公开(公告)号：US20170172979A1

公开(公告)日：2017-06-22

申请号：US15118196

申请日：2015-02-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Menachem RUBINSTEIN ,  Efrat DVASH-RIESENFELD

IPC: A61K31/366 ,  A61K31/381 ,  A61K31/41

CPC classification number: A61K31/366 ,  A61K31/166 ,  A61K31/192 ,  A61K31/381 ,  A61K31/404 ,  A61K31/41 ,  A61K31/426 ,  A61K31/47 ,  A61K2300/00

Abstract: The present invention relates to the alleviation of adverse side effects resulting from statin therapy. The present invention further relates to the use of an inhibitor of leukotriene C4 (LTC4) mediated activity for alleviating at least one side effects of statin therapy.

公开(公告)号：US20170141835A1

公开(公告)日：2017-05-18

申请号：US15346747

申请日：2016-11-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Avishay Gal-Yam ,  Barak Zackay ,  Eran Ofek

IPC: H04B7/08 ,  H04B17/20

CPC classification number: H04B7/0851 ,  H04B17/20 ,  H04B17/318 ,  H04B17/3912

Abstract: A method for detecting a dispersed pulse in a received signal that has been dispersed by a dispersive medium includes obtaining an input army of cells, each indicating an intensity of a frequency component of the signal at a representative time. A fast dispersion measure transform (FDMT) is applied to concurrently sum the cells of the input array that lie along different dispersion curves, each curve defined by a known non-linear functional form and being uniquely characterized by a time coordinate and by a value of the dispersion measure. Application of FDMT includes initially generating a plurality of sub-arrays, each representing a frequency sub-band and iteratively combining pairs of adjacent sub-arrays in accordance with an addition rule until all of the initially generated plurality of sub-arrays are combined into an output army of the sums, in which a cell of the output array that is indicative of a transmitted pulse is identified.

公开(公告)号：US20170128365A1

公开(公告)日：2017-05-11

申请号：US15319005

申请日：2015-06-15

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Jasmine SEROR ,  Weifeng LIN ,  Reut MASHIACH

IPC: A61K9/127 ,  A61K9/00 ,  A61K31/728

CPC classification number: A61K9/127 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  B65D35/00 ,  B65D75/36

Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.

公开(公告)号：US20170121668A1

公开(公告)日：2017-05-04

申请号：US14929363

申请日：2015-11-01

Applicant: Ariel-University Research and Development Company Ltd. ,  Yeda Research and Development Co. Ltd. ,  Indian Institute of Technology Bombay

Inventor： Mordechai SHEVES ,  Irishi N.N. NAMBOOTHIRI ,  Guy PATCHORNIK

IPC: C12N1/00 ,  C07K14/215

CPC classification number: C07K14/215 ,  C12N1/06 ,  C12N1/20

Abstract: A method of precipitating cell membrane fragments from a cell lysate is disclosed. The method comprises contacting the cell lysate with a hydrophobic chelator and a metal ion under conditions that allow precipitation of the cell membrane fragments. Kits for precipitating cell membrane fragments are also disclosed.

公开(公告)号：US20170105645A1

公开(公告)日：2017-04-20

申请号：US15292147

申请日：2016-10-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Elisha MOSES ,  Jodie Naim FEIL ,  Dominik FRECHE ,  Nava LEVIT-BINNUN

IPC: A61B5/0478 ,  A61N2/00 ,  A61B5/0408

CPC classification number: A61B5/0478 ,  A61B5/04085 ,  A61B5/0476 ,  A61B5/7217 ,  A61N2/004 ,  A61N2/006

Abstract: A system includes an array of electroencephalography (EEG) electrodes for placement on the head of a subject and a transcranial magnetic stimulation (TMS) device. A controller is configured to operate the array of EEG electrodes to acquire a plurality of EEG signals concurrently with operation of the TMS device to apply a TMS pulse to the head of the subject. The controller is further configured to select an initial set of EEG signals from the EEG signals and to fit an initial decreasing rational function of time to a TMS artifact component of each EEG signal of the initial set. The TMS artifact component of each remaining EEG signal is fit to a linear combination of the initial decreasing rational functions. Each EEG signal is corrected by removing from the EEG signal the function that is fit to the TMS artifact component of the EEG signal.

公开(公告)号：US20170087190A1

公开(公告)日：2017-03-30

申请号：US15379528

申请日：2016-12-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michael WALKER ,  Yoav SOEN ,  Revital SHARIVKIN

IPC: A61K35/39 ,  G01N33/569 ,  C12N5/071

CPC classification number: A61K35/39 ,  C12N5/0676 ,  C12N2501/415 ,  C12N2501/50 ,  C12N2501/505 ,  C12N2501/585 ,  C12N2501/599 ,  G01N33/56966 ,  G01N2333/70596 ,  G01N2333/71 ,  G01N2500/10

Abstract: Methods of isolating distinct specific cell types within mixed populations of cells. Methods of isolating specific cell types among pancreatic cells, particularly from human islets of Langerhans. Markers and combinations thereof for use in methods of isolating insulin producing islet beta cells for treatment of diabetes.

