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公开(公告)号：US20230012449A1
公开(公告)日：2023-01-12
申请号：US17241138
申请日：2021-04-27
Applicant: Gilead Sciences, Inc.
Inventor： Steven S. Bondy , Carina E. Cannizzaro , Chien-Hung Chou , Randall L. Halcomb , Yunfeng E. Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC: C07D401/12 , C07D213/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/04 , C07D495/04 , C07C403/14 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D409/14 , C07D413/14 , C07D491/052
Abstract: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号：US10752636B2
公开(公告)日：2020-08-25
申请号：US16364487
申请日：2019-03-26
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Elbert Chin , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , John O. Link , Nathan Shapiro , Teresa Alejandra Trejo Martin , Zheng-Yu Yang
IPC: C07D405/14 , C07D487/08 , C07D491/04 , A61P31/18 , C07D403/12 , C07C275/16 , C07D401/12 , C07D471/08 , C07D487/10 , C07C243/28 , A61K31/52 , A61K31/55 , A61K31/553 , A61K31/685 , A61K31/688 , A61K45/06
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US20190308983A1
公开(公告)日：2019-10-10
申请号：US16364487
申请日：2019-03-26
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Elbert Chin , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , John O. Link , Nathan Shapiro , Teresa Alejandra Trejo Martin , Zheng-Yu Yang
IPC: C07D487/08 , C07C243/28 , A61K31/688 , C07D487/10 , C07D471/08 , C07D401/12 , C07C275/16 , C07D405/14 , C07D403/12 , A61K45/06 , A61P31/18 , A61K31/52 , A61K31/55 , A61K31/553 , A61K31/685 , C07D491/04
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herin. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US10202353B2
公开(公告)日：2019-02-12
申请号：US15121643
申请日：2015-02-26
Applicant: Gilead Sciences, Inc.
Inventor： Steven S. Bondy , Chien-Hung Chou , John O. Link , Winston C. Tse
IPC: C07D403/12 , C07D231/56 , C07D231/54 , C07D401/12 , C07D409/12 , C07D417/12 , C07D491/10 , A61K31/357 , A61K31/416 , A61K31/4162 , A61K31/4178 , A61K31/427 , A61K31/4439 , A61K31/522 , A61K45/06 , C07D319/08 , C07D405/12 , C07D473/06 , C07D491/113
Abstract: Compounds of Formula I, or salts thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, intermediates useful for preparing compounds of Formula I and therapeutic, methods for treating a Retroviridae viral infection, in particular infection caused by the HIV virus.
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公开(公告)号：US10005774B2
公开(公告)日：2018-06-26
申请号：US15150038
申请日：2016-05-09
Applicant: Gilead Sciences, Inc.
Inventor： Peter A. Blomgren , Jayaraman Chandrasekhar , Kevin S. Currie , Zhimin Du , Julie Farand , Juan A. Guerrero , Ashley A. Katana , Darryl Kato , Jeffrey E. Kropf , Scott E. Lazerwith , Seung H. Lee , Jiayao Li , John O. Link , Jennifer R. Lo , Nicholas Mai , Scott A. Mitchell , Gregory Notte , Hyung-jung Pyun , Michael Sangi , Aaron C. Schmitt , Adam J. Schrier , Kirk L. Stevens , Chandrasekar Venkataramani , William J. Watkins , Jin-Ming Xiong , Jianjun Xu , Zheng-Yu Yang , Jeff Zablocki , Zhongdong Zhao , Sheila Zipfel
IPC: C07D471/04 , C07D401/14 , C07D403/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D407/14 , C07D417/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D491/08 , C07D498/04 , C07D519/00
CPC classification number: C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/08 , C07D498/04 , C07D519/00
Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.
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Patent Agency Ranking
公开(公告)号：US09944619B2
公开(公告)日：2018-04-17
申请号：US15357290
申请日：2017-02-03
Applicant: Gilead Sciences, Inc.
Inventor： Steven S. Bondy , Carina E. Cannizzaro , Chien-Hung Chou , Randall L. Halcomb , Yunfeng Eric Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC: A01N43/00 , A61K31/00 , C07D401/12 , C07D213/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D409/14 , C07D413/14 , C07D491/052
CPC classification number: C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/04 , C07D491/052 , C07D495/04
Abstract: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号：US20170369502A1
公开(公告)日：2017-12-28
申请号：US15679014
申请日：2017-08-16
Applicant: Gilead Sciences, Inc.
Inventor： John O. Link , Jeromy J. Cottell , Teresa Alejandra Trejo Martin , Elizabeth M. Bacon
IPC: C07D491/052 , A61K45/06 , A61K38/21 , A61K31/7072 , A61K31/7068 , A61K31/7056 , A61K31/4188 , C07D491/04 , A61K31/352
CPC classification number: C07D491/052 , A61K31/352 , A61K31/4188 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K38/21 , A61K45/06 , C07D491/04
Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20170313745A1
公开(公告)日：2017-11-02
申请号：US15455508
申请日：2017-03-10
Applicant: Gilead Sciences, Inc.
Inventor： Kyla L. Bjornson , Kapil K. Karki , John O. Link , Hyung-jung Pyun , Adam J. Schrier , Kirk L. Stevens , James G. Taylor , Randall W. Vivian , Jeff Zablocki , Sheila M. Zipfel
IPC: C07K7/64 , C07D487/02 , C07D487/00 , C07D203/02 , A61K31/519 , C07D498/22 , A61K31/437
CPC classification number: C07K7/64 , A61K31/437 , A61K31/519 , C07D203/02 , C07D487/00 , C07D487/02 , C07D498/22
Abstract: Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.
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公开(公告)号：US09789089B2
公开(公告)日：2017-10-17
申请号：US14943931
申请日：2015-11-17
Applicant: Gilead Sciences, Inc.
Inventor： Steven S. Bondy , Carina E. Cannizzaro , Chien-Hung Chou , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC: A61K31/4178 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/4192 , A61K31/4196 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K45/06 , A61K31/422
CPC classification number: A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K45/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号：US20160130300A1
公开(公告)日：2016-05-12
申请号：US14996961
申请日：2016-01-15
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
Abstract translation: 公开的式I化合物及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
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