公开(公告)号：US11293042B2

公开(公告)日：2022-04-05

申请号：US16927700

申请日：2020-07-13

Applicant: GLYCOM A/S

Inventor： Margit Pedersen ,  Manos Papadakis ,  Peter Becker ,  Eric Samain ,  Pauline Peltier-Pain ,  Katrine Bych ,  Ted Johanson ,  Elise Champion ,  Gyula Dekany

IPC: C12P19/00 ,  C12P19/12

Abstract: The invention relates to a genetically modified microorganism for making a oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source.

公开(公告)号：US11278558B2

公开(公告)日：2022-03-22

申请号：US16490027

申请日：2018-03-01

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell

IPC: A61K31/702 ,  A23L33/125 ,  A23L33/135 ,  A61P1/00 ,  A61K31/7004

Abstract: The invention relates to a method and composition for modulating the microbiota in the gastro-intestinal tracts of non-infant humans, particularly for increasing the abundance of Bifidobacterium longum and/or Bifidobacterium bifidum in the gut microbiota of non-infant humans.

公开(公告)号：US20220072017A1

公开(公告)日：2022-03-10

申请号：US17417029

申请日：2019-12-19

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A61K35/20 ,  A61P1/14 ,  A61K9/48 ,  A61K9/16 ,  A61K9/00 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61K47/24

Abstract: A synthetic composition and method for use in providing a source of oligosaccharides to a human consuming a low-FODMAP diet, increasing the abundance of bifidobacteria in the colon of a human consuming a low-FODMAP diet, and/or reintroducing FODMAPs into the diet of a human consuming a low-FODMAP diet. The composition contains one or more human milk oligosaccharides.

公开(公告)号：US11214588B2

公开(公告)日：2022-01-04

申请号：US16626245

申请日：2018-06-27

Applicant: GLYCOM A/S

Inventor： Nikolay Khanzhin ,  Markus Jondelius Hederos

IPC: A23L33/00 ,  C12P19/18 ,  C08B37/00 ,  B01D61/02 ,  B01D61/58 ,  B01D69/12 ,  C07H3/06 ,  C12P19/04 ,  B01D61/14 ,  C07H1/06 ,  B01D61/04 ,  B01D69/02 ,  B01D71/56 ,  B01D71/58 ,  C12P19/12

Abstract: This invention relates to a method for the enzymatic synthesis of oligosaccharides, preferably human milk oligosaccharides (HMOs) The method comprises the enzymatic transfer of a glycosyl moiety and subsequent removal of by-products, such as lactose, by nanofiltration using a membrane comprising an active polyamide layer.

公开(公告)号：US20210308159A1

公开(公告)日：2021-10-07

申请号：US17353730

申请日：2021-06-21

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Emma Elison ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A61P1/12 ,  A61K31/7016

Abstract: The application relates to a method for the prophylaxis or treatment of non-infectious diarrhea in a human, the method comprising administering to the human an effective amount of one or more human milk oligosaccharides.

公开(公告)号：US11040050B2

公开(公告)日：2021-06-22

申请号：US15906911

申请日：2018-02-27

Applicant: Glycom A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Elison

IPC: A61K31/702 ,  A61K31/7016 ,  A61P1/12 ,  A61P1/00

Abstract: This invention relates generally to compositions and methods for preventing or treating mast cell mediated visceral pain.

公开(公告)号：US10987368B2

公开(公告)日：2021-04-27

申请号：US15183431

申请日：2016-06-15

Applicant: GLYCOM A/S

Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Emma Elison

IPC: A61K31/702 ,  A61K35/745 ,  A61K9/20 ,  A61K9/48 ,  A23L33/21 ,  A23L33/135 ,  A61K35/00

Abstract: The invention relates to HMOs and compositions comprising thereof for reducing the risk of, preventing, or treating CVD and/or CDV associated pathological conditions or diseases in humans, particularly in overweight and obese humans.

公开(公告)号：US10899782B2

公开(公告)日：2021-01-26

申请号：US16082848

申请日：2017-03-07

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Nikolay Khanzhin ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C07H1/08 ,  C07H1/06 ,  B01D61/14 ,  C08B37/00 ,  B01D61/16 ,  C07H13/04 ,  A23L33/195 ,  B01D15/36 ,  C07H23/00 ,  C12P19/04 ,  C12P19/18 ,  B01D61/02 ,  B01D61/58 ,  C07H13/02

Abstract: The present invention relates to a method for separating sialylated oligosaccharides from a fermentation broth in which they are produced by a genetically modified microorganism The separation comprises the steps of: i) ultrafiltration; ii) nano-filtration; iii) optionally, activated charcoal treatment; and iv) treatment with strong anion and/or cation exchange resin.

公开(公告)号：US10857168B2

公开(公告)日：2020-12-08

申请号：US16079959

申请日：2017-02-24

Applicant: Glycom A/S

Inventor： Bruce McConnell ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A61K45/06 ,  A61P31/00 ,  A61P3/10 ,  A61P29/00 ,  A61K35/20 ,  A61K35/00

Abstract: This invention relates to a method and composition for modulating the microbiota in the gastro-intestinal tracts of non-infant humans who are carriers of the human fucosyltransferase 2 (FUT2) genetic mutation.

公开(公告)号：US10731193B2

公开(公告)日：2020-08-04

申请号：US15321996

申请日：2015-06-29

Applicant: GLYCOM A/S

Inventor： Eric Samain ,  Pauline Peltier-Pain ,  Katrine Bych ,  Ted Johanson ,  Elise Champion ,  Gyula Dekany

IPC: C12P19/18 ,  C07K14/245 ,  C12N15/52 ,  C12N9/10 ,  C12N9/12 ,  C12N9/24 ,  C12N9/38

Abstract: The invention relates to a genetically modified microorganism for making a recombinant oligosaccharide, preferably of 3-8 monosaccharide units, more preferably of 3-5 monosaccharide units, particularly a HMO, which comprises one or more genes encoding a sucrose utilization system, so the microorganism can use sucrose as a carbon and energy source. The one or more genes encoding a sucrose utilization system are preferably one or more genes encoding a heterologous PTS-dependent sucrose utilization transport system, such as the scr genes.