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    Feature value extraction apparatus and place estimation apparatus
    121.
    发明授权
    Feature value extraction apparatus and place estimation apparatus 有权
    特征值提取装置和位置估计装置

    公开(公告)号：US09396396B2

    公开(公告)日：2016-07-19

    申请号：US14440768

    申请日：2013-11-06

    Applicant: Tokyo Institute of Technology

    Inventor： Osamu Hasegawa ,  Gangchen Hua

    IPC: G06K9/00 ,  G01B11/00 ,  G06T7/20 ,  G06K9/46 ,  G06K9/62

    CPC classification number: G06K9/00691 ,  G01B11/00 ,  G06K9/00704 ,  G06K9/4671 ,  G06K9/6211 ,  G06K2209/29 ,  G06T7/246 ,  G06T2207/10016

    Abstract: A place estimation apparatus performs a place estimation process by using position-invariant feature values extracted by a feature value extraction unit. The feature value extraction unit includes local feature value extraction unit that extracts local feature values from each of input images formed from successively-shot successive images, feature value matching unit that obtains matching between successive input images based on the extracted local feature values, corresponding feature value selection unit that selects matched feature values as corresponding feature values, and position-invariant feature value extraction unit that obtains position-invariant feature values based on the corresponding feature values. The position-invariant feature value extraction unit extracts, from among the corresponding feature values, corresponding feature values whose position change is equal to or less than a predetermined threshold as the position-invariant feature values.

    Abstract translation: 位置估计装置通过使用由特征值提取单元提取的位置不变特征值来执行位置估计处理。 特征值提取单元包括局部特征值提取单元，其从连续拍摄的连续图像形成的每个输入图像中提取局部特征值，基于提取的局部特征值获得连续输入图像之间的匹配的特征值匹配单元，相应的特征 选择匹配特征值作为对应特征值的值选择单元，以及基于相应特征值获取位置不变特征值的位置不变特征值提取单元。 位置不变特征值提取单元从相应的特征值中提取位置变化等于或小于预定阈值的相应特征值作为位置不变特征值。

    PEPTIDE-PRESENTING PROTEIN AND PEPTIDE LIBRARY USING SAME
    123.
    发明申请
    PEPTIDE-PRESENTING PROTEIN AND PEPTIDE LIBRARY USING SAME 审中-公开
    使用相同的肽代谢蛋白和肽图书馆

    公开(公告)号：US20160145605A1

    公开(公告)日：2016-05-26

    申请号：US14786416

    申请日：2014-04-23

    Applicant: TOKYO INSTITUTE OF TECHNOLOGY

    Inventor： Tetsuya KADONOSONO ,  Shinae KONDOH

    IPC: C12N15/10 ,  C12N9/10 ,  C07K7/08 ,  C07K7/06 ,  G01N33/68 ,  C07K14/435

    CPC classification number: C12N15/1037 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001 ,  C07K14/43595 ,  C07K2319/60 ,  C12N9/1088 ,  C12N15/1034 ,  C12N15/1044 ,  C12N15/1093 ,  C12Q1/37 ,  C12Y205/01018 ,  G01N33/6845 ,  G01N2333/96466

    Abstract: The object of the present invention is to provide a method for screening peptide(s) highly specific to a target molecule. The object can be solved by a peptide-presenting protein wherein a peptide is presented in a presentation region consisting of the 131st to 139th amino acids in the amino acid sequence of the SEQ ID NO: 54, wherein the peptide consisting of 4 to 15 amino acids is inserted in the 131st to 139th amino acids sequence, or substituted for any of 1 to 9 amino acid(s) sequence in the 131st to 139th amino acids sequence; and a total length of an amino acid sequence corresponding to the 131st to 139th amino acids sequence is 15 or less.

    Abstract translation: 本发明的目的是提供一种筛选对靶分子高度特异性的肽的方法。 该目的可以通过肽呈递蛋白来解决，其中肽在由SEQ ID NO：54的氨基酸序列中的第131个至第139个氨基酸组成的呈递区域中存在，其中由4至15个氨基 将酸插入第131至第139个氨基酸序列，或在第131至139个氨基酸序列中取代1至9个氨基酸序列中的任何一个; 对应于第131〜139位氨基酸序列的氨基酸序列的总长度为15以下。

    Sequence Conversion and Signal Amplifier DNA Having Poly DNA Spacer Sequences and Detection Methods Using Same
    124.
    发明申请
    Sequence Conversion and Signal Amplifier DNA Having Poly DNA Spacer Sequences and Detection Methods Using Same 审中-公开
    具有聚DNA间隔序列的序列转换和信号放大器DNA及其检测方法

    公开(公告)号：US20160102345A1

    公开(公告)日：2016-04-14

    申请号：US14882109

    申请日：2015-10-13

    Applicant: Abbott Japan Co., Ltd. ,  Tokyo Institute Of Technology

    Inventor： Ken KOMIYA ,  Makoto KOMORI ,  Toru YOSHIMURA

    IPC: C12Q1/68

    CPC classification number: C12Q1/682 ,  C12Q1/6844 ,  C12Q2525/113 ,  C12Q2525/131 ,  C12Q2525/185 ,  C12Q2531/119

    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting said sample, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide. Also disclosed are methods for detecting a target nucleic acid in a sample in which said sample is contacted, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide and a signal amplifier oligonucleotide. The disclosure also provides compositions and kits comprising such sequence conversion and signal amplifier oligonucleotides.

