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公开(公告)号：US11209436B2
公开(公告)日：2021-12-28
申请号：US16799113
申请日：2020-02-24
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Marzia Giuliani , Elena Mori
IPC: A61K39/095 , C07K14/22 , C07K16/12 , G01N33/577 , G01N33/569
Abstract: The invention uses ELISA or similar assays for analysing a meningococcal vaccine. The assay uses antibodies which bind to meningococcal proteins within the vaccine, and in particular monoclonal antibodies which are bactericidal for meningococcus and/or which recognise conformational epitopes within the meningococcal proteins. By performing the assay on a series of dilutions of a test vaccine, and by comparing the results with those obtained using a reference vaccine of known potency, it is possible to determine the relative potency of the test vaccine. This value can be used as a parameter for determining whether a manufactured batch of a vaccine is suitable for release to the public, or whether it has experienced a production failure and so should not be used.
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公开(公告)号：US20210386846A1
公开(公告)日：2021-12-16
申请号：US17397379
申请日：2021-08-09
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Marie-Ange DEMOITIÉ , Marie-Noëlle DONNER , Nadia OUAKED
IPC: A61K39/04 , A61K35/761 , A61K39/12 , A61K39/39 , A61K45/00 , A61P31/06 , C07K14/005 , C07K14/35 , C12N7/00 , C12N15/85 , C12N15/86 , A61K9/00
Abstract: The present invention relates to methods for inducing an immune response, in particular methods for inducing an immune response against mycobacterial infections or disease comprising (i) at least one administration of a polypeptide Rv1196 related antigen and at least one administration of an adenovirus encoding a Rv1196 related antigen or (ii) at least one administration of a polypeptide Rv0125 related antigen and at least one administration of an adenovirus encoding a Rv0125 related antigen. Associated compositions, adenoviral constructs and polynucleotide sequences are also provided.
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公开(公告)号：US20210371440A1
公开(公告)日：2021-12-02
申请号：US17043549
申请日：2019-04-12
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Helene BAZIN-LEE
IPC: C07F9/6561 , A61K39/39 , C07D473/18
Abstract: The invention relates to a novel lipidated oxoadenine compound of formula (I) and its use as a vaccine adjuvant and as a TLR7 and/or TLR8 agonist.
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公开(公告)号：US20210269489A1
公开(公告)日：2021-09-02
申请号：US17314649
申请日：2021-05-07
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Kurt SWANSON , Andrea CARFI
IPC: C07K14/005 , A61K39/12 , A61K39/155
Abstract: The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.
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公开(公告)号：US20210268116A1
公开(公告)日：2021-09-02
申请号：US17320482
申请日：2021-05-14
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Roberto Adamo , Francesco Berti , Qi-Ying Hu
Abstract: This disclosure provides novel saccharide derivatives, conjugates, and methods for making the derivatives and conjugates.
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Patent Agency Ranking
公开(公告)号：US20210246468A1
公开(公告)日：2021-08-12
申请号：US16973630
申请日：2019-06-11
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Virginia AMMENDOLA , Stefania CAPONE , Stefano COLLOCA , Antonella FOLGORI , Rosella MERONE
Abstract: The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.
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167.发明申请公开(公告)号：US20210189422A1
公开(公告)日：2021-06-24
申请号：US16756380
申请日：2018-10-16
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Stefano COLLOCA
IPC: C12N15/86 , A61K39/235
Abstract: An adenoviral vector comprising two expression cassettes, wherein each expression cassette comprises a transgene and a promoter, and wherein each transgene encodes an RSV antigenic protein or a fragment thereof.
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公开(公告)号：US20210189420A1
公开(公告)日：2021-06-24
申请号：US16756373
申请日：2018-10-16
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Stefano COLLOCA
IPC: C12N15/86 , A61K39/155 , A61P37/04
Abstract: A new promoter comprising: (i) an hCMV enhancer sequence; (ii) an hCMV promoter sequence; (iii) a splice donor region; (iv) a cell-derived enhancer sequence; and (v) a splice acceptor region.
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公开(公告)号：US11026964B2
公开(公告)日：2021-06-08
申请号：US15691042
申请日：2017-08-30
Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
Inventor： Andrew Geall , Katrin Ramsauer , Gillis Otten , Christian Mandl
IPC: A61K31/7088 , A61K39/12 , C12N15/11 , A61K39/155 , A61K39/00
Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.
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公开(公告)号：US11021522B2
公开(公告)日：2021-06-01
申请号：US16458365
申请日：2019-07-01
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew Bottomley , Enrico Malito , Manuele Martinelli , Maria Scarselli
IPC: A61P37/04 , C07K14/22 , A61K39/095 , A61K39/00
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
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