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公开(公告)号：US20190192288A1
公开(公告)日：2019-06-27
申请号：US16201800
申请日：2018-11-27
Applicant: Edwards Lifesciences Corporation
Inventor： Tamir S. Levi , Son V. Nguyen , Netanel Benichou , David Maimon , Ziv Yohanan , Nikolay Gurovich , Bella Felsen , Larisa Dadonkina , Ron Sharoni , Elena Sherman
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2220/0075 , A61F2230/0054 , A61F2250/0036 , A61F2250/0097
Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
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公开(公告)号：US10299923B2
公开(公告)日：2019-05-28
申请号：US16202980
申请日：2018-11-28
Applicant: Edwards Lifesciences Corporation
Inventor： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh A. Khanna , Son V. Nguyen , Tamir S. Levi , Itai Pelled
Abstract: A method of crimping an implantable prosthetic valve can include placing protective material over at least a portion of the implantable prosthetic valve. The protective material can be configured to occupy space between open cells of a frame of the implantable prosthetic valve to prevent damage to a leaflet structure of the implantable prosthetic valve. The method can also include crimping the implantable prosthetic valve with the protective material on the implantable prosthetic valve, and removing the protective material from between the frame and the leaflet structure of the implantable prosthetic valve.
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公开(公告)号：US10130468B2
公开(公告)日：2018-11-20
申请号：US15403458
申请日：2017-01-11
Applicant: Edwards Lifesciences Corporation
Inventor： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
Abstract: A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.
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公开(公告)号：US20180228606A1
公开(公告)日：2018-08-16
申请号：US15953991
申请日：2018-04-16
Applicant: Edwards Lifesciences Corporation
Inventor： David Alon , Netanel Benichou , Oded Meiri
CPC classification number: A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/9517 , A61F2002/9522 , A61F2002/9528 , A61F2002/9534 , A61F2210/0076 , A61F2220/005 , A61F2220/0075 , A61F2230/001 , A61F2230/0054 , A61F2230/0076 , A61F2250/0039
Abstract: Embodiments of the present disclosure provide methods of loading a prosthetic heart valve within a delivery apparatus such that it can be used for delivery of the prosthetic heart valve to a native valve site via the human vasculature. The methods can include attaching the prosthetic heart valve to a valve-retaining mechanism at a distal end of the catheter and causing a torque shaft of the delivery apparatus to rotate relative to the catheter, wherein the torque shaft extends within the catheter and is coupled to the valve delivery sheath. Rotation of the torque shaft relative to the catheter can cause relative longitudinal movement between the valve sheath and the prosthetic heart valve such that the prosthetic heart valve is covered by the valve sheath.
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公开(公告)号：US20180200055A1
公开(公告)日：2018-07-19
申请号：US15918240
申请日：2018-03-12
Applicant: Edwards Lifesciences Corporation
Inventor： David Alon , Netanel Benichou , Oded Meiri
CPC classification number: A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/9517 , A61F2002/9522 , A61F2002/9528 , A61F2002/9534 , A61F2210/0076 , A61F2220/005 , A61F2220/0075 , A61F2230/001 , A61F2230/0054 , A61F2230/0076 , A61F2250/0039
Abstract: Embodiments of the present disclosure provide a prosthetic heart valve usable with a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue. The prosthetic heart valve can have a curved shape that tapers inwardly from the inflow end to a reduced diameter section, increases in diameter from the reduced diameter section to an intermediate section, and then tapers from the intermediate section to the outflow end
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Patent Agency Ranking
公开(公告)号：US20180021127A1
公开(公告)日：2018-01-25
申请号：US15697740
申请日：2017-09-07
Applicant: Edwards Lifesciences Corporation
Inventor： Ziv Yohanan , Tamir S. Levi , Netanel Benichou , Michael Bukin , Nikolay Gurovich , Elena Sherman
IPC: A61F2/24
CPC classification number: A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2220/0075 , A61F2230/0013 , A61F2230/0054 , A61F2250/0036 , A61F2250/0039
Abstract: A prosthetic heart valve can comprise a radially collapsible and expandable annular frame and a leaflet structure comprising a plurality of leaflets mounted within the frame. The frame can have commissure attachment portions that are configured to support the commissures of the leaflets in unique ways. For example, commissure attachment portions can include at least two struts defining a gap therebetween. Additionaly, angularly-spaced commissure attachment portions can comprise inner struts and outer struts. Adjacent side portions of leaflets can extend through a gap between the inner struts of a corresponding commissure attachment portion. Further features and arrangements are also possible.
