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公开(公告)号：US09725497B2
公开(公告)日：2017-08-08
申请号：US14086250
申请日：2013-11-21
Applicant: Janssen Biotech, Inc.
Inventor： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC: C07K19/00 , C07K14/78 , A61K45/06 , C07K16/28 , C07K14/705 , C07K14/71 , C07K14/47 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US09695228B2
公开(公告)日：2017-07-04
申请号：US14085340
申请日：2013-11-20
Applicant: Janssen Biotech, Inc.
Inventor： Anderson Mark , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC: C07K16/46 , A61K39/395 , C07K14/78 , A61K45/06 , C07K16/28 , C07K14/705 , C07K14/71 , C07K14/47 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：US20170183630A1
公开(公告)日：2017-06-29
申请号：US15457956
申请日：2017-03-13
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
IPC: C12N5/071
Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.
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公开(公告)号：US09683046B2
公开(公告)日：2017-06-20
申请号：US14790144
申请日：2015-07-02
Applicant: Janssen Biotech, Inc.
Inventor： John Chen , Johan Fransson , Natalie Fursov , Damon Hamel , Thomas Malia , Galina Obmolova , Tatiana Ort , Michael Rycyzyn , Michael Scully , Raymond Sweet , Alexey Teplyakov , John Wheeler , Juan Carlos Almagro
CPC classification number: C07K16/2878 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
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公开(公告)号：US20170145090A1
公开(公告)日：2017-05-25
申请号：US15423189
申请日：2017-02-02
Applicant: Janssen Biotech, Inc.
Inventor： Juan Carlos Almagro , William DuBell , Johann Fransson , Jose Pardinas , Gopalan Raghunathan
IPC: C07K16/24
CPC classification number: C07K16/248 , A61K2039/505 , A61K2039/54 , C07H21/00 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/09
Abstract: Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.
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Patent Agency Ranking
公开(公告)号：US09644023B2
公开(公告)日：2017-05-09
申请号：US14565069
申请日：2014-12-09
Applicant: New York University , Janssen Biotech, Inc.
Inventor： Victor J. Torres , Randall J. Brezski , Anthony Lynch , William Strohl , Brian Whitaker , Mark Chiu , Peter T. Buckley , Keri Dorn , Michelle Kinder
IPC: C07K19/00 , C07K16/12 , G01N33/569
CPC classification number: C07K16/1271 , C07K14/78 , C07K2317/30 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2318/00 , C07K2319/70 , G01N33/56938 , G01N2469/10
Abstract: The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.
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公开(公告)号：US20170081378A1
公开(公告)日：2017-03-23
申请号：US15312027
申请日：2015-05-21
Inventor： C. Cheng KAO , Divyendu SINGH , Lani Rose SAN MATEO
CPC classification number: C07K14/4723 , A61K31/505 , A61K31/7036 , A61K31/704 , A61K38/1729 , A61K45/06 , A61K2300/00
Abstract: This disclosure is related to the peptide antagonist of LL-37, an antimicrobial peptide that has multiple functions in both innate and adaptive immune response. Specifically, the identified peptide antagonists of LL-37 provide inhibition to detrimental autoimmune inflammatory response, whereas at the same time retain LL-37's antibacterial activity.
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公开(公告)号：US20170080033A1
公开(公告)日：2017-03-23
申请号：US15366947
申请日：2016-12-01
Applicant: Janssen Biotech, Inc.
Inventor： Ian R. Harris , Jing Cao , Nadine Dejneka
CPC classification number: A61K35/51 , A61K9/0048 , A61K45/06
Abstract: Methods and compositions for treating and reducing retinal degeneration using progenitor cells and conditioned media from progenitor cells, such as postpartum-derived cells are disclosed. Trophic factors and other agents secreted by the progenitor cells that protect retinal cells and inhibit apoptosis of retinal cells such as photoreceptor cells are also disclosed.
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公开(公告)号：US09593310B2
公开(公告)日：2017-03-14
申请号：US14840297
申请日：2015-08-31
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
CPC classification number: C12N5/0676 , C12N2501/117 , C12N2501/119 , C12N2501/16 , C12N2501/385 , C12N2501/40 , C12N2501/41 , C12N2501/415 , C12N2501/70 , C12N2501/727 , C12N2506/02 , C12N2533/90
Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.
Abstract translation: 本发明提供促进多能干细胞分化成胰岛素生成细胞的方法。 特别地，本发明提供了一种产生表达特征性胰岛内分泌谱系特异性标志物的方法，其共表达NKX6.1和胰岛素和最小量的胰高血糖素。
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公开(公告)号：US20170058041A1
公开(公告)日：2017-03-02
申请号：US15345860
申请日：2016-11-08
Applicant: Janssen Biotech, Inc.
Inventor： Mark Cunningham , Yiqing Feng , Katharine Heeringa , Jinquan Luo , Robert Rauchenberger , Mark Rutz , Lani San Mateo , Robert Sarisky , Raymond Sweet , Fang Teng , Alexey Teplyakov , Sheng-Jiun Wu
IPC: C07K16/28
CPC classification number: C07K16/2896 , A61K39/39533 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N5/12 , C12N15/117 , C12N15/63 , C12N2310/17 , A61K39/00 , A61K2300/00
Abstract: Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
Abstract translation: 公开了Toll样受体3（TLR3）抗体拮抗剂，编码TLR3抗体拮抗剂或其片段的多核苷酸，以及制备和使用前述物质的方法。
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