公开(公告)号：US20160042284A1

公开(公告)日：2016-02-11

申请号：US14775403

申请日：2014-03-12

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Filippo MENCZER ,  Lilian WENG ,  Yong Yeol AHN, Jr.

IPC: G06N5/04

CPC classification number: G06N5/04 ,  G06Q30/0202 ,  G06Q50/01

Abstract: Systems and methods for predicting virality of a content item are disclosed. A method includes: receiving a social network structure; identifying communities within the social network structure, where communities are identified as dense subnetworks in the social network structure; receiving social network content that includes one or more content items; and identifying one or more content items that are predicted to become viral based on utilization of the content items between different communities in the social network structure.

Abstract translation: 公开了用于预测内容项的病毒的系统和方法。 一种方法包括：接收社交网络结构; 识别社会网络结构中的社区，社区被确定为社交网络结构中的密集子网络; 接收包括一个或多个内容项的社交网络内容; 以及基于所述社交网络结构中不同社区之间的内容项目的利用来识别被预测为病毒的一个或多个内容项目。

公开(公告)号：US09200333B2

公开(公告)日：2015-12-01

申请号：US13950825

申请日：2013-07-25

Applicant: Indiana University Research and Technology Corporation

Inventor： Lindsey Mayo

IPC: G01N1/00 ,  C12Q1/68 ,  G01N33/68 ,  C12Q1/25

CPC classification number: C12Q1/6897 ,  C12Q1/25 ,  G01N33/6875 ,  G01N2333/9015 ,  G01N2440/00 ,  G01N2440/14 ,  G01N2500/10

Abstract: The disclosure is directed to methods of identifying compounds that modulate murine double-minute 2. More particularly, the disclosure is directed to methods of identifying compounds that modulate murine double-minute 2 neddylation activity.

Abstract translation: 本公开涉及鉴定调节鼠双分钟2的化合物的方法。更具体地，本公开涉及鉴定调节鼠双分钟二聚体化活性的化合物的方法。

公开(公告)号：US20150338374A1

公开(公告)日：2015-11-26

申请号：US14815313

申请日：2015-07-31

Applicant: Indiana University Research and Technology Corporation

Inventor： David Edward Clemmer ,  Michael A. Ewing ,  Steven M. Zucker ,  Christopher R. P. Conant

IPC: G01N27/62 ,  H01J49/26 ,  H01J49/00

CPC classification number: G01N27/622 ,  H01J49/0031 ,  H01J49/26

Abstract: In a drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a method of separating ions as a function of ion mobility includes repeatedly, and alternating between at least two different time durations, establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube at one or more frequencies which include one or more overtones of a fundamental frequency at which ions having the predefined mobility or range of mobilities are transmitted through the drift tube with the electric drift fields and electric repulsive fields repeatedly established with uniform time durations.

Abstract translation: 在分隔成多个级联漂移管段的漂移管中，每个随后都有一个离子消除区，离子迁移的函数之间分离离子的方法包括重复地在至少两个不同的时间间隔之间进行交替，建立电漂移场 漂移管段和一些离子消除区域，同时在其他离子消除区域中建立电排斥场，使得具有预定迁移率或迁移率范围的离子以一个或多个频率透过漂移管，其包括一个或多个 具有预定迁移率或迁移率范围的离子通过漂移管传播的基频的更多泛音，电漂移场和电排斥场以均匀的时间持续时间重复建立。

公开(公告)号：US20150290206A1

公开(公告)日：2015-10-15

申请号：US14647387

申请日：2013-12-03

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Vincent Gattone ,  Bonnie Blazer-Yost

IPC: A61K31/5377 ,  A61M27/00 ,  A61K31/18

CPC classification number: A61K31/5377 ,  A61K31/00 ,  A61K31/165 ,  A61K31/18 ,  A61K31/202 ,  A61K31/225 ,  A61K31/28 ,  A61K31/405 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/55 ,  A61M27/006

Abstract: The present invention provides uses of TRPV4 antagonists in the treatment or prevention of hydrocephalus symptoms, also known as hydrocephaly, including hydrocephalus as a result of any structural defect, any metabolic defect, any injury (direct force to the head, indirect force to the head, shock waves, pressure changes, etc.), any insult (microbial, chemical, toxins, allergic reactions or other inflammatory process, or other pathology, eg. cancer, benign tumor, etc.). Related materials and methods are also provided herein.

Abstract translation: 本发明提供TRPV4拮抗剂用于治疗或预防脑积水症状，也称为脑积水，包括由于任何结构缺陷导致的脑积水，任何代谢缺陷，任何损伤（对头部的直接力，对头部的间接力） ，冲击波，压力变化等），任何侮辱（微生物，化学，毒素，过敏反应或其他炎症过程或其他病理学，例如癌症，良性肿瘤等）。 本文还提供了相关材料和方法。

公开(公告)号：US20150231148A1

公开(公告)日：2015-08-20

申请号：US14626101

申请日：2015-02-19

Applicant: Indiana University Research and Technology Corporation

Inventor： Yang Sun

IPC: A61K31/55 ,  A61K31/381 ,  A61K9/00 ,  A61K31/496

CPC classification number: A61K31/55 ,  A61K9/0048 ,  A61K31/381 ,  A61K31/496

Abstract: Methods for reducing intraocular pressure and treating glaucoma are disclosed. The methods include administering to an individual a composition comprising a TRPV4 agonist.

