公开(公告)号：US09315848B2

公开(公告)日：2016-04-19

申请号：US13817285

申请日：2011-08-17

Applicant: Hossam Haick ,  Nir Peled

Inventor： Hossam Haick ,  Nir Peled

IPC: C12Q1/02 ,  C12Q1/48 ,  G01N30/00 ,  H01J49/00 ,  C12Q1/68 ,  G01N33/574 ,  G01N30/88

CPC classification number: C12Q1/025 ,  C12Q1/485 ,  C12Q1/6886 ,  C12Q2600/156 ,  G01N30/00 ,  G01N33/57423 ,  G01N2030/8854 ,  G01N2333/71 ,  G01N2333/82 ,  H01J49/0027 ,  Y10T436/212 ,  Y10T436/214 ,  Y10T436/216 ,  Y10T436/24

Abstract: The present invention provides methods of identifying a genetic abnormality such as mutation in EGFR or KRAS or ALK which is associated with the management of lung cancer or diagnosing, prognosing or monitoring the treatment of pre-cancerous conditions of the lung, such as bronchial dysplasia or atypical alveolar hyperplasia (AAH), through the detection of at least one volatile organic compound indicative of these states.

Abstract translation: 本发明提供鉴定EGFR或KRAS或ALK的突变的遗传异常的方法，其与肺癌的管理相关联或诊断，预后或监测肺的癌前病症的治疗，例如支气管发育不良或 通过检测指示这些状态的至少一种挥发性有机化合物，非典型性肺泡增生（AAH）。

公开(公告)号：US08903661B2

公开(公告)日：2014-12-02

申请号：US12933439

申请日：2009-03-26

Applicant: Hossam Haick ,  Ekaterina Dovgolevsky

Inventor： Hossam Haick ,  Ekaterina Dovgolevsky

IPC: G01N33/22 ,  G01N33/00 ,  B82Y15/00 ,  B82Y30/00

CPC classification number: G01N33/0057 ,  B82Y15/00 ,  B82Y30/00 ,  Y10T436/17

Abstract: The present application describes a sensor apparatus, especially an electronic nose, based on 2D films or 3D assemblies of cubic nanoparticles capped with an organic coating. The organic coating is modified with unique compositions of functional moieties, e.g. cyclodextrins, to provide the detection of volatile and non-volatile compounds derived from explosive materials, e.g. PETN, RDX, TNT etc. with very high sensitivity. The nose employs pattern recognition algorithms and methods, e.g. PCA, for detecting and quantifying specific explosive compounds.

Abstract translation: 本申请描述了基于用有机涂层覆盖的立方体纳米颗粒的2D膜或3D组件的传感器装置，特别是电子鼻。 有机涂层用功能部分的独特组合，例如， 环糊精，以提供从爆炸性材料衍生的挥发性和非挥发性化合物的检测。 PETN，RDX，TNT等，灵敏度非常高。 鼻子采用模式识别算法和方法，例如 PCA，用于检测和定量特定的爆炸性化合物。

公开(公告)号：US20140328123A1

公开(公告)日：2014-11-06

申请号：US14260292

申请日：2014-04-24

Applicant: Technion Research and Development Foundation LTD.

Inventor： Yitzhak Birk ,  Amit Berman

IPC: G11C16/10 ,  G11C16/04

CPC classification number: G11C16/10 ,  G11C7/1006 ,  G11C11/5628 ,  G11C11/5678 ,  G11C13/0004 ,  G11C13/0064 ,  G11C16/0483 ,  G11C16/3468 ,  G11C2013/0076 ,  G11C2211/5621 ,  G11C2211/5648

Abstract: A method for writing data, the method may include evaluating current levels of multiple memory cells that belong to a certain set of memory cells or receiving an indication about the current levels of the multiple memory cells; encoding a new data unit to provide an encoded data unit to be written to the multiple memory cells while minimizing an amount of changes in levels of the maximum cell level among the multiple memory cells required for storing the encoded data unit; and writing the encoded data unit to the multiple memory cells.

Abstract translation: 一种用于写入数据的方法，所述方法可以包括评估属于某组存储器单元的多个存储器单元的当前电平或者接收关于多个存储器单元的当前电平的指示; 对新的数据单元进行编码以提供要写入多个存储器单元的编码数据单元，同时最小化存储编码数据单元所需的多个存储单元中的最大单元级的电平变化量; 以及将编码数据单元写入多个存储单元。

公开(公告)号：US08865223B2

公开(公告)日：2014-10-21

申请号：US12867215

申请日：2009-02-11

Applicant: Yechezkel Barenholz ,  Dganit Danino

Inventor： Yechezkel Barenholz ,  Dganit Danino

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A23L1/305 ,  A23J1/22 ,  A23B4/03 ,  A61K31/665 ,  A61K31/415 ,  A61K9/00 ,  A61K9/107 ,  A61K31/573

CPC classification number: A61K9/00 ,  A61K9/1075 ,  A61K31/415 ,  A61K31/573 ,  A61K31/58 ,  A61K31/663 ,  A61K47/42

Abstract: Nanoparticulate assemblies of isolated beta-casein, are useful for encapsulation of bioactive therapeutic substances, particularly therapeutic agents with poor bioavailability. These nano-sized beta-casein assemblies are preferably formed at pH values which are at least one or more pH units below or above the pI of the protein. Pharmaceutical compositions comprising the beta-casein micelles may be used to administer the agents to the GI tract for treatment of local or systemic conditions. These carriers are stable over a wide temperature range (optionally at least from about 1° C. to at least about 45° C.).

