公开(公告)号：US20060236434A1

公开(公告)日：2006-10-19

申请号：US11471754

申请日：2006-06-21

申请人： Mark Conkling ,  Yan Li

发明人： Mark Conkling ,  Yan Li

IPC分类号： A24C5/34 ,  A01H5/00 ,  A24C5/32

CPC分类号： C12N15/8223 ,  C07K14/415 ,  C12N9/1077 ,  C12N15/8216 ,  C12N15/8222 ,  C12N15/8227 ,  C12N15/8243 ,  C12N15/8251 ,  C12N15/8257

摘要： The present application describes isolated nucleic acids that contain a Nic gene product responsive element, and the use thereof in methods of producing transgenic tobacco plants having reduced levels of nicotine and/or TSNA therein, as well as other plants or host cells that contain altered levels of a protein of interest therein due to inclusion of a cis-acting decoy element therein.

公开(公告)号：US20060209592A1

公开(公告)日：2006-09-21

申请号：US11083514

申请日：2005-03-16

申请人： Yan Li ,  Seungpil Lee ,  Siu Chan

发明人： Yan Li ,  Seungpil Lee ,  Siu Chan

IPC分类号： G11C16/04

CPC分类号： G11C11/5642 ,  G11C16/26 ,  G11C2211/5621

摘要： A non-volatile memory device capable of reading and writing a large number of memory cells with multiple read/write circuits in parallel has features to reduce power consumption during read, and program/verify operations. A read or program verify operation includes one or more sensing cycles relative to one or more demarcation threshold voltages to determine a memory state. In one aspect, selective memory cells among the group being sensed in parallel have their conduction currents turned off when they are determined to be in a state not relevant to the current sensing cycle. In another aspect, a power-consuming period is minimized by preemptively starting any operations that would prolong the period. In a program/verify operation cells not to be programmed have their bit lines charged up in the program phase. Power is saved when a set of these bit lines avoids re-charging at every passing of a program phase.

公开(公告)号：US20060192107A1

公开(公告)日：2006-08-31

申请号：US11242842

申请日：2005-10-05

申请人： Donald DeVoe ,  Yingxin Wang ,  Cheng Lee ,  Yan Li

发明人： Donald DeVoe ,  Yingxin Wang ,  Cheng Lee ,  Yan Li

IPC分类号： B01D59/44

CPC分类号： B05B5/025 ,  G01N27/44717 ,  G01N30/7266

摘要： Disclosed are an apparatus, system, and method for performing electrospray of biomolecules, particularly peptides, polypeptides, and proteins. The apparatus comprises at least (1) a microfluidic substrate for containing an electrospray microchannel for delivering analyte molecules to a side edge of the substrate, and (2) a porous membrane attached to the side edge for performing electrospray from the exposed membrane surface. In one preferred embodiment, the exposed membrane surface is positioned above a target surface for depositing analyte molecules onto the target surface by electrospray. In another preferred embodiment, a proteolytic enzyme is bound to the porous membrane for performing protein digestion during electrospray.

摘要翻译： 公开了用于进行生物分子，特别是肽，多肽和蛋白质的电喷雾的装置，系统和方法。 该装置至少包括（1）微流体衬底，用于容纳用于将分析物分子输送到衬底的侧边缘的电喷射微通道，和（2）附着到侧边缘的用于从暴露的膜表面进行电喷雾的多孔膜。 在一个优选实施例中，暴露的膜表面位于靶表面上方，用于通过电喷射将分析物分子沉积到靶表面上。 在另一个优选的实施方案中，蛋白水解酶与多孔膜结合，用于在电喷雾期间进行蛋白质消化。

公开(公告)号：US20060191039A1

公开(公告)日：2006-08-24

申请号：US11416569

申请日：2006-05-03

申请人： Mark Conkling ,  Yan Li

发明人： Mark Conkling ,  Yan Li

IPC分类号： A01H5/00 ,  A01H1/00 ,  C12N15/82

CPC分类号： C12N15/8223 ,  C07K14/415 ,  C12N9/1077 ,  C12N15/8216 ,  C12N15/8222 ,  C12N15/8227 ,  C12N15/8243 ,  C12N15/8251 ,  C12N15/8257

摘要： The present application describes isolated nucleic acids that contain a Nic gene product responsive element, and the use thereof in methods of producing transgenic tobacco plants having reduced levels of nicotine and/or TSNA therein, as well as other plants or host cells that contain altered levels of a protein of interest therein due to inclusion of a cis-acting decoy element therein.

