公开(公告)号：US09868752B2

公开(公告)日：2018-01-16

申请号：US13862651

申请日：2013-04-15

Applicant: University of South Dakota

Inventor： Zhenqiang Wang ,  Feng-Rong Dai

IPC: B01J20/32 ,  C02F1/28 ,  C07F15/06 ,  B01D15/00 ,  C07F3/02 ,  C07F15/04 ,  C07D341/00

CPC classification number: C07F15/06 ,  B01D15/00 ,  B01J20/3219 ,  B01J20/3242 ,  C02F1/281 ,  C02F1/285 ,  C02F1/286 ,  C07D341/00 ,  C07F3/02 ,  C07F15/04

Abstract: A new strategy to design container molecules is presented. Sulfonylcalix[4]arenes, which are synthetic macrocyclic containers, are used as building blocks that are combined with various metal ions and tricarboxylate ligands to construct metal-organic ‘super-containers’ (MOSCs). These MOSCs possess both endo and exo cavities and thus mimic the structure of viruses. The synthesis of MOSCs is highly modular, robust, and predictable.

公开(公告)号：US09623103B2

公开(公告)日：2017-04-18

申请号：US14413385

申请日：2013-07-18

Applicant: SOUTH DAKOTA BOARD OF REGENTS ,  CAMBRIDGE ENTERPRISE LIMITED ,  ACADEMISCH ZIEKENHUIS LEIDEN ,  UNIVERSITY COLLEGE CORK

Inventor： Ying Fang ,  Eric John Snijder ,  Andrew E. Firth ,  John F. Atkins ,  Emma Elisabeth Treffers ,  Ali Tas ,  Yanhua Li

IPC: A61K39/12 ,  C12N7/00 ,  C07K16/10 ,  C07K14/005 ,  G06F19/18 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  C12N2770/10011 ,  C12N2770/10022 ,  C12N2770/10034 ,  C12N2770/10062 ,  G06F19/18

Abstract: The invention provides the discovery and characterization of a novel arterivirus protein (nsp2TF), whose expression is dependent on −2 ribosomal frameshifting at a site located in the nsp2 coding region. The coding region for the unique TF domain of nsp2TF overlaps the part of ORF1a that encodes the transmembrane region of nsp2 in arteriviruses, including PRRSV, LDV and SHFV. Mutations affecting the expression of nsp2TF impair PRRSV replication and result in a smaller plaque phenotype. Provided herein are arteriviruses that display reduced translation of nsp2TF and/or altered translation of one or more downstream products, arteriviruses in which nsp2TF function is reduced and/or absent, and vaccines comprising said arteriviruses. Also provided herein are diagnostic methods, methods for identifying compounds that inhibit −2 frameshifting, and gene expression tools for eukaryotic systems utilizing −2 frameshifting.

公开(公告)号：US09396853B2

公开(公告)日：2016-07-19

申请号：US14143453

申请日：2013-12-30

Applicant: GEORGIA TECH RESEARCH CORPORATION ,  SOUTH DAKOTA BOARD OF REGENTS

Inventor： Haiping Hong ,  G. P. “Bud” Peterson

IPC: H01F1/44

CPC classification number: H01F1/445 ,  B82Y30/00 ,  C08K3/04 ,  C08K3/045 ,  C08K3/046 ,  C08K2003/2272 ,  C08K2003/2275 ,  C08K2201/01 ,  C08K2201/011 ,  H01F1/44 ,  Y10S977/742

Abstract: The present invention is a nanoparticle mixture or suspension or nanofluid comprising nonmagnetically sensitive nanoparticles, magnetically sensitive nanoparticles, and surfactant(s). The present invention also relates to methods of preparing and using the same.

