公开(公告)号：US20110272296A1

公开(公告)日：2011-11-10

申请号：US13135816

申请日：2011-07-15

申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

IPC分类号： G01N27/26 ,  G01N33/50

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/48771 ,  Y10T29/49002

摘要： A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1. The so-constructed biosensor can be formed by a simple method, and a biosensor which is excellent in a measuring accuracy as well as a biosensor in which a reagent layer is placed uniformly on the electrodes regardless of a reagent liquid composition, and which has a uniform performance can be realized.

公开(公告)号：US20110147234A1

公开(公告)日：2011-06-23

申请号：US12930957

申请日：2011-01-20

申请人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

发明人： Shoji Miyazaki ,  Hiroyuki Tokunaga ,  Masaki Fujiwara ,  Eriko Yamanishi ,  Yoshinobu Tokuno

IPC分类号： G01N27/416

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  G01N33/48771 ,  Y10T29/49002

摘要： A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1. The so-constructed biosensor can be formed by a simple method, and a biosensor which is excellent in a measuring accuracy as well as a biosensor in which a reagent layer is placed uniformly on the electrodes regardless of a reagent liquid composition, and which has a uniform performance can be realized.

公开(公告)号：US07955492B2

公开(公告)日：2011-06-07

申请号：US10598001

申请日：2005-04-18

申请人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

发明人： Masaki Fujiwara ,  Teppei Shinno ,  Shin Ikeda

IPC分类号： G01N27/26 ,  G01N27/327

CPC分类号： G01N27/3272 ,  A61B5/14546 ,  A61B5/1486 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3274 ,  G01N27/3277 ,  G01N27/413 ,  G01N33/49

摘要： The present invention provides a method of measuring a component in blood, by which the amounts of blood cells and an interfering substance can be measured with high accuracy and high reliability and the amount of the component can be corrected accurately based on the amounts of the blood cells and the interfering substance. In a sensor for measuring a blood component, a first working electrode 13 measures a current that flows during a redox reaction of a blood component, a second working electrode 17 measures the amount of blood cells, and a third working electrode 12 measures the amount of an interfering substance. Next, based on the measurement results, the amount of the blood component to be measured is corrected. Thus, more accurate and precise measurement of the amount of the blood component can be realized.

摘要翻译： 本发明提供一种测定血液成分的方法，通过该方法能够以高精度，高可靠性测定血细胞量和干扰物质的量，并且能够根据血液的量准确地校正成分的量 细胞和干扰物质。 在用于测量血液成分的传感器中，第一工作电极13测量在血液成分的氧化还原反应期间流动的电流，第二工作电极17测量血细胞的量，第三工作电极12测量 干扰物质。 接下来，基于测定结果，校正被测量的血液成分的量。 因此，可以实现对血液成分量的更准确和精确的测量。

公开(公告)号：US20110027816A1

公开(公告)日：2011-02-03

申请号：US12935803

申请日：2009-04-02

申请人： Masaki Fujiwara

发明人： Masaki Fujiwara

IPC分类号： C12Q1/26 ,  C12M1/34

CPC分类号： G01N27/3273 ,  C12Q1/26 ,  G01N27/3274

摘要： The present invention provides a biosensor system that can prevent a measurement error caused by the temperature of the environment in use from occurring. A biosensor system 100 includes a measuring instrument 101 having an operation part 306, and a sensor chip 200 that is insertable into and removable from the measuring instrument 101 and into which a blood sample is introduced. The sensor chip 200 includes a measurement part 41 (a measurement part A) that acquires Data a related to the concentration of an analyte in a blood sample based on the amount of electric current that flows in the blood sample due to a reaction in which an oxidoreductase with the analyte used as a substrate is involved, and a measurement part 42 (a measurement part B) that acquires, from the blood sample, Data b for temperature correction of Data a. The operation part 306 has a function of determining the concentration of the analyte in the blood sample, with the concentration having been corrected according to the temperature of the blood sample based on Data a and Data b.

