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235 条记录 (耗时 0.06 秒)

    Method and apparatus for dependent coding in low-delay video compression
    161.
    发明授权
    Method and apparatus for dependent coding in low-delay video compression 有权
    低延迟视频压缩中依赖编码的方法和装置

    公开(公告)号：US07734106B1

    公开(公告)日：2010-06-08

    申请号：US11314628

    申请日：2005-12-21

    申请人： Rui Zhang ,  Jiangtao Wen

    发明人： Rui Zhang ,  Jiangtao Wen

    IPC分类号： G06K9/34 ,  G06K9/46

    CPC分类号： H04N19/119 ,  H04N19/124 ,  H04N19/147 ,  H04N19/17 ,  H04N19/176 ,  H04N19/521 ,  H04N19/61

    摘要： An apparatus comprising an encoder circuit and a storage circuit. The encoder circuit may be configured to generate a reliability score and a referral score for each partition in an input data stream. The input data stream may be encoded based upon the reliability score and the referral score for each partition. The storage circuit may be configured to store the reliability score for each partition of the input data stream.

    摘要翻译： 一种包括编码器电路和存储电路的装置。 编码器电路可以被配置为为输入数据流中的每个分区生成可靠性分数和推荐得分。 输入数据流可以基于每个分区的可靠性分数和推荐得分进行编码。 存储电路可以被配置为存储输入数据流的每个分区的可靠性分数。

    TECHNIQUE TO ENABLE EFFICIENT ADAPTIVE STREAMING AND TRANSCODING OF VIDEO AND OTHER SIGNALS
    163.
    发明申请
    TECHNIQUE TO ENABLE EFFICIENT ADAPTIVE STREAMING AND TRANSCODING OF VIDEO AND OTHER SIGNALS 有权
    实现有效自适应流动和视频和其他信号的转换技术

    公开(公告)号：US20100104025A1

    公开(公告)日：2010-04-29

    申请号：US12562583

    申请日：2009-09-18

    申请人： Kenneth Rose ,  Rui Zhang ,  Shankar Regunathan

    发明人： Kenneth Rose ,  Rui Zhang ,  Shankar Regunathan

    IPC分类号： H04N7/26

    CPC分类号： H04N21/2404 ,  H04N19/102 ,  H04N19/147 ,  H04N19/177 ,  H04N19/188 ,  H04N19/19 ,  H04N19/194 ,  H04N19/30 ,  H04N19/40 ,  H04N19/61 ,  H04N19/65 ,  H04N19/67 ,  H04N19/89 ,  H04N21/234 ,  H04N21/235 ,  H04N21/435 ,  H04N21/6377 ,  H04N21/6473 ,  H04N21/64769 ,  H04N21/658

    摘要： A method is described for efficiently determining total end-to-end distortion of a pre-compressed data stream, such as video streams or other media streams, at the time of delivery over a lossy-network, and for providing adaptive error-resilient delivery schemes based on distortion estimates. The methods can be utilized with single or multilayer packet streams and are particularly well suited for video streams. By way of example, distortion estimates are performed by generating side-information at the time of data stream compression, wherein the side-information is used in conjunction with information about the network status to determine an estimated distortion for the group of packets when the data stream is transported over the network to a destination end. This estimation may be utilized within described resiliency techniques in which the error correction mechanism is selected in response to the estimated distortion, which may be additionally refined in reference to cost factors.

    摘要翻译： 描述了一种用于在通过有损网络传送时有效地确定预压缩数据流（例如视频流或其他媒体流）的总端对端失真的方法，并且用于提供自适应的错误弹性传递 基于失真估计的方案。 这些方法可以用于单个或多个分组流，并且特别适合于视频流。 作为示例，通过在数据流压缩时生成旁侧信息来执行失真估计，其中，侧信息结合关于网络状态的信息使用，以确定数据组的估计失真 流通过网络传输到目的地端。 可以在所述的弹性技术中使用该估计，其中响应于估计的失真来选择纠错机制，这可以参考成本因素进一步细化。

    Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
    165.
    发明授权
    Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo 有权
    重组人EPO-Fc融合蛋白具有延长的半衰期和增强体内红细胞生成活性

    公开(公告)号：US07625564B2

    公开(公告)日：2009-12-01

    申请号：US11340661

    申请日：2006-01-27

    申请人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

    发明人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

    IPC分类号： A61K39/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： C07K14/505 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/6811 ,  C07K2317/53 ,  C07K2319/30

    摘要： A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.