Abstract translation: 本发明是包含非磁性敏感纳米颗粒，磁敏纳米颗粒和表面活性剂的纳米颗粒混合物或悬浮液或纳米流体。 本发明还涉及其制备和使用方法。

公开(公告)号：US09312046B2

公开(公告)日：2016-04-12

申请号：US14577552

申请日：2014-12-19

Applicant: SOUTH DAKOTA BOARD OF REGENTS ,  GEORGIA TECH RESEARCH CORPORATION

Inventor： Haiping Hong ,  G.P. (Bud) Peterson ,  David R. Salem

IPC: H01B1/24 ,  H01F1/01 ,  C08K3/04 ,  H01B1/04 ,  C08K3/22

CPC classification number: H01B1/24 ,  C08K3/04 ,  C08K3/041 ,  C08K3/042 ,  C08K3/045 ,  C08K3/046 ,  C08K3/08 ,  C08K3/22 ,  C08K2003/2265 ,  C08K2003/2272 ,  C08K2003/2275 ,  C08K2003/2289 ,  C08K2003/2293 ,  C08K2201/011 ,  H01B1/04 ,  H01F1/01 ,  H01F1/447 ,  C08L63/00

Abstract: Magnetically aligned carbon nanoparticle composites have enhanced electrical properties. The composites comprise carbon nanoparticles, a host material, magnetically sensitive nanoparticles and a surfactant. In addition to enhanced electrical properties, the composites can have enhanced mechanical and thermal properties.

Abstract translation: 磁性排列的碳纳米颗粒复合材料具有增强的电性能。 复合材料包括碳纳米颗粒，主体材料，磁敏纳米颗粒和表面活性剂。 除了增强的电学性能，复合材料可以具有增强的机械和热性能。

公开(公告)号：US20150228388A1

公开(公告)日：2015-08-13

申请号：US14178948

申请日：2014-02-12

Applicant: GEORGIA TECH RESEARCH CORPORATION ,  SOUTH DAKOTA BOARD OF REGENTS

Inventor： Haiping Hong ,  G.P. (Bud) Peterson ,  David R. Salem

IPC: H01F1/44

CPC classification number: H01F1/445 ,  B82Y30/00 ,  C08K3/04 ,  C08K3/045 ,  C08K3/046 ,  C08K2003/2272 ,  C08K2003/2275 ,  C08K2201/01 ,  C08K2201/011 ,  H01F1/44 ,  Y10S977/742

Abstract: The present invention relates to magnetically aligned carbon nanoparticle composites and methods of preparing the same. The composites comprise carbon nanoparticles, host material, magnetically sensitive nanoparticles and surfactant. The composites may have enhanced mechanical, thermal, and/or electrical properties.

Abstract translation: 本发明涉及磁性排列的碳纳米颗粒复合材料及其制备方法。 复合材料包括碳纳米颗粒，主体材料，磁敏纳米颗粒和表面活性剂。 复合材料可能具有增强的机械，热和/或电性能。

公开(公告)号：US20250015356A1

公开(公告)日：2025-01-09

申请号：US18763591

申请日：2024-07-03

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： Weibing Xing ,  Amir Abdul Razzaq ,  Christopher Poches ,  Regan Ogilvie ,  Haiden Studer

IPC: H01M10/0569 ,  H01M4/02 ,  H01M4/36 ,  H01M4/38 ,  H01M4/525 ,  H01M10/0525 ,  H01M10/0567 ,  H01M10/0568 ,  H01M10/058 ,  H01M10/42

Abstract: The present disclosure relates to lithium-ion energy storage systems, methods of manufacturing a lithium-ion battery, and lithium-ion batteries having an Ni-rich cathode, an anode, an electrolyte, and a separator. Preferably, the electrolyte is located between the anode and the cathode, and includes a fluorinated solvent, an additive, and a lithium salt.

公开(公告)号：US20240341325A1

公开(公告)日：2024-10-17

申请号：US18608400

申请日：2024-03-18

Applicant: THE SOUTH DAKOTA BOARD OF REGENTS, AS GOVERNING BOARD FOR SOUTH DAKOTA STATE UNIVERSITY

Inventor： William Gibbons ,  Michael L. Brown

IPC: A23J1/12 ,  A23J1/14 ,  A23K10/14 ,  A23K10/38 ,  A23K20/147 ,  A23K40/20 ,  A23K40/25 ,  A23K50/80

CPC classification number: A23J1/125 ,  A23J1/14 ,  A23J1/148 ,  A23K10/14 ,  A23K10/38 ,  A23K20/147 ,  A23K40/20 ,  A23K40/25 ,  A23K50/80 ,  Y02A40/818

Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.