摘要翻译： 本发明提供一种生物传感器系统，其能够防止由于使用中的环境的温度而引起的测量误差的发生。 生物传感器系统100包括具有操作部分306的测量仪器101和可插入到测量仪器101中并可从其移除的传感器芯片200，其中引入血液样本。 传感器芯片200包括测量部分41（测量部分A），其基于由于反应而在血液样本中流动的电流量，获取与血液样本中的分析物的浓度相关的Data a， 涉及用作底物的分析物的氧化还原酶，以及从血液取样获取Data a的温度校正用的数据b的测定部42（测定部B）。 操作部306具有根据数据a和数据b，根据血液样本的温度校正血液样本中的分析物的浓度的功能。

公开(公告)号：US20100324395A1

公开(公告)日：2010-12-23

申请号：US12866308

申请日：2009-02-06

申请人： Masahiro Kitagawa ,  Masaki Fujiwara ,  Keisuke Matsumura

发明人： Masahiro Kitagawa ,  Masaki Fujiwara ,  Keisuke Matsumura

IPC分类号： A61B5/1468

CPC分类号： A61B5/441 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/6843

摘要： Provided are a blood sensor that is highly reliable and does not contaminate the interior of the main body of the device, a blood testing device and a blood analysis method. The blood sensor (30) is provided with a plate-shaped base (31), a blood storage part (45) set roughly in the center of the base (31), a supply path (44), one end of which is connected to the storage part (45) and the other end of which is connected to an air pore (43b), multiple detecting electrodes (32-35) laid on one surface of the supply path (44), connecting electrodes (32a-35a), each coming out of these detection electrodes (32-35), and skin detection electrodes (47a, 47b) in the storage part (45) or near the storage part (45). The blood detecting device (101) is provided with a skin detecting circuit (200) that detects skin contact by measuring sensor (30) conduction or impedance changes.

摘要翻译： 提供一种高度可靠的血液传感器，并且不会污染装置的主体内部，血液检查装置和血液分析方法。 血液传感器（30）设置有大致位于基座（31）的中心的板状基部（31），血液存储部（45），供给路径（44），其一端连接 连接到供给路径（44）的一个表面上的多个检测电极（32-35），连接电极（32a〜35a） （32-35），以及存储部（45）或存储部（45）附近的皮肤检测电极（47a，47b）。 血液检测装置（101）设置有通过测量传感器（30）导电或阻抗变化来检测皮肤接触的皮肤检测电路（200）。

公开(公告)号：US07657801B2

公开(公告)日：2010-02-02

申请号：US11735422

申请日：2007-04-13

申请人： Masaki Fujiwara

发明人： Masaki Fujiwara

IPC分类号： G11C29/00 ,  G01R31/28 ,  G01R31/26

CPC分类号： G11C29/56 ,  G11C29/56004 ,  G11C2029/1806

摘要： There is provided a test apparatus that tests a device under test. The test apparatus includes an address generating circuit that generates a physical address to be supplied to a memory block inside the device under test, a plurality of mask registers being provided in correspondence with a plurality of memory input bits constituting at least a part of a memory input address to be supplied to the device under test, where the plurality of mask registers set values indicating whether a plurality of physical bits constituting the physical address is masked every the physical bit, a plurality of mask arithmetic circuits being provided in correspondence with each of the plurality of memory input bits, where the plurality of mask arithmetic circuits respectively mask the physical address in accordance with the value of the mask register corresponding to this memory input bit, a plurality of logical operation circuits being provided in correspondence with each of the plurality of memory input bits, where the plurality of logical operation circuits respectively output bit data obtained by performing a predetermined logical operation on a masking result by the mask arithmetic circuit as the memory input bit, and an address supplier that supplies the input address including the plurality of memory input bits output from the plurality of logical operation circuits to the device under test.

