公开(公告)号：US20170288112A1

公开(公告)日：2017-10-05

申请号：US15627593

申请日：2017-06-20

申请人： University of Houston System ,  Massachusetts Institute of Technology

发明人： Qing Jie ,  Zhifeng Ren ,  Gang Chen

IPC分类号： H01L35/34 ,  H01L35/20 ,  H01L35/22 ,  H01L35/08

摘要： Disclosed are methods for the manufacture of n-type and p-type filled skutterudite thermoelectric legs of an electrical contact. A first material of CoSi2 and a dopant are ball-milled to form a first powder which is thermo-mechanically processed with a second powder of n-type skutterudite to form a n-type skutterudite layer disposed between a first layer and a third layer of the doped-CoSi2. In addition, a plurality of components such as iron, and nickel, and at least one of cobalt or chromium are ball-milled form a first powder that is thermo-mechanically processed with a p-type skutterudite layer to form a p-type skutterudite layer “second layer” disposed between a first and a third layer of the first powder. The specific contact resistance between the first layer and the skutterudite layer for both the n-type and the p-type skutterudites subsequent to hot-pressing is less than about 10.0 μΩ·cm2 .

公开(公告)号：US09761446B2

公开(公告)日：2017-09-12

申请号：US14270973

申请日：2014-05-06

申请人： The University of Houston System

发明人： Haibing Peng ,  Guoxiong Su ,  Debtanu De

IPC分类号： H01L21/205 ,  H01L21/02 ,  H01L23/544

CPC分类号： H01L21/0262 ,  H01L21/02381 ,  H01L21/0242 ,  H01L21/02488 ,  H01L21/02521 ,  H01L21/02568 ,  H01L21/0259 ,  H01L23/544 ,  H01L2223/5442 ,  H01L2223/54426 ,  H01L2223/54453 ,  H01L2924/0002 ,  H01L2924/00

摘要： Methods of producing arrays of thin crystal grains of layered semiconductors, including the creation of stable atomic-layer-thick to micron-thick membranes of crystalline semiconductors by chemical vapor deposition.

公开(公告)号：US09733315B2

公开(公告)日：2017-08-15

申请号：US13762622

申请日：2013-02-08

申请人： University of Houston

发明人： Dmitri Litvinov ,  Richard Willson

IPC分类号： G01R33/00 ,  G01R33/12

CPC分类号： G01R33/00 ,  G01N2446/00 ,  G01R33/1269

摘要： A biomolecular sensor system includes an array of magnetoresistive nanosensors designed for sensing biomolecule-conjugated superparamagnetic nanoparticles. Materials and geometry of each sensor element are designed for optimized sensitivity. The system includes magnetic field generators to apply forces to superparamagnetic nanoparticles for 1) nanoparticle manipulation, 2) sensor magnetic biasing, 3) magnetic pull-off measurement for differentiation against non-specific association, and 4) removal of all particles from the sensor array surface.

公开(公告)号：US09725452B2

公开(公告)日：2017-08-08

申请号：US14214360

申请日：2014-03-14

申请人： President and Fellows of Harvard College ,  Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences ,  Tufts University ,  University of Houston

发明人： Junying Yuan ,  Alexei Degterev ,  Gregory D. Cuny

IPC分类号： A61K31/4025 ,  A61K31/404 ,  C07D207/30 ,  C07D209/04 ,  C07D487/04 ,  C07D401/14 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D401/14 ,  C07D471/04

摘要： The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3.

公开(公告)号：US09694388B2

公开(公告)日：2017-07-04

申请号：US14277325

申请日：2014-05-14

申请人： Seamus Curran ,  Kang-Shyang Liao ,  Nigel Alley ,  Amrita Haldar ,  Alexander Wang ,  Renat Tatarin

发明人： Seamus Curran ,  Kang-Shyang Liao ,  Nigel Alley ,  Amrita Haldar ,  Alexander Wang ,  Renat Tatarin

IPC分类号： B05D5/08 ,  B05D1/18 ,  D06M23/00

CPC分类号： B05D5/083 ,  B05D1/185 ,  B05D2350/60 ,  D06M13/503 ,  D06M13/507 ,  D06M13/513 ,  D06M13/517 ,  D06M23/00 ,  D06M2200/05

摘要： A process of fabricating the waterproof coating may include selecting a substrate, utilizing a sol-gel comprising a silane or silane derivative and metal oxide precursor to coat the substrate, and optionally coating the substrate with a hydrophobic chemical agent and/or other chemical agents to create a surface with nanoscopic or microscopic features. The process may utilize an all solution process or controlled environment for fabricating self-cleaning and waterproof coating that prevent wetting or staining of a substrate, or may utilize a controlled environment.

