摘要:
This invention offers the compounds which exhibit a coronary blood vessel dilating action which is long-acting.(Constitution)Novel imidazolinoxyl derivatives represented by a general formula (1). A compound A in which R is COOH is given in an example. ##STR1## (Merit) The compounds of the present invention can be directly administered, after diluting to a suitable concentration with a phosphate buffer or the like, to blood vessel which is required to be relaxed and dilated whereby a significant and long-acting relaxing action is resulted though, in a blood flow, they are quickly inactivated and excreted and no side effect is noted.
摘要:
A microcomputer system includes: a plurality of DMA data transfer paths for use with a random access memory, at least one of the data transfer paths being set up by a central processing unit under control of a program stored in a read only memory; a plurality of memory locations of the random access memory assigned to the plurality of DMA data transfer paths respectively, each memory location storing time setting data; a timing signal generating unit for outputting a timing signal at predetermined intervals; a DMA control unit for reading out each time setting value from first memory locations through first DMA data transfer paths respectively in synchronism with the timing signal; a detecting unit for detecting whether the time setting value is equal to zero; a plurality of subtraction registers for decrementing the time setting value by one when the time setting value is detected to be unequal to zero; and a writing unit for writing the decremented time setting value into corresponding one of the first memory locations through corresponding one of the first DMA data transfer paths in conjunction with the DMA control unit.
摘要:
An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55080. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.
摘要:
(1) The imidazoline derivative represented by the following general formula (1) ##STR1## where R.sup.1 is a substituent endowed with water solubility or fat solubility, particularly carboxyl group or carboxymethoxy group or a pharmaceutically acceptable salt thereof, (2) The method for producing the above-mentioned compound, and (3) A therapeutic agent containing as its active ingredient the above-mentioned imidazoline derivative or an imidazoline derivative wherein R.sup.1 indicated in the formula (1) is hydrogen atom. The imidazoline derivative set forth under (1) above is a novel substance; and this compound itself and its derivative having R.sup.1 as indicated in the general formula (1) is hydrogen atom are useful as a therapeutic agent for treatment of shock from the fall in blood pressure by virtue of their ability to remove excess NO which is the vascular endothelium-derived relaxing factor (EDRF).
摘要:
The present invention relates to a method of controlling an output order for copy images, comprises the steps of, reading respective images of a plurality of manuscripts to be copied, storing respective image data relating to the read respective images, scaling down respective image data relating the read respective images and printing on a sheet a multi-shot image data including a plurality of the scaled down imager reading other images described on the printed sheet, the other images defining an output order, and printing the respective imager on the other sheets in an order specified by the read other images.
摘要:
A storage device includes a substrate, a magnetic storage medium provided on the substrate, information being magnetically stored in the magnetic storage medium, a head unit, and a reciprocating mechanism provided on the substrate, the reciprocating mechanism causing the head unit to reciprocate in a plane parallel to a surface of the magnetic storage medium, wherein, while the head unit is being moved by the reciprocating mechanism, information is recorded in or reproduced from the magnetic storage medium via the head unit. The reciprocating motion of the head unit is provided by piezoelectric elements on arms supporting the head, which move the head with a predetermined stroke width in simple harmonic motion.
摘要:
The present invention provides a new copper alloy containing silver from 4 to 32 at. %, which is useful for a magnet conductor, an IC lead frame, etc., having simultaneously a high strength and a high conductivity, manufactured by blending from 4 to 32 at. % silver into copper, casting, rapidly cooling and cold-working wherein the cold-working step includes a hot working treatment at a reduction rate of 40% to 70% at temperatures of from 300.degree. to 500.degree. C.
摘要:
A wrapping sheet is disposed on a roll so that marginal portions of the wrapping sheet extend beyond the respective side faces of the roll. A wrapping sheet winding apparatus for winding the wrapping sheet around the roll has a pair of chucks which are drivingly engaged with a core of the roll and rotate the roll to wind therearound the wrapping sheet. Each of the chucks is provided with suction holes formed on the outer peripheral surface thereof.
摘要:
An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
摘要:
The invention provides a superoxide dismutase derivative of the general formula[SOD][Z]wherein [SOD] represents a superoxide dismutase having 1 to 22 or 24 groups each derived from an amino groups by removal of one hydrogen atom in lieu of amino groups; [Z] represents a monovalent copolymer group, constituting units of which are a group of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a hydrogen atom or a residue derived by a removal of a hydroxyl group from an alkanol of 1 to 8 carbon atoms, an ethylene glycol monoalkyl ether containing an alkyl moiety of 1 to 4 carbon atoms or a glycerin dialkyl ether containing alkyl moieties of 1 to 4 carbon atoms, provided that either R.sup.1 or R.sup.2 and either R.sup.3 or R.sup.4 each represents a hydrogen atom, and a residue derived from the group of the above-mentioned formula by removal of OR.sup.1, OR.sup.2, OR.sup.3 or OR.sup.4 group from one of its COOR.sup.1, COOR.sup.2, COOR.sup.3 and COOR.sup.4 groups (where the bond on the carbon atom of the carbonyl group is attached to [SOD]), said monovalent copolymer group having an average molecular weight of 500 to 200,000; and n represents an integer of 1 to 22 or 24 corresponding to the number of said groups each derived from an amino group by removal of one hydrogen atom in said [SOD], or a pharmaceutically acceptable salt thereof. There also is provided a method for producing the above derivative and salt. The invention is further directed to medicinal uses and pharmaceutical compositions for oral administration.