公开(公告)号：US20140212457A1

公开(公告)日：2014-07-31

申请号：US13965144

申请日：2013-08-12

申请人： Abdalla Rifai

发明人： Abdalla Rifai

IPC分类号： C07H17/07 ,  C08B37/02 ,  C08B15/00 ,  C08B37/08

CPC分类号： C08B37/003 ,  A23L33/25 ,  A23L33/26 ,  A23V2002/00 ,  A61K31/00 ,  A61K31/715 ,  A61K31/717 ,  A61K31/722 ,  A61K47/585 ,  A61K47/59 ,  A61K47/61 ,  C07H17/07 ,  C08B3/22 ,  C08B5/04 ,  C08B11/20 ,  C08B15/00 ,  C08B15/06 ,  C08B31/00 ,  C08B37/00 ,  C08B37/0012 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/0024 ,  C08B37/0033 ,  C08B37/0039 ,  C08B37/0042 ,  C08B37/0045 ,  C08B37/006 ,  C08B37/0084 ,  C08B37/0087 ,  C08B37/009 ,  C08B37/0093 ,  C08B37/0096

摘要： The present invention relates to compounds which are capable of exerting an inhibitory effect on the Na+ glucose cotransporter SGLT in order to hinder glucose and galactose absorption, as well as on lipase thus reducing dietary triglyceride metabolism, for use in the treatment of conditions which benefit therefrom (diabetes. Metabolic Syndrome, obesity, prevention of weight gain or aiding weight loss). These compounds comprise a non-absorbable, non-digestible polymer having a glucopyranosyl or galactopyranosyl or equivalent moiety stably and covalently linked thereto, said glucopyranosyl or galactopyranosyl moiety being able to occupy the glucose-binding pocket of a SGLT transporter.

摘要翻译： 本发明涉及能够对Na +葡萄糖协同转运体SGLT具有抑制作用以阻碍葡萄糖和半乳糖吸收的化合物，以及由此降低膳食甘油三酯代谢的脂肪酶用于治疗从中受益的病症 （糖尿病，代谢综合征，肥胖症，预防体重增加或辅助减肥）。 这些化合物包含不可吸收的不可消化的聚合物，其具有稳定且共价连接的吡喃葡萄糖基或吡喃半乳糖基或等效部分，所述吡喃葡萄糖基或吡喃半乳糖基部分能够占据SGLT转运蛋白的葡萄糖结合口袋。

公开(公告)号：US08629252B2

公开(公告)日：2014-01-14

申请号：US12521308

申请日：2007-12-18

申请人： Marco Bosco ,  Luca Stucchi ,  Fabrizio Picotti ,  Rita Gianni

发明人： Marco Bosco ,  Luca Stucchi ,  Fabrizio Picotti ,  Rita Gianni

IPC分类号： C08B37/08 ,  A01N43/04

CPC分类号： C08B31/04 ,  A61K8/73 ,  A61K8/731 ,  A61K8/732 ,  A61K8/735 ,  A61K8/736 ,  A61K47/36 ,  A61Q19/00 ,  C08B3/12 ,  C08B33/02 ,  C08B37/0018 ,  C08B37/003 ,  C08B37/0036 ,  C08B37/0063 ,  C08B37/0072 ,  C08B37/0084

摘要： Non-crosslinked derivatives of oligo/polysaccharides of formula wherein: X is OH, O−M, NH—R1, O—R1; M is an alkaline or alkaline-earth metal, transition metal, or cation containing a quaternary nitrogen atom; Y is H or R2; R1: the residue of an oligo/polysaccharide; R2: the residue of a C1-C4 linear chain aliphatic carboxylic acid or citric acid; provided that at least one X is NH—R1 or O—R1, while the other two X are present in acid (OH) or salified form (OM).

摘要翻译： 下式的低聚多糖的非交联衍生物其中：X是OH，O-M，NH-R1，O-R1; M是碱金属或碱土金属，过渡金属或含有季氮原子的阳离子; Y为H或R2; R1：寡糖/多糖的残基; R2：C1-C4直链脂肪族羧酸或柠檬酸的残基; 条件是至少一个X是NH-R 1或O-R 1，而另外两个X存在于酸（OH）或成盐形式（OM）中。

公开(公告)号：US20130316892A1

公开(公告)日：2013-11-28

申请号：US13994495

申请日：2011-12-14

申请人： Satoshi Nakamura ,  Tetsuo Fukuta ,  Kazuhiro Ikkyu ,  Yu Otani ,  Hiroshi Kawai

发明人： Satoshi Nakamura ,  Tetsuo Fukuta ,  Kazuhiro Ikkyu ,  Yu Otani ,  Hiroshi Kawai