Abstract translation: 分离的β-酪蛋白的纳米颗粒组合物可用于生物活性治疗物质的包封，特别是生物利用度差的治疗剂。 这些纳米尺寸β-酪蛋白集合体优选形成在pH值以下，该pH值是低于或高于蛋白质pI的至少一个或多个pH单位。 包含β-酪蛋白胶束的药物组合物可用于将药物施用于胃肠道以治疗局部或全身病症。 这些载体在宽温度范围（任选地至少约1℃至至少约45℃）下是稳定的。

公开(公告)号：US08759776B2

公开(公告)日：2014-06-24

申请号：US13141694

申请日：2009-12-22

Applicant: Yael Nemirovsky

Inventor： Yael Nemirovsky

IPC: G01J5/02 ,  G01T1/24

CPC classification number: G01J5/20 ,  G01J1/4228 ,  G01J5/024

Abstract: A TeraMOS sensor based on a CMOS-SOI-MEMS transistor, thermally isolated by the MEMS post-processing, designed specifically for the detection of THz radiation which may be directly integrated with the CMOS-SOI readout circuitry, in order to achieve a breakthrough in performance and cost. The TeraMOS sensor provides a low-cost, high performance THz passive or active imaging system (roughly in the range of 0.5-1.5 THz) by combining several leading technologies: Complementary Metal Oxide Semiconductor (CMOS)-Silicon on Insulator (SOI), Micro Electro Mechanical Systems (MEMS) and photonics. An array of TeraMOS sensors, integrated with readout circuitry and driving and supporting circuitry provides a monolithic focal plane array or imager. This imager is designed in a commercial CMOS-SOI Fab and the MEMS micromachining is provided as post-processing step in order to reduce cost. Thus the CMOS transistors and technology provide the sensors as well as the signal processing and additional readout circuitry both in the pixels as well as around the sensor array.

Abstract translation: 基于CMOS-SOI-MEMS晶体管的TeraMOS传感器，通过MEMS后处理热隔离，专门用于检测可与CMOS-SOI读出电路直接集成的THz辐射，以实现突破 性能和成本。 TeraMOS传感器通过组合几种领先的技术，提供了低成本，高性能的THz无源或有源成像系统（大致在0.5-1.5 THz范围内）：互补金属氧化物半导体（CMOS） - 绝缘体（SOI），微型 机电系统（MEMS）和光子学。 与读出电路和驱动和支持电路集成的一系列TeraMOS传感器提供单片焦平面阵列或成像器。 该成像器设计在商业CMOS-SOI Fab中，并且MEMS微加工作为后处理步骤提供以降低成本。 因此，CMOS晶体管和技术在像素以及传感器阵列周围提供传感器以及信号处理和附加读出电路。

公开(公告)号：US08673354B2

公开(公告)日：2014-03-18

申请号：US12741515

申请日：2008-11-05

Applicant: Havazelet Bianco-Peled ,  Ohad Kimhi

Inventor： Havazelet Bianco-Peled ,  Ohad Kimhi

IPC: A61K9/14

CPC classification number: A61L24/08 ,  A61K9/0024 ,  A61L15/585 ,  A61L24/043

Abstract: A composition including pre-gel including at least one phenol-based compound, excluding phloroglucinol and derivatives, at least one water miscible polymer, at least one cross linking agent capable of interacting with the polymer. The polymer is selected from one or more natural and/or synthetic carbohydrate, and salt of an anionic polysaccharide.

Abstract translation: 一种包含预凝胶的组合物，包括至少一种苯酚类化合物，不包括间苯三酚和衍生物，至少一种水混溶性聚合物，至少一种能够与聚合物相互作用的交联剂。 聚合物选自一种或多种天然和/或合成的碳水化合物和阴离子多糖的盐。

公开(公告)号：US20140045809A1

公开(公告)日：2014-02-13

申请号：US14016262

申请日：2013-09-03

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

Inventor： Moussa B.H. YOUDIM ,  Silvia MANDEL ,  Tamar AMIT ,  Orit BAR-AM ,  Lana KUPERSHMIDT ,  Zeev GROSS ,  Atif MAHAMMED ,  Irena SALTSMAN ,  Zoya OKUN

IPC: A61K31/555

CPC classification number: A61K31/555 ,  A61K31/00 ,  A61K31/409 ,  C07D487/22

Abstract: Transition metal complexes of amphiphilic corroles, optical isomers and pharmaceutically acceptable salts thereof are useful for neuroprotection and neurorescue, particularly for treatment of diabetes and neurodegenerative diseases. The amphiphilic corrole is preferably a 5,10,15-tris-aryl- or 5,10,15-tris-CF3-corrole, and said transition metal complex more preferably has the formula I defined in the specification. Also provided are propargyl-containing corroles carrying one or more radicals substituted by a propargylamino group or one or more nitrogen-containing heteroaryl radicals substituted by propargyl at the ring N atom.