摘要翻译： 本申请描述了含有Nic基因产物响应元件的分离的核酸，以及其在生产具有降低的尼古丁和/或TSNA水平的转基因烟草植物以及含有改变水平的其它植物或宿主细胞的方法中的用途 的由于在其中包含顺式作用的诱饵元件而引起的目的蛋白质。

公开(公告)号：US20060136222A1

公开(公告)日：2006-06-22

申请号：US11022464

申请日：2004-12-22

申请人： Charles Cross ,  Yan Li

发明人： Charles Cross ,  Yan Li

IPC分类号： G10L21/00

CPC分类号： H04M3/4938 ,  G10L15/19 ,  G10L15/26 ,  H04M2201/40

摘要： A method, system and apparatus for voice enabling a user preference interface in a multimodal content browser. A method for voice enabling a user preference interface in a multimodal content browser can include matching voice input to a bound command in a speech grammar and invoking logic in the user preference interface consistent with the bound command in the speech grammar. The matching step can include comparing voice input to entries in a markup language specified speech grammar and locating the bound command in the specified speech grammar based upon the comparison. In this regard, the method further can include identifying a variable in the bound command, looking up the variable in a table, retrieving a corresponding parameter for the variable from the table, and replacing the variable with the corresponding parameter in the bound command.

公开(公告)号：US20060126390A1

公开(公告)日：2006-06-15

申请号：US11013125

申请日：2004-12-14

申请人： Sergey Gorobets ,  Yan Li

发明人： Sergey Gorobets ,  Yan Li

IPC分类号： G11C11/34 ,  G11C16/06

CPC分类号： G11C16/3459 ,  G11C11/5628 ,  G11C16/0483 ,  G11C16/12 ,  G11C16/32 ,  G11C16/3454

摘要： The present invention presents techniques whereby a memory system interrupts a programming process and restarts it including additional data. More specifically, when a memory system programs data into a group of cells together as programming unit, programming can begin with less than the full data content which the group can hold. In one embodiment, the present invention allows overlapped programming of upper and lower data pages, where once the memory begins programming the lower logical data page, if data is received for the upper page assigned to the same physical page, programming is interrupted and recommenced with the concurrent programming of both the upper and the loser pages. In a complimentary embodiment, when a page contains multiple sectors of data, programming of the physical page can begin when one or more, but less than all, of the sectors forming the corresponding logical page have been received, stopped and restarted to include additional sectors of the page.

公开(公告)号：US07046548B2

公开(公告)日：2006-05-16

申请号：US11055776

申请日：2005-02-09

申请人： Raul-Adrian Cernea ,  Khandker N. Quader ,  Yan Li ,  Jian Chen ,  Yupin Fong

发明人： Raul-Adrian Cernea ,  Khandker N. Quader ,  Yan Li ,  Jian Chen ,  Yupin Fong

IPC分类号： G11C16/04

CPC分类号： G11C16/3427 ,  G11C11/5628 ,  G11C16/10 ,  G11C16/3418

摘要： Techniques of reducing erroneous readings of the apparent charge levels stored in a number of rows of memory cells on account of capacitive coupling between the cells. All pages of a first row are programmed with a first pass, followed by programming all pages of a second adjacent row with a first pass, after which the first row is programmed with a second pass, and then all pages of a third row are programmed with a first pass, followed by returning to program the second row with a second pass, and so on, in a back-and-forth manner across the rows of an array. This minimizes the effect on the apparent charge stored on rows of memory cells that can occur by later writing data into adjacent rows of memory cells.

