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    Polycationic amphiphiles as antimicrobial agents
    142.
    发明授权
    Polycationic amphiphiles as antimicrobial agents 有权

    公开(公告)号：US10136639B2

    公开(公告)日：2018-11-27

    申请号：US15034375

    申请日：2014-11-05

    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  VILLANOVA UNIVERSITY

    Inventor： William Wuest ,  Kevin Patrick Minbiole

    IPC: A01N25/08 ,  A01N33/12 ,  A01N43/40 ,  A61K31/132 ,  C07C211/63 ,  C07C323/25 ,  C07D213/22

    Abstract: The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula (I) or (II) R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH2, —NHR′, —NR′2, —N—C(O)R′, —N—C(O)CR′═CR′, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH2, —NHR′, —NR′2, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF3, and —OCF3. R′ is H or a C1-4 alkyl. X or Y is a halogen, m and n are integers in the range from 1 to 25.

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