Abstract translation: 两亲性腐蚀物的过渡金属络合物，光学异构体和其药学上可接受的盐可用于神经保护和神经保护，特别是用于治疗糖尿病和神经变性疾病。 两亲性糠醛优选为5,10,15-三 - 芳基 - 或5,10,15-三 - 三氟甲基 - 三氟甲基 - 糠醛，所述过渡金属配合物更优选具有本说明书中定义的式Ⅰ。 还提供了携带一个或多个被炔丙基氨基取代的基团或一个或多个在环N原子上被炔丙基取代的含氮杂芳基的炔基的冠状物。

公开(公告)号：US20130321421A1

公开(公告)日：2013-12-05

申请号：US13960852

申请日：2013-08-07

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

Inventor： Sagi Katz ,  Ayellet Tal

IPC: G06T15/20

CPC classification number: G06T15/20 ,  G06T15/40 ,  G06T15/60 ,  G06T2210/12

Abstract: A method for determining an optimal location for positioning an image capturing device within a volume, the method including, obtaining a plurality of points to be visible from the image capturing device, performing inversion on points located in the vicinity of the plurality of points thus creating a computerized inversed object, each point in the vicinity of the plurality of point is translated to a corresponding point in the computerized inversed object, defining a convex hull of the inversed object, determining if a point of the plurality of points is visible from the viewpoint according to the position of its corresponding point on the convex hull relative to its neighbor points, repeating said determining for multiple locations within the volume, determining whether a predetermined set of points is visible from each location, selecting the optimal location of the image capturing device based on the results of said repeated determining.

Abstract translation: 一种用于确定在体内定位图像捕获装置的最佳位置的方法，所述方法包括：从所述图像捕获装置获得可见的多个点，对位于所述多个点附近的点执行反转，由此产生 计算机化的反转对象，多个点附近的每个点被转换为计算机化的反转对象中的对应点，定义反转对象的凸包，确定多个点中的点是否从视点可见 根据其相对于其相邻点的凸包对应点的位置，重复对该体积内的多个位置的所述确定，确定从每个位置是否可见预定的一组点，选择图像捕获装置的最佳位置 基于所述重复确定的结果。

公开(公告)号：US20130296331A1

公开(公告)日：2013-11-07

申请号：US13989204

申请日：2011-11-24

Applicant: Zaid Abassi ,  Bishar Bishara

Inventor： Zaid Abassi ,  Bishar Bishara

IPC: A61K31/4985

CPC classification number: A61K31/4985 ,  A61K31/353 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/519 ,  A61K31/522 ,  A61K31/53

Abstract: The invention provides compositions and methods for ameliorating renal dysfunction induced by renal hypoperfusion or acute kidney injury, resulting for example from increased intra-abdominal pressure, using phosphodiesterase inhibitors, more particularly phosphodiesterase type inhibitors, or pharmaceutically acceptable salts or solvates thereof.

Abstract translation: 本发明提供了用于改善由肾脏低灌注或急性肾损伤引起的肾功能障碍的组合物和方法，其导致例如使用磷酸二酯酶抑制剂，更特别是磷酸二酯酶抑制剂，或其药学上可接受的盐或溶剂化物，引起腹内压升高。

公开(公告)号：US20130282694A1

公开(公告)日：2013-10-24

申请号：US13920110

申请日：2013-06-18

Applicant: Oded SHMUELI ,  Royi Ronen

Inventor： Oded SHMUELI ,  Royi Ronen

IPC: G06F17/30

CPC classification number: G06F17/30466 ,  G06F17/30498 ,  G06F17/30545

Abstract: A method and apparatus for resolving conjunctive queries, comprising relational predicates and external predicates, such as XML predicates. The method and apparatus obtain results from a relational engine or from an external engine, and then use the obtained results as input for the other engine, so as to optimize the activity of the other engine. The process may repeat further times, with the results obtained by the other engine being input to the first engine. The method and apparatus further disclose handling value, being isomorphic hierarchical sub-trees.

Abstract translation: 一种用于解决连接查询的方法和装置，包括关系谓词和外部谓词，如XML谓词。 该方法和装置从关系引擎或外部引擎获得结果，然后使用获得的结果作为另一引擎的输入，以便优化其他引擎的活动。 该过程可以重复进一步的时间，其他发动机获得的结果被输入到第一发动机。 该方法和装置进一步公开处理值，即同构分层子树。