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公开(公告)号：US20190338247A1
公开(公告)日：2019-11-07
申请号：US16478477
申请日：2018-01-18
Applicant: Yeda Research And Development Co. Ltd.
Inventor： Yair REISNER , Esther BACHAR-LUSTIG , Shlomit REICH-ZELIGER
IPC: C12N5/0783 , C07K14/725 , C12N5/00 , A61K35/17 , A61P35/04 , A61P35/00 , A61P35/02 , C07K16/32 , C07K16/30 , C07K16/28
Abstract: An isolated cytotoxic T-lymphocyte (CTL), said CTL being a tolerance inducing cell and substantially depleted of alloreactivity, and wherein said CTL does not comprise a central memory T-lymphocyte (Tcm) phenotype, the CTL being transduced to express a cell surface receptor comprising a T cell receptor signaling module, is disclosed. Methods of generating same and using same are also disclosed.
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公开(公告)号：US20190327974A1
公开(公告)日：2019-10-31
申请号：US16476559
申请日：2018-01-09
Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY , YEDA RESEARCH AND DEVELOPMENT CO. LTD. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Colin JACKSON , Nir LONDON , Galen CORREY , Janelle SAN JUAN
Abstract: This invention is directed to synergists for organophosphate (OP), carbamate (CM) and/or pyrethroid/synthetic pesticides (SP). This invention is further directed to a composition comprising organophosphate, carbamate, and/or pyrethroid/synthetic pyrethroid, and at least one boronic acid derivative. This invention further provides methods for killing insect pests.
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公开(公告)号：US10457999B2
公开(公告)日：2019-10-29
申请号：US15318459
申请日：2015-06-18
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Igor Lubomirsky , Valery Kaplan
Abstract: A method for recovery of platinum group metals from a spent catalyst is described. The method includes crushing the spent catalyst to obtain a catalyst particulate material including particles having a predetermined grain size. The method includes subjecting the catalyst particulate material to a chlorinating treatment in the reaction zone at a predetermined temperature for a predetermined time period by putting the catalyst particulate material in contact with the chlorine containing gas. The method also includes applying an electromagnetic field to the chlorine-containing gas in the reaction zone to provide ionization of chlorine; thereby to cause a chemical reaction between platinum group metals and chlorine ions and provide a volatile platinum group metal-containing chloride product in the reaction zone. Following this, the volatile platinum group metal-containing chloride product is cooled to convert the product into solid phase platinum group metal-containing materials.
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公开(公告)号：US20190322698A1
公开(公告)日：2019-10-24
申请号：US16466819
申请日：2017-12-05
Inventor： Qingeng LI , Tao WANG , Gang CHEN , Liang REN , Xin LIU
Abstract: The present invention relates to the field of medicine, and particularly relates to a water-soluble allopregnenolone (3β,5α-tetrahydroprogesterone) derivative, a pharmaceutical composition comprising the same, and use thereof in prevention or treatment of central nervous system diseases, in sedation and hypnosis, in treatment of Alzheimer's disease, in treatment of epilepsy or in treatment of depression, especially postpartum depression.
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公开(公告)号：US20190315804A1
公开(公告)日：2019-10-17
申请号：US16451081
申请日：2019-06-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Moshe OREN , Varda ROTTER , Perry TAL
Abstract: The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.
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Patent Agency Ranking
126.发明授权公开(公告)号：US10434121B2
公开(公告)日：2019-10-08
申请号：US14367923
申请日：2012-12-20
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yair Reisner , Esther Bachar-Lustig
IPC: A61K35/28 , A61K35/17 , A61K35/22 , A61K35/38 , A61K35/39 , A61K35/407 , A61K35/42 , A61K31/675 , A61K31/661 , A61K35/34 , A61K35/36 , C12N5/00 , A61K31/198 , A61K31/255 , A61K31/7076 , A61K39/395 , A61K39/00 , A61K35/12
Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoetic cells, wherein the T cell depleted immature hematopoetic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject, and wherein the T cell depleted immature hematopoetic cells are obtained by separating the T cells from the immature hematopoetic cells by magnetic cell sorting, and (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per body weight, thereby treating the subject.
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公开(公告)号：US10392352B2
公开(公告)日：2019-08-27
申请号：US15767009
申请日：2016-10-10
Inventor： Qingeng Li , Tao Wang , Lingguo Zeng , Guisheng Zhang , Xiangqing Xu , Liang Ren
IPC: C07D233/90 , A61P23/00
Abstract: The present invention discloses an etomidate derivative of Formula 1, or a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, a pharmaceutical composition and a kit comprising the same, as well as intermediates and methods for preparing the same, and use thereof. The etomidate derivative of the present invention not only has good anesthetic activity, rapid onset, and short duration of action, but also shows little inhibition to the secretion of corticosteroids in animals, and therefore has both favorable anesthetic effect and safety profiles.
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公开(公告)号：US10361003B2
公开(公告)日：2019-07-23
申请号：US15022643
申请日：2015-04-28
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Eran Segal , Eran Elinav
Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.
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公开(公告)号：US20190211016A1
公开(公告)日：2019-07-11
申请号：US16311700
申请日：2017-06-21
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Dvir GUR , Lia ADDADI , Stephen WEINER
IPC: C07D473/18
CPC classification number: C07D473/18 , C07B2200/13
Abstract: This invention is directed to synthetic co-crystals of anhydrous guanine and at least one additional material, wherein the co-crystals have a high refraction index and therefore, provide products with pearlescence or whiteness with high coverage. The invention is further directed to a process for the preparation of anhydrous guanine and of the co crystals.
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公开(公告)号：US20190203270A1
公开(公告)日：2019-07-04
申请号：US16319499
申请日：2016-07-24
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Ido AMIT , David LARA-ASTIASO , Meital GURY
IPC: C12Q1/6811 , C12Q1/6818 , C12Q1/6876
CPC classification number: C12Q1/6811 , C12Q1/6816 , C12Q1/6818 , C12Q1/6876 , C12Q2600/154 , C12Q2600/156 , G01N33/6875 , C12Q2522/101 , C12Q2563/185
Abstract: Methods of analyzing DNA molecules in a cell sample are provided. The DNA molecules have DNA binding moiety signatures which are defined by at least two non-identical DNA binding moieties. Kits for analyzing the DNA are also provided.
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