公开(公告)号：US11905609B2

公开(公告)日：2024-02-20

申请号：US17394711

申请日：2021-08-05

Applicant: South Dakota Board of Regents

Inventor： Alevtina Smirnova ,  Michael McGraw ,  Praveen Kolla

IPC: C25B3/00 ,  H01M4/90 ,  H01M4/60 ,  C08G61/12 ,  H01G11/48 ,  H01G11/86 ,  H01G9/028 ,  C25B11/055 ,  H10K85/10 ,  C08L65/00 ,  H10K71/60 ,  H10K102/00

CPC classification number: C25B3/00 ,  C08G61/121 ,  C08G61/126 ,  C25B11/055 ,  H01G9/028 ,  H01G11/48 ,  H01G11/86 ,  H01M4/608 ,  H01M4/9008 ,  H10K85/1135 ,  C08G2261/1424 ,  C08G2261/228 ,  C08G2261/3223 ,  C08G2261/40 ,  C08G2261/512 ,  C08G2261/91 ,  C08L65/00 ,  H10K71/60 ,  H10K2102/00 ,  Y02E10/549

Abstract: The present invention relates to a one-step process for preparation of “in-situ” or “ex-situ” self-organized and electrically conducting polymer nanocomposites using thermally initiated polymerization of a halogenated 3,4-ethylenedioxythiophene monomer or its derivatives. This approach does not require additional polymerization initiators or catalysts, produce gaseous products that are naturally removed without affecting the polymer matrix, and do not leave by-product contaminants. It is demonstrated that self-polymerization of halogenated 3,4-ethylenedioxythiophene monomer is not affected by the presence of a solid-state phase in the form of nanoparticles and results in formation of 3,4-polyethylenedioxythiophene (PEDOT) nanocomposites.

公开(公告)号：US20230414767A1

公开(公告)日：2023-12-28

申请号：US18192210

申请日：2023-03-29

Applicant: South Dakota Board of Regents

Inventor： Khosrow Rezvani ,  Grigoriy Sereda

IPC: A61K47/60 ,  A61K9/51 ,  A61P35/00 ,  A61K47/64 ,  A61K31/435

CPC classification number: A61K47/60 ,  A61K9/5115 ,  A61P35/00 ,  A61K9/5169 ,  A61K47/64 ,  A61K9/5161 ,  A61K47/645 ,  A61K31/435

Abstract: Disclosed herein are compositions for treating cancer comprising a modified veratridine. In certain aspects, the modified veratridine comprises a polyglutamic acid (PLE) or polyethylene glycol/polyglutamic acid (PEG-PLE) conjugated to the 4′ hemiketal thereof. Further disclosed is a method of treating colorectal cancer in a subject comprising administering to a subject an effective amount of the disclosed compositions.

公开(公告)号：US11824189B2

公开(公告)日：2023-11-21

申请号：US16660323

申请日：2019-10-22

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： David R. Salem ,  Chunhui Chen ,  Abdulmenan Hussein

IPC: H01M4/36 ,  H01M4/38 ,  H01M4/587 ,  H01M4/62 ,  H01M4/1393 ,  H01M4/1395 ,  H01M4/133 ,  H01M4/134 ,  H01M4/02 ,  H01M10/0525

CPC classification number: H01M4/366 ,  H01M4/133 ,  H01M4/134 ,  H01M4/1393 ,  H01M4/1395 ,  H01M4/386 ,  H01M4/587 ,  H01M4/625 ,  H01M10/0525 ,  H01M2004/027

Abstract: This application relates to anode compositions and methods of making and using the same. In particular, the anode compositions are preferably layered. Preferably, the methods of making the anode compositions comprise a surfactant mediated assembly of layers. The anode compositions have improved structural integrity and capacity while reducing capacity fade due to cycling.