IPC分类号： B01J20/281

CPC分类号： B01J20/281 ,  B01J20/267 ,  B01J20/285 ,  C08B1/003 ,  C08B15/10 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0039 ,  C08J3/16 ,  C08J3/24 ,  C08J2301/02 ,  C08K5/0025 ,  C08L1/02 ,  C08L1/28 ,  C08L5/00 ,  C08L5/02 ,  C08L5/08 ,  C08L5/12 ,  Y02P20/542

摘要： Provided are polymer particles which can be used at a high flow rate when used as a filler for chromatography, that is, has excellent resistance flow rate appropriate for processing in large quantities, and also has a high binding capacity for target molecules such as proteins when an appropriate ligand is contained in the particles, and a method for producing the polymer particles; specifically, crosslinked polymer particles and a method for producing the crosslinked polymer particles, polysaccharide composite particles and a method for producing the polysaccharide composite particles, a filler for chromatography using the polymer particles, and an adsorbent for antibody purification. Disclosed are: A. a method for producing polysaccharide composite particles, the method including the following steps (1) to (3): (1) a step of preparing a polysaccharide solution, in which two or more kinds of polysaccharides are dissolved in an ionic liquid; (2) a step of preparing a droplet dispersion liquid of the polysaccharide solution, in which liquid droplets of the polysaccharide solution are dispersed in an organic solvent having low compatibility with the ionic liquid; and (3) a coagulation step in which a composite of the polysaccharides are coagulated to obtain the polysaccharide composite particles; and B. a method for producing a crosslinked polymer particle, the method including a step of allowing a polymer dissolved in an ionic liquid, to react with a crosslinking agent while the polymer is subjected to droplet dispersion in an organic solvent having low compatibility with the ionic liquid.

摘要翻译： 提供当用作色谱填料时可以以高流速使用的聚合物颗粒，即具有适合于大量加工的优异的电阻流速，并且还具有对蛋白质等靶分子的高结合力 粒子中含有适当的配体，以及聚合物粒子的制造方法。 特别是交联聚合物颗粒和交联聚合物颗粒的制备方法，多糖复合颗粒和多糖复合颗粒的制备方法，使用该聚合物颗粒的色谱用填料和用于抗体纯化的吸附剂。 本发明涉及A.一种多糖复合粒子的制造方法，其特征在于，包括以下工序（1）〜（3）：（1）制备多糖溶液的工序，其中将2种以上的多糖溶解于 离子液体 （2）将多糖溶液的液滴分散在与离子液体的相容性低的有机溶剂中的多糖溶液的液滴分散液的制备工序; 和（3）将多糖的复合体凝结而得到多糖复合粒子的凝固工序; 和B.一种制备交联聚合物颗粒的方法，该方法包括使溶解在离子液体中的聚合物与交联剂反应的步骤，同时聚合物在与 离子液体。

公开(公告)号：US08580950B2

公开(公告)日：2013-11-12

申请号：US12973967

申请日：2010-12-21

申请人： Helen S. M. Lu ,  Steven W. Shuey

发明人： Helen S. M. Lu ,  Steven W. Shuey

IPC分类号： C08B1/00 ,  C08L1/02 ,  C08L1/28 ,  C08L5/02 ,  C08L5/08 ,  C08L5/12 ,  C08B11/02 ,  C08B11/04 ,  C08B11/08 ,  C08B11/12 ,  C08B31/18 ,  C08B37/02 ,  C08B37/12 ,  C08B37/18

CPC分类号： C08B15/02 ,  C08B31/18 ,  C08B37/00 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/0054 ,  C08B37/0072 ,  C08L1/04 ,  C08L3/10 ,  C08L5/00 ,  C08L5/02 ,  C08L5/08 ,  C08L5/12

摘要： Novel aldehyde-functionalized polysaccharide compositions containing pendant dialdehyde groups are described that are more stable in aqueous solution than oxidized polysaccharides. The aldehyde-functionalized polysaccharides may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.