摘要翻译： 提供了测试被测设备的测试装置。 测试装置包括产生要提供给被测器件内部的存储器块的物理地址的地址产生电路，与构成存储器的至少一部分的多个存储器输入位相对应地提供多个掩码寄存器 输入地址被提供给被测设备，其中多个屏蔽寄存器设定表示构成物理地址的多个物理位是否被每个物理位屏蔽，多个屏蔽运算电路被提供与每个 多个存储器输入位，其中多个屏蔽运算电路根据对应于该存储器输入位的掩码寄存器的值分别屏蔽物理地址;多个逻辑运算电路，与多个 的存储器输入位，其中多个逻辑运算电路相应 通过对由掩模运算电路作为存储器输入位的掩蔽结果执行预定的逻辑运算获得的输出位数据;以及地址供应器，其提供包括从多个逻辑运算电路输出的多个存储器输入位的输入地址 到被测设备

公开(公告)号：US20090002485A1

公开(公告)日：2009-01-01

申请号：US12133861

申请日：2008-06-05

申请人： Masaki Fujiwara

发明人： Masaki Fujiwara

IPC分类号： H04N5/232 ,  H04N7/18

CPC分类号： H04N5/2256 ,  G02B7/004 ,  G02B21/082 ,  G02B21/26 ,  G02B21/362

摘要： This invention provides an inexpensive image acquisition apparatus capable of capturing not only an image of a still object, but also an image of a moving object with the use of an appropriate quantity of illumination light. The image acquisition apparatus includes a head section incorporating an image acquisition device therein and including a lens module and an illuminating part, a main body section including an illumination light source, an image acquisition control part and an image processing part, and a cable section connecting between the main body section and the head section. The lens module is one of a first lens module incorporating therein a lens for high-speed observation and a second lens module incorporating therein a lens for enlargement observation, which is selectively attached to the head section. In a case where the first lens module is attached to the head section, the illuminating part is a first lens illumination unit for illuminating a region of which an image is captured by the first lens module. Herein, the first lens illumination unit is attached to the head section.

摘要翻译： 本发明提供一种廉价的图像采集装置，其能够利用适当数量的照明光捕获静止物体的图像，而且捕获移动物体的图像。 图像采集装置包括：头部，其中包括图像获取装置，包括透镜模块和照明部分，主体部分包括照明光源，图像获取控制部分和图像处理部分，以及连接 在主体部分和头部之间。 透镜模块是其中包括用于高速观察的透镜的第一透镜模块和其中包括用于放大观察的透镜的第二透镜模块之一，其被选择性地附接到头部。 在第一透镜模块附接到头部的情况下，照明部分是用于照亮第一透镜模块捕获图像的区域的第一透镜照明单元。 这里，第一透镜照明单元附接到头部。

公开(公告)号：US20070123803A1

公开(公告)日：2007-05-31

申请号：US11545468

申请日：2006-10-11

申请人： Masaki Fujiwara ,  Noriyoshi Terashima ,  Shusei Aibara

发明人： Masaki Fujiwara ,  Noriyoshi Terashima ,  Shusei Aibara

IPC分类号： A61B5/00 ,  A61M31/00

CPC分类号： A61B5/150977 ,  A61B5/14535 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150511 ,  A61B5/150541 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/157

摘要： A blood sensor comprises a base (12), a detection part (16) disposed on the base (12), a blood collection needle (13) disposed at a front end (12a) of the base (12), a negative pressure generation part (17) for applying negative pressure to a portion of the blood collection needle (13), and a supply path (15) for supplying blood collected by the blood collection needle (13) to a detection part (16).

摘要翻译： 血液传感器包括基座（12），设置在基座（12）上的检测部分（16），设置在基座（12）的前端（12a）处的采血针（13） 用于对采血针（13）的一部分施加负压的生成部（17）和用于将由采血针（13）收集的血液供给到检测部（16）的供给路径（15）。

公开(公告)号：US20050001357A1

公开(公告)日：2005-01-06

申请号：US10902466

申请日：2004-07-30

申请人： Masaki Fujiwara ,  Yuji Nakagawa ,  Masato Kurosaki ,  Shinako Kaneko ,  Gaku Harada ,  Toshihiko Nishiyama