    Abstract translation: 公开了用于检测样品中靶核酸的方法。 所述方法包括在聚合酶和内切核酸酶存在下将所述样品与序列转化寡核苷酸接触。 还公开了用于在聚合酶和内切核酸酶的存在下与序列转化寡核苷酸和信号放大寡核苷酸接触的样品中的靶核酸的检测方法。 本公开还提供了包含这种序列转化和信号放大器寡核苷酸的组合物和试剂盒。

    POLYMER PARTICLE CONTAINING FLUORESCENT MOLECULE AND METHOD FOR PRODUCING THE SAME
    126.
    发明申请
    POLYMER PARTICLE CONTAINING FLUORESCENT MOLECULE AND METHOD FOR PRODUCING THE SAME 审中-公开
    含有荧光分子的聚合物颗粒及其制造方法

    公开(公告)号：US20150233935A1

    公开(公告)日：2015-08-20

    申请号：US14705244

    申请日：2015-05-06

    Applicant: TOKYO INSTITUTE OF TECHNOLOGY

    Inventor： Hiroshi HANDA ,  Mamoru HATAKEYAMA ,  Satoshi SAKAMOTO ,  Yusuke MOCHIZUKI ,  Shintaro KAWADA

    IPC: G01N33/58 ,  H01F1/09

    CPC classification number: G01N33/582 ,  C08J3/12 ,  C08J3/128 ,  C08J2327/12 ,  G01N33/533 ,  G01N33/54326 ,  G01N2458/40 ,  H01F1/06 ,  H01F1/09

    Abstract: A method for preparing polymer magnetic particles comprising magnetic particles and a coating polymer layer covering the magnetic particles and containing fluorescent molecules, the method includes swelling a coating polymer layer of the polymer magnetic particles in a non-aqueous solvent-containing and absorbing the fluorescent molecules inside the swelled coating polymer layer, adding water to the non-aqueous solvent in which the polymer magnetic particles adsorbing the fluorescent molecules are present, and removing the non-aqueous solvent by evaporation; where the non-aqueous solvent has affinity with water, a lower boiling point, and a higher vapor pressure than those of water, and the fluorescent molecule is selected from rare earth metal chelate complexes.

    Abstract translation: 一种制备包含磁性颗粒的聚合物磁性颗粒和覆盖磁性颗粒并含有荧光分子的涂层聚合物层的方法，该方法包括使聚合物磁性颗粒的涂覆聚合物层溶胀在非水溶剂中并吸收荧光分子 在溶胀的涂料聚合物层的内部，向吸附有荧光分子的聚合物磁性粒子的非水溶剂中加入水，通过蒸发除去非水溶剂; 其中非水溶剂与水具有亲和性，沸点低，蒸气压高于水，荧光分子选自稀土金属螯合物。

    Suspension Processing Device Using Ultrasonic Waves
    127.
    发明申请
    Suspension Processing Device Using Ultrasonic Waves 有权
    使用超声波的悬挂处理装置

    公开(公告)号：US20150209696A1

    公开(公告)日：2015-07-30

    申请号：US14425929

    申请日：2013-08-07

    Applicant: Hitachi, Ltd. ,  Tokyo Institute of Technology

    Inventor： Takuya Kambayashi ,  Kentaro Nakamura

    IPC: B01D21/28

    CPC classification number: B01D21/283 ,  B01D43/00 ,  B01J19/10 ,  C02F1/36

    Abstract: A suspension processing method using ultrasonic waves has problems in that movement of solids in liquid do not follow movement of the sound field. Accordingly, application to a field that requires a high suspension processing performance or a high flow rate process is difficult. In order to achieve the high suspension processing performance, a design of adopting a long and large oscillator and the like is required. A suspension processing device (30) of separating and concentrating a component of solids in suspension (1a) using ultrasonic waves, includes: at least one supply port (32) for supplying the suspension (1a) into the device; a channel (31) through which the suspension flows; at least two outlet ports (33 and 34) for discharging processed suspension (1a); an oscillator (35) for emitting ultrasonic waves; and a reflection plate (36) for reflecting the emitted ultrasonic waves.

