公开(公告)号：US07381800B2

公开(公告)日：2008-06-03

申请号：US10874484

申请日：2004-06-24

申请人： Yanggu Shi ,  Paul E. Young ,  Reinhard Ebner ,  Daniel R. Soppet ,  Steven M. Ruben

发明人： Yanggu Shi ,  Paul E. Young ,  Reinhard Ebner ,  Daniel R. Soppet ,  Steven M. Ruben

IPC分类号： C12N5/10 ,  C12N5/12 ,  C12P21/08

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20080025981A1

公开(公告)日：2008-01-31

申请号：US11599845

申请日：2006-11-15

申请人： Paul Young ,  Reinhard Ebner ,  Zoe Weaver ,  Jeffrey Strovel ,  Stephen Horrigan ,  Martin Shea ,  Bernd Weigle ,  Michael Rieger ,  Jennifer Rick ,  Colyn Cain

发明人： Paul Young ,  Reinhard Ebner ,  Zoe Weaver ,  Jeffrey Strovel ,  Stephen Horrigan ,  Martin Shea ,  Bernd Weigle ,  Michael Rieger ,  Jennifer Rick ,  Colyn Cain

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/68

CPC分类号： G01N33/5011 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with methods for assaying for potential antitumor agents based on their modulation of the expression of these cancer-related genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing cancer using the gene sequences as well as the polypeptide sequences.

摘要翻译： 公开了与癌基因序列和衍生的氨基酸序列，以及基于它们对这些癌症相关基因表达的调节来测定潜在的抗肿瘤剂的方法。 还公开了与所公开的多肽反应的抗体以及使用抗体治疗癌性病症的方法，例如使用抗体靶向靶细胞体内的癌细胞用于递送治疗剂的目的。 还描述了使用基因序列以及多肽序列诊断癌症的方法。

公开(公告)号：US07163797B2

公开(公告)日：2007-01-16

申请号：US10970493

申请日：2004-10-22

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Reinhard Ebner

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Reinhard Ebner

IPC分类号： G01N33/53 ,  C12N5/00 ,  C12N5/02 ,  C12N1/20 ,  C12N5/06 ,  C12N5/16 ,  C12N5/12 ,  C12N5/22 ,  C07K16/00 ,  C07K16/18 ,  C12P21/08

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  G01N2800/042

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20060198784A1

公开(公告)日：2006-09-07

申请号：US11377165

申请日：2006-03-17

申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig Rosen

发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig Rosen

IPC分类号： A61K51/00 ,  A61K39/395 ,  G01N33/53

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

公开(公告)号：US20060193859A1

公开(公告)日：2006-08-31

申请号：US11382837

申请日：2006-05-11

申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

公开(公告)号：US06881401B1

公开(公告)日：2005-04-19

申请号：US09589285

申请日：2000-06-08

申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/24 ,  C12P21/08 ,  A61K38/18 ,  A61K38/19 ,  C07K14/475

CPC分类号： C07K16/24 ,  A61K38/00 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/622

摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

公开(公告)号：US06806351B2

公开(公告)日：2004-10-19

申请号：US09774639

申请日：2001-02-01

申请人： Steven M. Ruben ,  Daniel R. Soppet ,  Reinhard Ebner ,  Henrik S. Olsen ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Laurie A. Brewer ,  Fouad Janat

发明人： Steven M. Ruben ,  Daniel R. Soppet ,  Reinhard Ebner ,  Henrik S. Olsen ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen ,  Laurie A. Brewer ,  Fouad Janat

IPC分类号： C07K14435

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US06635743B1

公开(公告)日：2003-10-21

申请号：US09523323

申请日：2000-03-10

申请人： Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Stephen Ullrich ,  Yifan Zhai

发明人： Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Stephen Ullrich ,  Yifan Zhai

IPC分类号： C07K1600

CPC分类号： C07K16/2866 ,  A61K38/00 ,  A61K39/00 ,  A61K45/06 ,  A61K48/00 ,  C07K14/4747 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026 ,  C12N2799/027 ,  Y10S930/144

摘要： The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.

摘要翻译： 本发明涉及TNF-配体超家族的新成员。 更具体地，提供编码人细胞凋亡诱导分子II（AIM II）的分离的核酸分子。 还提供了AIM II多肽，载体，宿主细胞以及用于制备其的重组方法也是如此。 本发明还涉及用于鉴定AIM II活性的激动剂和拮抗剂的筛选方法。 还提供了治疗淋巴结病，异常骨发育，自身免疫和其他免疫系统疾病，移植物抗宿主病，类风湿性关节炎，骨关节炎和抑制肿瘤形成如肿瘤细胞生长的治疗方法。

公开(公告)号：US06566325B2

公开(公告)日：2003-05-20

申请号：US09904615

申请日：2001-07-16

申请人： Paul A. Moore ,  Steven M. Ruben ,  Henrik S. Olsen ,  Yanggu Shi ,  Craig A. Rosen ,  Kimberly A. Florence ,  Daniel R. Soppet ,  David W. LaFleur ,  Gregory A. Endress ,  Reinhard Ebner ,  George Komatsoulis ,  Roxanne D. Duan

发明人： Paul A. Moore ,  Steven M. Ruben ,  Henrik S. Olsen ,  Yanggu Shi ,  Craig A. Rosen ,  Kimberly A. Florence ,  Daniel R. Soppet ,  David W. LaFleur ,  Gregory A. Endress ,  Reinhard Ebner ,  George Komatsoulis ,  Roxanne D. Duan

IPC分类号： C07K1400

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：US06562579B1

公开(公告)日：2003-05-13

申请号：US09588947

申请日：2000-06-08

申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

IPC分类号： G01N3353

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。