Abstract:
The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases inflammatory diseases, and allergic diseases. The compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia).
Abstract:
A fluorescence correlation spectroscopy analyzer 1 is equipped with an excitation light illuminating optical system 21, a fluorescence imaging optical system 22, a CCD camera 15, and a data analyzer 16. The excitation light illuminating optical system 21 illuminates excitation light onto a predetermined region of a measured sample S. The fluorescence imaging optical system 22 images the fluorescence generated at the measured sample S onto the photodetection surface of the CCD camera 15. The CCD camera 15 performs photoelectric conversion of the fluorescence made incident onto the photodetection surface in accordance with the respective pixels and outputs the charges generated by the photoelectric conversion as detection signals from an output terminal. The data analyzer 16 inputs the detection signals based on the charges generated at the pixels, and computes autocorrelation functions of the input detection signals according to each pixel.
Abstract:
A semiconductor device is provided with a power supply circuit having a function to generate a power supply voltage from a wireless signal and an A/D converter circuit having a function to detect the strength of the wireless signal by an A/D conversion of a voltage generated from the wireless signal. This enables to provide a semiconductor device which does not require replacement of batteries, has few limitations on its physical shape and mass, and has a function to detect a physical position. By formation of the semiconductor device with use of a thin film transistor formed over a plastic substrate, a lightweight semiconductor device, which has flexibility in physical shape and a function to detect a physical location, can be provided at low cost.
Abstract:
In acquisition of a micro image of a sample S by a micro image acquiring unit 30, when a plurality of image acquiring ranges are set for the sample S as an object of image acquisition, a plurality of corresponding focus information are set, and furthermore, when a plurality of partial images acquired by scanning the sample S by the micro image acquiring unit 30 include a partial image including mixing of a plurality of image acquiring ranges, the focus information is switched in the middle of scanning of the partial image. With such a structure, even when a plurality of objects are contained in the sample S, images of the respective objects can be preferably acquired. Thereby, an image acquiring apparatus, an image acquiring method, and an image acquiring program which are capable of preferably acquiring images of a plurality of objects are realized even when the plurality of objects are contained in a sample S.
Abstract:
This invention relates to a method for preventing and/or treating bone diseases which comprises administering a potentiator of TGF-beta activity such as the compound of the formula [I] or pharmaceutically acceptable salts thereof to human being or animals. wherein R1 is hydrogen, etc., R2 is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic(lower)alkyl, etc., R3 is hydrogen, optionally substituted hydroxy, etc., R4 is hydrogen or lower alkyl, and X is CH or N.
Abstract translation:本发明涉及一种预防和/或治疗骨疾病的方法,其包括向人或动物施用TGF-β活化增强剂,例如式[I]化合物或其药学上可接受的盐。 其中R 1是氢等,R 2是任选取代的芳(低级)烷基或任选取代的杂环(低级)烷基等,R 3 H 2是氢,任选取代的羟基等,R 4是氢或低级烷基,X是CH或N.
Abstract:
This invention relates to a heterocyclic compound of the formula wherein a group of the formula: is a group of the formula X is O, S or N-R5, R1 is lower alkyl, etc., R5 is hydrogen, lower alkyl, etc., R2 is hydrogen, halogen, lower alkyl, etc., R3 is halogen, lower alkyl, etc., R4 is amino optionally having suitable substituent(s), and A is lower alkylene, and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.
Abstract:
This invention relates to a heterocyclic compound of the formula: ##STR1## wherein a group of the formula: ##STR2## is a group of the formula: ##STR3## etc., X is O, S or N--R.sup.5,R.sup.1 is lower alkyl, etc.,R.sup.5 is hydrogen, lower alkyl, etc.,R.sup.2 is hydrogen, halogen, lower alkyl, etc.,R.sup.3 is halogen, lower alkyl, etc.,R.sup.4 is amino optionally having suitable substituent(s), andA is lower alkylene,and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.
Abstract:
An upright vacuum cleaner includes a main body, a floor nozzle unit, and a float plate or float unit. The main body has a motor fan for generating a suction force and a dust-collection chamber for collecting dust. The motor fan provides the suction force to the dust collection chamber. The floor nozzle unit is disposed under the main body. The floor nozzle unit has an inlet port connected to the dust-collection chamber for attracting dust on a floor into the dust-collection chamber by the suction force of said motor fan. The float plate or float unit is disposed on a lower face of the floor nozzle unit. The float plate or float unit includes a floor opposing face where an outlet port is formed for spouting discharge air to the floor from the motor fan. The float face is located around the outlet port to receive a lifting force produced by pressure of the discharge air between the float face and the floor to be cleaned. The float unit has an elastic portion arranged on a lower portion of the float unit to contact a floor. Also, a pressure-regulating valve is provided for controlling the pressure of the discharge air so as to maintain the discharge air pressure under a predetermined safe pressure.
Abstract:
A radio communication apparatus comprising a modulating portion for modulating a carrier with a signal to transmit so as to produce a transmissible signal; a signal transmitting portion for transmitting the transmissible signal; a level adjusting portion for adjusting a level of the signal to transmit or a level of a control signal used for controlling the transmissible signal in accordance with digital control data supplied to the level adjusting portions; a memory for storing digital adjusting data; and a control unit for reading the digital adjusting data from the memory and supplying the level adjusting portion with the digital adjusting data read from the memory or modified digital adjusting data obtained based on the digital adjusting data read from the memory as the digital control data.