    摘要翻译： 描述了包含与免疫球蛋白肽部分连接的人促红细胞生成素肽部分的重组融合蛋白。 与天然存在的或重组的天然人促红细胞生成素相比，融合蛋白在体内具有延长的半衰期。 在本发明的一个实施方案中，蛋白质的体内半衰期比天然人促红细胞生成素高至少三倍。 与天然人促红细胞生成素相比，融合蛋白也表现出增强的红细胞生物活性。 在一个实施方案中，融合蛋白包含人促红细胞生成素（EPO）分子的完整肽序列和人免疫球蛋白IgG1的Fc片段的肽序列。 融合蛋白中的Fc片段包括人免疫球蛋白IgG1的铰链区，CH2和CH3结构域。 EPO分子可以直接连接到Fc片段，以避免外来的肽接头并且当在体内施用时减轻免疫原性应答的风险。 在一个实施方案中，铰链区是在氨基酸6具有非半胱氨酸残基的人Fc片段变体。本发明还涉及编码融合蛋白和转染的细胞系的核酸和氨基酸序列以及用于产生融合蛋白的方法。 本发明还包括包含融合蛋白的药物组合物和使用融合蛋白和/或药物组合物的方法，例如刺激需要治疗的受试者的红细胞生成。

    Recombinant human interferon-like proteins
    166.
    发明授权
    Recombinant human interferon-like proteins 有权
    重组人干扰素样蛋白

    公开(公告)号：US07625555B2

    公开(公告)日：2009-12-01

    申请号：US11764786

    申请日：2007-06-18

    申请人： Haitao Wang ,  Chunsheng Mao ,  Jizhi Li ,  Jing Xu ,  Rui Zhang ,  Ling Wang ,  Yong Du ,  Longbin Liu

    发明人： Haitao Wang ,  Chunsheng Mao ,  Jizhi Li ,  Jing Xu ,  Rui Zhang ,  Ling Wang ,  Yong Du ,  Longbin Liu

    IPC分类号： A61K38/21 ,  C07K14/00 ,  C08H1/02 ,  C12P21/04 ,  C07H21/04 ,  A61K38/00

    CPC分类号： C07K14/56 ,  A61K38/00 ,  C07K14/555

    摘要： This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.

    摘要翻译： 本申请涉及重组人类干扰素样蛋白。 在一个实施方案中，与天然存在的人干扰素α2b（HuIFN-α2b）相比，描述了通过基因改组技术产生的重组蛋白质具有增强的抗病毒和抗增殖活性。 本发明包括编码蛋白质的多核苷酸和包含多核苷酸的重组载体和宿主细胞。 优选地，多核苷酸选自各自具有与SEQ ID：No.1至少93％相同的序列的多核苷酸，并且所述蛋白质选自蛋白质组，其各自具有与SEQ ID NO：至少85％相同的氨基酸序列 否：2.包含蛋白质的蛋白质和组合物可用于治疗对干扰素治疗（例如病毒性疾病和癌症）有反应的病症。

    Muitiforms suspension microgranular bioreactor and methods of use
    169.
    发明申请
    Muitiforms suspension microgranular bioreactor and methods of use 审中-公开
    木质悬浮微粒生物反应器及其使用方法

    公开(公告)号：US20090186350A1

    公开(公告)日：2009-07-23

    申请号：US12221051

    申请日：2008-07-30

    申请人： Gang Guo ,  Rui Zhang ,  Jingyu Zhang ,  Dongchun Liang ,  Baoli Wang ,  Bei Sun

    发明人： Gang Guo ,  Rui Zhang ,  Jingyu Zhang ,  Dongchun Liang ,  Baoli Wang ,  Bei Sun

    IPC分类号： C12Q1/68 ,  C40B40/00 ,  C12M1/34

    CPC分类号： G01N33/50 ,  G01N33/5308 ,  G01N33/54313 ,  G01N33/585 ,  G01N33/6803

    摘要： A Multiform Suspension Microgranular Bioreactor (MSMB) is used to detect nucleic acids or peptides/proteins in molecular and biological samples. Polymer-based microgranules, coupled with biomass molecule probes, are constructed with different features. The biomass molecule probes include cDNA probes, oligonucleic acid probes, peptide or protein probes. These microgranules are differentiated according to their features including shape, size, color, fluorescence intensity, magnetic property, gravity, chemical luminal intensity, radioactivity, and other labels. The above microgranules are suspended in a sample solution and are used collectively as a microarray-like bioreactor device. Such MSMB-based microarrays are particularly useful in complicated biological detection assays with flow cytometry.

    摘要翻译： 多元悬浮微粒生物反应器（MSMB）用于检测分子和生物样品中的核酸或肽/蛋白质。 与生物质分子探针结合的基于聚合物的微粒由不同的特征构成。 生物质分子探针包括cDNA探针，寡核酸探针，肽或蛋白质探针。 这些微粒根据其特征进行区分，包括形状，大小，颜色，荧光强度，磁性，重力，化学腔强度，放射性等标记。 将上述微粒悬浮在样品溶液中，并且一起用作微阵列样生物反应器装置。 这种基于MSMB的微阵列在用流式细胞术的复杂生物检测测定中特别有用。