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公开(公告)号：US09878169B2
公开(公告)日：2018-01-30
申请号：US14650818
申请日：2013-12-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , Syed Hossainy
Inventor： Syed Hossainy
CPC classification number: A61N1/3756 , A61F7/12 , A61F2007/126 , A61M39/0247 , A61M2039/0258 , A61M2039/0261 , A61N1/3627 , A61N1/3785
Abstract: Various medical implants and methods of using the implants are disclosed. In an embodiment, the implants include piezoelectric polymers for treating unwanted medical conditions of a patient. The medical implants may be delivered to an organ of the patient to treat conditions of those organs.
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公开(公告)号：US08951595B2
公开(公告)日：2015-02-10
申请号：US12636079
申请日：2009-12-11
Applicant: John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
Inventor： John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
CPC classification number: A61L29/085 , A61F2/958 , A61F2250/0067 , A61L29/16 , A61L2300/204 , A61L2300/416 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105
Abstract: A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
Abstract translation: 提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。 可调涂层包括第一治疗剂和第一赋形剂，并且可以包括第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。
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公开(公告)号：US08808353B2
公开(公告)日：2014-08-19
申请号：US13015474
申请日：2011-01-27
Applicant: Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John E. Papp
Inventor： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John E. Papp
IPC: A61F2/82
CPC classification number: A61F2/89 , A61F2/82 , A61F2/915 , A61F2002/91508 , A61F2002/91575 , A61F2240/002 , A61M25/1034 , B23P11/005 , B29C55/24 , B29C69/00 , Y10T29/49908
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架还具有减小的卷曲轮廓和在冠部处的支架环结构的改进，其有助于减小卷曲轮廓。
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公开(公告)号：US08480620B2
公开(公告)日：2013-07-09
申请号：US12636124
申请日：2009-12-11
Applicant: John Stankus , Mikael Trollsas , Syed Hossainy
Inventor： John Stankus , Mikael Trollsas , Syed Hossainy
IPC: A61M37/00
CPC classification number: A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/608 , A61L2300/61
Abstract: A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
Abstract translation: 提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。 可调涂层包括第一治疗剂和第一赋形剂，以及第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。
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125.发明申请Drug Delivery System And Method Of Treatment Of Vascular Diseases Using Photodynamic Therapy 审中-公开药物输送系统及使用光动力疗法治疗血管疾病的方法公开(公告)号：US20120310142A1
公开(公告)日：2012-12-06
申请号：US13572507
申请日：2012-08-10
Applicant: Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Yuet Mei Khong , Jinping Wan
Inventor： Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Yuet Mei Khong , Jinping Wan
IPC: A61M37/00
CPC classification number: A61K31/409 , A61K9/0009 , A61K9/0019 , A61K9/1272 , A61K9/5146 , A61K41/0071 , A61L29/16 , A61L2300/224 , A61L2300/626 , A61M25/0045 , A61M25/10 , A61M2025/105 , A61M2025/1086
Abstract: This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.
Abstract translation: 本发明涉及使用两种纳米颗粒的易损斑块的光动力疗法（PDT），其一个包括对蓝绿色光敏感的PDT剂，其中纳米颗粒仅能穿透易损斑块的纤维帽和一个 多个包含对红光敏感的PDT剂，其中纳米颗粒能够渗入易损斑块的核心。
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Patent Agency Ranking
公开(公告)号：US20120225041A1
公开(公告)日：2012-09-06
申请号：US13472328
申请日：2012-05-15
Applicant: Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
Inventor： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
CPC classification number: A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
Abstract translation: 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。
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公开(公告)号：US08099849B2
公开(公告)日：2012-01-24
申请号：US11639079
申请日：2006-12-13
Applicant: David Gale , Bin Huang , Vincent Gueriguian , Syed Hossainy
Inventor： David Gale , Bin Huang , Vincent Gueriguian , Syed Hossainy
IPC: A61F2/06
CPC classification number: A61F2/95 , A61F2/91 , A61F2002/9522 , A61L31/06 , Y10T29/49771 , Y10T29/49908 , Y10T29/49913 , Y10T29/49938 , C08L67/04
Abstract: Disclosed herein is a method of fabricating a stent assembly comprising radially expanding a polymeric tube to an optimal degree of radial expansion; fabricating a stent from the expanded polymeric tube; and crimping the stent onto a catheter assembly, wherein the temperature of the stent during crimping is an optimal crimping temperature, wherein the optimal degree of radial expansion and the optimal crimping temperature correspond to an optimal fracture toughness exhibited by the crimped stent upon its deployment as a function of degree of radial expansion and crimping temperature.
Abstract translation: 本文公开了一种制造支架组件的方法，包括将聚合物管径向膨胀至最佳径向膨胀程度; 从扩张的聚合物管制造支架; 并将支架卷曲到导管组件上，其中在卷曲期间支架的温度是最佳卷曲温度，其中最佳径向膨胀程度和最佳卷曲温度对应于卷曲支架在展开时表现出的最佳断裂韧性 径向膨胀度和卷曲温度的函数。
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公开(公告)号：US20110144582A1
公开(公告)日：2011-06-16
申请号：US12636124
申请日：2009-12-11
Applicant: John Stankus , Mikael Trollsas , Syed Hossainy
Inventor： John Stankus , Mikael Trollsas , Syed Hossainy
IPC: A61M25/10
CPC classification number: A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/608 , A61L2300/61
Abstract: A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
Abstract translation: 提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。 可调涂层包括第一治疗剂和第一赋形剂，以及第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。
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129.发明申请Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers 审中-公开用生物可吸收载体处理病变部位的方法，组成和装置公开(公告)号：US20100222872A1
公开(公告)日：2010-09-02
申请号：US12782656
申请日：2010-05-18
Applicant: Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica Desnoyer , Florian N. Ludwig
Inventor： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica Desnoyer , Florian N. Ludwig
CPC classification number: A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.
Abstract translation: 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。 另外公开了用包括颗粒的涂层制造的植入式医疗装置或嵌入在医疗装置内的植入式医疗装置。
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公开(公告)号：US07674493B2
公开(公告)日：2010-03-09
申请号：US10819776
申请日：2004-04-06
Applicant: Syed Hossainy , Fuh-Wei Tang , Brian P. Cahill
Inventor： Syed Hossainy , Fuh-Wei Tang , Brian P. Cahill
IPC: B05D1/00
CPC classification number: A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0095 , A61F2230/0013 , A61F2250/0025 , A61F2250/0067 , A61F2250/0068
Abstract: A stent of variable surface area as determined by stent struts. The stent can have a variable surface area per unit length which accommodates a therapeutic agent. A patterned distribution of therapeutic agent can be provided throughout the stent. The stent can have an increased level of therapeutic agent near an end of the stent. A decreased level of therapeutic agent can be provided near an end of one embodiment of a stent. Indentations can be provided at the surface of the stent with therapeutic agent disposed therein. The stent can be cut with struts of variable thickness to provide the variable stent surface area.
Abstract translation: 由支架支柱确定的可变表面积的支架。 支架可以具有容纳治疗剂的每单位长度的可变表面积。 可以在整个支架中提供治疗剂的图案化分布。 支架可以在支架的端部附近具有增加的治疗剂水平。 在支架的一个实施方案的末端附近可以提供降低的治疗剂水平。 可以在支架的表面设置缺陷，其中设置有治疗剂。 可以用可变厚度的支柱切割支架，以提供可变的支架表面积。
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