摘要翻译： 描述了含有侧链二醛基团的新型醛官能化多糖组合物，其在水溶液中比氧化多糖更稳定。 醛官能化多糖可以与各种含胺聚合物反应以形成可用于医学应用的水凝胶组织粘合剂和密封剂，例如伤口闭合，补充或替换缝合或缝合在内部外科手术如肠吻合和血管吻合中 ，组织修复，防止流体如血液，胆汁，胃肠道液体和脑脊液的渗漏，眼科手术，药物递送和预防手术后粘连。

公开(公告)号：US20130245246A1

公开(公告)日：2013-09-19

申请号：US13836580

申请日：2013-03-15

申请人： ADOCIA

发明人： Remi Soula ,  Olivier Soula ,  Gerard Soula ,  Richard Charvet ,  David Duracher

IPC分类号： A61K47/48

CPC分类号： A61K47/61 ,  A61K31/70 ,  A61K38/00 ,  A61K47/36 ,  C08B37/0018 ,  C08B37/0021 ,  C08L5/00 ,  C08L5/02

摘要： A polysaccharide comprising carboxyl functional groups, at least one of which is substituted with at least one hydrophobic radical: the hydrophobic radical being a residue of a hydrophobic alcohol having a linear, branched or cyclic alkyl chain containing at least 6 carbon atoms, the hydrophobic radical being bonded to a linker arm R by a function G, the linker arm R being bonded to a carboxyl function of the polysaccharide by a bond F, R being an at least divalent radical of a chain including between 1 and 15 carbons, which is optionally branched and/or unsaturated, optionally including one or more heteroatoms, chosen amongst O, N and/or S, F being an amide function, G being a carbamate function, the unsubstituted carboxyl functions of the polysaccharide being in the form of a cation carboxylate, said cation being chosen amongst alkali metal cation.

摘要翻译： 一种包含羧基官能团的多糖，其中至少一个被至少一个疏水基团取代：所述疏水基团是具有至少6个碳原子的直链，支链或环状烷基链的疏水性醇的残基，所述疏水基团 通过功能G与连接臂R键合，连接臂R通过键F键合到多糖的羧基官能团，R是至少包含1至15个碳的链的二价基团，其任选地 任选地包括一个或多个选自O，N和/或S的杂原子，F是酰胺官能团，G是氨基甲酸酯官能团，多糖的未取代的羧基官能团是阳离子羧酸盐形式 所述阳离子选自碱金属阳离子。

公开(公告)号：US20130171126A1

公开(公告)日：2013-07-04

申请号：US13819437

申请日：2011-08-30

申请人： Didier Letourneur ,  Catherine Le Visage ,  Sidi Mohammed Derkaoui

发明人： Didier Letourneur ,  Catherine Le Visage ,  Sidi Mohammed Derkaoui

IPC分类号： A61K47/26

CPC分类号： A61K9/1652 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/1075 ,  A61K9/1682 ,  A61K47/26 ,  A61L27/20 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/20 ,  C08B37/0018 ,  C08B37/0021 ,  Y10T428/2982 ,  C08L5/00

摘要： The present inventions relates to beads as biocompatible material adapted for use within the human or animal body. Said beads are highly useful for tissue engineering, in situ tissue regeneration, as well as for drug and/or cells delivery. In addition, said beads may support biotechnological applications such as cell carriers.

摘要翻译： 本发明涉及适于在人或动物体内使用的生物相容性材料的珠粒。 所述珠对组织工程，原位组织再生以及药物和/或细胞递送非常有用。 此外，所述珠粒可以支持生物技术应用，例如细胞载体。

公开(公告)号：US20120142618A1

公开(公告)日：2012-06-07

申请号：US13333626

申请日：2011-12-21

申请人： Richard A. Gross

发明人： Richard A. Gross

IPC分类号： A61K31/7024 ,  A61P25/28 ,  A61P3/10 ,  A61P3/04 ,  A61P25/00 ,  A61P9/10 ,  A61P9/04 ,  C07H13/04 ,  A61P25/08

CPC分类号： C07H13/04 ,  C08B31/04 ,  C08B37/0018 ,  C08B37/0045 ,  C08B37/0093

摘要： A novel ketogenic compound is provided having general formula (R(OCH(CH3)CH2C(O))nO)m-A wherein n is a integer between I and 10, m is an integer of 1 to 200,000, A is a monosaccharide, polysaccharide or oligosaccharide residue and R is selected from the group consisting of H, C1-C6 alkyl and acetoacetyl-

摘要翻译： 提供了具有通式（R（OCH（CH 3）CH 2 C（O））n O）mA的新型致酮化合物，其中n是I与10之间的整数，m是1至200,000的整数，A是单糖，多糖或 寡糖残基，R选自H，C 1 -C 6烷基和乙酰乙酰基 -

公开(公告)号：US20120058054A1

公开(公告)日：2012-03-08

申请号：US13319118

申请日：2010-05-04

申请人： Kun Na ,  Hyeon A Yim

发明人： Kun Na ,  Hyeon A Yim

IPC分类号： A61K49/12 ,  A61P35/00 ,  C07H1/00

CPC分类号： A61K49/128 ,  C08B37/0018

摘要： Disclosed are a gadolinium complex formed by coordination of gadolinium to the diethylenetriaminepentaacetic acid dianhydride (DTPA) moiety of a pullulan-DTPA conjugate formed by an ester bond between pullulan and DTPA, a preparation method thereof, an MRI contrast composition comprising the complex, and a method of providing information for diagnosis of disease using the complex as an MRI contrast agent. The pullulan-DTPA-Gd complex has a long in vivo half-life, low toxicity, and high MRI signal intensity resulting in clear MRI images, compared to prior gadolinium complexes, indicating that it is advantageously used as an MRI contrast agent. In addition, it is possible to obtain MRI images allowing one to differentiate between diseased liver tissue and normal liver tissue, indicating that it is used as an MRI contrast agent for the liver.

