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    Apoptosis Inducing Molecule II and methods of use
    2.
    发明授权
    Apoptosis Inducing Molecule II and methods of use 有权
    细胞凋亡诱导分子II及其使用方法

    公开(公告)号：US06495520B2

    公开(公告)日：2002-12-17

    申请号：US09252656

    申请日：1999-02-19

    申请人： Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jun Zhang ,  Stephen Ullrich ,  Yifan Zhai

    发明人： Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jun Zhang ,  Stephen Ullrich ,  Yifan Zhai

    IPC分类号： A61K3818

    CPC分类号： C07K14/70575 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026 ,  C12N2799/027

    摘要： The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.

    摘要翻译： 本发明涉及TNF-配体超家族的新成员。 更具体地，提供编码人细胞凋亡诱导分子II（AIM II）的分离的核酸分子。 还提供了AIM II多肽，载体，宿主细胞以及用于制备其的重组方法也是如此。 本发明还涉及用于鉴定AIM II活性的激动剂和拮抗剂的筛选方法。 还提供了治疗淋巴结病，异常骨发育，自身免疫和其他免疫系统疾病，移植物抗宿主病，类风湿性关节炎，骨关节炎和抑制肿瘤形成如肿瘤细胞生长的治疗方法。

    Tumor necrosis factor receptors 6α and 6β
    6.
    发明授权
    Tumor necrosis factor receptors 6α and 6β 失效
    肿瘤坏死因子受体6α和6＆bgr;

    公开(公告)号：US08003386B1

    公开(公告)日：2011-08-23

    申请号：US09006352

    申请日：1998-01-13

    申请人： Reiner Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

    发明人： Reiner Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

    IPC分类号： C12N15/28 ,  C12N15/09 ,  C12N15/06 ,  C12N15/12 ,  C12N5/10 ,  C12P21/00

    CPC分类号： C07K14/70578

    摘要： The present invention relates to novel Tumor Necorsis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α＆-6＆bgr的分离的核酸分子; 蛋白质。 TNFR-6α＆-6＆bgr; 还提供多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定TNFR-6α和-6β的激动剂和拮抗剂的筛选方法。 活动。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。