发明人： Masaki Fujiwara ,  Yuji Nakagawa ,  Masato Kurosaki ,  Shinako Kaneko ,  Gaku Harada ,  Toshihiko Nishiyama

IPC分类号： H01M4/02 ,  H01M4/04 ,  H01M4/137 ,  H01M4/1399 ,  H01M4/60 ,  H01M10/05 ,  H01M10/36 ,  C08J5/00 ,  B29C43/00

CPC分类号： H01M4/137 ,  H01M4/04 ,  H01M4/606 ,  H01M4/608 ,  H01M10/05 ,  H01M10/36

摘要： A molded electrode into one-piece is obtained by hot pressing an electrode material obtained by mixing a polymer active material, a conductivity-enhancing agent and a plasticizer, and a current collector sheet. The electrode structure permits significant freedom when designing a secondary battery which uses this electrode with a high energy density and a high power density.

摘要翻译： 将通过混合聚合物活性材料，导电性增强剂和增塑剂获得的电极材料和集电体片材热压成一体成型电极。 当设计使用具有高能量密度和高功率密度的该电极的二次电池时，电极结构允许显着的自由度。

公开(公告)号：US06608217B2

公开(公告)日：2003-08-19

申请号：US10255099

申请日：2002-09-26

申请人： Takeo Komata ,  Masaki Fujiwara ,  Takanao Tarui ,  Yusuke Saito ,  Hiroshi Minesaki

发明人： Takeo Komata ,  Masaki Fujiwara ,  Takanao Tarui ,  Yusuke Saito ,  Hiroshi Minesaki

IPC分类号： C07D31104

CPC分类号： C07D311/58 ,  C07C45/46 ,  C07C45/673 ,  C07C49/84 ,  C07C49/825

摘要： The present invention relates to a first process for producing a 2,2-bis(fluoromethyl)-6-(perfluoroalkyl)-2H-1-benzopyran-4-carboxylic acid. The first process includes the steps of (a) reacting a 2,2-bis(fluoromethyl)-6-(perfluoroalkyl)-2H-1-benzopyran-4-one with a perfluoroalkanesulfonic acid anhydride in the presence of a base, thereby obtaining a perfluoroalkanesulfonic 2,2-bis(fluoromethyl)-6-(perfluoroalkyl)-2H- 1-benzopyran-4-yl ester; and (b) reacting the benzopyranyl ester with carbon monoxide in the presence of a palladium complex compound and a base, thereby obtaining the carboxylic acid. The present invention further relates to a second process for producing a 2-hydroxy-5-(perfluoroalkyl) acetophenone, which can be a raw material for producing the carboxylic acid. The second process includes the steps of (c) reacting a 4-(perfluoroalkyl)alkoxybenzene with acetic anhydride or an acyl halide in the presence of a Lewis acid, thereby obtaining a 2-alkoxy-5-(perfluoroalkyl)acetophenone; and (d) dealkylating the 2-alkoxy-5-(perfluoroalkyl) acetophenone by a dealkylating agent.

摘要翻译： 本发明涉及生产2,2-双（氟甲基）-6-（全氟烷基）-2H-1-苯并吡喃-4-羧酸的第一种方法。 第一种方法包括以下步骤：（a）在碱的存在下使2,2-双（氟甲基）-6-（全氟烷基）-2H-1-苯并吡喃-4-酮与全氟烷基磺酸酐反应，从而得到 全氟烷基磺酸2,2-双（氟甲基）-6-（全氟烷基）-2H-苯并吡喃-4-基酯; 和（b）在钯络合物和碱的存在下使苯并吡喃基酯与一氧化碳反应，由此得到羧酸。 本发明还涉及可用作生产羧酸的原料的2-羟基-5-（全氟烷基）苯乙酮的制备方法。 第二种方法包括以下步骤：（c）在路易斯酸存在下使4-（全氟烷基）烷氧基苯与乙酸酐或酰卤反应，由此得到2-烷氧基-5-（全氟烷基）苯乙酮; 和（d）通过脱烷基化剂使2-烷氧基-5-（全氟烷基）苯乙酮脱烷基化。