摘要翻译： 公开了通过将钆与由支链淀粉和DTPA之间的酯键形成的支链淀粉-DTPA缀合物的二亚乙基三胺五乙酸二酐（DTPA）部分配位形成的钆络合物，其制备方法，包含该复合物的MRI对比组合物和 提供用于诊断疾病的信息的方法，使用该复合物作为MRI造影剂。 与以前的钆配合物相比，支链淀粉-DTPA-Gd复合物具有长体内半衰期，低毒性和高MRI信号强度，导致清晰的MRI图像，表明其有利地用作MRI造影剂。 此外，可以获得允许人们区分患病肝组织和正常肝组织的MRI图像，表明它被用作肝脏的MRI造影剂。

公开(公告)号：US08039428B2

公开(公告)日：2011-10-18

申请号：US12760088

申请日：2010-04-14

申请人： Klin A. Rodrigues ,  John S. Thomaides ,  A. Levent Cimecioglu ,  Martin Crossman

发明人： Klin A. Rodrigues ,  John S. Thomaides ,  A. Levent Cimecioglu ,  Martin Crossman

IPC分类号： C11D3/22 ,  C11D3/37

CPC分类号： C02F5/14 ,  C02F5/02 ,  C02F5/10 ,  C02F2101/306 ,  C02F2101/308 ,  C02F2103/002 ,  C02F2103/023 ,  C02F2305/04 ,  C04B24/383 ,  C04B28/02 ,  C04B2103/0036 ,  C08B31/18 ,  C08B31/185 ,  C08B37/0018 ,  C09K8/467 ,  C09K8/528 ,  C11D3/223 ,  C11D3/228 ,  C04B14/06 ,  C04B2103/10 ,  C04B2103/20 ,  C04B2103/32 ,  C04B2103/54

摘要： Modified polysaccharide polymers for use as anti-sealant and dispersant. The polymers are useful in compositions used in aqueous systems. The modified polysaccharides are also useful in detergent formulations, water treatment, dispersants and oilfield applications and as fiberglass binders. Such applications include a modified polysaccharide having up to about 70 mole % carboxyl groups per mole of polysaccharide ASU and up to about 20 mole % aldehyde groups per mole of polysaccharide ASU. The applications can also include a blend of modified polysaccharides and other synthetic polymers.

摘要翻译： 用作抗密封剂和分散剂的改性多糖聚合物。 该聚合物可用于在水性体系中使用的组合物中。 改性多糖也可用于洗涤剂配方，水处理，分散剂和油田应用以及作为玻璃纤维粘合剂。 这样的应用包括每摩尔多糖ASU具有高达约70摩尔％羧基的修饰多糖和每摩尔多糖ASU高达约20摩尔％的醛基。 应用还可以包括改性多糖和其它合成聚合物的混合物。

公开(公告)号：US20110178011A1

公开(公告)日：2011-07-21

申请号：US12950616

申请日：2010-11-19

申请人： Remi SOULA ,  Olivier SOULA ,  Gerard SOULA ,  Richard CHARVET ,  David DURACHER

发明人： Remi SOULA ,  Olivier SOULA ,  Gerard SOULA ,  Richard CHARVET ,  David DURACHER

IPC分类号： A61K38/18 ,  C07K14/51

CPC分类号： A61K47/61 ,  A61K31/70 ,  A61K38/00 ,  A61K47/36 ,  C08B37/0018 ,  C08B37/0021 ,  C08L5/00 ,  C08L5/02

摘要： A complex of a polysaccharide and recombinant human BMP-2 and BMP-7, soluble at physiological pH, wherein the polysaccharide/BMP mass ratio is less than 15, the polysaccharide being selected from the group of polysaccharides having carboxyl functional groups, at least one of which is substituted with at least one hydrophobic radical.

摘要翻译： 在生理pH可溶的多糖和重组人BMP-2和BMP-7的复合物，其中多糖/ BMP质量比小于15，多糖选自具有羧基官能团的多糖，至少一种 其中至少一个疏水基团被取代。