.
    发明授权
    Tanacetum parthenium extract and method of obtaining same 有权
    Tan草提取物及其获得方法

    公开(公告)号：US06479080B2

    公开(公告)日：2002-11-12

    申请号：US09804037

    申请日：2001-03-13

    申请人： Ezio Bombardelli ,  Paolo Morazzoni

    发明人： Ezio Bombardelli ,  Paolo Morazzoni

    IPC分类号： A61K3578

    CPC分类号： A61K36/28 ,  A61K8/97 ,  A61Q19/00 ,  Y10S514/816 ,  Y10S514/885

    摘要： Extracts of Tanacetum parthenium with a reduced content of &agr;-unsaturated &ggr;-lactones, particularly of parthenolide, obtainable by elution on basic resins. The extracts of the invention have favorable pharmacological properties together with reduced risks of allergic reactions.

    摘要翻译： 具有降低的α-不饱和γ-内酯，特别是小白菊内酯含量的丹参醇提取物，可通过在碱性树脂上洗脱得到。 本发明的提取物具有良好的药理学特性以及过敏反应的风险降低。

    Phospholipid complexes of proanthocyanidin A2 as antiatherosclerotic agents
    106.
    发明授权
    Phospholipid complexes of proanthocyanidin A2 as antiatherosclerotic agents 有权
    原花色素A2的磷脂复合物作为抗动脉粥样硬化剂

    公开(公告)号：US06429202B1

    公开(公告)日：2002-08-06

    申请号：US09857804

    申请日：2001-06-11

    申请人： Ezio Bombardelli ,  Paolo Morazzoni

    发明人： Ezio Bombardelli ,  Paolo Morazzoni

    IPC分类号： A61K3135

    CPC分类号： A61K47/544

    摘要： The present invention relates to complexes of proanthocyanidin A2 and one or more phospholipids, pharmaceutical compositions containing the complex of proanthocyanidin A2 and one or more phospholipids, and methods of treating or preventing atherosclerosis and myocardial and cerebral infarction in a patient by administering the complex of proanthocyanidin A2 and one or more phospholipids, as well as methods of forming such complexes

    摘要翻译： 本发明涉及原花色素A2与一种或多种磷脂的复合物，含有原花青素A2和一种或多种磷脂的复合物的药物组合物，以及通过给予原花青素复合物来治疗或预防动脉粥样硬化和心肌和脑梗死的方法 A2和一种或多种磷脂，以及形成这种复合物的方法

    Extracts of zanthoxylum bungeanum, and pharmaceutical and cosmetic formulations containing same
    107.
    发明授权
    Extracts of zanthoxylum bungeanum, and pharmaceutical and cosmetic formulations containing same 有权
    花椒的提取物，以及含有其的药物和化妆品制剂

    公开(公告)号：US06419950B2

    公开(公告)日：2002-07-16

    申请号：US09749448

    申请日：2000-12-28

    申请人： Ezio Bombardelli ,  Bruno Gabetta

    发明人： Ezio Bombardelli ,  Bruno Gabetta

    IPC分类号： A61K948

    CPC分类号： A61K36/758 ,  A61K8/97 ,  A61Q19/00

    摘要： The extract of the pericarp of Zanthoxylum bungeanum, prepared by extraction with carbon dioxide in supercritical conditions, has remarkable analgesic activity without exerting the local anesthetic activity characteristic of the extracts obtained by solvent means. The product of the present invention is prepared by extracting the pericarp of Zanthoxylurn bungeanum, finely ground or transformed into pellets, with carbon dioxide under pressure conditions ranging from 150 to 300 bars at temperatures ranging from 35 to 55° C.

    摘要翻译： 通过在超临界条件下用二氧化碳提取制备的花椒的果皮提取物具有显着的镇痛作用，而不会发挥通过溶剂方法获得的提取物的局部麻醉活性。 本发明的产品是通过在35至55℃的温度范围内，在150-300巴的压力条件下，用二氧化碳将Zanthoxylurn bungeanum的果皮精细研磨或转化成颗粒来制备的。

    Soya extract, process for its preparation and pharmaceutical composition
    108.
    发明授权
    Soya extract, process for its preparation and pharmaceutical composition 有权
    大豆提取物，其制备方法和药物组成

    公开(公告)号：US06280777B1

    公开(公告)日：2001-08-28

    申请号：US09492921

    申请日：2000-01-28

    申请人： Ezio Bombardelli ,  Bruno Gabetta

    发明人： Ezio Bombardelli ,  Bruno Gabetta

    IPC分类号： A01N6500

    CPC分类号： A61K36/48 ,  Y10S514/811 ,  Y10S514/899

    摘要： A soya extract having a content of glucoside isoflavones of at least 13% by weight and a content of 0.6 to 1.5 parts by weight of group 3 soya saponins per 1 part by weight of glucoside isoflavones. Also, pharmaceutical compositions containing this extract and methods of administering the extract to treat conditions such as pre- or post-menopausal symptoms, cancer, such as breast or prostate cancer, or alcoholism. The extracts are made by a process which includes the steps of treating ripe whole soya beans or oil-free soya flour with an aliphatic alcohol to obtain a first extract; concentrating the first extract to form a concentrated first extract; purifying the concentrated first extract by treatment with at least one aliphatic hydrocarbon; and extracting active components from the purified concentrated first extract with a water-immiscible aliphatic alcohol to obtain a second extract. Preferably, the final extract is concentrated dried to form the desired soya extract.

    摘要翻译： 含有每1重量份葡萄糖苷异黄酮的至少13重量％的葡萄糖苷异黄酮含量和0.6〜1.5重量份的3组大豆皂苷的含量的大豆提取物。 此外，含有该提取物的药物组合物和施用提取物以治疗诸如绝经前或绝经后症状的癌症，癌症，例如乳腺癌或前列腺癌或酒精中毒的方法。 提取物通过包括用脂肪醇处理成熟的大豆或无油大豆粉以获得第一提取物的步骤的方法制备; 浓缩第一提取物以形成浓缩的第一提取物; 通过用至少一种脂族烃处理纯化浓缩的第一提取物; 并用水不混溶的脂族醇从纯化的浓缩的第一提取物提取活性成分，得到第二提取物。 优选将最终的提取物浓缩干燥以形成所需的大豆提取物。

    Semi-synthetic taxanes with anti-tumoural activity
    110.
    发明授权
    Semi-synthetic taxanes with anti-tumoural activity 失效
    具有抗肿瘤活性的半合成紫杉烷

    公开(公告)号：US5756776A

    公开(公告)日：1998-05-26

    申请号：US505924

    申请日：1995-07-24

    申请人： Ezio Bombardelli ,  Bruno Gabetta ,  Paolo De Bellis

    发明人： Ezio Bombardelli ,  Bruno Gabetta ,  Paolo De Bellis

    IPC分类号： A61K31/00 ,  A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/06 ,  C07D305/14

    CPC分类号： C07D305/14

    摘要： The present invention relates to novel derivatives obtained by oxidation and the stereospecific reduction of 10-deacetylbaccatine III, and successive esterification with a variously substituted isoserine chain to prepare taxol analogues. The products of the invention have cytotoxic and anti-tumoural activities and, when suitably formulated, can be administered by injection and/or orally.

    摘要翻译： 本发明涉及通过氧化和10-脱乙酰基浆果赤霉素III的立体特异性还原获得的新衍生物，以及用各种取代的异丝氨酸链连续酯化制备紫杉酚类似物。 本发明的产品具有细胞毒性和抗肿瘤活性，并且当适当配制时，可以通过注射和/或口服施用。