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    MPHOSPH1 PEPTIDES AND VACCINES INCLUDING THE SAME
    122.
    发明申请
    MPHOSPH1 PEPTIDES AND VACCINES INCLUDING THE SAME 有权
    MPHOSPH1肽和疫苗包括它们

    公开(公告)号：US20140154281A1

    公开(公告)日：2014-06-05

    申请号：US14131019

    申请日：2012-08-09

    申请人： Takuya Tsunoda ,  Ryuji Osawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe ,  Yusuke Nakamura

    发明人： Takuya Tsunoda ,  Ryuji Osawa ,  Sachiko Yoshimura ,  Tomohisa Watanabe ,  Yusuke Nakamura

    IPC分类号： C12N9/00 ,  A61K39/00

    CPC分类号： C12N9/93 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K14/4738 ,  C12N5/0639 ,  C12N5/10 ,  C12N9/14 ,  C12N2502/1114 ,  C12Y306/04004 ,  G01N33/505 ,  G01N33/57407 ,  G01N2440/14

    摘要： As discussed in greater detail herein, isolated epitope peptides derived from MPHOSPH1 bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines. The inventive peptides encompass both the above-mentioned MPHOSPH1-derived amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite CTL inducibility of the original sequences. Further provided are polynucleotides encoding any of the aforementioned peptides as well as pharmaceutical agents or compositions that include any of the aforementioned peptides or polynucleotides. The peptides, polynucleotides, and pharmaceutical agents or compositions of this invention find particular utility in either or both of the treatment and prevention of cancers and tumors, including, for example, bladder cancer, breast cancer, cervical cancer, cholangiocellular carcinoma, CML, colorectal cancer, gastric cancer, NSCLC, lymphoma, osteosarcoma, prostate cancer, renal cancer and soft tissue tumor.

    摘要翻译： 如本文更详细讨论的，衍生自MPHOSPH1的分离的表位肽结合HLA抗原并诱导细胞毒性T淋巴细胞（CTL），因此适用于癌症免疫治疗，特别是癌症疫苗的上下文中。 本发明的肽包括上述提供的MPHOSPH1衍生的氨基酸序列及其修饰形式，其中一个，两个或几个氨基酸被取代，缺失，插入或添加，只要这些修饰形式保持必需的CTL诱导性 原始序列。 还提供了编码任何前述肽的多核苷酸以及包括任何上述肽或多核苷酸的药物或组合物。 本发明的肽，多核苷酸和药物或组合物在癌症和肿瘤的治疗和预防中的任一个或两者中都具有特别的用途，包括例如膀胱癌，乳腺癌，宫颈癌，胆管细胞癌，CML，结肠直肠 癌症，胃癌，NSCLC，淋巴瘤，骨肉瘤，前列腺癌，肾癌和软组织肿瘤。

    SKELETAL MUSCLE-SPECIFIC ENHANCER
    123.
    发明申请
    SKELETAL MUSCLE-SPECIFIC ENHANCER 审中-公开
    骨骼肌特异增强

    公开(公告)号：US20140031417A1

    公开(公告)日：2014-01-30

    申请号：US14009971

    申请日：2012-04-05

    申请人： Frédéric Relaix ,  Keren Bismuth

    发明人： Frédéric Relaix ,  Keren Bismuth

    IPC分类号： C12N15/85

    CPC分类号： C12N15/85 ,  C07K14/4738 ,  C12N2830/008

    摘要： The invention relates to a novel skeletal muscle-specific p57 regulatory element. This element is useful to drive and enhance the specific skeletal muscle expression of therapeutic genes. It is therefore provided nucleic acids and vectors comprising said enhancer element, as well as pharmaceutical compositions comprising the vectors, and uses thereof.

    摘要翻译： 本发明涉及新型骨骼肌特异性p57调节元件。 该元件可用于驱动和增强治疗基因的特异性骨骼肌表达。 因此，提供了包含所述增强子元件的核酸和载体，以及包含载体的药物组合物及其用途。

    Cyclin Based Inhibitors of CDK2 and CDK4
    124.
    发明申请
    Cyclin Based Inhibitors of CDK2 and CDK4 审中-公开

    公开(公告)号：US20130289240A1

    公开(公告)日：2013-10-31

    申请号：US13851661

    申请日：2013-03-27

    申请人： Campbell McInnes ,  Shu Liu

    发明人： Campbell McInnes ,  Shu Liu

    IPC分类号： G06F19/12 ,  C07K5/11

    CPC分类号： G16B5/00 ,  C07K5/1019 ,  C07K14/4738

    摘要： Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.

    Mutant PCNA
    127.
    发明授权
    Mutant PCNA 有权
    突变型PCNA

    公开(公告)号：US08003346B2

    公开(公告)日：2011-08-23

    申请号：US11994437

    申请日：2006-07-04

    申请人： Tadaaki Tokida ,  Satoshi Hihara ,  Takashi Kudou ,  Akira Kawamura ,  Hirofumi Doi ,  Yoshizumi Ishino

    发明人： Tadaaki Tokida ,  Satoshi Hihara ,  Takashi Kudou ,  Akira Kawamura ,  Hirofumi Doi ,  Yoshizumi Ishino

    IPC分类号： G01N33/52 ,  C07H17/00 ,  C07K14/00

    CPC分类号： C07K14/4738 ,  C12N9/1252 ,  C12N15/69

    摘要： The present invention is to construct a DNA replication reaction system which is excellent in versatility and is easily used. An amino acid sequence of a PCNA monomer which is one of factors involved in DNA replication is prepared so that amino acid residues causing mutual charge repulsion constitute a site which causes, when an N terminal region of the PCNA monomer and a C terminal region of another PCNA monomer act as an interface to form a multimeric complex, an intermolecular interaction of the monomers in an interface region of the monomers.

    摘要翻译： 本发明是构建通用性优异且易于使用的DNA复制反应体系。 制备作为涉及DNA复制的因素之一的PCNA单体的氨基酸序列，使得导致相互电荷排斥的氨基酸残基构成了当PCNA单体的N末端区域和另一个的C末端区域时引起的位点 PCNA单体作为形成多聚体复合物的界面，单体在界面区域中的分子间相互作用。