公开(公告)号：US09658470B2

公开(公告)日：2017-05-23

申请号：US14191902

申请日：2014-02-27

申请人： Raymond A. Applegate ,  Jason D. Marsack ,  Konrad Pesudovs ,  Yue Shi

发明人： Raymond A. Applegate ,  Jason D. Marsack ,  Konrad Pesudovs ,  Yue Shi

IPC分类号： G02C3/00 ,  G02C7/00 ,  G02C7/02 ,  G02C7/04

CPC分类号： G02C7/04 ,  G02C7/027 ,  G02C2202/22

摘要： Provided herein is a computer program product comprising a non-transitory computer-readable medium storing an algorithm to optimize a wavefront guided correction for a custom ophthalmic lens. The correction is determined from inputs of quantified wavefront error and registration uncertainty and a metric predictive of a visual performance task of interest and provides a level of visual performance within a user-defined performance range. Also provided is a method for optimizing a wavefront guided correction for a custom ophthalmic lens via inputting residual wavefront error values and quantified translational and rotational movements into an algorithm configured to determine the optimal wavefront guided correction therefrom and a custom ophthalmic lens comprising the correction.

公开(公告)号：USD779983S1

公开(公告)日：2017-02-28

申请号：US29533255

申请日：2015-07-15

申请人： Seyed Mohammad Hossein Hosseiny

设计人： Seyed Mohammad Hossein Hosseiny

公开(公告)号：US09497134B1

公开(公告)日：2016-11-15

申请号：US14791679

申请日：2015-07-06

申请人： Yuhua Chen

发明人： Yuhua Chen

IPC分类号： H04B10/00 ,  H04L12/863 ,  H04Q11/00 ,  H04J14/02 ,  H04J14/00

CPC分类号： H04L47/625 ,  H04J14/0221 ,  H04L45/62 ,  H04L47/626 ,  H04Q11/00 ,  H04Q11/0066 ,  H04Q2011/0016 ,  H04Q2011/0064 ,  H04Q2011/0092

摘要： A Wavelength Division Multiplexing (WDM) multi-mode switching system and method and method provides concurrent switching in various switching modes including, but not limited to, an electronic packet switching (EPS) mode, optical circuit switching (OCS) mode, and optical burst switching (OBS) mode. Edge routers in the WDM multi-mode switching systems may provide a traffic management module that processes incoming data and routes the data for transmission in an electronic packet switching (EPS), optical burst switching (OBS), or optical circuit switching (OCS) modes via a WDM link.

公开(公告)号：US09439924B2

公开(公告)日：2016-09-13

申请号：US14680785

申请日：2015-04-07

申请人： UNIVERSITY OF HOUSTON

发明人： Yu Liu ,  Robert J Schwartz ,  Xiaopeng Shen

IPC分类号： A61K48/00 ,  A61K31/7105 ,  A61K45/06 ,  C12N5/077 ,  C12N15/00

CPC分类号： A61K48/0058 ,  A61K9/0019 ,  A61K9/14 ,  A61K31/7105 ,  A61K45/06 ,  A61K48/00 ,  A61K48/0025 ,  A61K48/0075 ,  A61K48/0083 ,  C12N5/0657 ,  C12N7/00 ,  C12N15/00 ,  C12N15/111 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2501/65 ,  C12N2506/02 ,  C12N2710/10043 ,  C12N2740/10043

摘要： The present disclosure describes the role for miR-322(424)/503 in the differentiation of cardiac precursor cells. Thus, the use of these molecules in the programming of resident stem/progenitor cells into cardiomyocytes, both in vitro and in vivo. Such methods find particular use in the treatment of patients post-myocardial infarction to prevent or limit scarring and to promote myocardial repair.

摘要翻译： 本公开描述了miR-322（424）/ 503在心脏前体细胞分化中的作用。 因此，这些分子在体外和体内在驻极体/祖细胞的编程中都被用于心肌细胞。 这种方法特别用于治疗心肌梗塞后的患者，以预防或限制瘢痕形成并促进心肌修复。

公开(公告)号：US09334307B2

公开(公告)日：2016-05-10

申请号：US14273375

申请日：2014-05-08

申请人： The University of Houston System

发明人： Zhang Weihua

IPC分类号： A61K31/422 ,  A61K31/70 ,  A61K31/5377 ,  A61K31/517 ,  A61K38/10 ,  A61K31/7042 ,  C07K7/08 ,  A61K45/06 ,  A61K31/7034 ,  A61K38/17

CPC分类号： A61K38/10 ,  A61K31/422 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/70 ,  A61K31/7034 ,  A61K31/7042 ,  A61K38/179 ,  A61K45/06 ,  C07K7/08 ,  A61K2300/00

摘要： A compound can destabilize a binding interaction between an epidermal growth factor receptor (EGFR) and a sodium/glucose co-transporter 1 (SGLT 1). In one embodiment, the compound is a peptide derived from the interacting domain of EGFR. In another embodiment, the peptide is administered to a patient to treat cancer.

摘要翻译： 化合物可以破坏表皮生长因子受体（EGFR）和钠/葡萄糖共转运体1（SGLT1）之间的结合相互作用。 在一个实施方案中，化合物是衍生自EGFR的相互作用结构域的肽。 在另一个实施方案中，将肽施用于患者以治疗癌症。