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    Microorganisms for producing 1,4-butanediol and methods related thereto
    151.
    发明授权
    Microorganisms for producing 1,4-butanediol and methods related thereto 有权

    公开(公告)号：US11572564B2

    公开(公告)日：2023-02-07

    申请号：US15018736

    申请日：2016-02-08

    Applicant: Genomatica, Inc.

    Inventor： Wei Niu

    IPC: C12N15/52 ,  C12N9/02 ,  C12P7/16 ,  C12P7/18 ,  C12P7/42

    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.

    ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USE
    154.
    发明申请
    ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USE 有权

    公开(公告)号：US20220325254A1

    公开(公告)日：2022-10-13

    申请号：US17697504

    申请日：2022-03-17

    Applicant: Genomatica, Inc.

    Inventor： Kevin Hoff ,  Cara Ann Tracewell ,  Kui Chan ,  Amit Shah ,  Joseph Warner ,  Michael Noble

    IPC: C12N9/02

    Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

    OLIVETOLIC ACID CYCLASE VARIANTS AND METHODS FOR THEIR USE
    155.
    发明申请
    OLIVETOLIC ACID CYCLASE VARIANTS AND METHODS FOR THEIR USE 有权

    公开(公告)号：US20220315969A1

    公开(公告)日：2022-10-06

    申请号：US17616842

    申请日：2020-06-05

    Applicant: Genomatica Inc.

    Inventor： Michael Angus Noble ,  Russell Scott Komor

    IPC: C12P17/06 ,  C12N1/20 ,  C12N15/70 ,  C12N15/52 ,  C12P7/42

    Abstract: Described herein are olivetolic acid cyclases (OAC) including non-natural variants capable of forming a 2,4-dihydroxy-6-alkylbenzoic acid from a 3,5,7-trioxoacyl-CoA or a 3,5,7-trioxocarboxylate substrate. In some examples, the non-natural OAC is capable of forming a 2,4-dihydroxy-6-alkylbenzoic acid from a 3,5,7-trioxoacyl-CoA or a 3,5,7-trioxocarboxylate substrate at a greater rate. In some examples, the non-natural OAC has a higher affinity for a 3,5,7-trioxoacyl-CoA or a 3,5,7-trioxocarboxylate substrate, as compared to the wild type OAC. The non-natural OAC can be used with olivetol synthase (OLS) to form the 2,4-dihydroxy-6-alkylbenzoic acid from malonyl-CoA and acyl-CoA through to a 3,5,7-trioxoacyl-CoAintermediate. The non-natural OAC (and OLS) can be expressed in an engineered cell having a pathway to form cannabinoids, which include CBGA, its analogs and derivatives. CBGA can be used for the preparation of cannabigerol (CBG), which can be used in therapeutic compositions.

    1,3-Fatty Diol Compounds And Derivatives Thereof
    159.
    发明申请
    1,3-Fatty Diol Compounds And Derivatives Thereof 有权

    公开(公告)号：US20220098133A1

    公开(公告)日：2022-03-31

    申请号：US17494303

    申请日：2021-10-05

    Applicant: Genomatica, Inc.

    Inventor： Haibo WANG

    IPC: C07C33/035 ,  C07H15/10

    Abstract: The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and derivatives thereof which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc.

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