中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

2847 records (took 0.038 seconds)

    Windowed sequencing
    143.
    发明授权
    Windowed sequencing 有权

    公开(公告)号：US11028438B2

    公开(公告)日：2021-06-08

    申请号：US16866653

    申请日：2020-05-05

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Mark Milgrew ,  Jonathan Schultz ,  Chris Papalias ,  Kim Johnson

    IPC: C12Q1/6874 ,  G16B30/00

    Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors.

    FLUID INTERFACE TO RECEIVE REMOVABLE CONTAINER
    145.
    发明申请
    FLUID INTERFACE TO RECEIVE REMOVABLE CONTAINER 有权

    公开(公告)号：US20210155466A1

    公开(公告)日：2021-05-27

    申请号：US17165196

    申请日：2021-02-02

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd ROSWECH ,  Jonathan SCHULTZ ,  Chun HO

    IPC: B67D7/02 ,  B67D7/76 ,  B01L3/00

    Abstract: A fluidic interconnect includes a first interface including a liquid port, a gas port, and a cradle; a second interface including a liquid port, a gas port, and a swing bar to engage the cradle, a weight of a container attached to one of the first or second interfaces to drive the liquid port of the first interface into connection with the liquid port of the second interface and the gas port of the first interface into connection with the gas port of the second interface.

    PENTA E POLYMORPHISMS FOR HUMAN IDENTIFICATION
    147.
    发明申请
    PENTA E POLYMORPHISMS FOR HUMAN IDENTIFICATION 有权

    公开(公告)号：US20210130913A1

    公开(公告)日：2021-05-06

    申请号：US17099621

    申请日：2020-11-16

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： CHANG ZHONG

    IPC: C12Q1/6888 ,  C12Q1/6881 ,  C12Q1/6858

    Abstract: Methods for human identification using polymorphisms in the Penta E short tandem repeat locus are significant in preventing allelic drop out. An exemplary method encompasses (a) contacting a first primer to a nucleic acid sample to be analyzed, (b) contacting a second primer to the nucleic acid sample, and (c) subjecting the nucleic acid sample, the first primer, and the second primer to an amplification reaction, and thereby forming an amplification product. The first primer, the second primer, or both the first and second primers can be labeled with a non-nucleic-acid label. Additionally, or alternatively, the amplification product can include an adenosine at position 14 from the 5′ end of SEQ ID NO:1, a thymidine at position 21 from the 5′ end of SEQ ID NO:2, or both an adenine at position 14 and a thymidine at position 21 from the 5′ end of SEQ ID NO:3.

    METHODS AND APPARATUS FOR MEASURING ANALYTES
    148.
    发明申请
    METHODS AND APPARATUS FOR MEASURING ANALYTES 有权

    公开(公告)号：US20210116414A1

    公开(公告)日：2021-04-22

    申请号：US17063621

    申请日：2020-10-05

    Applicant: Life Technologies Corporation

    Inventor： Todd REARICK ,  Melville DAVEY ,  Mark BEAUCHEMIN

    IPC: G01N27/416 ,  G16B30/00 ,  G01N27/414

    Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor array can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

    METHODS AND SYSTEMS FOR REDUCING PHASING ERRORS WHEN SEQUENCING NUCLEIC ACIDS USING TERMINATION CHEMISTRY
    149.
    发明申请
    METHODS AND SYSTEMS FOR REDUCING PHASING ERRORS WHEN SEQUENCING NUCLEIC ACIDS USING TERMINATION CHEMISTRY 有权

    公开(公告)号：US20210108254A1

    公开(公告)日：2021-04-15

    申请号：US17025763

    申请日：2020-09-18

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Earl HUBBELL

    IPC: C12Q1/6825 ,  C12Q1/6869 ,  C12Q1/6874

    Abstract: A method for nucleic acid sequencing may include disposing a plurality of template nucleic acid molecules in a plurality of defined spaces disposed on a sensor array, at least some of the plurality of template nucleic acid molecules having a sequencing primer and a polymerase operably bound therewith; advancing one or more nucleotide species over the plurality of template nucleic acid molecules with the sequencing primer and the polymerase operably bound therewith; measuring a signal generated by nucleotide incorporations resulting from advancing the one or more nucleotide species; and exposing the plurality of template nucleic acid molecules to a cleaving reagent subsequent to the advancing and measuring. The cleaving reagent can remove labeling reagents attached to the one or more nucleotide species. The advancing and measuring steps can be performed for different orders of the one or more nucleotide species prior to a subsequent exposing of the plurality of template nucleic acid molecules to the cleaving reagent.

Patent Agency Ranking