公开(公告)号：US20170081682A1

公开(公告)日：2017-03-23

申请号：US15101097

申请日：2014-12-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Arren BAR-EVEN ,  Ron MILO ,  Elad NOOR ,  Lior ZELCBUCH

IPC: C12P7/40 ,  C12N1/20 ,  C12N9/10 ,  C12P7/26 ,  C12P7/16 ,  C12P5/02 ,  C12P5/00 ,  C12P7/64 ,  C12N15/52 ,  C12P7/06

CPC classification number: C12P7/40 ,  C12N1/20 ,  C12N9/1029 ,  C12N15/52 ,  C12P5/007 ,  C12P5/023 ,  C12P5/026 ,  C12P7/06 ,  C12P7/16 ,  C12P7/26 ,  C12P7/649 ,  C12Y203/01054 ,  Y02E50/343

Abstract: An isolated microorganism is disclosed being genetically modified to express pyruvate formate lyase (PFL) or 2-ketobutyrate formate lyase, wherein acetyl-CoA of the microorganism is converted to pyruvate in the presence of formate in a single step reaction, wherein the net flux of the reaction is in the direction of pyruvate synthesis.Uses of the microorganism and products comprising same are also disclosed.

公开(公告)号：US20170029508A1

公开(公告)日：2017-02-02

申请号：US15261945

申请日：2016-09-10

Applicant: Yeda Research and Development Co. Ltd

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28

Abstract: The present specification discloses a pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS. The pharmaceutical composition is administered by a dosage regimen comprising at least one course of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.

Abstract translation: 本说明书公开了一种药物组合物，其包含活性剂，其导致个体中降低全身免疫抑制水平用于治疗CNS的疾病，病症，病状或损伤。 药物组合物通过包含至少一疗程疗程的给药方案施用，每个治疗过程依次包括治疗会话，然后是间歇疗程的非治疗。

公开(公告)号：US20170016895A1

公开(公告)日：2017-01-19

申请号：US15108889

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C12Q1/68

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

Abstract translation: 提供用于诊断受试者系统性红斑狼疮（SLE）的方法和试剂盒。 特别地，本发明涉及可用于诊断受试者中SLE的特异性寡核苷酸抗体反应性。

公开(公告)号：US20170002068A1

公开(公告)日：2017-01-05

申请号：US15271515

申请日：2016-09-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef YARDEN ,  Silvia CARVALHO ,  Moshit LINDZEN

IPC: C07K16/22 ,  G01N33/574 ,  A61K31/704 ,  A61K45/06 ,  A61K33/24

CPC classification number: C07K16/22 ,  A61K31/704 ,  A61K33/24 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  G01N33/57407 ,  G01N33/57438 ,  G01N33/57449 ,  G01N2333/485 ,  G01N2333/495 ,  G01N2800/52

Abstract: A method of determining the suitability of a subject to a treatment with an anti-amphiregulin antibody, wherein the subject has a cancer selected from the group consisting of ovarian cancer, head and neck cancer and pancreatic cancer exhibiting resistance to chemotherapy, is provided. The method comprising analyzing in a biological sample of the subject expression level of amphiregulin, transforming growth factor alpha (TGF-alpha) and heparin-binding epidermal growth factor (HB-EGF), wherein a level of expression of the amphiregulin above a predetermined threshold and no expression of the TGF-alpha and/or the HB-EGF or an expression below a predetermined level of the TGF-alpha and/or the HB-EGF is indicative of the suitability of the subject to treatment with the anti-amphiregulin antibody. Methods for treating cancer are also provided, as well as antibodies and pharmaceutical compositions.

Abstract translation: 本发明提供一种测定受试者用抗双抗调素抗体治疗的适应性的方法，其中所述受试者具有选自卵巢癌，头颈部癌症和表现出抗化学疗法的胰腺癌的癌症。 所述方法包括在生物样品中分析双调蛋白，转化生长因子α（TGF-α）和肝素结合表皮生长因子（HB-EGF）的受试者表达水平，其中所述双调蛋白的表达水平高于预定阈值 并且TGF-α和/或HB-EGF的表达或低于TGF-α和/或HB-EGF的预定水平的表达不表示受试者用抗两性调节蛋白抗体治疗的适合性 。 还提供了治疗癌症的方法，以及抗体和药物组合物。