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133 条记录 (耗时 0.063 秒)

    Silk-Based Adhesives
    121.
    发明申请
    Silk-Based Adhesives 审中-公开

    公开(公告)号：US20180361015A1

    公开(公告)日：2018-12-20

    申请号：US15780229

    申请日：2016-11-29

    申请人： Trustees of Tufts College

    发明人： Kelly A. Burke ,  David L. Kaplan

    IPC分类号： A61L24/10 ,  A61L24/04 ,  A61L24/00

    摘要： In some embodiments, the present invention provides compositions including silk fibroin, at least one hydrophilic agent, and at least one catechol donating agent, wherein the at least one hydrophilic agent and at least one catechol donating agent are conjugated to the silk fibroin. According to various embodiments, at least a portion of the silk fibroin may be crosslinked. In some embodiments, the silk fibroin is at least 50% (e.g., 60%, 70%, 80%, 90%, 95% or more) crosslinked. In some embodiments, the present invention also provides methods for making such compositions.

    METHODS OF GENERATING NEURAL STEM CELLS
    123.
    发明申请
    METHODS OF GENERATING NEURAL STEM CELLS 审中-公开

    公开(公告)号：US20180258389A1

    公开(公告)日：2018-09-13

    申请号：US15757056

    申请日：2016-09-09

    申请人： Trustees of Tufts College

    发明人： Dana Cairns ,  David L. Kaplan

    IPC分类号： C12N5/0797 ,  C12N15/67 ,  C12N15/85

    摘要： In some embodiments, the present invention provides methods including the steps of providing one or more human somatic cells, causing transient increased expression of OCT4, KLF4, SOX2, and cMYC in the somatic cells forming modified somatic cells, providing a plurality of inactivated embryonic fibroblasts, associating the modified somatic cells with the inactivated embryonic fibroblasts in a culture media comprising 20% KO DMEM xeno-free serum replacement and at least 15 ng/ml recombinant bFGF to form human induced neural stem cells.

    Silk nanospheres and microspheres and methods of making same
    130.
    发明授权
    Silk nanospheres and microspheres and methods of making same 有权
    丝纳米球和微球及其制备方法

    公开(公告)号：US09381164B2

    公开(公告)日：2016-07-05

    申请号：US14216756

    申请日：2014-03-17

    申请人： TRUSTEES OF TUFTS COLLEGE

    发明人： Xiaoqin Wang ,  David L. Kaplan

    IPC分类号： A61K9/50 ,  A61K9/127 ,  A61K9/51 ,  A61K9/14 ,  A61K9/16 ,  A61K31/352

    CPC分类号： A61K9/5169 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1647 ,  A61K9/5052 ,  A61K9/5089 ,  A61K9/5192 ,  A61K31/352 ,  Y10T428/2982

    摘要： The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped. The silk nano- and microparticles of the present invention are thus suitable for a variety of biomedical and pharmaceutical applications, such as drug delivery or tissue engineering.

    摘要翻译： 本发明提供了制备丝纳米颗粒和微粒的方法，将活性剂包封在丝纳米和微粒中的方法和包含这些丝颗粒的组合物。 特别地，丝球是通过丝和聚乙烯醇（PVA）的相分离制备的，而不暴露于有机溶剂。 该方法采用化学品PVA，它是FDA批准的药物制剂成分。 可以调整不同的参数，以在制造过程中控制丝球的尺寸和形状。 本发明的丝粒组合物也可以包封活性剂或化学物质。 这样的组合物允许活性剂可控地和可持续地释放到靶器官或组织。 包埋活性剂的丝绸组合物还为被捕获的活性剂提供长期的储存介质。 因此，本发明的丝素纳米颗粒和微粒子适用于各种生物医学和药物应用，例如药物递送或组织工程。