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公开(公告)号：US20170209265A1
公开(公告)日：2017-07-27
申请号：US15482555
申请日：2017-04-07
Applicant: Edwards Lifesciences Corporation
Inventor： Emil Karapetian , Maria Charles Vija Stanislaus , Gregory Bak-Boychuk , Christopher J. Olson , Cristobal R. Hernandez , William C. Brunnett , Netanel Benichou , Lauren R. Freschauf , Alexander J. Siegel
CPC classification number: A61F2/246 , A61F2/07 , A61F2/2409 , A61F2/2418 , A61F2/2436 , A61F2/2454 , A61F2/2466 , A61F2/88 , A61F2/91 , A61F2/958 , A61F2002/077 , A61F2002/825 , A61F2210/0061 , A61F2220/0016 , A61F2230/001 , A61F2230/0065 , A61F2230/0091 , A61F2250/0004 , A61F2250/0063
Abstract: This application relates to methods, systems, and apparatus for replacing native heart valves with prosthetic heart valves and treating valvular insufficiency. In a representative embodiment, a support frame configured to be implanted in a heart valve comprises an annular main body formed by a plurality of angled struts, the main body including a plurality of peaks formed by the intersection of respective adjacent struts. The support frame further comprises one or more leaflet-engaging mechanisms configured to engage leaflets of the heart valve. The support frame can be radially expandable and collapsible.
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公开(公告)号：US09662204B2
公开(公告)日：2017-05-30
申请号：US14483862
申请日：2014-09-11
Applicant: Edwards Lifesciences Corporation
Inventor： Ilia Hariton , Netanel Benichou , Yaacov Nitzan , Bella Felsen , Diana Nguyen-Thien-Nhon , Rajesh A. Khanna , Son V. Nguyen , Tamir S. Levi , Itai Pelled
CPC classification number: A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2475 , A61F2/95 , A61F2002/9522 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , Y10T29/49863
Abstract: An implantable prosthetic valve, according to one embodiment, comprises a frame, a leaflet structure, and a skirt member. The frame can have a plurality of axial struts interconnected by a plurality of circumferential struts. The leaflet structure comprises a plurality of leaflets (e.g., three leaflets arrange to form a tricuspid valve). The leaflet structure has a scalloped lower edge portion secured to the frame. The skirt member can be disposed between the leaflet structure and the frame.
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公开(公告)号：US09554903B2
公开(公告)日：2017-01-31
申请号：US14571141
申请日：2014-12-15
Applicant: Edwards Lifesciences Corporation
Inventor： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
CPC classification number: A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2445 , A61F2/90 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2220/0083 , A61F2230/0078 , A61F2250/006 , A61F2250/0098 , A61L27/3625
Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be expandable or a non-expandable type.
Abstract translation: 提供了可以在手术过程中快速且容易地植入的心脏瓣膜假体。 假体瓣膜包括部署在治疗部位的支撑结构。 假体瓣膜还包括构造成快速连接到支撑结构的阀构件。 支撑结构可以采取在天然瓣膜部位扩张的支架的形式。 如果需要，天然传单可以保留，并且支架可以用于保持天然瓣膜打开。 在这种情况下，支架可以是球囊可扩张的并且被配置为抵抗天然传单的强大后坐力。 支撑结构设置有用于附接到阀构件的联接装置，从而将阀构件的位置固定在主体中。 阀构件可以是可膨胀型或不可膨胀型。
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公开(公告)号：US09364325B2
公开(公告)日：2016-06-14
申请号：US14182169
申请日：2014-02-17
Applicant: Edwards Lifesciences Corporation
Inventor： David Alon , Netanel Benichou , Oded Meiri
CPC classification number: A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/9517 , A61F2002/9522 , A61F2002/9528 , A61F2002/9534 , A61F2210/0076 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076 , A61F2250/0039
Abstract: A method for delivering a self-expanding prosthetic heart valve comprises positioning the prosthetic heart valve in an annulus of a native heart valve while mounted in a radially compressed state in a delivery cylinder, the delivery cylinder coupled to a distal end portion of the torque shaft, and rotating a torque shaft coupled to the delivery cylinder. Rotating the torque shaft retracts the delivery cylinder, thereby exposing the prosthetic heart valve, allowing the prosthetic heart valve to self-expand in the native valve annulus. In some embodiments, the torque shaft is rotated by a motor disposed in a handle at a proximal end of the delivery device.
Abstract translation: 用于递送自膨胀假体心脏瓣膜的方法包括将假体心脏瓣膜定位在天然心脏瓣膜的环形空间中，同时以放射状压缩状态安装在输送圆筒中，输送圆筒联接到扭矩轴的远端部分 并且旋转联接到输送圆筒的扭矩轴。 旋转扭矩轴缩回输送缸，从而暴露假体心脏瓣膜，允许假体心脏瓣膜在天然瓣膜环中自扩张。 在一些实施例中，转矩轴由设置在输送装置的近端处的手柄中的电动机旋转。
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