摘要翻译： 考虑到电池之间的电容耦合，减少存储在多行存储器单元中的表观电荷水平的错误读数的技术。 第一行的所有页面都用第一遍编程，然后用第一遍编程第二相邻行的所有页面，之后第一行以第二遍编程，然后第三行的所有页面都被编程 第一遍，然后通过第二遍返回到第二行的程序，依次类推，跨越数组的行。 这最大程度地减少了通过稍后将数据写入存储器单元的相邻行中可能发生的对存储器单元行存储的视在电荷的影响。

公开(公告)号：US20060099672A1

公开(公告)日：2006-05-11

申请号：US11326265

申请日：2006-01-05

申请人： J. Dolly ,  Yan Li ,  Kuo Chan

发明人： J. Dolly ,  Yan Li ,  Kuo Chan

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N15/74 ,  C12N1/21 ,  C07K14/33

CPC分类号： C07K14/33 ,  A61K38/00 ,  C12N9/52 ,  Y02A50/469

摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.

摘要翻译： 包含可活化的重组神经毒素和由其衍生的多肽的组合物。 本发明还包括编码这种多肽的核酸，以及制备这种多肽和核酸的方法。

公开(公告)号：US20060050562A1

公开(公告)日：2006-03-09

申请号：US10678918

申请日：2003-10-02

申请人： Raul-Adrian Cernea ,  Yan Li

发明人： Raul-Adrian Cernea ,  Yan Li

IPC分类号： G11C11/34

CPC分类号： G11C7/062 ,  G11C7/067 ,  G11C11/5642 ,  G11C16/26

摘要： Source line bias is an error introduced by a non-zero resistance in the ground loop of the read/write circuits. During sensing the control gate voltage of a memory cell is erroneously biased by a voltage drop across the resistance. This error is minimized when the current flowing though the ground loop is reduced. A method for reducing source line bias is accomplished by read/write circuits with features and techniques for multi-pass sensing. When a page of memory cells are being sensed in parallel, each pass helps to identify and shut down the memory cells with conduction current higher than a given demarcation current value. In particular, the identified memory cells are shut down after all sensing in the current pass have been completed. In this way the shutting down operation does not disturb the sensing operation. Sensing in subsequent passes will be less affected by source line bias since the total amount of current flow is significantly reduced by eliminating contributions from the higher current cells. In another aspect of sensing improvement, a reference sense amplifier is employed to control multiple sense amplifiers to reduce their dependence on power supply and environmental variations.

摘要翻译： 源极偏置是由读/写电路的接地回路中的非零电阻引起的误差。 在感测期间，存储器单元的控制栅极电压被跨过电阻的电压降错误地偏置。 当通过接地回路的电流减小时，该误差被最小化。 用于减少源极偏置的方法通过具有用于多遍感测的特征和技术的读/写电路来实现。 当并行地检测到一页存储单元时，每次通过有助于识别和关闭具有高于给定分界电流值的传导电流的存储单元。 特别地，在当前通路中的所有感测完成之后，所识别的存储器单元关闭。 以这种方式，关闭操作不会影响感测操作。 在后续通过中的感测将受到源极偏置的影响较小，因为通过消除较高电流单元的贡献，电流流动的总量显着减少。 在感测改进的另一方面，采用参考读出放大器来控制多个读出放大器以减少它们对电源和环境变化的依赖。

公开(公告)号：US20060023502A1

公开(公告)日：2006-02-02

申请号：US11235985

申请日：2005-09-26

申请人： Raul-Adrian Cernea ,  Yan Li

发明人： Raul-Adrian Cernea ,  Yan Li

IPC分类号： G11C16/04

CPC分类号： G11C16/3459 ,  G11C8/08 ,  G11C8/10 ,  G11C11/5628 ,  G11C16/26 ,  G11C16/3418 ,  G11C16/3454

摘要： A memory device and a method thereof allow programming and sensing a plurality of memory cells in parallel in order to minimize errors caused by coupling from fields of neighboring cells and to improve performance. The memory device and method have the plurality of memory cells linked by the same word line and a read/write circuit is coupled to each memory cells in a contiguous manner. Thus, a memory cell and its neighbors are programmed together and the field environment for each memory cell relative to its neighbors during programming and subsequent reading is less varying. This improves performance and reduces errors caused by coupling from fields of neighboring cells, as compared to conventional architectures and methods in which cells on even columns are programmed independently of cells in odd columns.