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101.发明申请Methods and compositions for reducing label variation in array-based comparative genome hybridization assays 审中-公开基于阵列的比较基因组杂交测定中减少标记变异的方法和组合物公开(公告)号：US20060078899A1
公开(公告)日：2006-04-13
申请号：US10964505
申请日：2004-10-12
申请人： Alicia Scheffer , Paige Anderson , Diane Ilsley , Michael Barrett , Bo Curry
发明人： Alicia Scheffer , Paige Anderson , Diane Ilsley , Michael Barrett , Bo Curry
CPC分类号： C12Q1/6841 , C12Q2565/501 , C12Q2525/185
摘要： Methods and compositions for producing a labeled population of nucleic acids for use in an array-based comparative genome hybridization (CGH) assay are provided. In general, the methods involve cleaving a genomic source to produce a sample containing nucleic acid fragments, and end-labeling the nucleic acid fragments to provide a population of nucleic acids having a terminal label. Kits and systems for use in practicing the subject methods are also provided.
摘要翻译： 提供了用于生产用于基于阵列的比较基因组杂交（CGH）测定中的标记的核酸群的方法和组合物。 通常，所述方法包括切割基因组来源以产生含有核酸片段的样品，并且终止标记核酸片段以提供具有末端标记的核酸群体。 还提供了用于实践主题方法的套件和系统。
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公开(公告)号：US07011094B2
公开(公告)日：2006-03-14
申请号：US10627517
申请日：2003-07-25
申请人： Alan Rapacki , Michael Barrett
发明人： Alan Rapacki , Michael Barrett
CPC分类号： A61F2/04 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12104 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/12054 , A61B2090/061 , A61F2/06 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2220/0041 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0076 , A61F2230/0078 , A61F2230/0093 , F16K15/147 , Y10S128/912
摘要： A flow control device includes a sealing component that can be positioned within a bronchial lumen. The sealing component can comprise two or more overlapping segments that are movable relative to one another such that the segments collectively form a seal that can expand and contract in size to fit within and seal bronchial lumens of various sizes.
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公开(公告)号：US07001400B1
公开(公告)日：2006-02-21
申请号：US09651344
申请日：2000-08-29
IPC分类号： A61B17/32
CPC分类号： A61B17/0625 , A61B17/0057 , A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B2017/00637 , A61B2017/00641 , A61B2017/00663 , A61B2017/00672 , A61B2017/047 , A61B2017/0472 , A61B2017/0477 , A61B2017/0496 , A61B2017/06057 , A61B2017/2927
摘要： Devices, systems, and methods for suturing of body lumens allow the suturing of vascular puncture sites located at the distal end of a percutaneous tissue tract. An elongated articulated foot near a distal end of a shaft is inserted through the penetration and actuated so that the foot extends along the lumenal axis. The foot carries suturing attachment cuffs, and needles are advanced from the shaft through the vessel wall outside of the penetration and into engagement with the needle cuffs after the foot has been drawn proximally up against the endothelial surface of the blood vessel. The cross-section of the shaft within the tissue tract can be minimized by laterally deflecting the needles as they leave the shaft, while tapered depressions within the foot can guide the advancing needles into engagement with the cuffs. The cuffs lockingly engage the needles and can be withdrawn proximally along the needle paths and through the tissue tract so as to form a loop of suture across the puncture. The articulating foot may be realigned with the shaft and withdrawn proximally through the tissue tract without dilating the tissue tract.
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公开(公告)号：US20060020347A1
公开(公告)日：2006-01-26
申请号：US11075633
申请日：2005-03-08
申请人： Michael Barrett , Michael Hendricksen , Alan Rapacki , Ronald Hundertmark , Jeffrey Dolin , Robert George , John McCutcheon , Antony Fields
发明人： Michael Barrett , Michael Hendricksen , Alan Rapacki , Ronald Hundertmark , Jeffrey Dolin , Robert George , John McCutcheon , Antony Fields
IPC分类号： A61F2/04
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/12172 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/86 , A61F2/91 , A61F2002/043 , A61F2230/0054
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
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公开(公告)号：US20060000604A1
公开(公告)日：2006-01-05
申请号：US11143351
申请日：2005-06-02
IPC分类号： E21B47/00
CPC分类号： E21B47/122 , E21B47/12
摘要： A system for communicating information, particular for use in a hydrocarbon well, is described including one or more releasable vessels having radio frequency (RF) circuitry responsive, when in use, to an RF reader system, the vessel including counteracting means to reduce the effect of destabilizing flow forces thereby extending the coupling time with the reader system.
摘要翻译： 一种用于传送特别用于烃井的信息的系统被描述为包括具有射频（RF）电路的一个或多个可释放的容器，其在使用时响应于RF读取器系统，该容器包括用于减少效应的抵消装置 从而延长与阅读器系统的耦合时间。
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公开(公告)号：US20050233340A1
公开(公告)日：2005-10-20
申请号：US10828986
申请日：2004-04-20
申请人： Michael Barrett , Alicia Scheffer
发明人： Michael Barrett , Alicia Scheffer
CPC分类号： C12Q1/6888 , C12Q1/683 , C12Q1/6837 , C12Q2600/154 , C12Q2565/501 , C12Q2521/331
摘要： Methods and compositions for assessing CpG island methylation are provided. Specifically, the invention provides an unstructured nucleic acid (UNA) oligonucleotide that base pairs with, i.e., hybridizes to, CpG islands. The subject oligonucleotide may be present in an array, and find use in methods for evaluating methylation of CpG islands in cells. Kits and computer programming for use in practicing the subject methods are also provided.