    Abstract translation: 使用超声波的悬浮处理方法存在的问题在于液体中的固体的运动不跟随声场的移动。 因此，难以应用于需要高悬浮处理性能或高流量处理的领域。 为了实现高悬浮加工性能，需要采用长而大的振荡器等的设计。 使用超声波分离和浓缩悬浮液（1a）中的固体成分的悬浮处理装置（30）包括：用于将悬浮液（1a）供应到装置中的至少一个供给口（32） 悬挂液流过的通道（31）; 至少两个用于排出经处理的悬浮液（1a）的出口（33和34）; 用于发射超声波的振荡器（35）; 以及用于反射发射的超声波的反射板（36）。

    COVERED SEQUENCE CONVERSION DNA AND DETECTION METHODS
    128.
    发明申请
    COVERED SEQUENCE CONVERSION DNA AND DETECTION METHODS 审中-公开
    覆盖序列转化DNA和检测方法

    公开(公告)号：US20150197823A1

    公开(公告)日：2015-07-16

    申请号：US14597981

    申请日：2015-01-15

    Applicant: Abbott Japan Co., Ltd. ,  Tokyo Institute of Technology

    Inventor： KEN KOMIYA ,  MAKOTO KOMORI ,  TORU YOSHIMURA

    IPC: C12Q1/70 ,  C12Q1/68

    CPC classification number: C12Q1/707 ,  C12Q1/682 ,  C12Q1/6844 ,  C12Q1/689 ,  C12Q1/703 ,  C12Q1/706 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Q2521/301 ,  C12Q2525/301

    Abstract: Disclosed are methods for detecting a target nucleic acid in sample, which include contacting the sample with an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5′ to 3′ direction, an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to the target nucleic acid; a polymerase; and an endonuclease capable of nicking the endonuclease recognition site. The disclosure also provides compositions and kits comprising an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5′ to 3′ direction an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to a target nucleic acid.

    Abstract translation: 公开了用于检测样品中靶核酸的方法，其包括使样品与具有发夹结构的寡核苷酸接触，其中寡核苷酸在5'至3'方向上包含任意序列，用于切口的内切核酸酶识别位点 反应，与任意序列互补的序列和与靶核酸互补的序列; 聚合酶 和能够切割内切核酸酶识别位点的核酸内切酶。 本公开还提供了包含具有发夹结构的寡核苷酸的组合物和试剂盒，其中寡核苷酸在5'至3'方向上包含任意序列，用于切口反应的内切核酸酶识别位点，与任意序列互补的序列，以及 与靶核酸互补的序列。

    SIGNAL PROCESSING DEVICE, SIGNAL PROCESSING METHOD, AND PROGRAM
    130.
    发明申请
    SIGNAL PROCESSING DEVICE, SIGNAL PROCESSING METHOD, AND PROGRAM 审中-公开
    信号处理设备，信号处理方法和程序

    公开(公告)号：US20150134712A1

    公开(公告)日：2015-05-14

    申请号：US14395087

    申请日：2013-02-22

    Applicant: TOKYO INSTITUTE OF TECHNOLOGY

    Inventor： Isao Yamada ,  Daichi Kitahara

    IPC: G01S13/90 ,  G01R33/565

    CPC classification number: G01S13/90 ,  G01R33/56545

    Abstract: To improve the stability of numerical calculation for finding a continuous phase of a pair of signal sequences, provided is a signal processing device (10) wherein a spline calculation unit (13) approximates a pair of signal sequences acquired by a signal acquisition unit (11) by spline functions, and an unwrapping processing unit (18) performs phase unwrapping using polynomials. The phase unwrapping is performed according to a procedure where a polynomial-sequence calculation unit (15) calculates a polynomial sequence by applying a Euclidean algorithm to the polynomials of the spline functions, a sign counting unit (17) checks the number of changes of the sign of a numerical sequence formed by arranging the values of the polynomial sequence in each subinterval where the phase is found, and an unwrapping processing unit (18) determines an indefinite portion that is an integral multiple of π on the basis of the number of changes.

    Abstract translation: 为了提高用于找到一对信号序列的连续相位的数值计算的稳定性，提供了一种信号处理装置（10），其中样条计算单元（13）近似由信号获取单元（11）获取的一对信号序列 ），并且解卷处理单元（18）使用多项式执行相位展开。 根据多项式序列计算单元（15）通过对所述样条函数的多项式应用欧几里德算法来计算多项式序列的过程来执行相位展开，符号计数单元（17）检查所述多项式序列的变化次数 通过在找到相位的每个子间隔中排列多项式序列的值而形成的数字序列的符号，并且解包处理单元（18）确定作为＆pgr的整数倍的不确定部分; 在数量变化的基础上。

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