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    Methacrylate copolymers for medical devices
    124.
    发明申请
    Methacrylate copolymers for medical devices 有权

    公开(公告)号：US20060067908A1

    公开(公告)日：2006-03-30

    申请号：US10957265

    申请日：2004-09-30

    Applicant: Ni Ding

    Inventor： Ni Ding

    IPC: A61K31/74

    CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/222 ,  A61L2300/254 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/606 ,  A61L2420/06 ,  C08L33/12

    Abstract: A polymer of hydrophobic monomers and hydrophilic monomers is provided. It is also provided a polymer blend that contains the polymer and another biocompatible polymer. The polymer or polymer blend and optionally a biobeneficial material and/or a bioactive agent can form a coating on an implantable device such as a drug delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    Brachytherapy applicator
    126.
    发明申请
    Brachytherapy applicator 有权
    近距离放疗

    公开(公告)号：US20050070753A1

    公开(公告)日：2005-03-31

    申请号：US10742445

    申请日：2003-12-19

    Applicant: Michael Forman ,  Darius Francescatti ,  Ni Ding

    Inventor： Michael Forman ,  Darius Francescatti ,  Ni Ding

    IPC: A61M36/04 ,  A61N5/10

    CPC classification number: A61N5/1015 ,  A61N5/1027

    Abstract: A breast brachytherapy applicator providing a stable semi permanent/permanent in dwelling platform that is configured to replicate anatomically the excised cancer bed and allows for a more precise anatomically correct delivery of limited field radiation treatment. This device may be used to reconstitute a resected tissue space to its pre-operative size and shape to 1) facilitate the accurate and precise delivery of adjunctive breast brachytherapy following breast cancer surgery and 2) prevent/decrease post-operative deformity as a result of surgical resection, whether for benign or malignant disease, and in particular after radiation treatment of malignant disease in the post lumpectomy patient.

    Abstract translation: 一种乳房近距离放射治疗仪，其提供稳定的半永久/永久性住宅平台，其被配置为在解剖学上复制切除的癌床，并允许更精确的解剖学上正确的有限的放射治疗递送。 该装置可用于将切除的组织空间重建为其手术前的大小和形状，以便于1）促进乳腺癌手术后辅助乳房近距离放射治疗的准确和精确的传递，以及2）由于以下原因：预防/减少术后畸形 手术切除，无论是良性还是恶性疾病，特别是放射治疗乳房肿瘤切除术后患者的恶性疾病。

    Drug-releasing coatings for medical devices
    129.
    发明授权
    Drug-releasing coatings for medical devices 失效
    用于医疗器械的药物释放涂层

    公开(公告)号：US6042875A

    公开(公告)日：2000-03-28

    申请号：US260971

    申请日：1999-03-02

    Applicant: Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    Inventor： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    IPC: A61F2/82 ,  A61L27/34 ,  A61L27/50 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  B05D3/00 ,  B05D3/02 ,  B05D3/04

    CPC classification number: A61L27/50 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/258 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2300/802

    Abstract: The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the surface of medical devices through a reservoir concept. Specifically, the coating comprises at least two layers: an outer layer containing at least one drug-ionic surfactant complex overlying a reservoir layer containing a polymer and the drug which is substantially free of an ionic surfactant. Upon exposure to body tissue of a medical device covered with such coating, the ionically bound drug in the outer layer is released into body fluid or tissue. Following release of such bound drug, the ionic surfactant binding sites in the outer layer are left vacant. To maintain the pharmacological activity after delivery of the ionically bound drug, additional amounts of the drug are embedded or incorporated in the reservoir layer in a manner which allows the drug, which is substantially free of ionic surfactants, to complex with the vacant binding sites of the ionic surfactant of the outer layer. As a result, the surface of the medical device is enriched with the drug to provide sustained pharmacological activity to prevent the adverse reaction due to the presence of the medical device. The invention is further directed to medical devices with stabilized drug-releasing coatings. The coatings are stabilized by exposure to a low energy, relatively non-penetrating energy source, e.g., gas plasma or an electron beam energy source.

    Abstract translation: 本发明涉及具有药物释放涂层的医疗装置及其制造方法。 涂层允许通过储存器概念在医疗装置的表面上定时或延长药理活性。 具体地说，该涂层包括至少两层：包含至少一种药物 - 离子表面活性剂复合物的外层，其中包含聚合物的储存层和基本上不含离子表面活性剂的药物。 在暴露于用这种涂层覆盖的医疗装置的身体组织上时，外层中的离子结合药物被释放到体液或组织中。 释放这种结合药物后，外层中的离子表面活性剂结合位点留空。 为了在输送离子结合的药物之后保持药理活性，将额外量的药物以允许基本上不含离子表面活性剂的药物与储存层中的空位结合位点复合的方式嵌入或并入储存层中 外层的离子表面活性剂。 结果，医疗装置的表面富含药物以提供持续的药理活性，以防止由于存在医疗装置而引起的不良反应。 本发明进一步涉及具有稳定的药物释放涂层的医疗装置。 通过暴露于低能量，相对非穿透能量源（例如气体等离子体或电子束能量源）来使涂层稳定。

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