公开(公告)号：US20210254159A1

公开(公告)日：2021-08-19

申请号：US16973353

申请日：2019-06-07

Applicant: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Arthur M. FELDMAN

IPC: C12Q1/6883 ,  A61K48/00

Abstract: Identification of BAG3 (Bcl2-associated anthanogene 3) genetic variants were associated with the prevalence non-ischemic or ischemic dilated cardiomyopathy (DCM) and DCM outcomes in individuals of African ancestry.

公开(公告)号：US20210186364A1

公开(公告)日：2021-06-24

申请号：US17134622

申请日：2020-12-28

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Samuel Alex Weprin ,  John Noel ,  Daniel D. Eun

IPC: A61B5/06 ,  G01V3/08 ,  G01V13/00 ,  A61B5/00

Abstract: A magnetometer-based metal detection device and methods of use are described. The device includes a proximal portion, a central body and a distal portion, and at least one magnetometer positioned within or on the distal portion. The at least one magnetometer includes at least one sensor capable of sensing a magnetic field in three orthogonal axes. Also described is a method of calibrating the device to achieve rotational invariance, and a method of determining a directionality or directional line along which a target metal object lies.

公开(公告)号：US20210164118A1

公开(公告)日：2021-06-03

申请号：US16632602

申请日：2018-07-20

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Daniel R. Strongin ,  Akila C. Thenuwara

IPC: C25B11/075 ,  C25B11/061 ,  C25B1/04 ,  C25B1/50 ,  C25B11/052 ,  H01M4/90 ,  C25D9/08 ,  H01L31/0224

Abstract: Novel multi-metal catalysts comprising abundant Earth metals are described herein. Devices comprising the catalysts of the invention are also described.
Methods of producing the catalysts are also described herein.
Methods of producing hydrogen using the catalysts of the invention are also described herein.

公开(公告)号：US20210139771A1

公开(公告)日：2021-05-13

申请号：US17095520

申请日：2020-11-11

Applicant: Temple University- of the Commonwealth System of Higher Education

Inventor： Graham Dobereiner ,  William Sabbers ,  Weerasiri Arachchige Kushan Chandana Weerasiri

IPC: C09K11/06 ,  H01L51/00

Abstract: Provided herein are luminescent compounds, compositions including the same, and use and synthesis thereof.

公开(公告)号：US20210128634A1

公开(公告)日：2021-05-06

申请号：US16635687

申请日：2018-08-01

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Steven R. Houser ,  Hajime Kubo ,  Sadia Mohsin

IPC: A61K35/32 ,  C12N5/0775 ,  C12N15/113 ,  A61P9/10

Abstract: The present invention provides an isolated population of cortical bone stem cell (CBSC)-derived exosomes, and compositions comprising the exosomes and/or RNA thereof, for promoting cardiac repair when delivered to a diseased heart.

公开(公告)号：US10994013B2

公开(公告)日：2021-05-04

申请号：US14784079

申请日：2014-04-24

Applicant: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Kalpana N. Thakare ,  David B. Lebo

IPC: A61K47/36 ,  A61K31/192 ,  A61K9/16 ,  A61K9/14 ,  A61K9/50 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/4422 ,  A61K31/496

Abstract: Provided is a dosage form for delivery of a therapeutic agent comprising a polymer matrix comprising arabinogalactan and a therapeutic agent uniformly dispersed in said polymer matrix. In some embodiments, the dosage form is selected from the group consisting of a microsphere, a nanosphere, a powder, a tablet, a film or a pellet enclosed in a capsule. Also provided are methods for preparing the dosage form.

公开(公告)号：US10962555B2

公开(公告)日：2021-03-30

申请号：US16068738

申请日：2017-01-06

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Laura Goetzl ,  Edward Goetzl

IPC: G01N33/68 ,  C12Q1/6883

Abstract: The present invention provides for the first time the identification of fetal neural exosomal biomarkers isolated from maternal plasma useful in diagnosing fetal neurodevelopmental outcomes. The invention also provides the identification of neonatal neural exosomal biomarkers isolated from neonatal plasma useful in diagnosing neonatal neurodevelopmental outcomes The present invention therefore provides methods, kits and systems for diagnosing fetal neurodevelopmental outcomes, by examining relevant proteins and RNA in fetal neural exosomes isolated from a maternal plasma and neonatal neural exosomes isolated from neonatal plasma.

公开(公告)号：US20210069303A1

公开(公告)日：2021-03-11

申请号：US16874295

申请日：2020-05-14

Applicant: Temple University of The Commonwealth System of Higher Education

Inventor： Kamel Khalili ,  Wenhui Hu

IPC: A61K38/46 ,  C12N15/11 ,  A61K48/00 ,  A61K9/00 ,  A61K35/12 ,  A61K45/06 ,  C12N7/00 ,  C12N9/22

Abstract: A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.

公开(公告)号：US20210046213A1

公开(公告)日：2021-02-18

申请号：US16608381

申请日：2018-04-26

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Azadeh Timnak ,  Peter I. Lelkes ,  Yah-el H. Har-el

IPC: A61L27/22 ,  A61L27/26 ,  A61L27/56 ,  D01D5/00

Abstract: The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.

公开(公告)号：US10913056B2

公开(公告)日：2021-02-09

申请号：US15664795

申请日：2017-07-31

Applicant: Honda Motor Co., Ltd. ,  Temple University of The Commonwealth System of Higher Education

Inventor： Gugang Chen ,  Avetik Harutyunyan ,  Yi Rao ,  Xia Li

IPC: C01G3/02 ,  B01J31/40 ,  B01J15/00 ,  B01J23/72 ,  B01J23/94

Abstract: A simple approach to produce mixed Cu/Cu2O nanocrystals having a specific morphology by controlling the reaction temperature during Cu/Cu2O nanocrystals synthesis. Other variables are kept constant, such as the amount of reactants, while the reaction temperatures is maintained at a predetermined temperature of 70° C., 30° C. or 0° C., which are used to produce different and controlled morphologies for the Cu/Cu2O nanocrystals. The reaction mixture includes a copper ion contributor, a capping agent, a pH adjustor, and reducing agent. The reaction mixture is held at the predetermined temperature for three hours to produce the Cu/Cu2O nanocrystals. The synthesis method has advantages such as mass production, easy operation, and high reproducibility.