摘要翻译： 提供了用于评估CpG岛甲基化的方法和组合物。 具体地，本发明提供了与CpG岛碱基配对，即杂交的非结构化核酸（UNA）寡核苷酸。 受试寡核苷酸可以以阵列存在，并且可用于评估细胞中CpG岛的甲基化的方法。 还提供了用于实践主题方法的套件和计算机程序设计。
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公开(公告)号：US20050233338A1
公开(公告)日：2005-10-20
申请号：US10828892
申请日：2004-04-20
申请人： Michael Barrett , Alicia Scheffer
发明人： Michael Barrett , Alicia Scheffer
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q1/6881 , C12Q2600/156
摘要： Methods and compositions for assessing chromosome copy number are provided. Specifically, the invention provides an array containing a plurality of features including at least one feature that contains oligonucleotides that are complementary to a structural region of a chromosome. The subject methods and compositions may be used to detect chromosome copy number in a cell, and, as such, may be employed in a variety of diagnostic and research applications. Kits and computer programming for use in practicing the subject methods are also provided.
摘要翻译： 提供了评估染色体拷贝数的方法和组合物。 具体而言，本发明提供一种包含多个特征的阵列，其包括至少一个特征，其包含与染色体的结构区域互补的寡核苷酸。 本发明的方法和组合物可用于检测细胞中的染色体拷贝数，因此可用于多种诊断和研究应用。 还提供了用于实践主题方法的套件和计算机程序设计。
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公开(公告)号：US06932577B2
公开(公告)日：2005-08-23
申请号：US10719927
申请日：2003-11-21
申请人： J. Page Strohl , David G. Parker , Michael Barrett
发明人： J. Page Strohl , David G. Parker , Michael Barrett
摘要： A turbine blade including an airfoil having a profile in accordance with Table 1 is disclosed. The turbine blade has a plurality of cooling passages extending radially outward through the airfoil. The aerodynamic profile of the airfoil has been reconfigured to reduce airfoil stress for a given operating temperature, thereby resulting in increased creep rupture life of the airfoil.
摘要翻译： 公开了一种包括具有根据表1的轮廓的翼型的涡轮叶片。 涡轮机叶片具有径向向外延伸穿过翼型的多个冷却通道。 已经重构了翼型件的空气动力学特性，以减少给定工作温度下的翼型应力，从而导致翼型件的蠕变断裂寿命增加。
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公开(公告)号：US20050166925A1
公开(公告)日：2005-08-04
申请号：US11092123
申请日：2005-03-28
申请人： Peter Wilson , Antony Fields , Hanson Gifford , John McCutcheon , Michael Hendricksen , Alan Rapacki , David Tholfsen , Michael Barrett , Ronald Hundertmark , Douglas Sutton
发明人： Peter Wilson , Antony Fields , Hanson Gifford , John McCutcheon , Michael Hendricksen , Alan Rapacki , David Tholfsen , Michael Barrett , Ronald Hundertmark , Douglas Sutton
CPC分类号： A61F2/2412 , A61B2017/1205 , A61F2/04 , A61F2/06 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2002/9522 , Y10S128/912
摘要： Methods and systems for lung volume reduction of a patient are described. The methods include implanting a flow control device in a bronchial passageway of the lung. The flow control device regulates fluid flow through the bronchial passageway and includes a valve protector that at least partially surrounds a valve member. The valve protector has sufficient rigidity to maintain the shape of the valve member against compression.
摘要翻译： 描述了患者肺容积减少的方法和系统。 所述方法包括在肺的支气管通道中植入流量控制装置。 流量控制装置调节通过支气管通道的流体流动并且包括至少部分地围绕阀构件的阀保护器。 阀保护器具有足够的刚性以保持阀构件的形状不被压缩。
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公开(公告)号：US20050136416A1
公开(公告)日：2005-06-23
申请号：US10747004
申请日：2003-12-23
CPC分类号： G01N33/6893 , C12Q1/6837 , G01N33/5091 , C12Q2565/515
摘要： Patient specific array-based assays are provided. A feature of the subject patient specific array-based assays is that they include a step of interrogating a set of array features that have been previously identified by a general array-based assay to be relevant to a specific disease and condition of the subject being assayed. Also provided are methods of producing the subject patient specific array-based assays, as well as compositions and kits for use in practicing the subject assays.
摘要翻译： 提供了基于特定阵列的测定法。 基于患者特异性基于阵列的测定的特征在于它们包括询问一组阵列特征的步骤，其先前已经通过基于阵列的测定法被识别为与被测定的受试者的特定疾病和状况相关 。 还提供了产生基于患者特异性阵列的测定法的方法，以及用于实践受试者测定的组合物和试剂盒。
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