Abstract translation: 公开了降低眼内压和治疗青光眼的方法。 所述方法包括向个体施用包含TRPV4激动剂的组合物。

公开(公告)号：US20150184155A1

公开(公告)日：2015-07-02

申请号：US14415269

申请日：2013-07-18

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Christos Chatziantoniou ,  Jean-Claude Dussole ,  Simon J. Conway

IPC: C12N15/113 ,  C12N15/115 ,  C07K16/18

CPC classification number: C12N15/113 ,  C07K16/18 ,  C07K2317/76 ,  C12N15/1138 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/16 ,  C12N2310/315

Abstract: The present invention relates to methods for preventing and treating chronic kidney disease (CKD).

Abstract translation: 本发明涉及预防和治疗慢性肾脏疾病（CKD）的方法。

公开(公告)号：US20150045435A1

公开(公告)日：2015-02-12

申请号：US14452910

申请日：2014-08-06

Applicant: Indiana University Research and Technology Corporation

Inventor： William L. Scott ,  Martin J. O'Donnell

IPC: C07C233/63

CPC classification number: C07C233/63 ,  C07B2200/07 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D215/48

Abstract: The invention described herein pertains to compounds, compositions, methods and uses thereof. The compounds described herein are in a class of glucose-lowering drugs useful for treating diabetes. Generally, compounds of the Formula I are described herein.

Abstract translation: 本文描述的本发明涉及其化合物，组合物，方法和用途。 本文所述的化合物是用于治疗糖尿病的一类降血糖药物。 通常，本文描述式I的化合物。

公开(公告)号：US20150027953A1

公开(公告)日：2015-01-29

申请号：US14371193

申请日：2013-01-09

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Amanda K. Peterson Mann ,  Benjamin F. Mann ,  Sara E. Skrabalak ,  Milos V. Novotny

IPC: B01J20/286 ,  B01D15/38 ,  B01J20/283 ,  B01D15/08

CPC classification number: B01J20/286 ,  B01D15/08 ,  B01D15/3804 ,  B01D15/3823 ,  B01J20/103 ,  B01J20/28019 ,  B01J20/28061 ,  B01J20/28085 ,  B01J20/28092 ,  B01J20/283 ,  B01J20/3057 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3274 ,  B01J2220/80 ,  C01B33/18 ,  C07K1/22

Abstract: The present invention discloses a silica particle having a diameter less than or equal to 2 μη, wherein the particle is spherical and comprises interconnected pores having a diameter in the range from 50 nm to 300 nm. The silica particle is preferably produced by spray pyrolysis (=spray drying) of a silica colloid. In the production process, porosity is introduced by means of an inorganic salt, such as NaCl, KCI, LiCl, NaNO3 or Ll NO3, which serves as a pore template. The silica particle may further be functionalized with proteins, peptides, nucleic acids, polysaccharides and proteoglycans, preferably concanavalin A or avidin. The present invention further discloses the use of the silica particle in chromatography, in particular in affinity chromatography.

Abstract translation: 本发明公开了直径小于或等于2μe的二氧化硅颗粒，其中颗粒是球形的并且包含直径在50nm至300nm范围内的互连孔。 二氧化硅颗粒优选通过二氧化硅胶体的喷雾热解（=喷雾干燥）来制备。 在生产过程中，通过无机盐，例如NaCl，KCl，LiCl，NaNO 3或者作为孔模板的L 1 NO 3引入孔隙率。 二氧化硅颗粒还可以用蛋白质，肽，核酸，多糖和蛋白聚糖功能化，优选是伴刀豆球蛋白A或抗生物素蛋白。 本发明进一步公开了二氧化硅颗粒在色谱中的用途，特别是在亲和层析中。

公开(公告)号：US08859491B2

公开(公告)日：2014-10-14

申请号：US13679121

申请日：2012-11-16

Applicant: Indiana University Research and Technology Corporation

Inventor： Richard D. DiMarchi ,  Bin Yang

IPC: A61K38/00 ,  C07K14/605 ,  A61K38/26 ,  A61K31/56

CPC classification number: C07K14/605 ,  A61K38/00 ,  A61K47/554 ,  C07K2319/715

Abstract: Provided herein are glucagon superfamily peptides conjugated with GR ligands that are capable of acting at a glucocorticoid receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein are methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the conjugates of the invention.

Abstract translation: 本文提供了与能够作用于糖皮质激素受体的GR配体缀合的胰高血糖素超家族肽。 本文还提供了本发明的缀合物的药物组合物和试剂盒。 本文还提供了治疗疾病，例如代谢紊乱（例如糖尿病和肥胖症）的方法，其包括施用本发明的缀合物。

公开(公告)号：US20140248646A1

公开(公告)日：2014-09-04

申请号：US13784150

申请日：2013-03-04

Applicant: Indiana University Research and Technology Corporation

Inventor： Johnathon T. Hutt ,  Zachary David Aron ,  Dongwhan Lee ,  Junyong Jo

IPC: C09B57/00 ,  G01N21/64

CPC classification number: C07D471/04 ,  C09B57/00 ,  G01N21/6428 ,  G01N33/582 ,  G01N2021/6439

Abstract: A fluorophore and methods of detecting cations and hydrophobic environments using the fluorophore are disclosed. The fluorophore includes an imidazo[1,5-a]pyridinium ion core and has the formula where R1, R2, R3 and X− are as defined in the specification, and n is an integer from 1 to 4.

Abstract translation: 公开了荧光团和使用荧光团检测阳离子和疏水环境的方法。 荧光团包括咪唑并[1,5-a]吡啶鎓离子核，并具有下式，其中R1，R2，R3和X-如说明书中所定义，n是1至4的整数。